ATE260989T1 - Erkenntnisse der genomforschung für die suche nach neuartigen wirkstoffen - Google Patents
Erkenntnisse der genomforschung für die suche nach neuartigen wirkstoffenInfo
- Publication number
- ATE260989T1 ATE260989T1 AT98964070T AT98964070T ATE260989T1 AT E260989 T1 ATE260989 T1 AT E260989T1 AT 98964070 T AT98964070 T AT 98964070T AT 98964070 T AT98964070 T AT 98964070T AT E260989 T1 ATE260989 T1 AT E260989T1
- Authority
- AT
- Austria
- Prior art keywords
- insights
- search
- active ingredients
- genome research
- novel active
- Prior art date
Links
- 239000004480 active ingredient Substances 0.000 title 1
- 108020005187 Oligonucleotide Probes Proteins 0.000 abstract 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 abstract 1
- 238000003491 array Methods 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 230000001413 cellular effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 210000004962 mammalian cell Anatomy 0.000 abstract 1
- 108020004999 messenger RNA Proteins 0.000 abstract 1
- 238000012544 monitoring process Methods 0.000 abstract 1
- 239000002751 oligonucleotide probe Substances 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
- C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Pathology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Information Retrieval, Db Structures And Fs Structures Therefor (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6828997P | 1997-12-19 | 1997-12-19 | |
| PCT/US1998/026925 WO1999032660A1 (en) | 1997-12-19 | 1998-12-18 | Exploiting genomics in the search for new drugs |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE260989T1 true ATE260989T1 (de) | 2004-03-15 |
Family
ID=22081628
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98964070T ATE260989T1 (de) | 1997-12-19 | 1998-12-18 | Erkenntnisse der genomforschung für die suche nach neuartigen wirkstoffen |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US6333155B1 (de) |
| EP (1) | EP1040204B1 (de) |
| AT (1) | ATE260989T1 (de) |
| AU (1) | AU1926899A (de) |
| DE (1) | DE69822206T2 (de) |
| WO (1) | WO1999032660A1 (de) |
Families Citing this family (84)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6143557A (en) | 1995-06-07 | 2000-11-07 | Life Technologies, Inc. | Recombination cloning using engineered recombination sites |
| US6720140B1 (en) | 1995-06-07 | 2004-04-13 | Invitrogen Corporation | Recombinational cloning using engineered recombination sites |
| US6165709A (en) | 1997-02-28 | 2000-12-26 | Fred Hutchinson Cancer Research Center | Methods for drug target screening |
| JP4303418B2 (ja) | 1997-10-24 | 2009-07-29 | ライフ テクノロジーズ コーポレーション | 組換え部位を有する核酸を使用する組換えクローニング |
| US7351578B2 (en) | 1999-12-10 | 2008-04-01 | Invitrogen Corp. | Use of multiple recombination sites with unique specificity in recombinational cloning |
| US6593084B2 (en) | 1998-10-13 | 2003-07-15 | Robert E. Bird | Carcinogen assay |
| EP2119788A1 (de) | 1999-03-02 | 2009-11-18 | Life Technologies Corporation | Zusammensetzungen und Verfahren zur Verwendung beim Rekombinationsklonen von Nukleinsäuren |
| US7211390B2 (en) | 1999-09-16 | 2007-05-01 | 454 Life Sciences Corporation | Method of sequencing a nucleic acid |
| US7244559B2 (en) | 1999-09-16 | 2007-07-17 | 454 Life Sciences Corporation | Method of sequencing a nucleic acid |
| WO2001033228A2 (en) * | 1999-11-03 | 2001-05-10 | Oncotech, Inc. | Cancer diagnosis employing cell-sorting and gene-profiles |
| CN1757724B (zh) * | 1999-12-10 | 2014-06-11 | 茵维特罗根公司 | 具有独特特异性的多个重组位点在重组克隆中的用途 |
| US8288128B2 (en) | 2004-11-18 | 2012-10-16 | Eppendorf Array Technologies S.A. | Real-time quantification of multiple targets on a micro-array |
| US7829313B2 (en) | 2000-03-24 | 2010-11-09 | Eppendorf Array Technologies | Identification and quantification of a plurality of biological (micro)organisms or their components |
| WO2001073117A1 (de) * | 2000-03-31 | 2001-10-04 | MEMOREC STOFFEL GmbH - MEDIZINISCH-MOLEKULARE ENTWICKLUNG, KÖLN | Verwendung von partikeln, die signalgebende eigenschaften und mindestens eine affinitätsgruppierung für markierte nukleinsäuren besitzen |
| AU2001251086A1 (en) * | 2000-03-31 | 2001-10-15 | Sir Mortimer B. Davis Jewish General Hospital | Microchip arrays of regulatory genes |
| US7244560B2 (en) * | 2000-05-21 | 2007-07-17 | Invitrogen Corporation | Methods and compositions for synthesis of nucleic acid molecules using multiple recognition sites |
| US6743583B2 (en) * | 2000-07-14 | 2004-06-01 | The Board Of Trustees Of The Leland Stanford Junior University | Identification of drugs and drug targets by detection of the stress response |
| AU2001278968A1 (en) * | 2000-07-19 | 2002-01-30 | Pointilliste, Inc. | Nested sorting and high throughput screening |
| US7198924B2 (en) | 2000-12-11 | 2007-04-03 | Invitrogen Corporation | Methods and compositions for synthesis of nucleic acid molecules using multiple recognition sites |
| US6998234B2 (en) * | 2000-11-03 | 2006-02-14 | Oncotech, Inc. | Methods for cancer prognosis and diagnosis relating to tumor vascular endothelial cells |
| JP2004532636A (ja) * | 2001-05-21 | 2004-10-28 | インヴィトロジェン コーポレーション | 核酸分子の単離に用いるための組成物および方法 |
| US7415358B2 (en) | 2001-05-22 | 2008-08-19 | Ocimum Biosolutions, Inc. | Molecular toxicology modeling |
| US20050009022A1 (en) * | 2001-07-06 | 2005-01-13 | Weiner Michael P. | Method for isolation of independent, parallel chemical micro-reactions using a porous filter |
| US7447594B2 (en) | 2001-07-10 | 2008-11-04 | Ocimum Biosolutions, Inc. | Molecular cardiotoxicology modeling |
| US20030054396A1 (en) * | 2001-09-07 | 2003-03-20 | Weiner Michael P. | Enzymatic light amplification |
| US6956114B2 (en) | 2001-10-30 | 2005-10-18 | '454 Corporation | Sulfurylase-luciferase fusion proteins and thermostable sulfurylase |
| US6902921B2 (en) * | 2001-10-30 | 2005-06-07 | 454 Corporation | Sulfurylase-luciferase fusion proteins and thermostable sulfurylase |
| US20050124022A1 (en) * | 2001-10-30 | 2005-06-09 | Maithreyan Srinivasan | Novel sulfurylase-luciferase fusion proteins and thermostable sulfurylase |
| WO2003062402A2 (en) * | 2002-01-24 | 2003-07-31 | Pointilliste, Inc. | Use of collections of binding sites for sample profiling and other applications |
| US20030195431A1 (en) * | 2002-04-10 | 2003-10-16 | Sukhatme Vikas P. | Observation of effects of body fluids on indicator cells for disease diagnosis |
| US20040053319A1 (en) * | 2002-09-17 | 2004-03-18 | Mcwilliams Diana R. | Isolation of genetic molecules from a complex biological constrauct for use in genetic expression analysis |
| US7364846B2 (en) * | 2002-10-11 | 2008-04-29 | Molecular Devices Corporation | Gene expression profiling from FFPE samples |
| US7781163B2 (en) * | 2003-01-08 | 2010-08-24 | Lesley Davenport | G-quadruplex binding assays and compounds therefor |
| CA2513889A1 (en) | 2003-01-29 | 2004-08-19 | 454 Corporation | Double ended sequencing |
| US7575865B2 (en) | 2003-01-29 | 2009-08-18 | 454 Life Sciences Corporation | Methods of amplifying and sequencing nucleic acids |
| WO2004079000A1 (en) * | 2003-03-07 | 2004-09-16 | National Research Council Of Canada | The determination of function of mammalian proteins by analysis of global gene expression profiles |
| WO2004090161A1 (en) | 2003-04-14 | 2004-10-21 | Novartis Ag | Gene expression associated with osteoblast differentiation |
| US20050009059A1 (en) * | 2003-05-07 | 2005-01-13 | Affymetrix, Inc. | Analysis of methylation status using oligonucleotide arrays |
| EP1639089A4 (de) | 2003-06-06 | 2007-12-12 | Arborgen Llc | Transkriptionsfaktor |
| EP1639081A4 (de) | 2003-06-06 | 2007-11-07 | Arborgen Llc | Zusammensetzungen und verfahren zur regulierung von polysacchariden einer pflanzenzelle |
| US20050064462A1 (en) * | 2003-06-17 | 2005-03-24 | Bernd Stein | Methods, compositions, and kits for predicting the effect of compounds on hot flash symptoms |
| US20050064472A1 (en) * | 2003-07-23 | 2005-03-24 | Affymetrix, Inc. | Methods of monitoring gene expression |
| EP1675682B1 (de) * | 2003-10-24 | 2017-07-19 | Aushon Biosystems, Inc. | Vorrichtung und verfahren zur dosierung von flüssigen, halbfesten und festen proben |
| US8304189B2 (en) | 2003-12-01 | 2012-11-06 | Life Technologies Corporation | Nucleic acid molecules containing recombination sites and methods of using the same |
| AR047574A1 (es) | 2003-12-30 | 2006-01-25 | Arborgen Llc 2 Genesis Res 1 | Genes del ciclo celular y metodos de uso relacionados |
| WO2006023312A2 (en) | 2004-08-20 | 2006-03-02 | Carl Deirmengian | Diagnostic assay for source of inflammation |
| FI20041204A0 (fi) | 2004-09-16 | 2004-09-16 | Riikka Lund | Menetelmät immuunivälitteisiin sairauksiin liittyvien uusien kohdegeenien hyödyntämiseksi |
| US7799906B1 (en) | 2004-09-22 | 2010-09-21 | Arborgen, Llc | Compositions and methods for modulating lignin of a plant |
| JP5026978B2 (ja) | 2004-11-18 | 2012-09-19 | エッペンドルフ アレイ テクノロジーズ ソシエテ アノニム | マイクロアレイ上での複数標的のリアルタイム定量化 |
| WO2006089045A2 (en) | 2005-02-18 | 2006-08-24 | Monogram Biosciences, Inc. | Methods and compositions for determining hypersusceptibility of hiv-1 to non-nucleoside reverse transcriptase inhibitors |
| EP2522757A1 (de) | 2005-02-18 | 2012-11-14 | Monogram BioSciences, Inc. | Verfahren und Zusammensetzungen zur Bestimmung der Suszeptibilität für Anti-HIV-Mittel und des HIV-Replikationsvermögens |
| US20070072175A1 (en) * | 2005-05-13 | 2007-03-29 | Biogen Idec Ma Inc. | Nucleotide array containing polynucleotide probes complementary to, or fragments of, cynomolgus monkey genes and the use thereof |
| US20090087841A1 (en) * | 2005-05-27 | 2009-04-02 | Monogram Biosciences, Inc. | Methods and compositions for determining resistance of hiv-1 to protease inhibitors |
| WO2006133266A2 (en) | 2005-06-06 | 2006-12-14 | Monogram Biosciences, Inc. | Methods for determining resistance or susceptibility to hiv entry inhibitors |
| US8071284B2 (en) * | 2005-06-06 | 2011-12-06 | Monogram Biosciences, Inc. | Methods and compositions for determining altered susceptibility of HIV-1 to anti-HIV drugs |
| EP1736780A1 (de) | 2005-06-24 | 2006-12-27 | Eppendorf Array Technologies S.A. | Verfahren und Vorrichtungen zum Nachweis und/oder zur Quantifizierung hierarchischer, molekularer Veränderungen einer Zellantwort auf einen externen Stimulus |
| JP2009506778A (ja) * | 2005-09-02 | 2009-02-19 | ザ・ユニバーシティ・オブ・トレド | 生物学的状態の診断および／または治療に有用なバイオマーカを同定する方法および組成物 |
| EP1762628B1 (de) | 2005-09-13 | 2008-03-12 | Eppendorf Array Technologies SA | Verfahren zum Nachweis von homologen Sequenzen, welche sich durch eine Base unterscheiden, auf einem Mikroarray |
| US20070092903A1 (en) * | 2005-10-24 | 2007-04-26 | Fulmer-Smentek Stephanie B | One-color microarray analysis methods, reagents and kits |
| AU2005239672B2 (en) * | 2005-11-30 | 2009-06-11 | Canon Kabushiki Kaisha | Sortable collection browser |
| WO2007098065A2 (en) * | 2006-02-17 | 2007-08-30 | The United States Of America As Represented By The Department Of Veterans Affairs | Human sodium channel isoforms |
| EP1999668B1 (de) * | 2006-03-15 | 2014-07-30 | Bryan R. Soper | Verfahren für die suche nach und abbildung von phänotypischen und genotypischen variationen in zellen |
| US7901882B2 (en) | 2006-03-31 | 2011-03-08 | Affymetrix, Inc. | Analysis of methylation using nucleic acid arrays |
| US8257929B2 (en) | 2006-10-20 | 2012-09-04 | University Of Miami | Gene expression profiling of Parkinson's Disease |
| EP1935496A1 (de) | 2006-12-22 | 2008-06-25 | Eppendorf Array Technologies SA | Vorrichtung und/oder Verfahren zur Detektion erweiterter Nukleotidsequenzen auf Mikro-Arrays |
| WO2008106115A2 (en) | 2007-02-26 | 2008-09-04 | Monogram Biosciences, Inc. | Compositions and methods for determining whether a subject would benefit from co-receptor inhibitor therapy |
| EP1961825A1 (de) | 2007-02-26 | 2008-08-27 | INSERM (Institut National de la Santé et de la Recherche Medicale) | Verfahren zur Vorhersage des Auftretens von Metastasen bei Brustkrebspatienten |
| EP2107125A1 (de) | 2008-03-31 | 2009-10-07 | Eppendorf Array Technologies SA (EAT) | Echtzeit-PCR von Targets auf einem Mikroarray |
| US9332973B2 (en) | 2008-10-01 | 2016-05-10 | Covidien Lp | Needle biopsy device with exchangeable needle and integrated needle protection |
| US9782565B2 (en) | 2008-10-01 | 2017-10-10 | Covidien Lp | Endoscopic ultrasound-guided biliary access system |
| US20110190662A1 (en) * | 2008-10-01 | 2011-08-04 | Beacon Endoscopic Corporation | Rapid exchange fna biopsy device with diagnostic and therapeutic capabilities |
| US8968210B2 (en) | 2008-10-01 | 2015-03-03 | Covidien LLP | Device for needle biopsy with integrated needle protection |
| US9186128B2 (en) | 2008-10-01 | 2015-11-17 | Covidien Lp | Needle biopsy device |
| US11298113B2 (en) | 2008-10-01 | 2022-04-12 | Covidien Lp | Device for needle biopsy with integrated needle protection |
| JP2013515500A (ja) | 2009-12-29 | 2013-05-09 | ヒルズ・ペット・ニュートリシャン・インコーポレーテッド | 炎症性の病気の改善または予防のための、ショウガが含まれる組成物 |
| FI20105166A0 (fi) | 2010-02-19 | 2010-02-19 | Suomen Punainen Risti Veripalv | Menetelmä kantasolupopulaation erilaistumistilan osoittamiseksi |
| EP2369325A1 (de) | 2010-03-12 | 2011-09-28 | Eppendorf Ag | Arrayanalyse für Online-Detektion |
| US9988687B2 (en) | 2011-09-20 | 2018-06-05 | The George Washington Univeristy | Companion diagnostics for cancer and screening methods to identify companion diagnostics for cancer based on splicing variants |
| US9453261B2 (en) | 2011-09-20 | 2016-09-27 | The George Washington University | Alternative splicing variants of genes associated with prostate cancer risk and survival |
| EP3418397B1 (de) | 2012-01-24 | 2020-10-07 | CD Diagnostics, Inc. | System zum nachweis einer infektion in der synovialflüssigkeit |
| EP2664619B1 (de) * | 2012-05-16 | 2017-07-12 | Manros Therapeutics | Purinderivate als Werkzeuge zum Abtasten von Verbindungen gegen Alzheimer |
| WO2014047285A1 (en) | 2012-09-19 | 2014-03-27 | Paraskevi Giannakakou | Identifying taxane sensitivity in prostate cancer patients |
| EP3736570A1 (de) | 2019-05-09 | 2020-11-11 | Fundación Instituto de Estudios de Ciencias de la Salud de Castilla y León | Verfahren zur diagnose, subklassifizierung und prognose von akuter nierenverletzung durch detektion von cct7 |
| WO2025171393A1 (en) * | 2024-02-10 | 2025-08-14 | New York Genome Center, Inc. | Methods for drug target deconvolution |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8810400D0 (en) | 1988-05-03 | 1988-06-08 | Southern E | Analysing polynucleotide sequences |
| US5700637A (en) | 1988-05-03 | 1997-12-23 | Isis Innovation Limited | Apparatus and method for analyzing polynucleotide sequences and method of generating oligonucleotide arrays |
| US6040138A (en) | 1995-09-15 | 2000-03-21 | Affymetrix, Inc. | Expression monitoring by hybridization to high density oligonucleotide arrays |
| DK1157743T3 (da) * | 1993-10-28 | 2009-07-06 | Houston Advanced Res Ct | Mikrofremstillet poröst gennemströmningsapparat til diskret påvisning af bindingsreaktioner |
| JP2002515738A (ja) * | 1996-01-23 | 2002-05-28 | アフィメトリックス，インコーポレイティド | 核酸分析法 |
| WO1997029091A1 (en) | 1996-02-09 | 1997-08-14 | Phytera Symbion Aps | Balanol analogues |
| US5866702A (en) * | 1996-08-02 | 1999-02-02 | Cv Therapeutics, Incorporation | Purine inhibitors of cyclin dependent kinase 2 |
| US5965352A (en) | 1998-05-08 | 1999-10-12 | Rosetta Inpharmatics, Inc. | Methods for identifying pathways of drug action |
-
1998
- 1998-12-18 AT AT98964070T patent/ATE260989T1/de not_active IP Right Cessation
- 1998-12-18 DE DE69822206T patent/DE69822206T2/de not_active Expired - Lifetime
- 1998-12-18 EP EP98964070A patent/EP1040204B1/de not_active Expired - Lifetime
- 1998-12-18 AU AU19268/99A patent/AU1926899A/en not_active Abandoned
- 1998-12-18 US US09/215,207 patent/US6333155B1/en not_active Expired - Lifetime
- 1998-12-18 WO PCT/US1998/026925 patent/WO1999032660A1/en not_active Ceased
-
2001
- 2001-07-06 US US09/900,845 patent/US6524800B2/en not_active Expired - Lifetime
-
2003
- 2003-02-24 US US10/370,717 patent/US20030180774A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP1040204B1 (de) | 2004-03-03 |
| DE69822206D1 (de) | 2004-04-08 |
| US6524800B2 (en) | 2003-02-25 |
| AU1926899A (en) | 1999-07-12 |
| WO1999032660A9 (en) | 1999-09-23 |
| DE69822206T2 (de) | 2005-02-17 |
| WO1999032660A1 (en) | 1999-07-01 |
| US20010055771A1 (en) | 2001-12-27 |
| US20030180774A1 (en) | 2003-09-25 |
| US6333155B1 (en) | 2001-12-25 |
| EP1040204A1 (de) | 2000-10-04 |
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