ATE261988T1 - Peptidomimetische inhibitoren von der protease des menschlichen cytomegalovirus - Google Patents
Peptidomimetische inhibitoren von der protease des menschlichen cytomegalovirusInfo
- Publication number
- ATE261988T1 ATE261988T1 AT97951048T AT97951048T ATE261988T1 AT E261988 T1 ATE261988 T1 AT E261988T1 AT 97951048 T AT97951048 T AT 97951048T AT 97951048 T AT97951048 T AT 97951048T AT E261988 T1 ATE261988 T1 AT E261988T1
- Authority
- AT
- Austria
- Prior art keywords
- human cytomegalovirus
- protease
- inhibitors
- peptidomimmetic
- hcmv
- Prior art date
Links
- 241000701024 Human betaherpesvirus 5 Species 0.000 title abstract 3
- 108091005804 Peptidases Proteins 0.000 title abstract 2
- 239000004365 Protease Substances 0.000 title abstract 2
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 208000024697 human cytomegalovirus infection Diseases 0.000 abstract 1
- 239000000816 peptidomimetic Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1027—Tetrapeptides containing heteroatoms different from O, S, or N
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Virology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Biotechnology (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3404196P | 1996-12-27 | 1996-12-27 | |
| US5286097P | 1997-07-17 | 1997-07-17 | |
| US5980697P | 1997-09-23 | 1997-09-23 | |
| PCT/CA1997/001004 WO1998029435A1 (en) | 1996-12-27 | 1997-12-23 | Peptidomimetic inhibitors of the human cytomegalovirus protease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE261988T1 true ATE261988T1 (de) | 2004-04-15 |
Family
ID=27364549
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT97951048T ATE261988T1 (de) | 1996-12-27 | 1997-12-23 | Peptidomimetische inhibitoren von der protease des menschlichen cytomegalovirus |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US6291640B1 (de) |
| EP (1) | EP0948523B1 (de) |
| JP (1) | JP2001508418A (de) |
| AT (1) | ATE261988T1 (de) |
| CA (1) | CA2276109C (de) |
| DE (1) | DE69728164D1 (de) |
| WO (1) | WO1998029435A1 (de) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200404789A (en) * | 1999-03-15 | 2004-04-01 | Axys Pharm Inc | Novel compounds and compositions as protease inhibitors |
| US6649593B1 (en) * | 1999-10-13 | 2003-11-18 | Tularik Inc. | Modulators of SREBP processing |
| WO2001040262A1 (en) * | 1999-12-03 | 2001-06-07 | Bristol-Myers Squibb Pharma Company | Alpha-ketoamide inhibitors of hepatitis c virus ns3 protease |
| WO2002008187A1 (en) | 2000-07-21 | 2002-01-31 | Schering Corporation | Novel peptides as ns3-serine protease inhibitors of hepatitis c virus |
| US7244721B2 (en) | 2000-07-21 | 2007-07-17 | Schering Corporation | Peptides as NS3-serine protease inhibitors of hepatitis C virus |
| MXPA03000627A (es) | 2000-07-21 | 2004-07-30 | Schering Corp | Nuevos peptidos como inhibidores de proteasa serina-ns3 del virus de la hepatitis c. |
| AU2002213422A1 (en) | 2000-09-13 | 2002-03-26 | Georgetown University | Synthesis of 2-hydroxymethylglutamic acid and congeners thereof |
| CN1939529A (zh) * | 2002-01-29 | 2007-04-04 | Wyeth公司 | 用于调节连接蛋白半通道的组合物和方法 |
| HRP20220479T1 (hr) | 2016-06-01 | 2022-05-27 | Athira Pharma, Inc. | Spojevi |
| GB2563396B (en) * | 2017-06-12 | 2020-09-23 | Ustav Organicke Chemie A Biochemie Av Cr V V I | Inhibitors of Rhomboid Intramembrane Proteases |
| US12083099B2 (en) | 2020-10-28 | 2024-09-10 | Accencio LLC | Methods of treating symptoms of coronavirus infection with viral protease inhibitors |
| WO2022265577A2 (en) * | 2021-06-15 | 2022-12-22 | Agency For Science, Technology And Research | Coronavirus enzyme modulators, methods of synthesis and uses thereof |
| CN121293287B (zh) * | 2025-12-12 | 2026-04-03 | 杭州信海医药科技有限公司 | 一种依替巴肽的固相合成方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2021660A1 (en) * | 1989-07-26 | 1991-01-27 | Philippe Bey | Peptidase inhibitors |
| WO1997010231A1 (en) | 1995-09-14 | 1997-03-20 | Cephalon, Inc. | Ketomethylene group-containing cysteine and serine protease inhibitors |
-
1997
- 1997-12-23 JP JP52951198A patent/JP2001508418A/ja active Pending
- 1997-12-23 CA CA002276109A patent/CA2276109C/en not_active Expired - Fee Related
- 1997-12-23 AT AT97951048T patent/ATE261988T1/de not_active IP Right Cessation
- 1997-12-23 WO PCT/CA1997/001004 patent/WO1998029435A1/en not_active Ceased
- 1997-12-23 US US09/171,554 patent/US6291640B1/en not_active Expired - Fee Related
- 1997-12-23 EP EP97951048A patent/EP0948523B1/de not_active Expired - Lifetime
- 1997-12-23 DE DE69728164T patent/DE69728164D1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CA2276109A1 (en) | 1998-07-09 |
| US6291640B1 (en) | 2001-09-18 |
| WO1998029435A1 (en) | 1998-07-09 |
| CA2276109C (en) | 2003-11-18 |
| DE69728164D1 (de) | 2004-04-22 |
| EP0948523A1 (de) | 1999-10-13 |
| EP0948523B1 (de) | 2004-03-17 |
| JP2001508418A (ja) | 2001-06-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |