ATE262515T1 - Discodermolide verbindungen und deren pharmazeutische zusammensetzungen zur krebstherapie - Google Patents

Discodermolide verbindungen und deren pharmazeutische zusammensetzungen zur krebstherapie

Info

Publication number: ATE262515T1
Authority: AT; Austria
Prior art keywords: pharmaceutical compositions; compounds; cancer therapy; cancer cells; discodermolide compounds
Prior art date: 1995-12-05

Application number

AT96943591T

Other languages

English (en)

Inventor

Ross E Longley

Sarath P Gunasekera

Shirley Pomponi

Original Assignee

Harbor Branch Oceanographic

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-12-05

Filing date

1996-12-05

Publication date

2004-04-15

1996-12-05 Application filed by Harbor Branch Oceanographic filed Critical Harbor Branch Oceanographic

2004-04-15 Application granted granted Critical

2004-04-15 Publication of ATE262515T1 publication Critical patent/ATE262515T1/de

Links

AADVCYNFEREWOS-OBRABYBLSA-N Discodermolide Chemical class C=C\C=C/[C@H](C)[C@H](OC(N)=O)[C@@H](C)[C@H](O)[C@@H](C)C\C(C)=C/[C@H](C)[C@@H](O)[C@@H](C)\C=C/[C@@H](O)C[C@@H]1OC(=O)[C@H](C)[C@@H](O)[C@H]1C AADVCYNFEREWOS-OBRABYBLSA-N 0.000 title 1
238000011275 oncology therapy Methods 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1
206010028980 Neoplasm Diseases 0.000 abstract 2
201000011510 cancer Diseases 0.000 abstract 2
208000026310 Breast neoplasm Diseases 0.000 abstract 1
241001290275 Discodermia dissoluta Species 0.000 abstract 1
210000000481 breast Anatomy 0.000 abstract 1
210000003169 central nervous system Anatomy 0.000 abstract 1
208000025997 central nervous system neoplasm Diseases 0.000 abstract 1
210000001072 colon Anatomy 0.000 abstract 1
208000029742 colonic neoplasm Diseases 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
-1 lactone compounds Chemical class 0.000 abstract 1
208000032839 leukemia Diseases 0.000 abstract 1
208000037841 lung tumor Diseases 0.000 abstract 1
201000001441 melanoma Diseases 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/30—Oxygen atoms, e.g. delta-lactones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Epidemiology (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyrane Compounds (AREA)

AT96943591T 1995-12-05 1996-12-05 Discodermolide verbindungen und deren pharmazeutische zusammensetzungen zur krebstherapie ATE262515T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/567,442 US5681847A (en)	1995-12-05	1995-12-05	Methods of using discodermolide compounds
PCT/US1996/019344 WO1997020835A1 (en)	1995-12-05	1996-12-05	Discodermolide compounds and pharmaceutical compositions containing them for cancer therapy

Publications (1)

Publication Number	Publication Date
ATE262515T1 true ATE262515T1 (de)	2004-04-15

Family

ID=24267168

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT96943591T ATE262515T1 (de)	1995-12-05	1996-12-05	Discodermolide verbindungen und deren pharmazeutische zusammensetzungen zur krebstherapie

Country Status (10)

Country	Link
US (2)	US5681847A (de)
EP (1)	EP0873332B1 (de)
JP (1)	JP3293833B2 (de)
AT (1)	ATE262515T1 (de)
CA (1)	CA2233716C (de)
DE (1)	DE69631975T2 (de)
DK (1)	DK0873332T3 (de)
ES (1)	ES2218608T3 (de)
PT (1)	PT873332E (de)
WO (1)	WO1997020835A1 (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6870058B2 (en) *	1996-12-03	2005-03-22	The Trustees Of The University Of Pennsylvania	Compounds which mimic the chemical and biological properties of discodermolide
US20050065353A1 (en) *	1996-12-03	2005-03-24	Smith Amos B.	Synthetic techniques and intermediates for polyhydroxy dienyl lactones and mimics thereof
US5789605A (en) *	1996-12-03	1998-08-04	Trustees Of The University Of Pennsylvania	Synthetic techniques and intermediates for polyhydroxy, dienyl lactones and mimics thereof
US6242616B1 (en) *	1996-12-03	2001-06-05	The Trustees Of The University Of Pennsylvania	Synthetic techniques and intermediates for polyhydroxy, dienyl lactone derivatives
US6127406A (en) *	1998-10-09	2000-10-03	Harbor Branch Oceanographic Institution, Inc.	Discodermolide compounds and methods of use
US6858598B1 (en)	1998-12-23	2005-02-22	G. D. Searle & Co.	Method of using a matrix metalloproteinase inhibitor and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
US6833373B1 (en)	1998-12-23	2004-12-21	G.D. Searle & Co.	Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
US6384187B1 (en)	1999-05-15	2002-05-07	Harbor Branch Oceanographic Institution, Inc.	Antiproliferative activity of microsclerodermins
US6414015B1 (en) *	2000-01-28	2002-07-02	Utah State University	Laulimalide microtubule stabilizing agents
DE60108359T2 (de) *	2000-03-01	2005-12-22	Harbor Branch Oceanographic Institution, Inc., Fort Pierce	Biologisch wirksame, analoge verbindungen von discodermoliden
AU2000241948A1 (en) *	2000-04-04	2001-10-15	Novartis Ag	Method for treating cells resistant to antineoplastic agents
US6774143B1 (en)	2000-04-04	2004-08-10	Novartis Ag	Method for treating cells resistant to antineoplastic agents
IL160177A0 (en) *	2001-08-07	2004-07-25	Univ Pennsylvania	Compounds which mimic the chemical and biological properties of discodermolide
US6833367B2 (en) *	2001-11-16	2004-12-21	Novartis Ac	Certain substituted polyketides, pharmaceutical compositions containing them and their use in treating tumors
TW200408407A (en) *	2001-11-30	2004-06-01	Dana Farber Cancer Inst Inc	Methods and compositions for modulating the immune system and uses thereof
US7342124B2 (en) *	2003-04-02	2008-03-11	The Trustees Of The University Of Pennsylvania	Synthetic techniques and intermediates for polyhydroxy dienyl lactones and mimics thereof
WO2005084349A2 (en) *	2004-03-02	2005-09-15	Kosan Biosciences, Inc.	Compounds useful for the synthesis of (+)-discodermolide and methods therefor
US7214708B2 (en) *	2004-11-18	2007-05-08	Kosan Biosciences Incorporated	Synthetic discodermolide analogs
JP4954983B2 (ja)	2005-05-18	2012-06-20	ファーマサイエンス・インコーポレイテッド	Ｂｉｒドメイン結合化合物
CN101535300B (zh)	2006-05-16	2014-05-28	埃格拉医疗公司	Iap bir域结合化合物
RU2493147C2 (ru) *	2007-12-20	2013-09-20	Фарма Мар, С.А.	Противоопухолевые соединения
FR2937537A1 (fr)	2008-10-29	2010-04-30	Centre Nat Rech Scient	Nanoparticules de statine
EP2896632B1 (de)	2009-11-13	2017-10-25	Daiichi Sankyo Europe GmbH	Material und Verfahren zur Behandlung oder Vorbeugung von HER-3-assoziierten Erkrankungen
US9284350B2 (en)	2010-02-12	2016-03-15	Pharmascience Inc.	IAP BIR domain binding compounds
WO2012018404A2 (en)	2010-08-06	2012-02-09	U3 Pharma Gmbh	Use of her3 binding agents in prostate treatment
US10851121B2 (en) *	2016-12-09	2020-12-01	Akanocure Phamraceuticals, Inc.	Scalable polypropionate lactone stereotetrads
KR102491180B1 (ko)	2017-04-27	2023-01-20	파르마 마르 에스.에이.	항종양 화합물

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4206221A (en) *	1979-01-03	1980-06-03	The United States Of America As Represented By The Secretary Of Agriculture	Cephalomannine and its use in treating leukemic tumors
US5157049A (en) *	1988-03-07	1992-10-20	The United States Of America As Represented By The Department Of Health & Human Services	Method of treating cancers sensitive to treatment with water soluble derivatives of taxol
US4960790A (en) *	1989-03-09	1990-10-02	University Of Kansas	Derivatives of taxol, pharmaceutical compositions thereof and methods for the preparation thereof
US5010099A (en) *	1989-08-11	1991-04-23	Harbor Branch Oceanographic Institution, Inc.	Discodermolide compounds, compositions containing same and method of preparation and use
US4939168A (en) *	1989-08-11	1990-07-03	Harbor Branch Oceanographics Institution, Inc.	Discodermolide compounds, compositions containing same and methods of preparation and use

1995
- 1995-12-05 US US08/567,442 patent/US5681847A/en not_active Expired - Lifetime
1996
- 1996-12-05 PT PT96943591T patent/PT873332E/pt unknown
- 1996-12-05 WO PCT/US1996/019344 patent/WO1997020835A1/en not_active Ceased
- 1996-12-05 DK DK96943591T patent/DK0873332T3/da active
- 1996-12-05 US US08/761,106 patent/US5840750A/en not_active Expired - Lifetime
- 1996-12-05 ES ES96943591T patent/ES2218608T3/es not_active Expired - Lifetime
- 1996-12-05 AT AT96943591T patent/ATE262515T1/de not_active IP Right Cessation
- 1996-12-05 JP JP52141097A patent/JP3293833B2/ja not_active Expired - Fee Related
- 1996-12-05 DE DE69631975T patent/DE69631975T2/de not_active Expired - Lifetime
- 1996-12-05 EP EP96943591A patent/EP0873332B1/de not_active Expired - Lifetime
- 1996-12-05 CA CA002233716A patent/CA2233716C/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
CA2233716A1 (en)	1997-06-12
DE69631975D1 (de)	2004-04-29
WO1997020835A1 (en)	1997-06-12
DK0873332T3 (da)	2004-07-26
US5681847A (en)	1997-10-28
DE69631975T2 (de)	2005-01-20
EP0873332A1 (de)	1998-10-28
EP0873332B1 (de)	2004-03-24
CA2233716C (en)	2006-05-09
JP2000501710A (ja)	2000-02-15
PT873332E (pt)	2004-08-31
JP3293833B2 (ja)	2002-06-17
ES2218608T3 (es)	2004-11-16
US5840750A (en)	1998-11-24

Legal Events

Date

Code

Title

Description

2004-12-15

UEP

Publication of translation of european patent specification

Ref document number: 0873332

Country of ref document: EP

2011-09-15

REN

Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE262515T1 (de)	2004-04-15	Discodermolide verbindungen und deren pharmazeutische zusammensetzungen zur krebstherapie
ATE219363T1 (de)	2002-07-15	Lösliche prodrugs von paclitaxel
IT1276041B1 (it)	1997-10-24	Uso del taxol per la produzione di un medicamento per il trattamento delle forme cancerose
DE3689363D1 (de)	1994-01-20	Pharmazeutische Zusammensetzungen zur Behandlung der Metastasen von Krebstumoren.
DE69520880D1 (de)	2001-06-13	9-deoxotaxan verbindungen
IL87885A0 (en)	1989-03-31	Compounds having antiprogestational and anti-estrogenic activities for the treatment of tumours
GR3005457T3 (de)	1993-05-24
IT8027029A0 (it)	1980-12-31	Complessi platino-diamminici e formulazioni farmaceutiche per il trattamento del cancro che licontengono.
CZ143795A3 (en)	1995-11-15	7-halo and 7-beta, 8-betamethanotaxols, their anti-neoplastic use and pharmaceutical compositions containing thereof
DE69740175D1 (de)	2011-05-26	VERWENDUNG DES MELANOMDIFFERENZIERUNGS ASSOZIIERTEN GENS (mda-7) ZUR UMWANDLUNG EINES KREBSPHÄNOTYPS
MY130544A (en)	2007-06-29	Antineoplastic use and pharmaceutical compositions containing them
ATE171170T1 (de)	1998-10-15	7-äther-taxol ähnliche verbindungen antineoplastische verwendung und diese enthaltende pharmazeutische zusammenstellungen
IL123595A (en)	2000-10-31	Hydrolysis-promoting taxane hydrophobic derivatives and pharmaceutical compositions containing them
BR9808509A (pt)	2001-09-18	Composições e métodos para o tratamento e diagnóstico do câncer de mama
ATE82681T1 (de)	1992-12-15	2',3'-dideoxy-3'-fluorothymidin und verwandte verbindungen zur behandlung von adenovirusinfektionen.
GB1446536A (en)	1976-08-18	Pharmaceutically active compositions
AU1206292A (en)	1992-09-15	Therapeutic agents for the treatment of multidrug resistance to cancers
ATE237338T1 (de)	2003-05-15	Allogene parakrine cytokine tumor impfstoffe
SE8404283L (sv)	1986-03-01	Anvendning av ett specifikt tumorassocierat antigen, nemligen sialosyllaktotetraos, for diagnostiska och terapeutiska forfaranden vid cancersjukdomar
IT8720181A0 (it)	1987-04-17	Composizioni farmaceutiche contenenti alcoli superiori per il trattamento di patologie della prostata.
HU9401656D0 (en)	1994-09-28	Pharmaceutical composition for treating tumours, containing creatine phosphate or phospho-enol-pyruvic acid
JPS57150618A (en)	1982-09-17	Anticancer
ZA90962B (en)	1991-10-30	Phenylhydrazones,the manufacture thereof and therapeutic and cosmetic compositions prepared therefrom
ATE40987T1 (de)	1989-03-15	Acetylenische phenoxypropanolderivate und pharmazeutische zusammensetzungen fuer die behandlung von bluthochdruck.
DE69724472D1 (de)	2003-10-02	Selenophen-antitumormittel