ATE263761T1 - 5,6-dihydropyronderivate als proteaseinhibitoren und antiviralmittel - Google Patents
5,6-dihydropyronderivate als proteaseinhibitoren und antiviralmittelInfo
- Publication number
- ATE263761T1 ATE263761T1 AT01114943T AT01114943T ATE263761T1 AT E263761 T1 ATE263761 T1 AT E263761T1 AT 01114943 T AT01114943 T AT 01114943T AT 01114943 T AT01114943 T AT 01114943T AT E263761 T1 ATE263761 T1 AT E263761T1
- Authority
- AT
- Austria
- Prior art keywords
- derivatives
- dihydropyron
- protease inhibitors
- antiviral agents
- present
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/22—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and doubly-bound oxygen atoms bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/86—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/32—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/96—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings spiro-condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- AIDS & HIV (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Pyrane Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15544393A | 1993-11-19 | 1993-11-19 | |
| US08/319,820 US5840751A (en) | 1993-11-19 | 1994-10-12 | 5,6-dihydropyrone derivatives as protease inhibitors and antiviral agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE263761T1 true ATE263761T1 (de) | 2004-04-15 |
Family
ID=26852338
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01114943T ATE263761T1 (de) | 1993-11-19 | 1994-10-26 | 5,6-dihydropyronderivate als proteaseinhibitoren und antiviralmittel |
Country Status (18)
| Country | Link |
|---|---|
| EP (1) | EP0729464A1 (no) |
| JP (1) | JP3684426B2 (no) |
| AT (1) | ATE263761T1 (no) |
| AU (1) | AU689158B2 (no) |
| CA (1) | CA2176043A1 (no) |
| DE (1) | DE69433705T2 (no) |
| DK (1) | DK1142887T3 (no) |
| ES (1) | ES2219457T3 (no) |
| FI (1) | FI962022A7 (no) |
| HR (1) | HRP940935B1 (no) |
| HU (1) | HUT77668A (no) |
| IL (1) | IL111674A0 (no) |
| NO (1) | NO316172B1 (no) |
| NZ (1) | NZ275961A (no) |
| PT (1) | PT1142887E (no) |
| RU (1) | RU2140917C1 (no) |
| SI (1) | SI1142887T1 (no) |
| WO (1) | WO1995014012A1 (no) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100693944B1 (ko) * | 1995-08-11 | 2007-03-12 | 제논 인바이런멘탈 인코포레이티드 | 수직한 중공사 멤브레인 다발 및 섬유 표면을 깨끗하게유지시키는 방법 |
| US5834506A (en) * | 1996-11-01 | 1998-11-10 | Warner-Lambert Company | Dihydropyrones with improved antiviral activity |
| JP4462760B2 (ja) * | 1997-09-11 | 2010-05-12 | ファルマシア・アンド・アップジョン・カンパニー・エルエルシー | プロテアーゼインヒビターとして有用な４−ヒドロキシ−２−オキソ−ピラン誘導体の製法 |
| KR20010085780A (ko) * | 1998-09-11 | 2001-09-07 | 로즈 암스트롱, 크리스틴 에이. 트러트웨인 | Ｈｉｖ 프로테아제 억제제 |
| US6288235B1 (en) | 1999-04-14 | 2001-09-11 | Ortho-Mcneil Pharmaceutical, Inc. | Methods for the synthesis of highly substituted 2,4-dioxopiperidine libraries |
| DE10030094A1 (de) * | 2000-06-19 | 2001-12-20 | Bayer Ag | Phenylsubstituierte 5,6-Dihydro-pyron-Derivate |
| US6710058B2 (en) | 2000-11-06 | 2004-03-23 | Bristol-Myers Squibb Pharma Company | Monocyclic or bicyclic carbocycles and heterocycles as factor Xa inhibitors |
| US7141681B2 (en) | 2001-02-22 | 2006-11-28 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Continuous process for preparing dihydropyrones |
| DE10108471C1 (de) | 2001-02-22 | 2002-11-21 | Boehringer Ingelheim Pharma | Kontinuierliches Verfahren zur Herstellung von 5,6-Dihydro-4-hydroxy-2-pyronen |
| DE10108470A1 (de) * | 2001-02-22 | 2002-09-05 | Boehringer Ingelheim Pharma | Verfahren zur Herstellung optisch aktiver Dihydropyrone |
| US6500963B2 (en) | 2001-02-22 | 2002-12-31 | Boehringer Ingelheim Pharma Kg | Process for preparing optically active dihydropyrones |
| TW200307667A (en) | 2002-05-06 | 2003-12-16 | Bristol Myers Squibb Co | Sulfonylaminovalerolactams and derivatives thereof as factor Xa inhibitors |
| DOP2003000641A (es) | 2002-05-10 | 2003-11-15 | Pfizer | Inhibidores de las arn polimerasa dependiente de arn del virus de las hepatitis c y composiciones y tratamiento que los usan |
| TW200500341A (en) * | 2002-11-12 | 2005-01-01 | Astrazeneca Ab | Novel compounds |
| US7148226B2 (en) | 2003-02-21 | 2006-12-12 | Agouron Pharmaceuticals, Inc. | Inhibitors of hepatitis C virus RNA-dependent RNA polymerase, and compositions and treatments using the same |
| SE0302487D0 (sv) * | 2003-09-18 | 2003-09-18 | Astrazeneca Ab | Novel compounds |
| UA88909C2 (ru) | 2004-08-18 | 2009-12-10 | Пфайзер Инк. | Ингибиторы рнк-зависимой рнк-полимеразы вируса гепатита с, фармацевтическая композиция на их основе и их применение |
| DE102005059469A1 (de) | 2005-12-13 | 2007-06-14 | Bayer Cropscience Ag | Insektizide Zusammensetzungen mit verbesserter Wirkung |
| DE102006007882A1 (de) | 2006-02-21 | 2007-08-30 | Bayer Cropscience Ag | Cycloalkyl-phenylsubstituierte cyclische Ketoenole |
| HRP20110845T1 (hr) * | 2006-06-16 | 2011-12-31 | Pharma Mar | Antitumorski dihidropiran-2-onski spojevi |
| CN102348684B (zh) | 2009-03-11 | 2014-11-12 | 拜尔农作物科学股份公司 | 被卤代烷基亚甲基氧基苯基取代的酮烯醇 |
| DE102010008644A1 (de) | 2010-02-15 | 2011-08-18 | Bayer Schering Pharma Aktiengesellschaft, 13353 | Zyklische Ketoenole zur Therapie |
| RU2461555C1 (ru) * | 2011-07-07 | 2012-09-20 | Государственное образовательное учреждение высшего профессионального образования "Пермский государственный университет" | Способ получения 5-арил-3-фенил-2-оксаспиро[5,6]додец-3-ен-1-онов, проявляющих анальгетическую активность |
| KR102030337B1 (ko) | 2012-01-26 | 2019-10-10 | 바이엘 인텔렉쳐 프로퍼티 게엠베하 | 어류 기생충 방제용의 페닐-치환된 케토에놀 |
| KR20150090912A (ko) | 2012-11-28 | 2015-08-06 | 스미또모 가가꾸 가부시끼가이샤 | 디히드로피론 화합물 및 상기를 포함하는 제초제 |
| SE539512C2 (sv) * | 2015-12-02 | 2017-10-03 | Ultupharma Ab | Compounds and methods of treating bacterial infections |
| CN115916752B (zh) * | 2020-06-26 | 2025-05-06 | 日本农药株式会社 | 芳基四氢吡啶衍生物或其盐类、和含有该化合物的杀虫剂及其使用方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3818046A (en) * | 1972-12-18 | 1974-06-18 | Dow Chemical Co | Sulfur-containing hydroxy pyrones and alkali metal salts thereof |
| CH617569A5 (en) * | 1975-09-29 | 1980-06-13 | Ciba Geigy Ag | Pesticides containing, as active ingredient, a 3-N-phenyl-carbamoyl-4-hydroxy-1,2-(benzo)pyrone derivative. |
| SU950728A1 (ru) * | 1981-01-23 | 1982-08-15 | Пермский государственный фармацевтический институт | Способ получени 6-арил-3-ароил-4-окси-5-бромпиран-2-онов |
| ZA938019B (en) * | 1992-11-13 | 1995-04-28 | Upjohn Co | Pyran-2-ones and 5,6-dihydropyran-2-ones useful for treating HIV and other retroviruses |
-
1994
- 1994-10-26 DE DE69433705T patent/DE69433705T2/de not_active Expired - Fee Related
- 1994-10-26 PT PT01114943T patent/PT1142887E/pt unknown
- 1994-10-26 NZ NZ275961A patent/NZ275961A/en unknown
- 1994-10-26 HU HU9601348A patent/HUT77668A/hu not_active Application Discontinuation
- 1994-10-26 AT AT01114943T patent/ATE263761T1/de not_active IP Right Cessation
- 1994-10-26 EP EP95900429A patent/EP0729464A1/en not_active Withdrawn
- 1994-10-26 DK DK01114943T patent/DK1142887T3/da active
- 1994-10-26 CA CA002176043A patent/CA2176043A1/en not_active Abandoned
- 1994-10-26 SI SI9430463T patent/SI1142887T1/xx unknown
- 1994-10-26 JP JP51445895A patent/JP3684426B2/ja not_active Expired - Fee Related
- 1994-10-26 FI FI962022A patent/FI962022A7/fi unknown
- 1994-10-26 RU RU96113098/04A patent/RU2140917C1/ru not_active IP Right Cessation
- 1994-10-26 AU AU81256/94A patent/AU689158B2/en not_active Ceased
- 1994-10-26 WO PCT/US1994/012269 patent/WO1995014012A1/en not_active Ceased
- 1994-10-26 ES ES01114943T patent/ES2219457T3/es not_active Expired - Lifetime
- 1994-11-17 IL IL11167494A patent/IL111674A0/xx unknown
- 1994-11-17 HR HR940935A patent/HRP940935B1/xx not_active IP Right Cessation
-
1996
- 1996-05-15 NO NO19962017A patent/NO316172B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| FI962022L (fi) | 1996-07-12 |
| ES2219457T3 (es) | 2004-12-01 |
| FI962022A0 (fi) | 1996-05-13 |
| DE69433705D1 (de) | 2004-05-13 |
| PT1142887E (pt) | 2004-08-31 |
| DK1142887T3 (da) | 2004-06-21 |
| AU8125694A (en) | 1995-06-06 |
| SI1142887T1 (en) | 2004-08-31 |
| FI962022A7 (fi) | 1996-07-12 |
| NO316172B1 (no) | 2003-12-22 |
| HRP940935A2 (en) | 1997-04-30 |
| AU689158B2 (en) | 1998-03-26 |
| WO1995014012A1 (en) | 1995-05-26 |
| HU9601348D0 (en) | 1996-07-29 |
| JP3684426B2 (ja) | 2005-08-17 |
| RU2140917C1 (ru) | 1999-11-10 |
| NZ275961A (en) | 2001-11-30 |
| NO962017L (no) | 1996-07-08 |
| CA2176043A1 (en) | 1995-05-26 |
| IL111674A0 (en) | 1995-01-24 |
| JPH09505294A (ja) | 1997-05-27 |
| NO962017D0 (no) | 1996-05-15 |
| DE69433705T2 (de) | 2005-03-10 |
| EP0729464A1 (en) | 1996-09-04 |
| HUT77668A (hu) | 1998-07-28 |
| HRP940935B1 (en) | 2004-08-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE263761T1 (de) | 5,6-dihydropyronderivate als proteaseinhibitoren und antiviralmittel | |
| PT729463E (pt) | Derivados de 5,6-dihidropirona como inibidores de protease e agentes antivirais | |
| MY138860A (en) | Hiv protease inhibitors. | |
| FI915819A0 (fi) | Hiv- proteas-inhibitorer. | |
| MD960171A (ro) | Derivaţi ai pironei folosiţi ca inhibitori ai proteazei şi agenţi antivirali | |
| HU9601350D0 (en) | Pyrone derivatives as protease inhibitors and antiviral agents | |
| WO1995014014A3 (en) | Pyrone derivatives as protease inhibitors and antiviral agents | |
| UA41338C2 (uk) | Спосіб інгібування ретровірусної інфекції, яка викликана вірусом імунодефіциту людини (віл), спосіб інгібування вірусу імунодефіциту людини (віл) |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1142887 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |