NO995722L - Nye triptolidderivater som er anvendbare ved behandling av autoimmune sykdommer - Google Patents

Nye triptolidderivater som er anvendbare ved behandling av autoimmune sykdommer

Info

Publication number
NO995722L
NO995722L NO995722A NO995722A NO995722L NO 995722 L NO995722 L NO 995722L NO 995722 A NO995722 A NO 995722A NO 995722 A NO995722 A NO 995722A NO 995722 L NO995722 L NO 995722L
Authority
NO
Norway
Prior art keywords
treatment
autoimmune diseases
derivatives useful
triptolide derivatives
new
Prior art date
Application number
NO995722A
Other languages
English (en)
Other versions
NO995722D0 (no
Inventor
Michel Jean Jung
Mahinda Wickramaratne
Michael Hepperle
Original Assignee
Hoechst Marion Roussel Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Marion Roussel Inc filed Critical Hoechst Marion Roussel Inc
Publication of NO995722D0 publication Critical patent/NO995722D0/no
Publication of NO995722L publication Critical patent/NO995722L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Furan Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
NO995722A 1997-05-23 1999-11-22 Nye triptolidderivater som er anvendbare ved behandling av autoimmune sykdommer NO995722L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US86248997A 1997-05-23 1997-05-23
PCT/US1998/008562 WO1998052933A1 (en) 1997-05-23 1998-04-27 Novel triptolide derivatives useful in the treatment of autoimmune diseases

Publications (2)

Publication Number Publication Date
NO995722D0 NO995722D0 (no) 1999-11-22
NO995722L true NO995722L (no) 2000-01-21

Family

ID=25338618

Family Applications (1)

Application Number Title Priority Date Filing Date
NO995722A NO995722L (no) 1997-05-23 1999-11-22 Nye triptolidderivater som er anvendbare ved behandling av autoimmune sykdommer

Country Status (17)

Country Link
EP (1) EP0983256B1 (no)
JP (1) JP2002500647A (no)
KR (1) KR20010012820A (no)
AR (1) AR012737A1 (no)
AT (1) ATE261434T1 (no)
AU (1) AU741209B2 (no)
BR (1) BR9809673A (no)
CA (1) CA2288327A1 (no)
DE (1) DE69822297T2 (no)
ES (1) ES2213279T3 (no)
HU (1) HUP0003244A3 (no)
IL (1) IL133089A0 (no)
NO (1) NO995722L (no)
NZ (1) NZ500699A (no)
TW (1) TW462966B (no)
WO (1) WO1998052933A1 (no)
ZA (1) ZA984177B (no)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6569893B2 (en) * 2001-03-15 2003-05-27 Pharmagenesis, Inc. Amino acid derivatives of triptolide compounds as immune modulators and anticancer agents
JP4680589B2 (ja) 2002-05-31 2011-05-11 ファーマジェネシス， インコーポレイテッド アポトーシスおよび免疫抑制の調節のためのトリプトリド誘導体
US7820834B2 (en) 2003-12-24 2010-10-26 Pharmagenesis, Inc. Triptolide 5,6-derivatives as immunomodulators and anticancer agents
CN1917893A (zh) 2004-02-09 2007-02-21 美国泛华医药公司 从雷公藤多苷中分离雷公藤内酯醇化合物的方法
DK1732536T3 (da) 2004-03-02 2012-06-25 Pharmagenesis Inc Tripolidlactonringderivater som immunomodulatorer og anticancermidler
WO2006115509A2 (en) 2004-06-24 2006-11-02 Novartis Vaccines And Diagnostics Inc. Small molecule immunopotentiators and assays for their detection
US8617906B2 (en) 2004-10-13 2013-12-31 Pharmagenesis, Inc. Identification and screening of triptolide target molecules
US20120020954A1 (en) 2009-03-30 2012-01-26 Anat Achiron Methods of predicting clinical course and treating multiple sclerosis
WO2012123938A1 (en) 2011-03-17 2012-09-20 Tel Hashomer Medical Research Infrastructure And Services Ltd. Quinolone analogs for treating autoimmune diseases
WO2015079411A1 (en) 2013-11-28 2015-06-04 Tel Hashomer Medical Research Infrastructure And Services Ltd. Rna polymerase i inhibitors and uses thereof
CN113768939A (zh) * 2021-09-30 2021-12-10 深圳艾克斯恩生物科技有限公司 雷公藤二醇在制备预防和/或治疗nlrp3炎症小体介导的炎症性疾病药物中的应用
KR102875701B1 (ko) * 2022-12-28 2025-10-23 구주제약주식회사 신규 트립톨라이드 유도체 및 이의 용도

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994026265A1 (en) * 1993-05-06 1994-11-24 Pharmagenesis, Inc. 16-hydroxytriptolide composition and method for immunotherapy
US5663335A (en) * 1996-03-01 1997-09-02 Pharmagenesis, Inc. Immunosuppressive compounds and methods

Also Published As

Publication number Publication date
AR012737A1 (es) 2000-11-08
ATE261434T1 (de) 2004-03-15
JP2002500647A (ja) 2002-01-08
ES2213279T3 (es) 2004-08-16
AU741209B2 (en) 2001-11-22
DE69822297D1 (de) 2004-04-15
KR20010012820A (ko) 2001-02-26
NO995722D0 (no) 1999-11-22
TW462966B (en) 2001-11-11
ZA984177B (en) 1998-11-23
NZ500699A (en) 2001-08-31
HUP0003244A3 (en) 2001-09-28
HK1025954A1 (en) 2000-12-01
HUP0003244A2 (en) 2001-03-28
DE69822297T2 (de) 2004-07-29
BR9809673A (pt) 2000-07-11
AU7363498A (en) 1998-12-11
CA2288327A1 (en) 1998-11-26
EP0983256B1 (en) 2004-03-10
WO1998052933A1 (en) 1998-11-26
EP0983256A1 (en) 2000-03-08
IL133089A0 (en) 2001-03-19

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