ATE262178T1 - Identifizierung und charakterisierung von interagierenden molekülen - Google Patents

Identifizierung und charakterisierung von interagierenden molekülen

Info

Publication number
ATE262178T1
ATE262178T1 AT98965192T AT98965192T ATE262178T1 AT E262178 T1 ATE262178 T1 AT E262178T1 AT 98965192 T AT98965192 T AT 98965192T AT 98965192 T AT98965192 T AT 98965192T AT E262178 T1 ATE262178 T1 AT E262178T1
Authority
AT
Austria
Prior art keywords
interacting molecules
identification
present
characterization
positive clones
Prior art date
Application number
AT98965192T
Other languages
English (en)
Inventor
Erich Wanker
David Bancroft
Hans Lehrach
Niels Wedemeyer
Elmar Maier
Sebastian Meier-Ewert
Original Assignee
Max Planck Gesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Max Planck Gesellschaft filed Critical Max Planck Gesellschaft
Application granted granted Critical
Publication of ATE262178T1 publication Critical patent/ATE262178T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00—Methods of screening libraries
    • C40B30/04—Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1055—Protein x Protein interaction, e.g. two hybrid selection
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Plant Pathology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Vending Machines For Individual Products (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AT98965192T 1997-11-27 1998-11-27 Identifizierung und charakterisierung von interagierenden molekülen ATE262178T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP97120880 1997-11-27
EP97120879 1997-11-27
EP97120867 1997-11-27
PCT/EP1998/007656 WO1999028744A1 (en) 1997-11-27 1998-11-27 Identification and characterization of interacting molecules

Publications (1)

Publication Number Publication Date
ATE262178T1 true ATE262178T1 (de) 2004-04-15

Family

ID=27238345

Family Applications (2)

Application Number Title Priority Date Filing Date
AT98965193T ATE269974T1 (de) 1997-11-27 1998-11-27 Identifizierung und charakterisierung von interagierenden molekülen mittels automatisierter interagierender paarung
AT98965192T ATE262178T1 (de) 1997-11-27 1998-11-27 Identifizierung und charakterisierung von interagierenden molekülen

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT98965193T ATE269974T1 (de) 1997-11-27 1998-11-27 Identifizierung und charakterisierung von interagierenden molekülen mittels automatisierter interagierender paarung

Country Status (10)

Country Link
US (1) US6664048B1 (de)
EP (3) EP1042670B1 (de)
JP (3) JP2002507386A (de)
AT (2) ATE269974T1 (de)
AU (3) AU762954B2 (de)
CA (3) CA2311896A1 (de)
DE (2) DE69824757T2 (de)
GB (1) GB2338711B (de)
IL (3) IL136392A0 (de)
WO (3) WO1999028745A1 (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7029847B2 (en) 2000-05-16 2006-04-18 Massachusetts Institute Of Technology Methods and compositions for interaction trap assays
AU2001263155A1 (en) 2000-05-16 2001-11-26 Massachusetts Institute Of Technology Methods and compositions for interaction trap assays
DE60127867T2 (de) * 2000-06-13 2008-01-17 Glaxo Group Ltd., Greenford Hochdurchsatzscreening von verbindungen für biologische wirksamkeit
PT1292710E (pt) * 2000-06-23 2007-12-04 Domantis Ltd Método de rastreio de matriz
JP4024994B2 (ja) 2000-06-30 2007-12-19 株式会社東芝 半導体発光素子
AU2001278872A1 (en) 2000-07-06 2002-01-21 Genvec, Inc. Method of identifying a binding partner of a gene product
JP4823470B2 (ja) 2000-07-13 2011-11-24 シーティー−コンセプト・ホールディング・アクチェンゲゼルシャフト 電力半導体スイッチの過渡状態を状態に応じて制御する方法と装置
US7390458B2 (en) * 2000-10-13 2008-06-24 Irm Llc High throughput processing system and method of using
CA2439263C (en) 2001-03-02 2012-10-23 Frank Becker Three hybrid assay system
EP1243327A1 (de) * 2001-03-19 2002-09-25 BioChip Technologies GmbH Oberfläche mit einem Muster aus Zellen und Verfahren zu deren Herstellung
US7219016B2 (en) * 2001-04-20 2007-05-15 Yale University Systems and methods for automated analysis of cells and tissues
WO2002103608A2 (en) * 2001-06-14 2002-12-27 Ramot University Authority For Applied Research & Industrial Development Ltd. Method of expanding a biological network
DE10141522C1 (de) * 2001-08-24 2003-03-06 Siemens Ag Verfahren zur Herstellung einer Leuchtstoffschicht
US20020094519A1 (en) * 2002-03-07 2002-07-18 Agencourt Bioscience Corporation Detection of protein interactions
US20040067532A1 (en) 2002-08-12 2004-04-08 Genetastix Corporation High throughput generation and affinity maturation of humanized antibody
US20050074780A1 (en) * 2003-10-01 2005-04-07 Bryhan Marie D. Device for analyzing slides
WO2006040154A2 (en) * 2004-10-14 2006-04-20 Dublin City University Prokaryotic two hybrid system
US8034180B2 (en) 2005-10-11 2011-10-11 Applied Materials, Inc. Method of cooling a wafer support at a uniform temperature in a capacitively coupled plasma reactor
US8092638B2 (en) 2005-10-11 2012-01-10 Applied Materials Inc. Capacitively coupled plasma reactor having a cooled/heated wafer support with uniform temperature distribution
US8157951B2 (en) 2005-10-11 2012-04-17 Applied Materials, Inc. Capacitively coupled plasma reactor having very agile wafer temperature control
US7988872B2 (en) 2005-10-11 2011-08-02 Applied Materials, Inc. Method of operating a capacitively coupled plasma reactor with dual temperature control loops
US20070091540A1 (en) 2005-10-20 2007-04-26 Applied Materials, Inc. Method of processing a workpiece in a plasma reactor using multiple zone feed forward thermal control
US7932030B2 (en) * 2007-04-05 2011-04-26 The Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College System for pulling out regulatory elements using yeast
US8877688B2 (en) 2007-09-14 2014-11-04 Adimab, Llc Rationally designed, synthetic antibody libraries and uses therefor
US12529164B2 (en) 2007-09-14 2026-01-20 Adimab, Llc Rationally designed, synthetic antibody libraries and uses therefor
JP5933894B2 (ja) 2007-09-14 2016-06-15 アディマブ， エルエルシー 合理的に設計された、合成抗体ライブラリおよびその使用
KR102810907B1 (ko) 2010-07-16 2025-05-21 아디맵 엘엘씨 항체 라이브러리
WO2018011422A1 (en) * 2016-07-15 2018-01-18 Danmarks Tekniske Universitet Plating cells and corresponding picking colonies
US20210285062A1 (en) * 2017-05-16 2021-09-16 The Regents Of The University Of California Fluorescence detection in yeast colonies
US20210147790A1 (en) * 2019-11-06 2021-05-20 General Automation Lab Technologies Inc. Method for picking biological sample

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5283173A (en) * 1990-01-24 1994-02-01 The Research Foundation Of State University Of New York System to detect protein-protein interactions
US5789184A (en) 1993-03-31 1998-08-04 Cadus Pharmaceutical Corporation Yeast cells engineered to produce pheromone system protein surrogates, and uses therefor
US5503977A (en) 1994-04-22 1996-04-02 California Institute Of Technology Split ubiquitin protein sensor
ATE352638T1 (de) * 1995-04-11 2007-02-15 Gen Hospital Corp REVERSE ßTWO-HYBRIDß-SYSTEME
US5569588A (en) * 1995-08-09 1996-10-29 The Regents Of The University Of California Methods for drug screening
EP0790304A1 (de) * 1995-12-21 1997-08-20 AMERSHAM INTERNATIONAL plc Auf Nachweismethoden bezogene Verbesserungen
US6083693A (en) * 1996-06-14 2000-07-04 Curagen Corporation Identification and comparison of protein-protein interactions that occur in populations
AU4159697A (en) * 1996-08-23 1998-03-06 President And Fellows Of Harvard College Interaction trap assay, reagents and uses thereof

Also Published As

Publication number Publication date
GB2338711B (en) 2000-11-15
EP1036324B1 (de) 2004-06-23
EP1042670A1 (de) 2000-10-11
IL136393A0 (en) 2001-06-14
EP1042670B1 (de) 2004-03-17
IL136392A0 (en) 2001-06-14
US6664048B1 (en) 2003-12-16
DE69824757D1 (de) 2004-07-29
ATE269974T1 (de) 2004-07-15
AU2050499A (en) 1999-06-16
CA2311705A1 (en) 1999-06-10
DE69822510T2 (de) 2005-03-24
GB2338711A (en) 1999-12-29
WO1999031509A1 (en) 1999-06-24
WO1999028744A1 (en) 1999-06-10
AU1757599A (en) 1999-07-05
DE69824757T2 (de) 2005-10-20
AU762954B2 (en) 2003-07-10
GB2338711A8 (en) 2000-01-26
WO1999028745A1 (en) 1999-06-10
JP2001525186A (ja) 2001-12-11
EP1036329A1 (de) 2000-09-20
AU2050599A (en) 1999-06-16
GB9923293D0 (en) 1999-12-08
EP1036324A1 (de) 2000-09-20
AU760908B2 (en) 2003-05-22
IL136394A0 (en) 2001-06-14
JP2002507386A (ja) 2002-03-12
JP2002508517A (ja) 2002-03-19
CA2311896A1 (en) 1999-06-24
CA2311927A1 (en) 1999-06-10
DE69822510D1 (de) 2004-04-22

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