ATE259369T1 - Neue geranylgeranylderivate, verfahren zu deren herstellung und entsprechende pharmazeutische zusammensetzungen - Google Patents

Neue geranylgeranylderivate, verfahren zu deren herstellung und entsprechende pharmazeutische zusammensetzungen

Info

Publication number
ATE259369T1
ATE259369T1 AT96941022T AT96941022T ATE259369T1 AT E259369 T1 ATE259369 T1 AT E259369T1 AT 96941022 T AT96941022 T AT 96941022T AT 96941022 T AT96941022 T AT 96941022T AT E259369 T1 ATE259369 T1 AT E259369T1
Authority
AT
Austria
Prior art keywords
pharmaceutical compositions
new
production
derivatives
corresponding pharmaceutical
Prior art date
Application number
AT96941022T
Other languages
English (en)
Inventor
Aldo Balsamo
Bruno Macchia
Marco Macchia
Massimo Baldacci
Romano Danesi
Tacca Mario Del
Original Assignee
Baldacci Lab Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baldacci Lab Spa filed Critical Baldacci Lab Spa
Application granted granted Critical
Publication of ATE259369T1 publication Critical patent/ATE259369T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3808—Acyclic saturated acids which can have further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C307/00—Amides of sulfuric acids, i.e. compounds having singly-bound oxygen atoms of sulfate groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C307/04—Diamides of sulfuric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C307/00—Amides of sulfuric acids, i.e. compounds having singly-bound oxygen atoms of sulfate groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C307/04—Diamides of sulfuric acids
    • C07C307/06—Diamides of sulfuric acids having nitrogen atoms of the sulfamide groups bound to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3808—Acyclic saturated acids which can have further substituents on alkyl
    • C07F9/3821—Acyclic saturated acids which can have further substituents on alkyl substituted by B, Si, P or a metal
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3826—Acyclic unsaturated acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT96941022T 1995-11-23 1996-11-21 Neue geranylgeranylderivate, verfahren zu deren herstellung und entsprechende pharmazeutische zusammensetzungen ATE259369T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT95MI002431A IT1276162B1 (it) 1995-11-23 1995-11-23 Geranilgeranil-derivati,procedimento per la loro preparazione e relative composizioni farmaceutiche
PCT/EP1996/005202 WO1997019091A1 (en) 1995-11-23 1996-11-21 Novel geranylgeranyl-derivatives, process for the preparation thereof and related pharmaceutical compositions

Publications (1)

Publication Number Publication Date
ATE259369T1 true ATE259369T1 (de) 2004-02-15

Family

ID=11372579

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96941022T ATE259369T1 (de) 1995-11-23 1996-11-21 Neue geranylgeranylderivate, verfahren zu deren herstellung und entsprechende pharmazeutische zusammensetzungen

Country Status (12)

Country Link
US (1) US6242433B1 (de)
EP (1) EP0862575B1 (de)
JP (1) JP2000500758A (de)
AT (1) ATE259369T1 (de)
AU (1) AU1031697A (de)
BR (1) BR9611642A (de)
CA (1) CA2238389C (de)
DE (1) DE69631542T2 (de)
ES (1) ES2216075T3 (de)
IT (1) IT1276162B1 (de)
PT (1) PT862575E (de)
WO (1) WO1997019091A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6117641A (en) 1996-04-11 2000-09-12 Mitotix, Inc. Assays and reagents for identifying anti-fungal agents and uses related thereto
US6727082B1 (en) 1996-04-11 2004-04-27 Gpc Biotech Inc. Assays and reagents for identifying anti-fungal agents, and uses related thereto
KR20000005397A (ko) 1996-04-11 2000-01-25 맨수리 무잠밀 엠 항-진균제를확인하기위한검정방법및시약,및이의용도
JP2002518448A (ja) * 1998-06-24 2002-06-25 メルク エンド カムパニー インコーポレーテッド 高血中コレステロールを治療する組成物および方法
FR2781228B1 (fr) * 1998-07-16 2000-09-29 Pf Medicament Phosphonates insatures derives d'indole
FR2833266B1 (fr) * 2001-12-11 2004-10-22 Mayoly Spindler Lab Nouveaux derives phosphonates, leur procede de preparation, leur utilisation comme modulateurs de l'activite des lymphocytes tgamma9 delta2
US20050065205A1 (en) * 2002-03-07 2005-03-24 Daniel Alkon Methods for Alzheimer's disease treatment and cognitive enhance
DE10242106A1 (de) * 2002-09-11 2004-04-15 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Phosphorgruppenhaltige Carbonsäurederivate mit organisch polymerisierbaren Gruppen
JP4691041B2 (ja) 2003-11-20 2011-06-01 チルドレンズ ホスピタル メディカル センター Ｇｔｐアーゼ阻害剤および使用方法
WO2007016539A2 (en) 2005-07-29 2007-02-08 Children's Hospital Medical Center Gtpase inhibitors and methods of use and crystal structure of rac-1 gtpase
US9980942B2 (en) 2012-05-02 2018-05-29 Children's Hospital Medical Center Rejuvenation of precursor cells
AU2013286683B2 (en) * 2012-07-05 2017-07-13 University Of Iowa Research Foundation Therapeutic bisphosphonates
US10028503B2 (en) 2014-06-18 2018-07-24 Children's Hospital Medical Center Platelet storage methods and compositions for same
CN114450027A (zh) 2019-08-16 2022-05-06 儿童医院医疗中心 用cdc42特异性抑制剂治疗受试者的方法
WO2021178850A1 (en) * 2020-03-06 2021-09-10 Board Of Trustees Of Michigan State University Method to produce the anti-microbial diterpenoid leubethanol and related serrulatane-type diterpenes
CN120484035B (zh) * 2025-07-16 2025-09-23 江西省林业科学院 一种山香圆叶中抑菌单体化合物的提取方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0356866A3 (de) 1988-08-29 1991-03-27 E.R. SQUIBB & SONS, INC. Phosphor enthaltende Squalen-Synthetase-Inhibitoren und Verfahren
US5254715A (en) 1990-11-07 1993-10-19 Warner-Lambert Company Aminosulfonyl carbamates
JPH05239075A (ja) 1991-08-27 1993-09-17 Eisai Co Ltd 含リンイソプレノイド誘導体
US5298655A (en) * 1991-09-27 1994-03-29 Merck & Co., Inc. Farnesyl pyrophosphate analogs
WO1994019357A1 (en) 1993-02-23 1994-09-01 Merrell Dow Pharmaceuticals Inc. Farnesyl:protein transferase inhibitors as anticancer agents
US5510510A (en) * 1994-05-10 1996-04-23 Bristol-Meyers Squibb Company Inhibitors of farnesyl protein transferase
US5574025A (en) 1994-10-26 1996-11-12 Merck & Co., Inc. Inhibitors of prenyl-protein transferases

Also Published As

Publication number Publication date
US6242433B1 (en) 2001-06-05
EP0862575B1 (de) 2004-02-11
AU1031697A (en) 1997-06-11
CA2238389A1 (en) 1997-05-29
ITMI952431A1 (it) 1997-05-23
ES2216075T3 (es) 2004-10-16
BR9611642A (pt) 1999-06-01
ITMI952431A0 (de) 1995-11-23
CA2238389C (en) 2005-10-18
DE69631542T2 (de) 2004-12-30
WO1997019091A1 (en) 1997-05-29
IT1276162B1 (it) 1997-10-27
PT862575E (pt) 2004-06-30
EP0862575A1 (de) 1998-09-09
DE69631542D1 (de) 2004-03-18
JP2000500758A (ja) 2000-01-25

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