ATE262042T1 - Pflanzliche mittelkettige thioesterasen - Google Patents
Pflanzliche mittelkettige thioesterasenInfo
- Publication number
- ATE262042T1 ATE262042T1 AT92913220T AT92913220T ATE262042T1 AT E262042 T1 ATE262042 T1 AT E262042T1 AT 92913220 T AT92913220 T AT 92913220T AT 92913220 T AT92913220 T AT 92913220T AT E262042 T1 ATE262042 T1 AT E262042T1
- Authority
- AT
- Austria
- Prior art keywords
- thioestereses
- medium chain
- vegetable medium
- plant thioesterases
- vegetable
- Prior art date
Links
- 235000013311 vegetables Nutrition 0.000 title 1
- 102000005488 Thioesterase Human genes 0.000 abstract 2
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 108020002982 thioesterase Proteins 0.000 abstract 2
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 150000004667 medium chain fatty acids Chemical class 0.000 abstract 1
- 150000007523 nucleic acids Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23D—EDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS OR COOKING OILS
- A23D9/00—Other edible oils or fats, e.g. shortenings or cooking oils
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
- C12N15/8247—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine involving modified lipid metabolism, e.g. seed oil composition
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
- C12P7/6409—Fatty acids
- C12P7/6418—Fatty acids by hydrolysis of fatty acid esters
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Plant Pathology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cell Biology (AREA)
- Nutrition Science (AREA)
- Botany (AREA)
- Polymers & Plastics (AREA)
- Gastroenterology & Hepatology (AREA)
- Food Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- General Chemical & Material Sciences (AREA)
- Enzymes And Modification Thereof (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Fats And Perfumes (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US70486191A | 1991-05-21 | 1991-05-21 | |
| US77309691A | 1991-10-07 | 1991-10-07 | |
| US78226391A | 1991-10-24 | 1991-10-24 | |
| US07/824,247 US5512482A (en) | 1990-04-26 | 1992-01-22 | Plant thioesterases |
| PCT/US1992/004332 WO1992020236A1 (en) | 1991-05-21 | 1992-05-21 | Plant medium-chain thioesterases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE262042T1 true ATE262042T1 (de) | 2004-04-15 |
Family
ID=27505488
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT92913220T ATE262042T1 (de) | 1991-05-21 | 1992-05-21 | Pflanzliche mittelkettige thioesterasen |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US5512482A (de) |
| EP (1) | EP0557469B1 (de) |
| JP (1) | JP2002238386A (de) |
| AT (1) | ATE262042T1 (de) |
| CA (1) | CA2109580C (de) |
| DE (1) | DE69233323T2 (de) |
| ES (1) | ES2217253T3 (de) |
| WO (1) | WO1992020236A1 (de) |
Families Citing this family (86)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7053267B2 (en) * | 1990-03-16 | 2006-05-30 | Calgene Llc | Plant seed oils |
| US6028247A (en) * | 1990-04-26 | 2000-02-22 | Voelker; Toni Alois | Plant C18:1 preferring thioesterases |
| US5512482A (en) * | 1990-04-26 | 1996-04-30 | Calgene, Inc. | Plant thioesterases |
| US5455167A (en) * | 1991-05-21 | 1995-10-03 | Calgene Inc. | Medium-chain thioesterases in plants |
| GB9204583D0 (en) * | 1992-03-03 | 1992-04-15 | Unilever Plc | Recombinant plant enzyme |
| US5850022A (en) * | 1992-10-30 | 1998-12-15 | Calgene, Inc. | Production of myristate in plant cells |
| US5654495A (en) * | 1992-10-30 | 1997-08-05 | Calgene, Inc. | Production of myristate in plant cells |
| US5910631A (en) * | 1993-09-03 | 1999-06-08 | Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. | Middle chain-specific thioesterase genes from Cuphea lanceolata |
| US6133506A (en) * | 1993-09-04 | 2000-10-17 | Max-Planck-Gesellschaft Zur Forerung Der Wissenschaft E.V. | Keto-acyl-(ACP) reductase promoter from cuphea lanceolata |
| EP0728212A1 (de) * | 1993-11-10 | 1996-08-28 | Calgene, Inc. | Pflanzen acyl-acp thioesterase sequenzen |
| US5807893A (en) * | 1993-11-18 | 1998-09-15 | Voelker; Toni Alois | Plant thioesterases and use for modification of fatty acid composition in plant seed oils |
| US5910630A (en) * | 1994-04-06 | 1999-06-08 | Davies; Huw Maelor | Plant lysophosphatidic acid acyltransferases |
| US6093568A (en) * | 1994-04-06 | 2000-07-25 | Calgene, Inc. | Plant lysophosphatidic acid acyltransferases |
| US5563058A (en) * | 1994-04-06 | 1996-10-08 | Calgene, Inc. | Plant lysophosphatidic acid acyltransferases |
| SK280486B6 (sk) * | 1994-05-10 | 2000-02-14 | Unilever Nv | Úplne stužený tukový materiál, spôsob jeho výroby, |
| PL319103A1 (en) * | 1994-08-31 | 1997-07-21 | Du Pont | Sequences of nucleotides of palmiotolylo-acp thioesterase in colza and soya and their application in regulating content of fatty acids in oil obtained from seeds of colza and soya |
| JP3256952B2 (ja) | 1994-11-09 | 2002-02-18 | 日本製紙株式会社 | 植物への遺伝子導入用ベクター、並びにこれを用いた遺伝子導入植物の作成方法及び植物への遣伝子多重導入方法 |
| US6150512A (en) | 1995-05-15 | 2000-11-21 | Yuan; Ling | Engineering plant thioesterases and disclosure of plant thioesterases having novel substrate specificity |
| JPH11505115A (ja) * | 1995-05-15 | 1999-05-18 | カルジーン,インコーポレーテッド | 植物チオエステラーゼの遺伝子操作および新規な基質特異性を有する植物チオエステラーゼの開示 |
| US5955329A (en) * | 1995-05-15 | 1999-09-21 | Calgene, Inc. | Engineering plant thioesterases for altered substrate specificity |
| WO1997012047A1 (en) * | 1995-09-29 | 1997-04-03 | Calgene, Inc. | Plant stearoyl-acp thioesterase sequences and methods to increase stearate content in plant seed oils |
| HUP9903513A3 (en) | 1995-11-10 | 2000-11-28 | Unilever Nv | Edible fat spread |
| WO1997038588A1 (en) * | 1996-04-15 | 1997-10-23 | Calgene, Inc. | Food products containing structured triglycerides |
| US5968809A (en) | 1997-04-11 | 1999-10-19 | Abbot Laboratories | Methods and compositions for synthesis of long chain poly-unsaturated fatty acids |
| US6051754A (en) * | 1997-04-11 | 2000-04-18 | Abbott Laboratories | Methods and compositions for synthesis of long chain poly-unsaturated fatty acids in plants |
| US7745694B1 (en) | 1997-04-11 | 2010-06-29 | Monsanto Technology Llc | Methods and compositions for synthesis of long chain polyunsaturated fatty acids in plants |
| US6075183A (en) * | 1997-04-11 | 2000-06-13 | Abbott Laboratories | Methods and compositions for synthesis of long chain poly-unsaturated fatty acids in plants |
| US5972664A (en) * | 1997-04-11 | 1999-10-26 | Abbott Laboratories | Methods and compositions for synthesis of long chain poly-unsaturated fatty acids |
| AR013633A1 (es) | 1997-04-11 | 2001-01-10 | Calgene Llc | METODO PARA LA ALTERACIoN DE LA COMPOSICIoN DE ÁCIDOS GRASOS DE CADENA MEDIA EN SEMILLAS VEGETALES QUE EXPRESAN UNA TIOESTERASA QUE PREFIERE CADENA MEDIA VEGETAL HETERoLOGA. |
| US6331664B1 (en) | 1997-05-05 | 2001-12-18 | Dow Agrosciences Llc | Acyl-ACP thioesterase nucleic acids from maize and methods of altering palmitic acid levels in transgenic plants therewith |
| US7455999B2 (en) * | 1998-01-22 | 2008-11-25 | Metabolix, Inc. | Transgenic systems for the manufacture of poly (3-hydroxy-butyrate-co-3-hydroxyhexanoate) |
| US6426448B1 (en) * | 1998-05-11 | 2002-07-30 | E. I. Du Pont De Nemours And Company | Gene combinations that alter the quality and functionality of soybean oil |
| US6365802B2 (en) | 1998-08-14 | 2002-04-02 | Calgene Llc | Methods for increasing stearate content in soybean oil |
| ES2265945T3 (es) | 1999-06-04 | 2007-03-01 | Consejo Superior De Investigaciones Cientificas | Plantas, semillas y aceites de girasol con un contenido alto de oleico y alto de estearico. |
| US7592015B2 (en) | 1999-06-04 | 2009-09-22 | Consejo Superior De Investigaciones Cientificas | Use of high oleic high stearic oils |
| US6388113B1 (en) | 1999-06-04 | 2002-05-14 | Consejo Superior De Investigaciones Cientificas ( Csic) | High oleic/high stearic sunflower oils |
| EP1232250A2 (de) * | 1999-11-24 | 2002-08-21 | E.I. Du Pont De Nemours And Company | Oleoyl-acylträgerprotein thioesterasen aus pflanzen |
| EP1303616A2 (de) | 2000-07-25 | 2003-04-23 | Calgene LLC | Beta-ketoacyl synthase kodierende nukeleinsäure sequenzen und deren verwendungen |
| CA2468838A1 (en) * | 2001-11-28 | 2003-06-05 | Mj Bioworks Incorporated | Methods of using improved polymerases |
| EP2216405A1 (de) | 2002-05-03 | 2010-08-11 | Monsanto Technology LLC | Saatspezifische USP-Promotoren zur Expression von Genen in Pflanzen |
| US7078234B2 (en) | 2002-12-18 | 2006-07-18 | Monsanto Technology Llc | Maize embryo-specific promoter compositions and methods for use thereof |
| BRPI0408896A (pt) | 2003-03-28 | 2006-04-25 | Monsanto Technology Llc | promotores de planta para uso no desenvolvimento precoce de sementes |
| US20090031440A1 (en) | 2005-02-26 | 2009-01-29 | Basf Plant Science Gmbh | Expression Cassettes for Seed-Preferential Expression in Plants |
| US8034994B2 (en) * | 2005-04-19 | 2011-10-11 | Basf Plant Science Gmbh | Starchy-endosperm and/or germinating embryo-specific expression in mono-cotyledonous plants |
| CA2605393A1 (en) | 2005-04-20 | 2006-10-26 | Basf Plant Science Gmbh | Expression cassettes for seed-preferential expression in plants |
| EP1882037A2 (de) | 2005-05-10 | 2008-01-30 | BASF Plant Science GmbH | Expressionskassetten zur bevorzugten expression in pflanzensamen |
| WO2008100251A1 (en) * | 2007-02-13 | 2008-08-21 | Ls9, Inc. | Modified microorganism uses therefor |
| US8110670B2 (en) | 2006-05-19 | 2012-02-07 | Ls9, Inc. | Enhanced production of fatty acid derivatives |
| US20100242345A1 (en) | 2006-05-19 | 2010-09-30 | LS9, Inc | Production of fatty acids & derivatives thereof |
| US8029579B2 (en) | 2006-06-28 | 2011-10-04 | COH Inc. | Fatty acid blends and uses therefor |
| TW200826924A (en) * | 2006-09-08 | 2008-07-01 | Kaneka Corp | Composition containing reduced coenzyme Q10 and lysolecithin |
| CA2675926A1 (en) | 2007-02-16 | 2008-08-21 | Basf Plant Science Gmbh | Nucleic acid sequences for regulation of embryo-specific expression in monocotyledonous plants |
| JP5677839B2 (ja) | 2007-07-09 | 2015-02-25 | バイエル・クロップサイエンス・エヌ・ヴェーBayer Cropscience N.V. | 突然変異脂肪酸アシル−acpチオエステラーゼ対立遺伝子を含むアブラナ属植物 |
| DK2234994T3 (da) * | 2007-12-27 | 2017-11-13 | Cibus Europe Bv | Fedtsyre-butylester-blandinger |
| EP2419514A4 (de) | 2009-04-17 | 2012-10-24 | Basf Plant Science Co Gmbh | In endospermata betreibbarer pflanzenpromotor und verwendungen davon |
| CA3020943A1 (en) | 2009-04-22 | 2010-10-28 | Basf Plant Science Company Gmbh | Whole seed specific promoter |
| EP2425007A4 (de) | 2009-04-27 | 2013-01-02 | Ls9 Inc | Herstellung von fettsäureestern |
| WO2011008565A1 (en) | 2009-06-29 | 2011-01-20 | Synthetic Genomics, Inc. | Acyl-acp thioesterase genes and uses therefor |
| AU2010270309A1 (en) | 2009-07-10 | 2012-02-02 | Basf Plant Science Company Gmbh | Expression cassettes for endosperm-specific expression in plants |
| WO2011011568A2 (en) | 2009-07-24 | 2011-01-27 | The Regenst Of The University Of California | Methods and compositions for the production of fatty acids in photosynthetic prokaryotic microorganisms |
| EP2507375A4 (de) | 2009-12-03 | 2013-04-24 | Basf Plant Science Co Gmbh | Expressionskassetten für embryospezifische expression in pflanzen |
| JP5764339B2 (ja) | 2010-05-06 | 2015-08-19 | 花王株式会社 | チオエステラーゼ及びそれを用いた脂肪酸又は脂質の製造方法 |
| WO2012138423A1 (en) | 2011-02-17 | 2012-10-11 | The Procter & Gamble Company | Compositions comprising mixtures of c10-c13 alkylphenyl sulfonates |
| MX2013009546A (es) | 2011-02-17 | 2013-11-22 | Procter & Gamble | Alquilfenil sulfonatos lineales de base biologica. |
| US20140357727A1 (en) | 2011-12-20 | 2014-12-04 | Codexis, Inc. | Fatty alcohol forming acyl reductase (far) variants and methods of use |
| US20150133698A1 (en) | 2012-04-20 | 2015-05-14 | Codexis, Inc. | Production of fatty alcohols from engineered microorganisms |
| WO2014015278A1 (en) | 2012-07-20 | 2014-01-23 | Codexis, Inc. | Production of fatty alcohols from engineered microorganisms |
| US9512447B2 (en) | 2012-12-14 | 2016-12-06 | Codexis, Inc. | Modified native beta-ketoacyl-ACP synthases and engineered microorganisms |
| AU2013367325B2 (en) | 2012-12-27 | 2019-12-19 | Kao Corporation | Acyl-ACP thioesterase |
| US9567615B2 (en) | 2013-01-29 | 2017-02-14 | Terravia Holdings, Inc. | Variant thioesterases and methods of use |
| US9816079B2 (en) | 2013-01-29 | 2017-11-14 | Terravia Holdings, Inc. | Variant thioesterases and methods of use |
| MX2015011507A (es) * | 2013-03-15 | 2016-04-07 | Solazyme Inc | Tioesterasas y celulas para producir aceites diseñados. |
| US9290749B2 (en) | 2013-03-15 | 2016-03-22 | Solazyme, Inc. | Thioesterases and cells for production of tailored oils |
| US9783836B2 (en) | 2013-03-15 | 2017-10-10 | Terravia Holdings, Inc. | Thioesterases and cells for production of tailored oils |
| US9828613B2 (en) | 2013-07-12 | 2017-11-28 | Kao Corporation | Acyl-ACP thioesterase |
| CN105829521A (zh) | 2013-10-04 | 2016-08-03 | 索拉兹米公司 | 定制油 |
| US10550412B2 (en) | 2014-06-20 | 2020-02-04 | Kao Corporation | Method of producing lipid |
| EP3660149A1 (de) | 2014-07-24 | 2020-06-03 | Corbion Biotech, Inc. | Variante thioesterasen und verfahren zur verwendung |
| CN107208103A (zh) | 2014-09-18 | 2017-09-26 | 泰拉瑞亚控股公司 | 酰基‑acp硫酯酶及其突变体 |
| WO2016076231A1 (ja) | 2014-11-14 | 2016-05-19 | 花王株式会社 | アシル-acpチオエステラーゼを用いた脂質の製造方法 |
| BR112017021421A2 (pt) | 2015-04-06 | 2018-07-24 | Terravia Holdings Inc | microalgas oleaginosas que têm uma ablação de lpaat |
| JP6587468B2 (ja) | 2015-09-11 | 2019-10-09 | 花王株式会社 | 脂質の製造方法 |
| US20180142218A1 (en) | 2016-10-05 | 2018-05-24 | Terravia Holdings, Inc. | Novel acyltransferases, variant thioesterases, and uses thereof |
| JP7022556B2 (ja) | 2017-10-06 | 2022-02-18 | 花王株式会社 | 脂質の製造方法 |
| WO2020041521A1 (en) | 2018-08-22 | 2020-02-27 | Corbion Biotech, Inc. | β-KETOACYL-ACP SYNTHASE II VARIANTS |
| EP4090735A1 (de) | 2020-01-16 | 2022-11-23 | Corbion Biotech, Inc. | Beta-ketoacyl-acp-synthase-iv-varianten |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL8003143A (nl) * | 1980-05-30 | 1982-01-04 | Unilever Nv | Hardvet, dat in margarine-, halvarine-, bak- en braad- vetten kan worden verwerkt, en margarine, halvarine, bak- en braadvetten die daarmee zijn bereid. |
| US4410557A (en) * | 1981-12-21 | 1983-10-18 | Scm Corporation | Rearranged triglycerides and process for making same |
| GB8317248D0 (en) * | 1983-06-24 | 1983-07-27 | Wyeth John & Brother Ltd | Fat compositions |
| NZ221259A (en) * | 1986-07-31 | 1990-05-28 | Calgene Inc | Seed specific transcriptional regulation |
| ATE187303T1 (de) * | 1987-12-31 | 1999-12-15 | Pioneer Hi Bred Int | Raps mit erhöhtem ölsäuregehalt |
| US5344771A (en) * | 1990-04-26 | 1994-09-06 | Calgene, Inc. | Plant thiosterases |
| US5512482A (en) * | 1990-04-26 | 1996-04-30 | Calgene, Inc. | Plant thioesterases |
-
1992
- 1992-01-22 US US07/824,247 patent/US5512482A/en not_active Expired - Lifetime
- 1992-05-21 ES ES92913220T patent/ES2217253T3/es not_active Expired - Lifetime
- 1992-05-21 DE DE69233323T patent/DE69233323T2/de not_active Expired - Lifetime
- 1992-05-21 AT AT92913220T patent/ATE262042T1/de not_active IP Right Cessation
- 1992-05-21 EP EP92913220A patent/EP0557469B1/de not_active Expired - Lifetime
- 1992-05-21 CA CA002109580A patent/CA2109580C/en not_active Expired - Lifetime
- 1992-05-21 WO PCT/US1992/004332 patent/WO1992020236A1/en not_active Ceased
-
2001
- 2001-11-22 JP JP2001358370A patent/JP2002238386A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| DE69233323D1 (de) | 2004-04-22 |
| EP0557469A1 (de) | 1993-09-01 |
| ES2217253T3 (es) | 2004-11-01 |
| CA2109580C (en) | 2009-08-04 |
| EP0557469B1 (de) | 2004-03-17 |
| WO1992020236A1 (en) | 1992-11-26 |
| EP0557469A4 (de) | 1993-07-14 |
| JP2002238386A (ja) | 2002-08-27 |
| DE69233323T2 (de) | 2005-02-24 |
| CA2109580A1 (en) | 1992-11-26 |
| US5512482A (en) | 1996-04-30 |
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