ATE263368T1 - Quantitativer nachweis von viren mittels lichtstreuung - Google Patents

Quantitativer nachweis von viren mittels lichtstreuung

Info

Publication number
ATE263368T1
ATE263368T1 AT00973391T AT00973391T ATE263368T1 AT E263368 T1 ATE263368 T1 AT E263368T1 AT 00973391 T AT00973391 T AT 00973391T AT 00973391 T AT00973391 T AT 00973391T AT E263368 T1 ATE263368 T1 AT E263368T1
Authority
AT
Austria
Prior art keywords
viruses
light scattering
virus
quantitative detection
contaminants
Prior art date
Application number
AT00973391T
Other languages
English (en)
Inventor
Mark G P Saifer
L David Williams
Original Assignee
Mountain View Pharmaceuticals
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mountain View Pharmaceuticals filed Critical Mountain View Pharmaceuticals
Application granted granted Critical
Publication of ATE263368T1 publication Critical patent/ATE263368T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/02—Investigating particle size or size distribution
    • G01N15/0205—Investigating particle size or size distribution by optical means
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N21/49—Scattering, i.e. diffuse reflection within a body or fluid
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/38—Flow patterns
    • G01N30/42—Flow patterns using counter-current
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/74—Optical detectors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/96—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation using ion-exchange

Landscapes

  • Chemical & Material Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Dispersion Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
AT00973391T 1999-09-29 2000-09-28 Quantitativer nachweis von viren mittels lichtstreuung ATE263368T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/408,290 US6316185B1 (en) 1999-09-29 1999-09-29 Quantitation of viruses by light scattering
PCT/US2000/026697 WO2001038852A1 (en) 1999-09-29 2000-09-28 Quantitative detection of viruses by light scattering

Publications (1)

Publication Number Publication Date
ATE263368T1 true ATE263368T1 (de) 2004-04-15

Family

ID=23615662

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00973391T ATE263368T1 (de) 1999-09-29 2000-09-28 Quantitativer nachweis von viren mittels lichtstreuung

Country Status (8)

Country Link
US (2) US6316185B1 (de)
EP (1) EP1218722B1 (de)
JP (1) JP2003515159A (de)
AT (1) ATE263368T1 (de)
AU (1) AU1190201A (de)
CA (1) CA2384901C (de)
DE (1) DE60009527D1 (de)
WO (1) WO2001038852A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0968284B1 (de) * 1996-11-20 2006-12-13 Introgen Therapeutics, Inc. Ein verbessertes verfahren zur produktion und reinigung von adenoviralen vektoren
US7732129B1 (en) 1998-12-01 2010-06-08 Crucell Holland B.V. Method for the production and purification of adenoviral vectors
US6316185B1 (en) * 1999-09-29 2001-11-13 Mountain View Pharmaceuticals, Inc. Quantitation of viruses by light scattering
ES2261921T3 (es) * 2002-02-20 2006-11-16 MERCK & CO., INC. Procedimiento para determinar la concentracion de particulas de adenovirus.
US20030224354A1 (en) * 2002-05-30 2003-12-04 Introgen Therapeutics Inc. Quantifying viral particles with intrinsic fluorescence
WO2004057330A1 (ja) * 2002-12-20 2004-07-08 Shigeki Higashiyama 細胞増殖抑制剤のスクリーニング方法および細胞増殖抑制剤
US20060046279A1 (en) * 2004-08-24 2006-03-02 Truong Palestrina R Analytical methods utilizing real-time energy/particle interaction-based determination techniques
CN101080488A (zh) * 2004-11-03 2007-11-28 因特罗根治疗公司 生产和纯化腺病毒载体的新方法
WO2009141393A1 (en) * 2008-05-20 2009-11-26 Zimmer Spine System for stabilizing at least three vertebrae
SG184833A1 (en) 2010-04-14 2012-11-29 Emd Millipore Corp Methods of producing high titer, high purity virus stocks and methods of use thereof
US20150355147A1 (en) * 2014-06-06 2015-12-10 Biogénesis Bagó Uruguay S.A. High throughput quantification and characterization of foot and mouth disease virus and products thereof
JP7233880B2 (ja) * 2018-10-22 2023-03-07 キヤノンメディカルシステムズ株式会社 ウイルスｒｎａ単離方法及びウイルス定量方法
AU2020211990A1 (en) * 2019-01-22 2021-08-12 2Seventy Bio, Inc. Methods and systems for manufacturing viral vectors
US12038376B2 (en) * 2020-07-26 2024-07-16 Wyatt Technology, Llc Purifying a sample solution via real-time multi-angle light scattering
US12066368B2 (en) * 2020-10-15 2024-08-20 Robert R. Alfano Compact optical virus detection analyzer of nano- and micro-size bio particles using light scattering and fluorescence

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2531718B1 (fr) * 1982-08-16 1986-11-21 Sanofi Sa Reactif permettant un dosage de tres haute sensibilite de l'antigene caracteristique du virus de l'hepatite b dans les liquides biologiques humains
JPS61139049A (ja) * 1984-12-10 1986-06-26 Mitsubishi Electric Corp 半導体装置の製造方法
US4884886A (en) 1985-02-08 1989-12-05 The United States Of America As Represented By The Department Of Energy Biological particle identification apparatus
JP2502148B2 (ja) * 1989-04-20 1996-05-29 日本電信電話株式会社 非分離型レ―ザ磁気免疫測定方法及び測定装置
US5269937A (en) 1990-10-23 1993-12-14 Cetus Corporation HPLC light scattering detector for biopolymers
CA2065716A1 (en) * 1991-04-29 1992-10-30 Amikam Horowitz Biotoxicity test for chemicals
JP3332167B2 (ja) * 1992-10-30 2002-10-07 和光純薬工業株式会社 マイクロプレートリーダー
US5837520A (en) * 1995-03-07 1998-11-17 Canji, Inc. Method of purification of viral vectors
US5772888A (en) 1995-07-27 1998-06-30 Massachusetts Institute Of Technology Separation and/or concentration of an analyte from a mixture using a two-phase aqueous micellar system
JP3395468B2 (ja) * 1995-08-04 2003-04-14 株式会社日立製作所 蛍光検出装置
JPH09327294A (ja) * 1996-05-23 1997-12-22 Toa Medical Electronics Co Ltd 遺伝子検出法
US6316185B1 (en) * 1999-09-29 2001-11-13 Mountain View Pharmaceuticals, Inc. Quantitation of viruses by light scattering

Also Published As

Publication number Publication date
US6316185B1 (en) 2001-11-13
US20020028439A1 (en) 2002-03-07
EP1218722B1 (de) 2004-03-31
US6544770B2 (en) 2003-04-08
DE60009527D1 (de) 2004-05-06
CA2384901A1 (en) 2001-05-31
EP1218722A1 (de) 2002-07-03
CA2384901C (en) 2011-12-13
WO2001038852A1 (en) 2001-05-31
AU1190201A (en) 2001-06-04
JP2003515159A (ja) 2003-04-22

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