ATE261581T1 - Verfahren zum entwerfen und herstellung von zielmolekulbindenden liganden - Google Patents

Verfahren zum entwerfen und herstellung von zielmolekulbindenden liganden

Info

Publication number
ATE261581T1
ATE261581T1 AT99119066T AT99119066T ATE261581T1 AT E261581 T1 ATE261581 T1 AT E261581T1 AT 99119066 T AT99119066 T AT 99119066T AT 99119066 T AT99119066 T AT 99119066T AT E261581 T1 ATE261581 T1 AT E261581T1
Authority
AT
Austria
Prior art keywords
target molecule
ligand
designing
binding ligands
molecule binding
Prior art date
Application number
AT99119066T
Other languages
English (en)
Inventor
Stephen W Fesik
Philip J Hajduk
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24218250&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE261581(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Abbott Lab filed Critical Abbott Lab
Application granted granted Critical
Publication of ATE261581T1 publication Critical patent/ATE261581T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/542—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N24/00—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects
    • G01N24/08—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects by using nuclear magnetic resonance
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/20—Screening for compounds of potential therapeutic value cell-free systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Compounds Of Iron (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
AT99119066T 1995-11-14 1996-11-13 Verfahren zum entwerfen und herstellung von zielmolekulbindenden liganden ATE261581T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/555,691 US5698401A (en) 1995-11-14 1995-11-14 Use of nuclear magnetic resonance to identify ligands to target biomolecules

Publications (1)

Publication Number Publication Date
ATE261581T1 true ATE261581T1 (de) 2004-03-15

Family

ID=24218250

Family Applications (2)

Application Number Title Priority Date Filing Date
AT96940448T ATE189063T1 (de) 1995-11-14 1996-11-13 Verwendung von kernspinresonanz zur auffindung von liganden für bindungsmoleküle
AT99119066T ATE261581T1 (de) 1995-11-14 1996-11-13 Verfahren zum entwerfen und herstellung von zielmolekulbindenden liganden

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT96940448T ATE189063T1 (de) 1995-11-14 1996-11-13 Verwendung von kernspinresonanz zur auffindung von liganden für bindungsmoleküle

Country Status (13)

Country Link
US (2) US5698401A (de)
EP (2) EP0866967B2 (de)
JP (1) JP3032301B2 (de)
AT (2) ATE189063T1 (de)
AU (1) AU701810B2 (de)
CA (1) CA2237343C (de)
DE (2) DE69606324T3 (de)
DK (1) DK0866967T4 (de)
ES (1) ES2143793T5 (de)
GR (1) GR3032361T3 (de)
IL (2) IL155988A (de)
PT (1) PT866967E (de)
WO (1) WO1997018471A1 (de)

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US6344330B1 (en) * 1998-03-27 2002-02-05 The Regents Of The University Of California Pharmacophore recombination for the identification of small molecule drug lead compounds
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Also Published As

Publication number Publication date
MX9803810A (es) 1998-09-30
EP0981049B1 (de) 2004-03-10
AU7732896A (en) 1997-06-05
PT866967E (pt) 2000-04-28
IL155988A (en) 2005-07-25
DE69606324D1 (de) 2000-02-24
DK0866967T4 (da) 2007-12-10
US5698401A (en) 1997-12-16
WO1997018471A1 (en) 1997-05-22
CA2237343A1 (en) 1997-05-22
DE69606324T2 (de) 2000-07-06
AU701810B2 (en) 1999-02-04
EP0866967B2 (de) 2007-08-08
EP0866967A1 (de) 1998-09-30
ATE189063T1 (de) 2000-02-15
ES2143793T3 (es) 2000-05-16
DK0866967T3 (da) 2000-06-26
EP0981049A1 (de) 2000-02-23
CA2237343C (en) 2009-01-20
IL123923A (en) 2005-07-25
DE69631842D1 (de) 2004-04-15
JP3032301B2 (ja) 2000-04-17
US5804390A (en) 1998-09-08
IL155988A0 (en) 2003-12-23
JPH11513498A (ja) 1999-11-16
ES2143793T5 (es) 2008-03-01
DE69606324T3 (de) 2008-02-07
EP0866967B1 (de) 2000-01-19
GR3032361T3 (en) 2000-04-27

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