ATE260923T1 - Verfahren zur herstellung von 7-amino-3- methoxymethyl-3-cephem-4-carbonsäure - Google Patents

Verfahren zur herstellung von 7-amino-3- methoxymethyl-3-cephem-4-carbonsäure

Info

Publication number: ATE260923T1
Authority: AT; Austria
Prior art keywords: cephem; methoxymethyl; amino; producing; carbonic acid
Prior art date: 1999-10-13

Application number

AT00970265T

Other languages

English (en)

Inventor

Gwan Sun Lee

Jae Heon Lee

Young Kil Chang

Chul Hyun Park

Gha Seung Park

Cheol Kyung Jugong Kim

Wabu-Eup

Original Assignee

Hanmi Pharm Ind Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-10-13

Filing date

2000-10-13

Publication date

2004-03-15

2000-10-13 Application filed by Hanmi Pharm Ind Co Ltd filed Critical Hanmi Pharm Ind Co Ltd

2004-03-15 Application granted granted Critical

2004-03-15 Publication of ATE260923T1 publication Critical patent/ATE260923T1/de

Links

238000004519 manufacturing process Methods 0.000 title 1
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 abstract 2
BDSDFCVDQUGOFB-XNCJUZBTSA-N (6s,7s)-7-amino-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid Chemical compound S1CC(COC)=C(C(O)=O)N2C(=O)[C@H](N)[C@H]12 BDSDFCVDQUGOFB-XNCJUZBTSA-N 0.000 abstract 1
HSHGZXNAXBPPDL-HZGVNTEJSA-N 7beta-aminocephalosporanic acid Chemical compound S1CC(COC(=O)C)=C(C([O-])=O)N2C(=O)[C@@H]([NH3+])[C@@H]12 HSHGZXNAXBPPDL-HZGVNTEJSA-N 0.000 abstract 1
229940098779 methanesulfonic acid Drugs 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
WRECIMRULFAWHA-UHFFFAOYSA-N trimethyl borate Chemical compound COB(OC)OC WRECIMRULFAWHA-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/22—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with radicals containing only hydrogen and carbon atoms, attached in position 3
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Cephalosporin Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

AT00970265T 1999-10-13 2000-10-13 Verfahren zur herstellung von 7-amino-3- methoxymethyl-3-cephem-4-carbonsäure ATE260923T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
KR1019990044322A KR100343434B1 (ko)	1999-10-13	1999-10-13	7-아미노-3-메톡시메틸-3-세펨-4-카복실산의 제조방법
PCT/KR2000/001144 WO2001027117A1 (en)	1999-10-13	2000-10-13	Process for preparing 7-amino-3-methoxymethyl-3-cephem-4-carboxylic acid

Publications (1)

Publication Number	Publication Date
ATE260923T1 true ATE260923T1 (de)	2004-03-15

Family

ID=19615184

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT00970265T ATE260923T1 (de)	1999-10-13	2000-10-13	Verfahren zur herstellung von 7-amino-3- methoxymethyl-3-cephem-4-carbonsäure

Country Status (14)

Country	Link
US (1)	US6620930B1 (de)
EP (1)	EP1220859B1 (de)
JP (1)	JP3860750B2 (de)
KR (1)	KR100343434B1 (de)
CN (1)	CN1148371C (de)
AT (1)	ATE260923T1 (de)
AU (1)	AU755155B2 (de)
BR (1)	BR0014727A (de)
CA (1)	CA2387223A1 (de)
DE (1)	DE60008772T2 (de)
ES (1)	ES2213615T3 (de)
IL (1)	IL148978A0 (de)
TR (1)	TR200200995T2 (de)
WO (1)	WO2001027117A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IN192344B (de) *	2001-01-30	2004-04-10	Ranbaxy Lab Ltd
EP1587374A4 (de)	2002-06-26	2007-03-28	Ctb Inc	Geflügelfütterungsvorrichtung
CN102746322B (zh) *	2012-07-20	2015-06-17	山东睿鹰先锋制药有限公司	头孢中间体7-氨基-3-甲氧甲基-2-头孢烯-2-羧酸的制备方法
EP3426663B1 (de)	2016-03-07	2020-01-29	Dhanuka Laboratories Ltd.	Verfahren zur alkylierung der hydroxymethylgruppe an position -3 von cephalosporinen
KR101808192B1 (ko) *	2016-08-26	2018-01-18	아미코젠주식회사	7-아미노세팔로스포란산의 고농도 생산 재조합 아크레모니움 크리소제눔 균주의 제조방법 및 이 방법으로 제조된 균주
CN109956958B (zh) *	2019-04-02	2020-06-16	河北合佳医药科技集团股份有限公司	一种7-氨基-3-甲氧基甲基-3-头孢烯-4-羧酸合成方法
CN112480144A (zh) *	2020-12-07	2021-03-12	湖北凌晟药业有限公司	一种7-氨基-3-甲氧甲基-3-头孢烯-4-羧酸的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5896091A (ja) *	1981-12-01	1983-06-07	Sankyo Co Ltd	３−アルコキシメチルセフアロスポリン類の製造法
JP2612493B2 (ja) *	1988-05-24	1997-05-21	旭化成工業株式会社	３―置換メチル―３―セフェム―４―カルボン酸類の製造方法
DK0485204T3 (da) *	1990-11-07	1995-10-16	Sankyo Co	Fremgangsmåde til fremstilling af 3-alkoxymethyl-cephalosporin-derivater
JP3302417B2 (ja) *	1992-11-11	2002-07-15	三共有機合成株式会社	３−アルコキシメチル−セファロスポリン誘導体の製造法

1999
- 1999-10-13 KR KR1019990044322A patent/KR100343434B1/ko not_active Expired - Fee Related
2000
- 2000-10-13 EP EP00970265A patent/EP1220859B1/de not_active Expired - Lifetime
- 2000-10-13 AU AU79667/00A patent/AU755155B2/en not_active Ceased
- 2000-10-13 ES ES00970265T patent/ES2213615T3/es not_active Expired - Lifetime
- 2000-10-13 CN CNB008123470A patent/CN1148371C/zh not_active Expired - Fee Related
- 2000-10-13 BR BR0014727-3A patent/BR0014727A/pt not_active IP Right Cessation
- 2000-10-13 US US10/110,162 patent/US6620930B1/en not_active Expired - Lifetime
- 2000-10-13 WO PCT/KR2000/001144 patent/WO2001027117A1/en not_active Ceased
- 2000-10-13 IL IL14897800A patent/IL148978A0/xx unknown
- 2000-10-13 DE DE60008772T patent/DE60008772T2/de not_active Expired - Lifetime
- 2000-10-13 AT AT00970265T patent/ATE260923T1/de not_active IP Right Cessation
- 2000-10-13 TR TR2002/00995T patent/TR200200995T2/xx unknown
- 2000-10-13 JP JP2001530335A patent/JP3860750B2/ja not_active Expired - Fee Related
- 2000-10-13 CA CA002387223A patent/CA2387223A1/en not_active Abandoned

Also Published As

Publication number	Publication date
TR200200995T2 (tr)	2002-06-21
CN1377359A (zh)	2002-10-30
ES2213615T3 (es)	2004-09-01
AU755155B2 (en)	2002-12-05
DE60008772D1 (de)	2004-04-08
CN1148371C (zh)	2004-05-05
DE60008772T2 (de)	2004-07-29
KR100343434B1 (ko)	2002-07-11
EP1220859A1 (de)	2002-07-10
BR0014727A (pt)	2002-06-25
CA2387223A1 (en)	2001-04-19
JP3860750B2 (ja)	2006-12-20
KR20010037039A (ko)	2001-05-07
WO2001027117A1 (en)	2001-04-19
AU7966700A (en)	2001-04-23
IL148978A0 (en)	2002-11-10
EP1220859B1 (de)	2004-03-03
EP1220859A4 (de)	2003-04-02
US6620930B1 (en)	2003-09-16
JP2003511455A (ja)	2003-03-25

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Legal Events

Date	Code	Title	Description
2004-09-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties