ATE260912T1 - Oxazol ppar antagonisten - Google Patents

Oxazol ppar antagonisten

Info

Publication number: ATE260912T1
Authority: AT; Austria
Prior art keywords: agonist; lxr; propyl; ppar; formula
Prior art date: 1999-09-08

Application number

AT00959913T

Other languages

English (en)

Inventor

Jeffrey Edmond Cobb

Barry George Shearer

Original Assignee

Glaxo Group Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-09-08

Filing date

2000-09-01

Publication date

2004-03-15

2000-09-01 Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd

2004-03-15 Application granted granted Critical

2004-03-15 Publication of ATE260912T1 publication Critical patent/ATE260912T1/de

Links

102000003728 Peroxisome Proliferator-Activated Receptors Human genes 0.000 title abstract 3
108090000029 Peroxisome Proliferator-Activated Receptors Proteins 0.000 title abstract 3
239000005557 antagonist Substances 0.000 title abstract 3
ZCQWOFVYLHDMMC-UHFFFAOYSA-N Oxazole Chemical compound C1=COC=N1 ZCQWOFVYLHDMMC-UHFFFAOYSA-N 0.000 title 1
239000000556 agonist Substances 0.000 abstract 4
102100038495 Bile acid receptor Human genes 0.000 abstract 2
101000603876 Homo sapiens Bile acid receptor Proteins 0.000 abstract 2
HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 abstract 2
QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 abstract 2
OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 abstract 2
101150095442 Nr1h2 gene Proteins 0.000 abstract 2
QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 abstract 2
230000004913 activation Effects 0.000 abstract 2
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 2
HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 abstract 2
125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 abstract 2
102000004311 liver X receptors Human genes 0.000 abstract 2
108090000865 liver X receptors Proteins 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 abstract 2
102000005962 receptors Human genes 0.000 abstract 2
108020003175 receptors Proteins 0.000 abstract 2
OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 abstract 2
102000000536 PPAR gamma Human genes 0.000 abstract 1
108010016731 PPAR gamma Proteins 0.000 abstract 1
229940125388 beta agonist Drugs 0.000 abstract 1
239000002876 beta blocker Substances 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
229910052799 carbon Inorganic materials 0.000 abstract 1
238000007385 chemical modification Methods 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 abstract 1
238000009510 drug design Methods 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
239000012453 solvate Substances 0.000 abstract 1
229910052717 sulfur Inorganic materials 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Diabetes (AREA)
Public Health (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Obesity (AREA)
Hematology (AREA)
Endocrinology (AREA)
Emergency Medicine (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Child & Adolescent Psychology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

AT00959913T 1999-09-08 2000-09-01 Oxazol ppar antagonisten ATE260912T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US15276199P	1999-09-08	1999-09-08
US19996900P	2000-04-27	2000-04-27
PCT/US2000/024364 WO2001017994A1 (en)	1999-09-08	2000-09-01	Oxazole ppar antagonists

Publications (1)

Publication Number	Publication Date
ATE260912T1 true ATE260912T1 (de)	2004-03-15

Family

ID=26849844

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT00959913T ATE260912T1 (de)	1999-09-08	2000-09-01	Oxazol ppar antagonisten

Country Status (8)

Country	Link
US (1)	US6506781B1 (de)
EP (1)	EP1210345B1 (de)
JP (1)	JP2003508529A (de)
AT (1)	ATE260912T1 (de)
AU (1)	AU7115300A (de)
DE (1)	DE60008763T2 (de)
ES (1)	ES2215719T3 (de)
WO (1)	WO2001017994A1 (de)

Families Citing this family (54)

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ATE323674T1 (de) *	2001-08-29	2006-05-15	Warner Lambert Co	Orale antidiabetische wirkstoffe
BR0212512A (pt)	2001-09-14	2004-10-26	Tularik Inc	Composto, composição farmacêutica e métodos para tratar um distúrbio, condição ou doença, elevar os nìveis do colesterol hdl, reduzir os nìveis de triglicerìdeo, tratar diabete, diminuir a resistência à insulina ou diminuir a pressão arterial e modular a ppardelta
US7056906B2 (en)	2001-09-21	2006-06-06	Schering Corporation	Combinations of hormone replacement therapy composition(s) and sterol absorption inhibitor(s) and treatments for vascular conditions in post-menopausal women
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BR0312503A (pt) *	2002-07-09	2007-06-26	Bristol Myers Squibb Co	derivados heterocìclicos substituìdos úteis como agentes antidiabéticos e antiobesidade, composição farmacêutica, uso e combinação dos mesmos
US7137963B2 (en) *	2002-08-26	2006-11-21	Flowcardia, Inc.	Ultrasound catheter for disrupting blood vessel obstructions
WO2004024705A1 (ja)	2002-09-10	2004-03-25	Takeda Pharmaceutical Company Limited	５員複素環化合物
WO2004043457A1 (en)	2002-11-06	2004-05-27	Schering Corporation	Cholesterol absorptions inhibitors for the treatment of autoimmune disorders
AU2004207444B2 (en) *	2003-01-17	2008-07-31	Merck & Co., Inc.	N-cyclohexylaminocarbonyl benzenesulfonamide derivatives
JP2006518215A (ja) *	2003-01-22	2006-08-10	メルク　エンド　カムパニー　インコーポレーテッド	ペルオキシソーム増殖因子活性化受容体
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JP2006519869A (ja)	2003-03-07	2006-08-31	シェーリング　コーポレイション	置換アゼチジノン化合物、置換アゼチジノン化合物を調製するためのプロセス、それらの処方物および使用
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CN100436430C (zh) *	2004-05-24	2008-11-26	北京摩力克科技有限公司	作为hPPARα和hPPARγ激动剂的烷酰基取代的酪氨酸衍生物
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2000
- 2000-09-01 AT AT00959913T patent/ATE260912T1/de not_active IP Right Cessation
- 2000-09-01 EP EP00959913A patent/EP1210345B1/de not_active Expired - Lifetime
- 2000-09-01 WO PCT/US2000/024364 patent/WO2001017994A1/en not_active Ceased
- 2000-09-01 JP JP2001522217A patent/JP2003508529A/ja not_active Withdrawn
- 2000-09-01 DE DE60008763T patent/DE60008763T2/de not_active Expired - Fee Related
- 2000-09-01 AU AU71153/00A patent/AU7115300A/en not_active Abandoned
- 2000-09-01 ES ES00959913T patent/ES2215719T3/es not_active Expired - Lifetime
- 2000-09-01 US US10/070,474 patent/US6506781B1/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
AU7115300A (en)	2001-04-10
WO2001017994A1 (en)	2001-03-15
ES2215719T3 (es)	2004-10-16
JP2003508529A (ja)	2003-03-04
EP1210345B1 (de)	2004-03-03
DE60008763T2 (de)	2005-02-10
US6506781B1 (en)	2003-01-14
EP1210345A1 (de)	2002-06-05
DE60008763D1 (de)	2004-04-08

Legal Events

Date	Code	Title	Description
2004-09-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE60008763D1 (de)	2004-04-08	Oxazol ppar antagonisten
DK1173433T3 (da)	2006-05-15	Cyanopyrroler som progesteronreceptoragonister
HUP0303339A2 (hu)	2004-01-28	Heteroaril-karbamid neuropeptid Y Y5 receptor antagonisták, alkalmazásuk és ezeket tartalmazó gyógyszerkészítmények
ATE401066T1 (de)	2008-08-15	Methoden zur behandlung der essstörungen
NO20003671L (no)	2000-09-18	4-(2-keto-1-benzimidazolinyl)piperidin-forbindelser som orl1- reseptor agonister
MY141559A (en)	2010-05-14	Triazole derivatives as tachykinin receptor antagonists
JP2004532209A5 (de)	2005-12-22
CO5611063A2 (es)	2006-02-28	Pirazolilcarboxanilidas disubstituidas
DE69619479D1 (de)	2002-04-04	Azaheterocyclische Tachykinin Rezeptor Antagoniste; NK1 und NK2
RU2007121850A (ru)	2008-12-20	Производные фосфонооксихиназолина и их фармацевтическое применение
BR9508292A (pt)	1997-12-23	Processos para a sintese enãncio-seletiva de um composto,(-)-5-metóxi-2[[(4-metóxi-3,5-dimetil-2-piridinil) metil]sulfinil]-1h-benzimidazol,(+)-5-fluoro-2-(((4-ciclopropilmetóxi-2-piridinil) metil) sulfinil)-1h-benzimidazol,(-)-5-fluoro-2-(((4-ciclopropilmetóxi-2-piridinil) metil) sulfinil)-1h-benzimidazol,(-)-5-fluoro-2-(((4-ciclopropilmetóxi-2-piridinil) metil) sulfinil)-1h-benzimidazol,(-)-5-carbometóxi-6-metil-2-[[(3,4-dimetóxi-2-piridinil) metil] sulfinil]-1h-benzimidazol,(+)-5-carbometóxi-6-metil-2-[[(3,4-dimetóxi-2-piridinil) metil] sulfinil]-1h benzimidazol composto e uso dos compostos
DE60218703D1 (de)	2007-04-19	(-)-1-(3,4-dichlorphenyl)-3-azabicyclo ä3.1.0ühexan, zusammensetzungen davon und verwendung als dopamin-wiederaufnahme-hemmer
ATE496620T1 (de)	2011-02-15	1h-benzo(f)indazol-5-yl-derivate als selektive glucocorticoid-rezeptor-modulatoren
UA72917C2 (en)	2005-05-16	Cyclic carbamates derivatives, pharmaceutical composition containing said derivatives of cyclic carbamates and active ingredients as modulators of the progesterone receptor
HRP20080226T3 (en)	2008-06-30	Quinoline and quinazoline derivatives having affinity for 5ht1-type receptors
SE9900274D0 (sv)	1999-01-28	New compound
WO2004013101A3 (fr)	2004-05-13	Derives de n-[phenyl(piperidin-2-yl)methyl]benzamide, leur preparation et leur application en therapeutique
DE60007347D1 (de)	2004-01-29	Isoxazolcarboxamid-derivate als antagonisten des alpha1-adrenergischen rezeptors
PE20011212A1 (es)	2001-11-21	Compuestos para el tratamiento de la fibromialgia y el sindrome de fatiga cronica
NO992226L (no)	1999-05-27	Nye forbindelser for anvendelse som neuro-protektive midler
MXPA04002495A (es)	2004-05-31	Compuestos de imidazopiridin como moduladores del receptor 5-ht4.
DK1487424T3 (da)	2007-01-08	4-(4-Methylpiperazin-1-ylmethyl)-N-(4-methyl-3-(4-pyridin-3-yl)-pyrimidin-2-yl-amino)phenyl-benzamid til behandling af Ang II-medierede sygdomme
NO20014855D0 (no)	2001-10-05	N-(2-fenyl-4-aminobutyl)-1-naftamider som neurokinin-1- reseptorantagonister
ATE366572T1 (de)	2007-08-15	5-ht 1b/1d rezeptor agonisten zur behandlung von kopfschmerz der aus der verabreichung von endothelin rezeptor antagonisten resultiert
ATE206419T1 (de)	2001-10-15	N-benzensulfonyl-l-prolinderivate als bradykininrezeptor b2 antagonisten