DK0873332T3 - Discodermolidforbindelser samt farmaceutiske sammensætninger indeholdende dem til cancerterapi - Google Patents

Discodermolidforbindelser samt farmaceutiske sammensætninger indeholdende dem til cancerterapi

Info

Publication number: DK0873332T3
Authority: DK; Denmark
Prior art keywords: well; pharmaceutical compositions; compositions containing; cancer therapy; compounds
Prior art date: 1995-12-05

Application number

DK96943591T

Other languages

Danish (da)

English (en)

Inventor

Ross E Longley

Sarath P Gunasekera

Shirley Pomponi

Original Assignee

Harbor Branch Oceanographic

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-12-05

Filing date

1996-12-05

Publication date

2004-07-26

1996-12-05 Application filed by Harbor Branch Oceanographic filed Critical Harbor Branch Oceanographic

2004-07-26 Application granted granted Critical

2004-07-26 Publication of DK0873332T3 publication Critical patent/DK0873332T3/da

Links

AADVCYNFEREWOS-OBRABYBLSA-N Discodermolide Chemical class C=C\C=C/[C@H](C)[C@H](OC(N)=O)[C@@H](C)[C@H](O)[C@@H](C)C\C(C)=C/[C@H](C)[C@@H](O)[C@@H](C)\C=C/[C@@H](O)C[C@@H]1OC(=O)[C@H](C)[C@@H](O)[C@H]1C AADVCYNFEREWOS-OBRABYBLSA-N 0.000 title 1
238000011275 oncology therapy Methods 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1
206010028980 Neoplasm Diseases 0.000 abstract 2
201000011510 cancer Diseases 0.000 abstract 2
208000026310 Breast neoplasm Diseases 0.000 abstract 1
241001290275 Discodermia dissoluta Species 0.000 abstract 1
210000000481 breast Anatomy 0.000 abstract 1
210000003169 central nervous system Anatomy 0.000 abstract 1
208000025997 central nervous system neoplasm Diseases 0.000 abstract 1
210000001072 colon Anatomy 0.000 abstract 1
208000029742 colonic neoplasm Diseases 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
-1 lactone compounds Chemical class 0.000 abstract 1
208000032839 leukemia Diseases 0.000 abstract 1
208000037841 lung tumor Diseases 0.000 abstract 1
201000001441 melanoma Diseases 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/30—Oxygen atoms, e.g. delta-lactones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyrane Compounds (AREA)

DK96943591T 1995-12-05 1996-12-05 Discodermolidforbindelser samt farmaceutiske sammensætninger indeholdende dem til cancerterapi DK0873332T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/567,442 US5681847A (en)	1995-12-05	1995-12-05	Methods of using discodermolide compounds
PCT/US1996/019344 WO1997020835A1 (en)	1995-12-05	1996-12-05	Discodermolide compounds and pharmaceutical compositions containing them for cancer therapy

Publications (1)

Publication Number	Publication Date
DK0873332T3 true DK0873332T3 (da)	2004-07-26

Family

ID=24267168

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK96943591T DK0873332T3 (da)	1995-12-05	1996-12-05	Discodermolidforbindelser samt farmaceutiske sammensætninger indeholdende dem til cancerterapi

Country Status (10)

Country	Link
US (2)	US5681847A (de)
EP (1)	EP0873332B1 (de)
JP (1)	JP3293833B2 (de)
AT (1)	ATE262515T1 (de)
CA (1)	CA2233716C (de)
DE (1)	DE69631975T2 (de)
DK (1)	DK0873332T3 (de)
ES (1)	ES2218608T3 (de)
PT (1)	PT873332E (de)
WO (1)	WO1997020835A1 (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20050065353A1 (en) *	1996-12-03	2005-03-24	Smith Amos B.	Synthetic techniques and intermediates for polyhydroxy dienyl lactones and mimics thereof
US6870058B2 (en) *	1996-12-03	2005-03-22	The Trustees Of The University Of Pennsylvania	Compounds which mimic the chemical and biological properties of discodermolide
US5789605A (en) *	1996-12-03	1998-08-04	Trustees Of The University Of Pennsylvania	Synthetic techniques and intermediates for polyhydroxy, dienyl lactones and mimics thereof
US6242616B1 (en) *	1996-12-03	2001-06-05	The Trustees Of The University Of Pennsylvania	Synthetic techniques and intermediates for polyhydroxy, dienyl lactone derivatives
US6127406A (en) *	1998-10-09	2000-10-03	Harbor Branch Oceanographic Institution, Inc.	Discodermolide compounds and methods of use
US6833373B1 (en)	1998-12-23	2004-12-21	G.D. Searle & Co.	Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
US6858598B1 (en)	1998-12-23	2005-02-22	G. D. Searle & Co.	Method of using a matrix metalloproteinase inhibitor and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
US6384187B1 (en)	1999-05-15	2002-05-07	Harbor Branch Oceanographic Institution, Inc.	Antiproliferative activity of microsclerodermins
US6414015B1 (en) *	2000-01-28	2002-07-02	Utah State University	Laulimalide microtubule stabilizing agents
US6495594B2 (en)	2000-03-01	2002-12-17	Harbor Branch Oceanographic Institution, Inc.	Biologically active analogs of discodermolide
EP1274422A1 (de) *	2000-04-04	2003-01-15	Novartis AG	Verfahren zur behandlung von antineoplastika-resistenten zellen
US6774143B1 (en)	2000-04-04	2004-08-10	Novartis Ag	Method for treating cells resistant to antineoplastic agents
KR20040032898A (ko) *	2001-08-07	2004-04-17	더 트러스티스 오브 더 유니버시티 오브 펜실바니아	디스코데르몰리드의 화학적 및 생물학적 성질을 모사하는화합물
US6833367B2 (en) *	2001-11-16	2004-12-21	Novartis Ac	Certain substituted polyketides, pharmaceutical compositions containing them and their use in treating tumors
TW200408407A (en) *	2001-11-30	2004-06-01	Dana Farber Cancer Inst Inc	Methods and compositions for modulating the immune system and uses thereof
WO2004101508A2 (en) *	2003-04-02	2004-11-25	The Trustees Of The University Of Pennsylvania	Synthetic techniques and intermediates for polyhydroxy dienyl lactones and mimics thereof
US7348436B2 (en) *	2004-03-02	2008-03-25	Kosan Biosciences Incorporated	Compounds useful for the synthesis of (+)-discodermolide and methods thereof
US7214708B2 (en) *	2004-11-18	2007-05-08	Kosan Biosciences Incorporated	Synthetic discodermolide analogs
US7772177B2 (en)	2005-05-18	2010-08-10	Aegera Therapeutics, Inc.	BIR domain binding compounds
SG171682A1 (en)	2006-05-16	2011-06-29	Aegera Therapeutics Inc	Iap bir domain binding compounds
JP5727228B2 (ja)	2007-12-20	2015-06-03	ファルマ・マール・ソシエダード・アノニマ	抗腫瘍化合物
FR2937537A1 (fr)	2008-10-29	2010-04-30	Centre Nat Rech Scient	Nanoparticules de statine
MX358013B (es)	2009-11-13	2018-08-01	Amgen Inc	Materiales y metodos para el tratamiento o prevencion de enfermedades asociadas al her-3.
EP3263583A1 (de)	2010-02-12	2018-01-03	Pharmascience Inc.	Iap-bir-domänen bindende verbindungen
CA2815154A1 (en)	2010-08-06	2012-02-09	U3 Pharma Gmbh	Use of her3 binding agents in prostate treatment
ES2982231T3 (es) *	2016-12-09	2024-10-15	Akanocure Pharmaceuticals Inc	Estereotetradas escalables de polipropionato lactona
SI4101855T1 (sl)	2017-04-27	2024-03-29	Pharma Mar S.A.	Protitumorske spojine

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4206221A (en) *	1979-01-03	1980-06-03	The United States Of America As Represented By The Secretary Of Agriculture	Cephalomannine and its use in treating leukemic tumors
US5157049A (en) *	1988-03-07	1992-10-20	The United States Of America As Represented By The Department Of Health & Human Services	Method of treating cancers sensitive to treatment with water soluble derivatives of taxol
US4960790A (en) *	1989-03-09	1990-10-02	University Of Kansas	Derivatives of taxol, pharmaceutical compositions thereof and methods for the preparation thereof
US4939168A (en) *	1989-08-11	1990-07-03	Harbor Branch Oceanographics Institution, Inc.	Discodermolide compounds, compositions containing same and methods of preparation and use
US5010099A (en) *	1989-08-11	1991-04-23	Harbor Branch Oceanographic Institution, Inc.	Discodermolide compounds, compositions containing same and method of preparation and use

1995
- 1995-12-05 US US08/567,442 patent/US5681847A/en not_active Expired - Lifetime
1996
- 1996-12-05 CA CA002233716A patent/CA2233716C/en not_active Expired - Fee Related
- 1996-12-05 EP EP96943591A patent/EP0873332B1/de not_active Expired - Lifetime
- 1996-12-05 WO PCT/US1996/019344 patent/WO1997020835A1/en not_active Ceased
- 1996-12-05 ES ES96943591T patent/ES2218608T3/es not_active Expired - Lifetime
- 1996-12-05 JP JP52141097A patent/JP3293833B2/ja not_active Expired - Fee Related
- 1996-12-05 DK DK96943591T patent/DK0873332T3/da active
- 1996-12-05 PT PT96943591T patent/PT873332E/pt unknown
- 1996-12-05 US US08/761,106 patent/US5840750A/en not_active Expired - Lifetime
- 1996-12-05 AT AT96943591T patent/ATE262515T1/de not_active IP Right Cessation
- 1996-12-05 DE DE69631975T patent/DE69631975T2/de not_active Expired - Lifetime

Also Published As

Publication number	Publication date
DE69631975D1 (de)	2004-04-29
JP2000501710A (ja)	2000-02-15
US5840750A (en)	1998-11-24
ES2218608T3 (es)	2004-11-16
EP0873332B1 (de)	2004-03-24
US5681847A (en)	1997-10-28
DE69631975T2 (de)	2005-01-20
CA2233716A1 (en)	1997-06-12
PT873332E (pt)	2004-08-31
CA2233716C (en)	2006-05-09
WO1997020835A1 (en)	1997-06-12
ATE262515T1 (de)	2004-04-15
JP3293833B2 (ja)	2002-06-17
EP0873332A1 (de)	1998-10-28

Publication	Publication Date	Title
DK0873332T3 (da)	2004-07-26	Discodermolidforbindelser samt farmaceutiske sammensætninger indeholdende dem til cancerterapi
IL107109A0 (en)	1993-12-28	Compounds for modifying drug resistance and pharmaceutical compositions containing the same
BR9710255A (pt)	1999-08-10	Método para o tratamento de cáncer composto de retinóide de adamantila composição farmacéutica ou cosmética de matéria método de tratamento ou de prevenção e método para controlar
CZ143795A3 (en)	1995-11-15	7-halo and 7-beta, 8-betamethanotaxols, their anti-neoplastic use and pharmaceutical compositions containing thereof
EP0280474A3 (en)	1990-01-31	Macromolecular platinum antitumor compounds
IT8027029A0 (it)	1980-12-31	Complessi platino-diamminici e formulazioni farmaceutiche per il trattamento del cancro che licontengono.
DE3689363D1 (de)	1994-01-20	Pharmazeutische Zusammensetzungen zur Behandlung der Metastasen von Krebstumoren.
EP0957941A4 (de)	2001-09-05	VERWENDUNG DES MELANOMDIFFERENZIERUNGS ASSOZIIERTEN GENS (mda-7) ZUR UMWANDLUNG EINES KREBSPHÄNOTYPS
DE69713526D1 (de)	2002-07-25	Lösliche prodrugs von paclitaxel
GR3005457T3 (de)	1993-05-24
MX9305798A (es)	1994-05-31	Composiciones de lapiz labial humedecedor.
MY130544A (en)	2007-06-29	Antineoplastic use and pharmaceutical compositions containing them
HUP9900905A2 (hu)	1999-08-30	D4-Vitamin származékok alkalmazása rák kezelésére szolgáló gyógyászati készítmények előállítására
ES8406477A1 (es)	1984-08-01	Procedimiento para la preparacion de b-carbolinas
CS404781A2 (en)	1985-06-13	Zpusob vyroby kyselin 3 (4 (2 hydroxy 3 isopropylaminopropoxy)fenyl)alkanovych
DK0767786T3 (da)	1999-06-14	7-ether-taxol-analoge, antineoplastisk anvendelse deraf og farmaceutiske præparater indeholdende disse forbindelser
BG102250A (en)	1999-02-26	The use of marigold-extracted glycosides for the treatment of psoriasis
AU6319480A (en)	1981-04-30	2-hydroxyalkyl-3,4,5-trihydroxypiperidines
DE69627527D1 (en)	2003-05-22	Allogene parakrine cytokine tumor impfstoffe
IT8720181A0 (it)	1987-04-17	Composizioni farmaceutiche contenenti alcoli superiori per il trattamento di patologie della prostata.
AU549890B2 (en)	1986-02-20	Para-substituted-3-phenoxy-1-alkoxycarbenyl-alkylamino- propanol-2 compounds
EP0626866A4 (en)	1994-12-21	The use of carotenoporphyrins as tumor localizing agents for diagnosis, visualization and delivery of sensitizers to tumor tissues.
ES8304582A1 (es)	1983-03-01	Procedimiento para preparar compuestos de estano.
ATE87314T1 (de)	1993-04-15	Platin-arzneimittel.
DE3160437D1 (en)	1983-07-21	Water soluble polyesters and polycarbonates for use as antitumor agents