IT1276162B1 - Geranilgeranil-derivati,procedimento per la loro preparazione e relative composizioni farmaceutiche - Google Patents
Geranilgeranil-derivati,procedimento per la loro preparazione e relative composizioni farmaceuticheInfo
- Publication number
- IT1276162B1 IT1276162B1 IT95MI002431A ITMI952431A IT1276162B1 IT 1276162 B1 IT1276162 B1 IT 1276162B1 IT 95MI002431 A IT95MI002431 A IT 95MI002431A IT MI952431 A ITMI952431 A IT MI952431A IT 1276162 B1 IT1276162 B1 IT 1276162B1
- Authority
- IT
- Italy
- Prior art keywords
- derivatives
- preparation
- pharmaceutical compositions
- geranylgeranil
- procedure
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 230000001028 anti-proliverative effect Effects 0.000 abstract 1
- 210000003527 eukaryotic cell Anatomy 0.000 abstract 1
- 125000002686 geranylgeranyl group Chemical group [H]C([*])([H])/C([H])=C(C([H])([H])[H])/C([H])([H])C([H])([H])/C([H])=C(C([H])([H])[H])/C([H])([H])C([H])([H])/C([H])=C(C([H])([H])[H])/C([H])([H])C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3808—Acyclic saturated acids which can have further substituents on alkyl
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C307/00—Amides of sulfuric acids, i.e. compounds having singly-bound oxygen atoms of sulfate groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C307/04—Diamides of sulfuric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C307/00—Amides of sulfuric acids, i.e. compounds having singly-bound oxygen atoms of sulfate groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C307/04—Diamides of sulfuric acids
- C07C307/06—Diamides of sulfuric acids having nitrogen atoms of the sulfamide groups bound to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3808—Acyclic saturated acids which can have further substituents on alkyl
- C07F9/3821—Acyclic saturated acids which can have further substituents on alkyl substituted by B, Si, P or a metal
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3826—Acyclic unsaturated acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Priority Applications (12)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT95MI002431A IT1276162B1 (it) | 1995-11-23 | 1995-11-23 | Geranilgeranil-derivati,procedimento per la loro preparazione e relative composizioni farmaceutiche |
| AT96941022T ATE259369T1 (de) | 1995-11-23 | 1996-11-21 | Neue geranylgeranylderivate, verfahren zu deren herstellung und entsprechende pharmazeutische zusammensetzungen |
| PT96941022T PT862575E (pt) | 1995-11-23 | 1996-11-21 | Novos derivados de geranilgeranilo processo para a sua preparacao e composicoes farmaceuticas relacionadas |
| EP96941022A EP0862575B1 (en) | 1995-11-23 | 1996-11-21 | Novel geranylgeranyl-derivatives, process for the preparation thereof and related pharmaceutical compositions |
| ES96941022T ES2216075T3 (es) | 1995-11-23 | 1996-11-21 | Nuevos derivados de geranilgeranilo, procedimiento para la preparacion de estos y composiciones farmaceuticas relacionadas. |
| DE69631542T DE69631542T2 (de) | 1995-11-23 | 1996-11-21 | Neue geranylgeranylderivate, verfahren zu deren herstellung und entsprechende pharmazeutische zusammensetzungen |
| US09/077,196 US6242433B1 (en) | 1995-11-23 | 1996-11-21 | Geranylgeranyl-derivatives, process for the preparation thereof and related pharmaceutical compositions |
| JP9519409A JP2000500758A (ja) | 1995-11-23 | 1996-11-21 | 新規なゲラニルゲラニル誘導体、その製造方法および関連する薬剤組成物 |
| CA002238389A CA2238389C (en) | 1995-11-23 | 1996-11-21 | Novel geranylgeranyl-derivatives, process for the preparation thereof and related pharmaceutical compositions |
| AU10316/97A AU1031697A (en) | 1995-11-23 | 1996-11-21 | Novel geranylgeranyl-derivatives, process for the preparation thereof and related pharmaceutical compositions |
| PCT/EP1996/005202 WO1997019091A1 (en) | 1995-11-23 | 1996-11-21 | Novel geranylgeranyl-derivatives, process for the preparation thereof and related pharmaceutical compositions |
| BR9611642A BR9611642A (pt) | 1995-11-23 | 1996-11-21 | Compostos composição farmacéutica e processo para a preparação de compostos |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT95MI002431A IT1276162B1 (it) | 1995-11-23 | 1995-11-23 | Geranilgeranil-derivati,procedimento per la loro preparazione e relative composizioni farmaceutiche |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| ITMI952431A0 ITMI952431A0 (it) | 1995-11-23 |
| ITMI952431A1 ITMI952431A1 (it) | 1997-05-23 |
| IT1276162B1 true IT1276162B1 (it) | 1997-10-27 |
Family
ID=11372579
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT95MI002431A IT1276162B1 (it) | 1995-11-23 | 1995-11-23 | Geranilgeranil-derivati,procedimento per la loro preparazione e relative composizioni farmaceutiche |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US6242433B1 (it) |
| EP (1) | EP0862575B1 (it) |
| JP (1) | JP2000500758A (it) |
| AT (1) | ATE259369T1 (it) |
| AU (1) | AU1031697A (it) |
| BR (1) | BR9611642A (it) |
| CA (1) | CA2238389C (it) |
| DE (1) | DE69631542T2 (it) |
| ES (1) | ES2216075T3 (it) |
| IT (1) | IT1276162B1 (it) |
| PT (1) | PT862575E (it) |
| WO (1) | WO1997019091A1 (it) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6117641A (en) | 1996-04-11 | 2000-09-12 | Mitotix, Inc. | Assays and reagents for identifying anti-fungal agents and uses related thereto |
| US6727082B1 (en) | 1996-04-11 | 2004-04-27 | Gpc Biotech Inc. | Assays and reagents for identifying anti-fungal agents, and uses related thereto |
| KR20000005397A (ko) | 1996-04-11 | 2000-01-25 | 맨수리 무잠밀 엠 | 항-진균제를확인하기위한검정방법및시약,및이의용도 |
| JP2002518448A (ja) * | 1998-06-24 | 2002-06-25 | メルク エンド カムパニー インコーポレーテッド | 高血中コレステロールを治療する組成物および方法 |
| FR2781228B1 (fr) * | 1998-07-16 | 2000-09-29 | Pf Medicament | Phosphonates insatures derives d'indole |
| FR2833266B1 (fr) * | 2001-12-11 | 2004-10-22 | Mayoly Spindler Lab | Nouveaux derives phosphonates, leur procede de preparation, leur utilisation comme modulateurs de l'activite des lymphocytes tgamma9 delta2 |
| US20050065205A1 (en) * | 2002-03-07 | 2005-03-24 | Daniel Alkon | Methods for Alzheimer's disease treatment and cognitive enhance |
| DE10242106A1 (de) * | 2002-09-11 | 2004-04-15 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Phosphorgruppenhaltige Carbonsäurederivate mit organisch polymerisierbaren Gruppen |
| JP4691041B2 (ja) | 2003-11-20 | 2011-06-01 | チルドレンズ ホスピタル メディカル センター | Ｇｔｐアーゼ阻害剤および使用方法 |
| WO2007016539A2 (en) | 2005-07-29 | 2007-02-08 | Children's Hospital Medical Center | Gtpase inhibitors and methods of use and crystal structure of rac-1 gtpase |
| US9980942B2 (en) | 2012-05-02 | 2018-05-29 | Children's Hospital Medical Center | Rejuvenation of precursor cells |
| AU2013286683B2 (en) * | 2012-07-05 | 2017-07-13 | University Of Iowa Research Foundation | Therapeutic bisphosphonates |
| US10028503B2 (en) | 2014-06-18 | 2018-07-24 | Children's Hospital Medical Center | Platelet storage methods and compositions for same |
| CN114450027A (zh) | 2019-08-16 | 2022-05-06 | 儿童医院医疗中心 | 用cdc42特异性抑制剂治疗受试者的方法 |
| WO2021178850A1 (en) * | 2020-03-06 | 2021-09-10 | Board Of Trustees Of Michigan State University | Method to produce the anti-microbial diterpenoid leubethanol and related serrulatane-type diterpenes |
| CN120484035B (zh) * | 2025-07-16 | 2025-09-23 | 江西省林业科学院 | 一种山香圆叶中抑菌单体化合物的提取方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0356866A3 (en) | 1988-08-29 | 1991-03-27 | E.R. SQUIBB & SONS, INC. | Phosphorus-containing squalene synthetase inhibitors and method |
| US5254715A (en) | 1990-11-07 | 1993-10-19 | Warner-Lambert Company | Aminosulfonyl carbamates |
| JPH05239075A (ja) | 1991-08-27 | 1993-09-17 | Eisai Co Ltd | 含リンイソプレノイド誘導体 |
| US5298655A (en) * | 1991-09-27 | 1994-03-29 | Merck & Co., Inc. | Farnesyl pyrophosphate analogs |
| WO1994019357A1 (en) | 1993-02-23 | 1994-09-01 | Merrell Dow Pharmaceuticals Inc. | Farnesyl:protein transferase inhibitors as anticancer agents |
| US5510510A (en) * | 1994-05-10 | 1996-04-23 | Bristol-Meyers Squibb Company | Inhibitors of farnesyl protein transferase |
| US5574025A (en) | 1994-10-26 | 1996-11-12 | Merck & Co., Inc. | Inhibitors of prenyl-protein transferases |
-
1995
- 1995-11-23 IT IT95MI002431A patent/IT1276162B1/it active IP Right Grant
-
1996
- 1996-11-21 ES ES96941022T patent/ES2216075T3/es not_active Expired - Lifetime
- 1996-11-21 PT PT96941022T patent/PT862575E/pt unknown
- 1996-11-21 AT AT96941022T patent/ATE259369T1/de not_active IP Right Cessation
- 1996-11-21 JP JP9519409A patent/JP2000500758A/ja active Granted
- 1996-11-21 CA CA002238389A patent/CA2238389C/en not_active Expired - Fee Related
- 1996-11-21 WO PCT/EP1996/005202 patent/WO1997019091A1/en not_active Ceased
- 1996-11-21 US US09/077,196 patent/US6242433B1/en not_active Expired - Fee Related
- 1996-11-21 EP EP96941022A patent/EP0862575B1/en not_active Expired - Lifetime
- 1996-11-21 BR BR9611642A patent/BR9611642A/pt not_active IP Right Cessation
- 1996-11-21 AU AU10316/97A patent/AU1031697A/en not_active Abandoned
- 1996-11-21 DE DE69631542T patent/DE69631542T2/de not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US6242433B1 (en) | 2001-06-05 |
| EP0862575B1 (en) | 2004-02-11 |
| AU1031697A (en) | 1997-06-11 |
| CA2238389A1 (en) | 1997-05-29 |
| ITMI952431A1 (it) | 1997-05-23 |
| ES2216075T3 (es) | 2004-10-16 |
| BR9611642A (pt) | 1999-06-01 |
| ITMI952431A0 (it) | 1995-11-23 |
| CA2238389C (en) | 2005-10-18 |
| DE69631542T2 (de) | 2004-12-30 |
| ATE259369T1 (de) | 2004-02-15 |
| WO1997019091A1 (en) | 1997-05-29 |
| PT862575E (pt) | 2004-06-30 |
| EP0862575A1 (en) | 1998-09-09 |
| DE69631542D1 (de) | 2004-03-18 |
| JP2000500758A (ja) | 2000-01-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 0001 | Granted |