ATE262507T1 - Substituierte n-phenyl-2-hydroxy-2-methyl-3,3,3- trifluorpropanamid-derivative zur erhöhung der pyruvatdehydrogenaseaktivität - Google Patents

Substituierte n-phenyl-2-hydroxy-2-methyl-3,3,3- trifluorpropanamid-derivative zur erhöhung der pyruvatdehydrogenaseaktivität

Info

Publication number
ATE262507T1
ATE262507T1 AT00956672T AT00956672T ATE262507T1 AT E262507 T1 ATE262507 T1 AT E262507T1 AT 00956672 T AT00956672 T AT 00956672T AT 00956672 T AT00956672 T AT 00956672T AT E262507 T1 ATE262507 T1 AT E262507T1
Authority
AT
Austria
Prior art keywords
trifluoropanamide
hydroxy
phenyl
derivative
substituted
Prior art date
Application number
AT00956672T
Other languages
English (en)
Inventor
Roger John Butlin
Janet Elizabeth Pease
Michael Howard Block
Thorsten Nowak
Jeremy Nicholas Burrows
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9920814.2A external-priority patent/GB9920814D0/en
Priority claimed from GB0006641A external-priority patent/GB0006641D0/en
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Application granted granted Critical
Publication of ATE262507T1 publication Critical patent/ATE262507T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C317/32—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C317/34—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring
    • C07C317/38—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring with the nitrogen atom of at least one amino group being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfones
    • C07C317/42—Y being a hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • C07C317/48—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C317/50—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/64—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton
    • C07C323/65—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton containing sulfur atoms of sulfone or sulfoxide groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Obesity (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Pyrrole Compounds (AREA)
AT00956672T 1999-09-04 2000-08-30 Substituierte n-phenyl-2-hydroxy-2-methyl-3,3,3- trifluorpropanamid-derivative zur erhöhung der pyruvatdehydrogenaseaktivität ATE262507T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9920814.2A GB9920814D0 (en) 1999-09-04 1999-09-04 Chemical compounds
GB0006641A GB0006641D0 (en) 2000-03-21 2000-03-21 Chemical compounds
PCT/GB2000/003314 WO2001017956A1 (en) 1999-09-04 2000-08-30 Substituted n-phenyl 2-hydroxy-2-methyl-3,3,3-trifluoropropanamide derivatives which elevate pyruvate dehydrogenase activity

Publications (1)

Publication Number Publication Date
ATE262507T1 true ATE262507T1 (de) 2004-04-15

Family

ID=26243905

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00956672T ATE262507T1 (de) 1999-09-04 2000-08-30 Substituierte n-phenyl-2-hydroxy-2-methyl-3,3,3- trifluorpropanamid-derivative zur erhöhung der pyruvatdehydrogenaseaktivität

Country Status (32)

Country Link
US (1) US6689909B1 (de)
EP (1) EP1214296B1 (de)
JP (1) JP2003508515A (de)
KR (1) KR100692232B1 (de)
CN (1) CN1235877C (de)
AR (1) AR035163A1 (de)
AT (1) ATE262507T1 (de)
AU (1) AU760061B2 (de)
BG (1) BG65099B1 (de)
BR (1) BR0013694A (de)
CA (1) CA2381581A1 (de)
CO (1) CO5190690A1 (de)
CZ (1) CZ2002773A3 (de)
DE (1) DE60009319T2 (de)
DK (1) DK1214296T3 (de)
EE (1) EE05080B1 (de)
ES (1) ES2216940T3 (de)
HK (1) HK1045496B (de)
HU (1) HUP0202725A3 (de)
IL (2) IL148111A0 (de)
IS (1) IS2069B (de)
MX (1) MXPA02002319A (de)
MY (1) MY127036A (de)
NO (1) NO20021040L (de)
NZ (1) NZ517147A (de)
PL (1) PL353887A1 (de)
PT (1) PT1214296E (de)
RU (1) RU2255085C2 (de)
SK (1) SK286774B6 (de)
TR (1) TR200200550T2 (de)
TW (1) TW577867B (de)
WO (1) WO2001017956A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003508509A (ja) 1999-09-04 2003-03-04 アストラゼネカ アクチボラグ ピルビン酸デヒドロゲナーゼの阻害剤としてのアミド
GB0012012D0 (en) * 2000-05-19 2000-07-05 Astrazeneca Ab Chemical compound
GB0120471D0 (en) * 2001-08-23 2001-10-17 Astrazeneca Ab Chemical compounds
US7399775B2 (en) * 2001-12-27 2008-07-15 Daiichi Pharmaceutical Co., Ltd. β-amyloid protein production/secretion inhibitor
WO2012151448A1 (en) * 2011-05-03 2012-11-08 Agios Pharmaceuticals, Inc. Pyruvate kinase activators for use in therapy
CA2890664A1 (en) 2012-11-08 2014-05-15 Agios Pharmaceuticals, Inc. Therapeutic compounds and compositions and their use as pkm2 modulators
WO2014139144A1 (en) 2013-03-15 2014-09-18 Agios Pharmaceuticals, Inc. Therapeutic compounds and compositions
CN111032045B (zh) 2017-08-15 2023-08-15 安吉奥斯医药品有限公司 用于治疗血液病症的丙酮酸激酶激活剂
CN109096186B (zh) * 2018-09-29 2020-08-04 中南大学 一种2-芳磺酰基喹啉衍生物的合成方法
JPWO2023032940A1 (de) * 2021-09-01 2023-03-09

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2862100D1 (en) 1977-10-12 1983-01-05 Ici Plc Acylanilides, process for their manufacture and pharmaceutical and veterinary compositions containing them
US4191775A (en) 1977-12-15 1980-03-04 Imperial Chemical Industries Limited Amide derivatives
NZ197008A (en) 1980-05-22 1984-10-19 Ici Ltd Acylanilide derivatives and pharmaceutical compositions
AU8961382A (en) 1981-11-06 1983-05-12 Imperial Chemical Industries Plc Amide derivatives
US4537618A (en) 1982-05-26 1985-08-27 Ciba Geigy Corporation N-phenylsulfonyl-N'-pyrimidinylureas
ATE28864T1 (de) 1982-07-23 1987-08-15 Ici Plc Amide-derivate.
GB8617653D0 (en) 1986-07-18 1986-08-28 Ici Plc Amide derivatives
GB8617652D0 (en) 1986-07-18 1986-08-28 Ici Plc Acylanilide derivatives
GB9116069D0 (en) * 1991-07-25 1991-09-11 Ici Plc Therapeutic amides
GB9214120D0 (en) * 1991-07-25 1992-08-12 Ici Plc Therapeutic amides
EP0539329A1 (de) 1991-10-25 1993-04-28 Ciba-Geigy Ag Acetylen-Verbindungen, verwendbar als Leukotrien-Antagonisten
SE9103397D0 (sv) 1991-11-18 1991-11-18 Kabi Pharmacia Ab Nya substituerade salicylsyror
IL105558A (en) 1992-05-18 1998-04-05 Zeneca Ltd Tertiary carbinols having potassium channel activity, process for their preparation and pharmaceutical compositions containing them
GB9305295D0 (en) * 1993-03-15 1993-05-05 Zeneca Ltd Therapeutic compounds
GB9309716D0 (en) 1993-05-12 1993-06-23 Zeneca Ltd Heterocyclic derivatives
GB9310095D0 (en) 1993-05-17 1993-06-30 Zeneca Ltd Therapeutic compounds
GB9310069D0 (en) 1993-05-17 1993-06-30 Zeneca Ltd Heterocyclic compounds
GB2278054A (en) 1993-05-18 1994-11-23 Zeneca Ltd Compounds for the treatment of urinary incontinence
GB9505082D0 (en) 1995-03-14 1995-05-03 Zeneca Ltd Medicament
GB9607458D0 (en) 1996-04-10 1996-06-12 Zeneca Ltd Enzymatic process for stereoselective preparation of therapeutic amides
GB9804648D0 (en) 1998-03-06 1998-04-29 Zeneca Ltd Chemical compounds
GB9805520D0 (en) 1998-03-17 1998-05-13 Zeneca Ltd Chemical compounds
GB9811427D0 (en) * 1998-05-29 1998-07-22 Zeneca Ltd Chemical compounds

Also Published As

Publication number Publication date
RU2002108508A (ru) 2004-01-20
CN1235877C (zh) 2006-01-11
NO20021040D0 (no) 2002-03-01
HUP0202725A3 (en) 2005-04-28
MY127036A (en) 2006-11-30
TW577867B (en) 2004-03-01
IL148111A0 (en) 2002-09-12
KR100692232B1 (ko) 2007-03-09
SK3002002A3 (en) 2002-07-02
CZ2002773A3 (cs) 2002-06-12
IS6285A (is) 2002-02-26
ES2216940T3 (es) 2004-11-01
RU2255085C2 (ru) 2005-06-27
CA2381581A1 (en) 2001-03-15
HK1045496A1 (en) 2002-11-29
NO20021040L (no) 2002-05-02
HK1045496B (en) 2004-10-21
KR20020067498A (ko) 2002-08-22
IS2069B (is) 2005-11-15
BR0013694A (pt) 2002-05-21
DK1214296T3 (da) 2004-07-05
BG106520A (en) 2003-03-31
IL148111A (en) 2007-05-15
DE60009319T2 (de) 2005-03-31
HUP0202725A2 (hu) 2003-01-28
DE60009319D1 (de) 2004-04-29
BG65099B1 (bg) 2007-02-28
SK286774B6 (sk) 2009-05-07
PL353887A1 (en) 2003-12-15
AU760061B2 (en) 2003-05-08
AU6854300A (en) 2001-04-10
TR200200550T2 (tr) 2002-06-21
US6689909B1 (en) 2004-02-10
WO2001017956A1 (en) 2001-03-15
CO5190690A1 (es) 2002-08-29
MXPA02002319A (es) 2002-07-30
CN1387509A (zh) 2002-12-25
EE05080B1 (et) 2008-10-15
EE200200113A (et) 2003-06-16
JP2003508515A (ja) 2003-03-04
EP1214296B1 (de) 2004-03-24
AR035163A1 (es) 2004-05-05
NZ517147A (en) 2003-11-28
EP1214296A1 (de) 2002-06-19
PT1214296E (pt) 2004-08-31

Similar Documents

Publication Publication Date Title
LU93311I2 (fr) Mancozèbe, valifenalate
PT1177185E (pt) Derivados de 4, 5, 6, 7-tetra-hidroindazole como agentes antitumorais
NO20013814L (no) Nede i hullet traktor
IS5714A (is) Ný 3-arýl-2-hýdroxýprópíonsýruafleiða (I)
NO20006114D0 (no) Nytt 3-aryl-2-hydroksypropionsyrederivat III
DE60012883D1 (de) 2,3,4,5-tetrahydro-1h-[1,4]benzodiazepin-3-hydroxamsäure als matrix metalloproteinaseinhibitoren
EP1185172A4 (de) Agrochemische zusammensetzng
PT1246810E (pt) Piperidiniloxi- e pirrolidiniloxifeniloxazolidinonas como antibacterianos
DE60009319D1 (de) Substituierte n-phenyl-2-hydroxy-2-methyl-3,3,3-trifluorpropanamid-derivative zur erhöhung der pyruvatdehydrogenaseaktivität
DE60025958D1 (de) 14,15-beta-methylen substituierte androgene
NO20023172D0 (no) 10, 11-difluormetylendioksycamptothecin-forbindelser med topoisomerase I inhibering
DE60005462D1 (de) Tintenzusammensetzungen enthaltend 1,3,5-Trioxan
DE50010816D1 (de) Landwirtschaftliche Verteilmaschine
DE60000826D1 (de) 14.beta.,17-alpha-hydroxymethylandrostan derivate als androgene
ES1044850Y (es) Juguete de composicion.
PL368615A1 (en) Substituted n-phenyl 2-hydroxy-2-methyl-3,3,3-trifluropropanamide derivatives which elevate pyruvate dehydrogenase activity
DE50003051D1 (de) Landwirtschaftliche Verteilmaschine
DK1099364T3 (da) Landbrugsspredemaskine
BR7901267Y1 (pt) disposição construtiva aplicada em conjunto rolete.
AU2001234198A1 (en) Composition with acaricidal activity derived from plants
ES1044994Y (es) Casita infantil perfeccionada.
PT102826B (pt) Compostos de diorgano-estanho derivados de acidos aril-hidroxamicos, com actividade anti-cancerigena
IT1301933B1 (it) Accendino perfezionato, particolarmente studiato per accendere lepipe
IT1313124B1 (it) Salva-cravatta indossata,a perdere
ATA4212003A (de) Strahlungsempfindliche zusammensetzung

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1214296

Country of ref document: EP

REN Ceased due to non-payment of the annual fee