ATE261988T1 - Peptidomimetische inhibitoren von der protease des menschlichen cytomegalovirus - Google Patents

Peptidomimetische inhibitoren von der protease des menschlichen cytomegalovirus

Info

Publication number
ATE261988T1
ATE261988T1 AT97951048T AT97951048T ATE261988T1 AT E261988 T1 ATE261988 T1 AT E261988T1 AT 97951048 T AT97951048 T AT 97951048T AT 97951048 T AT97951048 T AT 97951048T AT E261988 T1 ATE261988 T1 AT E261988T1
Authority
AT
Austria
Prior art keywords
human cytomegalovirus
protease
inhibitors
peptidomimmetic
hcmv
Prior art date
Application number
AT97951048T
Other languages
English (en)
Inventor
Murray Bailey
Gulrez Fazal
Pierre Lavallee
William Ogilvie
Marc-Andre Poupart
Original Assignee
Boehringer Ingelheim Ca Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Ca Ltd filed Critical Boehringer Ingelheim Ca Ltd
Application granted granted Critical
Publication of ATE261988T1 publication Critical patent/ATE261988T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1027—Tetrapeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
AT97951048T 1996-12-27 1997-12-23 Peptidomimetische inhibitoren von der protease des menschlichen cytomegalovirus ATE261988T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US3404196P 1996-12-27 1996-12-27
US5286097P 1997-07-17 1997-07-17
US5980697P 1997-09-23 1997-09-23
PCT/CA1997/001004 WO1998029435A1 (en) 1996-12-27 1997-12-23 Peptidomimetic inhibitors of the human cytomegalovirus protease

Publications (1)

Publication Number Publication Date
ATE261988T1 true ATE261988T1 (de) 2004-04-15

Family

ID=27364549

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97951048T ATE261988T1 (de) 1996-12-27 1997-12-23 Peptidomimetische inhibitoren von der protease des menschlichen cytomegalovirus

Country Status (7)

Country Link
US (1) US6291640B1 (de)
EP (1) EP0948523B1 (de)
JP (1) JP2001508418A (de)
AT (1) ATE261988T1 (de)
CA (1) CA2276109C (de)
DE (1) DE69728164D1 (de)
WO (1) WO1998029435A1 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200404789A (en) * 1999-03-15 2004-04-01 Axys Pharm Inc Novel compounds and compositions as protease inhibitors
US6649593B1 (en) * 1999-10-13 2003-11-18 Tularik Inc. Modulators of SREBP processing
US6774212B2 (en) * 1999-12-03 2004-08-10 Bristol-Myers Squibb Pharma Company Alpha-ketoamide inhibitors of hepatitis C virus NS3 protease
SK742003A3 (en) 2000-07-21 2003-06-03 Schering Corp Novel peptides as NS3-serine protease inhibitors of hepatitis C virus
US7244721B2 (en) 2000-07-21 2007-07-17 Schering Corporation Peptides as NS3-serine protease inhibitors of hepatitis C virus
CN1498224A (zh) 2000-07-21 2004-05-19 ���鹫˾ 用作丙型肝炎病毒ns3-丝氨酸蛋白酶抑制剂的新型肽
WO2002022622A2 (en) 2000-09-13 2002-03-21 Georgetown University Synthesis of 2-hydroxymethylglutamic acid and congeners thereof
CN1638790A (zh) * 2002-01-29 2005-07-13 Wyeth公司 用于调节连接蛋白半通道的组合物和方法
EP4067368A1 (de) 2016-06-01 2022-10-05 Athira Pharma, Inc. Verbindungen
GB2563396B (en) * 2017-06-12 2020-09-23 Ustav Organicke Chemie A Biochemie Av Cr V V I Inhibitors of Rhomboid Intramembrane Proteases
US12083099B2 (en) 2020-10-28 2024-09-10 Accencio LLC Methods of treating symptoms of coronavirus infection with viral protease inhibitors
WO2022265577A2 (en) * 2021-06-15 2022-12-22 Agency For Science, Technology And Research Coronavirus enzyme modulators, methods of synthesis and uses thereof
CN121293287B (zh) * 2025-12-12 2026-04-03 杭州信海医药科技有限公司 一种依替巴肽的固相合成方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA905737B (en) * 1989-07-26 1991-05-29 Merrell Dow Pharma Novel peptidase inhibitors
WO1997010231A1 (en) 1995-09-14 1997-03-20 Cephalon, Inc. Ketomethylene group-containing cysteine and serine protease inhibitors

Also Published As

Publication number Publication date
EP0948523B1 (de) 2004-03-17
CA2276109A1 (en) 1998-07-09
JP2001508418A (ja) 2001-06-26
WO1998029435A1 (en) 1998-07-09
US6291640B1 (en) 2001-09-18
DE69728164D1 (de) 2004-04-22
EP0948523A1 (de) 1999-10-13
CA2276109C (en) 2003-11-18

Similar Documents

Publication Publication Date Title
ATE218541T1 (de) Hydroxyethylaminosulfonamide verwendbar als inhibitoren retroviraler proteasen
DE69831506D1 (en) 4-hydroxychinolin-3-carboxamide und hydrazide als antivirale wirkstoffe
DE69717268D1 (de) M-amidinophenyl-analoga als faktor-xa-inhibitoren
DE69728164D1 (de) Peptidomimetische inhibitoren von der protease des menschlichen cytomegalovirus
DE69420564D1 (de) Immunsuppressive und antiallergische verbindungen; z.b. n-(3-oxohexanoyl)-homoserinlacton
ATE222894T1 (de) Substituierte aminophenylisoxazolinderivate verwendbar als antimikrobielle agenzien
TR199802767T2 (xx) Trombin �nleyiciler olarak yeni amidino t�revleri.
FI935778A7 (fi) HIV-proteaasin inhibiittoreita, jotka ovat hyödyllisiä AIDSin hoitoa varten
NZ309523A (en) Peptidyl heterocycles useful in the treatment of thrombin related disorders
NO983688L (no) Serin-protease-inhibitorer
AP9200410A0 (en) Retroviral protease inhibitors.
NZ502988A (en) 5-Acetamido-4-amino-2-propionyloxy-6-isopropoxy-1-cyclohexene useful for treating influenza
ATE250574T1 (de) Neue verbindungen
FI935777A0 (fi) Inhibitorer foer HIV-proteas anvaendbara vid behandling av AIDS
NO972379L (no) Metalloproteinaseinhibitorer
FI935780A7 (fi) HIV-proteaasin inhibiittoreita, jotka ovat hyödyllisiä AIDSin hoitoa varten
FI935779A7 (fi) HIV-proteaasin inhibiittoreita, jotka ovat hyödyllisiä AIDSin hoitoa varten
BR9610876A (pt) Inibidores de protease de guanidino
NO980643L (no) Propylendopeptidase inhibitorer
ATE92960T1 (de) Alpha-1-antitrypsin-varianten, besonders verwendbar als kallikrein-inhibitoren.
ATE214692T1 (de) Metalloproteinase-inhibitoren
ES2173634T3 (es) Compuestos heterociclicos que presentan actividad inhibidora de mmp y tnf.
BR9611520A (pt) Composto hemo-reguladores.

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties