ATE263971T1 - Methode zum nachweis von veränderungen zellulärer komponenten - Google Patents

Methode zum nachweis von veränderungen zellulärer komponenten

Info

Publication number
ATE263971T1
ATE263971T1 AT00900695T AT00900695T ATE263971T1 AT E263971 T1 ATE263971 T1 AT E263971T1 AT 00900695 T AT00900695 T AT 00900695T AT 00900695 T AT00900695 T AT 00900695T AT E263971 T1 ATE263971 T1 AT E263971T1
Authority
AT
Austria
Prior art keywords
state
bound
macromolecular component
sensor molecule
molecule
Prior art date
Application number
AT00900695T
Other languages
English (en)
Inventor
Philippe Igor Henri Bastiaens
Peter Joseph Jacques Parker
Original Assignee
Cancer Rec Tech Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cancer Rec Tech Ltd filed Critical Cancer Rec Tech Ltd
Application granted granted Critical
Publication of ATE263971T1 publication Critical patent/ATE263971T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/92—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving lipids, e.g. cholesterol, lipoproteins, or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/542—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/43504—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from invertebrates
    • G01N2333/43595—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from invertebrates from coelenteratae, e.g. medusae

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Endocrinology (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating Or Analyzing Materials By The Use Of Fluid Adsorption Or Reactions (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Burglar Alarm Systems (AREA)
  • Investigating Or Analyzing Materials Using Thermal Means (AREA)
AT00900695T 1999-01-19 2000-01-19 Methode zum nachweis von veränderungen zellulärer komponenten ATE263971T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9901072.0A GB9901072D0 (en) 1999-01-19 1999-01-19 Methods for detecting changes to a macromolecular component of a cell
PCT/GB2000/000118 WO2000043780A1 (en) 1999-01-19 2000-01-19 Methods for detecting changes to cellular components

Publications (1)

Publication Number Publication Date
ATE263971T1 true ATE263971T1 (de) 2004-04-15

Family

ID=10846082

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00900695T ATE263971T1 (de) 1999-01-19 2000-01-19 Methode zum nachweis von veränderungen zellulärer komponenten

Country Status (7)

Country Link
EP (1) EP1145004B1 (de)
JP (1) JP2002535655A (de)
AT (1) ATE263971T1 (de)
AU (1) AU3062300A (de)
DE (1) DE60009661D1 (de)
GB (1) GB9901072D0 (de)
WO (1) WO2000043780A1 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0007915D0 (en) * 2000-03-31 2000-05-17 Univ Bristol Protein kinase assay
US20030096243A1 (en) * 2000-09-28 2003-05-22 Busa William Brian Methods and reagents for live-cell gene expression quantification
AT410601B (de) * 2000-12-29 2003-06-25 Hoffmann La Roche Sensor zur lumineszenz-optischen bestimmung eines analyten sowie reagens, das nach dem fret-prinzip arbeitet
US7425430B2 (en) * 2001-03-23 2008-09-16 Japan Science And Technology Corporation Probe for visualizing phosphorylation/dephosphorylation of protein and method of detecting and quantifying phosphorylation/dephosphorylation of protein
FR2826666B1 (fr) * 2001-07-02 2004-07-02 Novaleads Procede de selection d'agents bio-actifs par couplage de luminescence et systeme cellulaire vivant pour la mise en oeuvre de ce procede
EP1499885B1 (de) 2001-08-01 2009-10-21 Cellomics, Inc. Neue fusionsproteine und molekulare bindungsassays
EP1436595A1 (de) * 2001-09-28 2004-07-14 Ciencia, Incorporated Verfahren zur verbesserung der empfindlichkeit von molekularbindungsassay mit phasenempfindlicher lumineszenzdetektion
GB0208989D0 (en) * 2002-04-19 2002-05-29 Amersham Biosciences Uk Ltd Methods for measuring enzyme activity
US20050046848A1 (en) 2003-08-26 2005-03-03 Blueshift Biotechnologies, Inc. Time dependent fluorescence measurements
WO2005040399A2 (en) 2003-10-21 2005-05-06 Orion Genomics Llc Methods for quantitative determination of methylation density in a dna locus
US7141378B2 (en) 2004-07-02 2006-11-28 Blueshift Biotechnologies, Inc. Exploring fluorophore microenvironments
AU2006315332A1 (en) * 2005-11-16 2007-05-24 Carnegie Institution Of Washington Multimeric biosensors and methods of using the same
BRPI0717416A2 (pt) 2006-09-21 2013-11-12 Prometheus Lab Inc Método para realizar um imunoensaio complexo de alta produtividade, e, arranjo
WO2008065540A2 (en) * 2006-11-27 2008-06-05 Cis Bio International Method for the detection of post-translational modifications
JP5545814B2 (ja) * 2007-06-18 2014-07-09 中外製薬株式会社 抗体依存性細胞障害活性を模擬する抗体の結合活性測定法
EP2179291B1 (de) 2007-07-13 2014-10-22 Nestec S.A. Arzneistoffauswahl für die lungenkrebstherapie unter verwendung von arrays auf antikörperbasis
EP2196794A4 (de) * 2007-08-30 2014-04-02 Mitsui Shipbuilding Eng Fret-nachweisverfahren und -vorrichtung
AU2009219437B2 (en) 2008-02-25 2014-10-16 Nestec S.A. Drug selection for breast cancer therapy using antibody-based arrays
JP5795311B2 (ja) 2009-07-15 2015-10-14 ネステク ソシエテ アノニム 抗体ベースのアレイを使用する胃癌療法のための薬物選択
US8950687B2 (en) 2010-09-21 2015-02-10 Honeywell International Inc. Remote control of an HVAC system that uses a common temperature setpoint for both heat and cool modes
US9719995B2 (en) 2011-02-03 2017-08-01 Pierian Holdings, Inc. Drug selection for colorectal cancer therapy using receptor tyrosine kinase profiling
EP2751562B1 (de) 2011-09-02 2015-09-16 Nestec S.A. Profilierung von signalwegproteinen zur bestimmung der therapeutischen wirksamkeit
CN108603037B (zh) * 2015-12-10 2020-11-17 希望之城 细胞穿透花青偶联抗体

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4540754B2 (ja) * 1996-06-04 2010-09-08 ユニバーシティ オブ ユタ リサーチ ファウンデーション Ｐｃｒ中のハイブリダイゼーションのモニタリング
DE69804446T3 (de) * 1997-04-07 2006-08-24 Bioimage A/S Verfahren um quantitativen informationen über einflüsse auf zelluläre reaktionen zu entnehmen

Also Published As

Publication number Publication date
JP2002535655A (ja) 2002-10-22
GB9901072D0 (en) 1999-03-10
WO2000043780A1 (en) 2000-07-27
EP1145004B1 (de) 2004-04-07
DE60009661D1 (de) 2004-05-13
EP1145004A1 (de) 2001-10-17
AU3062300A (en) 2000-08-07

Similar Documents

Publication Publication Date Title
ATE263971T1 (de) Methode zum nachweis von veränderungen zellulärer komponenten
ATE412050T1 (de) Fluoreszenzprotein-sensoren zur erkennung von analyten
DE69833378D1 (de) Fluoreszierende polarisation
ATE226323T1 (de) Nachweisverfahren mit hilfe von fluoreszent- energietransferliganden auf lipidfilmen
WO2002044720A3 (en) Membrane molecule indicator compositions and methods
WO2005029033A3 (en) Cyanide sensing compounds and uses thereof
ATE490466T1 (de) Als interne funktionskontrolle in tests zum nachweis von seltenen zellen verwendete markierte zellen
ATE394677T1 (de) Fret proben und verfahren zur erkennung aufeinander einwirkeneden moleküle
DE60038127D1 (de) Methoden und syteme zur überwachung intrazellulärer bindereaktionen
DK0716740T3 (da) Fremgangsmåde til aktivering af polyanioniske, fluorescerende farvestoffer i medier med lav dielektricitet ved hjælp af kvaternære oniumforbindelser
WO2003040670A3 (en) Method of identifying energy transfer sensors for analytes
CA2426479A1 (en) Dye pair for fluorescence resonance energy transfer (fret) measurements
TW200704778A (en) Screening using polarization anisotropy in fret emissions
EP1624071A3 (de) Nachweisverfahren für lebenfähige Zellen
DE602006012072D1 (de) Tests der molekularen oder subzellulären interaktivität unter verwendung von depolarisierung nach resonanzenergietransfer (daret)
Zhu et al. Designing label-free DNA sequences to achieve controllable turn-off/on fluorescence response for Hg 2+ detection
Lu et al. Label-free detection of histone based on cationic conjugated polymer-mediated fluorescence resonance energy transfer
ATE405837T1 (de) Festphase immunochromatographische testverfahren
WO2008078526A1 (ja) 蛍光共鳴エネルギー移動を用いたｄｎａとｄｎａ結合性タンパク質の相互作用の検出方法
ATE466884T1 (de) Holo-transcobalamin bindungspartner und ihre verwendung in cobalamintest
DE59907982D1 (de) Verfahren zum Nachweis einer bei Apoptose aktivierten Protease
DK1057021T3 (da) Fremgangsmåde til måling af totalanalyt
ATE354090T1 (de) Verfahren zum bestimmen von crp mit hilfe von phosphorylcholin
ATE396404T1 (de) Verfahren zum nachweis biologischer moleküle
DE69930843D1 (de) Verfahren zum bestimmen von autoantikörpern

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties