ATE206419T1 - N-benzensulfonyl-l-prolinderivate als bradykininrezeptor b2 antagonisten - Google Patents

N-benzensulfonyl-l-prolinderivate als bradykininrezeptor b2 antagonisten

Info

Publication number: ATE206419T1
Authority: AT; Austria
Prior art keywords: group; pct; benzenesulfonyl; antagonists; date jan
Prior art date: 1996-07-24

Application number

AT97935612T

Other languages

English (en)

Inventor

Pierre Dodey

Michel Bondoux

Patrick Houziaux

Martine Barth

Khan Ou

Original Assignee

Fournier Ind & Sante

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-07-24

Filing date

1997-07-23

Publication date

2001-10-15

1997-07-23 Application filed by Fournier Ind & Sante filed Critical Fournier Ind & Sante

2001-10-15 Application granted granted Critical

2001-10-15 Publication of ATE206419T1 publication Critical patent/ATE206419T1/de

Links

239000005557 antagonist Substances 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 2
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 1
125000006274 (C1-C3)alkoxy group Chemical group 0.000 abstract 1
101800004538 Bradykinin Proteins 0.000 abstract 1
QXZGBUJJYSLZLT-UHFFFAOYSA-N H-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-OH Natural products NC(N)=NCCCC(N)C(=O)N1CCCC1C(=O)N1C(C(=O)NCC(=O)NC(CC=2C=CC=CC=2)C(=O)NC(CO)C(=O)N2C(CCC2)C(=O)NC(CC=2C=CC=CC=2)C(=O)NC(CCCN=C(N)N)C(O)=O)CCC1 QXZGBUJJYSLZLT-UHFFFAOYSA-N 0.000 abstract 1
102100035792 Kininogen-1 Human genes 0.000 abstract 1
125000000320 amidine group Chemical group 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
QXZGBUJJYSLZLT-FDISYFBBSA-N bradykinin Chemical compound NC(=N)NCCC[C@H](N)C(=O)N1CCC[C@H]1C(=O)N1[C@H](C(=O)NCC(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CO)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)CCC1 QXZGBUJJYSLZLT-FDISYFBBSA-N 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical group 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
230000001225 therapeutic effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Pain & Pain Management (AREA)
Engineering & Computer Science (AREA)
Neurosurgery (AREA)
Diabetes (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Endocrinology (AREA)
Rheumatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Pyrrole Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

AT97935612T 1996-07-24 1997-07-23 N-benzensulfonyl-l-prolinderivate als bradykininrezeptor b2 antagonisten ATE206419T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR9609327A FR2751650B1 (fr)	1996-07-24	1996-07-24	Nouveaux composes de n-benzenesulfonyl-l-proline, procede de preparation et utilisation en therapeutique
PCT/FR1997/001377 WO1998003503A1 (fr)	1996-07-24	1997-07-23	Derives de n-benzenesulfonyl-l-proline en tant qu'agonistes de la bradykinine b2

Publications (1)

Publication Number	Publication Date
ATE206419T1 true ATE206419T1 (de)	2001-10-15

Family

ID=9494439

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT97935612T ATE206419T1 (de)	1996-07-24	1997-07-23	N-benzensulfonyl-l-prolinderivate als bradykininrezeptor b2 antagonisten

Country Status (14)

Country	Link
US (1)	US6071917A (de)
EP (1)	EP0925295B1 (de)
JP (1)	JP2000514818A (de)
AT (1)	ATE206419T1 (de)
AU (1)	AU3853697A (de)
CA (1)	CA2261743A1 (de)
DE (1)	DE69707141T2 (de)
DK (1)	DK0925295T3 (de)
ES (1)	ES2167768T3 (de)
FR (1)	FR2751650B1 (de)
PL (1)	PL186396B1 (de)
PT (1)	PT925295E (de)
TR (1)	TR199900096T2 (de)
WO (1)	WO1998003503A1 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2765222B1 (fr) *	1997-06-27	1999-12-31	Fournier Ind & Sante	Nouveaux composes de n-benzenesulfonyl-l-proline, procede de preparation et utilisation en therapeutique
KR100579792B1 (ko)	1998-05-13	2006-05-12	동화약품공업주식회사	신규 2,5-피리딘디카복실산 유도체
FR2790260B1 (fr) *	1999-02-26	2001-05-04	Fournier Ind & Sante	Nouveaux composes de n-(benzenesulfonamide), procede de preparation et utilisation en therapeutique
CA2364178C (en) *	2000-12-05	2006-01-10	Yasuhiro Katsu	N-benzenesulfonyl l-proline compounds as bradykinin antagonists
FR2819254B1 (fr) *	2001-01-08	2003-04-18	Fournier Lab Sa	Nouveaux composes de la n-(phenylsulfonyl) glycine, leur procede de preparation et leur utilisation pour obtenir des compostions pharmaceutiques
EP1914236A1 (de)	2002-04-10	2008-04-23	Ortho-McNeil Pharmaceutical, Inc.	Neue Heteroaryl-Alkylamid-Derivate als Bradykininrezeptormodulatoren
ITMI20021247A1 (it)	2002-06-07	2003-12-09	Menarini Ricerche Spa	Antagonisti basici non peptidici della bradichinina e loro impiego informulazioni farmaceutiche
FR2840897B1 (fr) *	2002-06-14	2004-09-10	Fournier Lab Sa	Nouveaux derives d'arylsulfonamides et leur utilisation en therapeutique
DE10304994A1 (de) *	2003-02-07	2004-09-02	Aventis Pharma Deutschland Gmbh	Die Verwendung von Antagonisten des Bradykinin-B2 Rezeptors zur Behandlung von Osteoarthrose
WO2004087700A1 (fr)	2003-03-25	2004-10-14	Laboratoires Fournier S.A.	Derives du benzenesulfonamide, leur procede de preparation et leur utilisation de la douleur
DE102005013967A1 (de) *	2004-11-05	2006-10-05	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Neue Bradykinin-B1-Antagonisten, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel
WO2025124698A1 (en)	2023-12-12	2025-06-19	Idorsia Pharmaceuticals Ltd	Aryl sulfone and sulfanone derivatives as orexin receptor modulators
WO2025132542A1 (en)	2023-12-19	2025-06-26	Idorsia Pharmaceuticals Ltd	Macrocyclic orexin agonists

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3617183A1 (de) *	1985-11-16	1987-05-27	Bayer Ag	Substituierte benzylether
DE3632329A1 (de) *	1986-09-24	1988-03-31	Bayer Ag	Substituierte phenylsulfonamide
AU686115B2 (en) *	1992-11-02	1998-02-05	Fujisawa Pharmaceutical Co., Ltd.	Imidazo (I,2-a) pyridine derivatives as bradykinin antagonists, pharmaceuticals and processes for their preparation
AU680870B2 (en) *	1993-04-28	1997-08-14	Astellas Pharma Inc.	New heterocyclic compounds
KR970707098A (ko) *	1994-10-27	1997-12-01	후지야마 아키라	브라디키닌 길항제로서 피리도피리미돈, 퀴놀린 및 융합된 N-헤테로사이클(Pyridopyrimidones, quinolines and fused N-heterocycles as bradykinin antagonists)
FR2735128B1 (fr) *	1995-06-07	1997-07-25	Fournier Ind & Sante	Nouveaux composes de benzenesulfonamide, leur procede de preparation et utilisation en therapeutique.
FR2737892B1 (fr) *	1995-08-17	1997-10-24	Fournier Ind & Sante	Nouveaux composes de benzenesulfonamide, procede de preparation et utilisation en therapeutique
FR2743073B1 (fr) *	1995-12-29	1998-02-20	Fournier Ind & Sante	Nouveaux composes de 1-benzenesulfonylpyrrolidine, procede de preparation et utilisation en therapeutique

1996
- 1996-07-24 FR FR9609327A patent/FR2751650B1/fr not_active Expired - Fee Related
1997
- 1997-07-23 PL PL97331347A patent/PL186396B1/pl not_active IP Right Cessation
- 1997-07-23 WO PCT/FR1997/001377 patent/WO1998003503A1/fr not_active Ceased
- 1997-07-23 TR TR1999/00096T patent/TR199900096T2/xx unknown
- 1997-07-23 ES ES97935612T patent/ES2167768T3/es not_active Expired - Lifetime
- 1997-07-23 DE DE69707141T patent/DE69707141T2/de not_active Expired - Fee Related
- 1997-07-23 CA CA002261743A patent/CA2261743A1/en not_active Abandoned
- 1997-07-23 AU AU38536/97A patent/AU3853697A/en not_active Abandoned
- 1997-07-23 PT PT97935612T patent/PT925295E/pt unknown
- 1997-07-23 EP EP97935612A patent/EP0925295B1/de not_active Expired - Lifetime
- 1997-07-23 DK DK97935612T patent/DK0925295T3/da active
- 1997-07-23 US US09/230,334 patent/US6071917A/en not_active Expired - Fee Related
- 1997-07-23 AT AT97935612T patent/ATE206419T1/de not_active IP Right Cessation
- 1997-07-23 JP JP10506663A patent/JP2000514818A/ja active Pending

Also Published As

Publication number	Publication date
FR2751650B1 (fr)	1998-10-09
FR2751650A1 (fr)	1998-01-30
TR199900096T2 (xx)	1999-03-22
WO1998003503A1 (fr)	1998-01-29
DK0925295T3 (da)	2002-01-28
DE69707141D1 (de)	2001-11-08
PL331347A1 (en)	1999-07-05
JP2000514818A (ja)	2000-11-07
US6071917A (en)	2000-06-06
AU3853697A (en)	1998-02-10
PT925295E (pt)	2002-03-28
EP0925295B1 (de)	2001-10-04
ES2167768T3 (es)	2002-05-16
EP0925295A1 (de)	1999-06-30
DE69707141T2 (de)	2002-06-27
CA2261743A1 (en)	1998-01-29
PL186396B1 (pl)	2004-01-30

Legal Events

Date	Code	Title	Description
2002-03-15	UEP	Publication of translation of european patent specification
2005-04-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
MY133223A (en)	2007-10-31	Neuropeptide y5 receptor antagonists
ATE206419T1 (de)	2001-10-15	N-benzensulfonyl-l-prolinderivate als bradykininrezeptor b2 antagonisten
DE69831937D1 (de)	2006-03-02	Bicyclische protein-farnesyl-transferase inhibitoren
DK1173433T3 (da)	2006-05-15	Cyanopyrroler som progesteronreceptoragonister
ATE401311T1 (de)	2008-08-15	Kondensierte heterozyklische verbindungen als petidase inhibitoren
DK0590919T3 (da)	2000-04-17	Terapeutiske midler mod Parkinsons sygdom
AP2003002720A0 (en)	2003-06-30	Carboxamide compounds and their use as antagonists of a human 11 CBY receptor.
DE69719350D1 (de)	2003-04-03	2-pyrimidinamin derivaten und verfahrens zu deren herstellung
DE69433984D1 (de)	2004-10-14	Arylpiperazinderivate von indol als liganden der rezeptoren 5 ht1-like, 5 ht1b und 5 ht1d
NO20001514L (no)	2000-03-23	Vitronectin-reseptor-antagonist
ATE219481T1 (de)	2002-07-15	1,7,7-trimethyl-bicyclo(2.2.1)heptane derivative
PT944618E (pt)	2004-02-27	Novos compostos de n-benzenossulfonilo-1-prolina processo de preparacao e utilizacao em terapia
DE60144246D1 (de)	2011-04-28	Imidazolderivate, verfahren zu deren herstellung und deren verwendung
MX9703671A (es)	1997-12-31	Compuesto de aminometil arilo y ligandos selectivos del subtipo de receptor de la dopamina.
NO953913D0 (no)	1995-10-02	Perhydroisoindolderivater, deres fremstilling samt farmasöytiske preparater inneholdende derivatene
DE60000405D1 (de)	2002-10-10	1,4-disubstitutierte cyclohexanderivate zur behandlung von depression
ATE154601T1 (de)	1997-07-15	4-amino-2-(hetero)aryl-butanamide verwenbar als 5-ht1a-antagonisten
ATE200673T1 (de)	2001-05-15	1,9-diazabicyclo(4.3.0)nona-3,8-dienderivate
EP0313311A3 (de)	1990-03-07	Herbizide Sulfonamide
ATE262522T1 (de)	2004-04-15	Benzimidazolverbindungen
ES2056025A1 (es)	1994-09-16	Nuevos derivados de indol.
ATE227718T1 (de)	2002-11-15	N-aryloxyethyl-indolyl-alkylamine zur behandlung von depressionen