ATE394677T1 - Fret proben und verfahren zur erkennung aufeinander einwirkeneden moleküle - Google Patents

Fret proben und verfahren zur erkennung aufeinander einwirkeneden moleküle

Info

Publication number
ATE394677T1
ATE394677T1 AT03776064T AT03776064T ATE394677T1 AT E394677 T1 ATE394677 T1 AT E394677T1 AT 03776064 T AT03776064 T AT 03776064T AT 03776064 T AT03776064 T AT 03776064T AT E394677 T1 ATE394677 T1 AT E394677T1
Authority
AT
Austria
Prior art keywords
action
methods
probe
detecting molecules
detecting
Prior art date
Application number
AT03776064T
Other languages
English (en)
Inventor
Dongen Jacobus Van
Frank Staal
Original Assignee
Univ Erasmus
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Erasmus filed Critical Univ Erasmus
Application granted granted Critical
Publication of ATE394677T1 publication Critical patent/ATE394677T1/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C12Q1/6818—Hybridisation assays characterised by the detection means involving interaction of two or more labels, e.g. resonant energy transfer
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y10/00—Nanotechnology for information processing, storage or transmission, e.g. quantum computing or single electron logic
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/542—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles
    • G01N33/54333—Modification of conditions of immunological binding reaction, e.g. use of more than one type of particle, use of chemical agents to improve binding, choice of incubation time or application of magnetic field during binding reaction

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Nanotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Food Science & Technology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Mathematical Physics (AREA)
  • Theoretical Computer Science (AREA)
  • Medical Informatics (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
AT03776064T 2002-11-07 2003-11-06 Fret proben und verfahren zur erkennung aufeinander einwirkeneden moleküle ATE394677T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP02079667 2002-11-07

Publications (1)

Publication Number Publication Date
ATE394677T1 true ATE394677T1 (de) 2008-05-15

Family

ID=32309414

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03776064T ATE394677T1 (de) 2002-11-07 2003-11-06 Fret proben und verfahren zur erkennung aufeinander einwirkeneden moleküle

Country Status (11)

Country Link
US (1) US7413862B2 (de)
EP (1) EP1561114B1 (de)
JP (1) JP4511363B2 (de)
CN (1) CN1735808A (de)
AT (1) ATE394677T1 (de)
AU (1) AU2003283860B2 (de)
CA (1) CA2505515C (de)
DE (1) DE60320828D1 (de)
ES (1) ES2306900T3 (de)
NZ (1) NZ540219A (de)
WO (1) WO2004042404A1 (de)

Families Citing this family (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1561114B1 (de) 2002-11-07 2008-05-07 Erasmus Universiteit Rotterdam Fret proben und verfahren zur erkennung aufeinander einwirkeneden moleküle
EP1634603A1 (de) * 2004-08-26 2006-03-15 Eberhard-Karls-Universität Tübingen Universitätsklinikum Behandlung von transformierten oder infizierten biologischen Zellen
KR100704011B1 (ko) 2005-02-16 2007-04-04 한국과학기술원 금속나노입자와 양자점의 ｆｒｅｔ에 의한 생체분자특이결합 검출 방법
JP4639935B2 (ja) * 2005-05-09 2011-02-23 ソニー株式会社 物質間の相互作用を検出する表面、ｄｎａチップその他のセンサーチップ、プローブ、並びにバックグラウンドノイズ蛍光の低減方法
EP1900822B1 (de) 2005-05-24 2016-02-03 Suzuki, Miho Verfahren zur gleichzeitigen analyse mehrerer biologischer reaktionen oder veränderungen unter in-vivo-bedingungen
EP1962961B1 (de) * 2005-11-29 2013-01-09 The University Of Sydney Demikörper: dimerisations-aktivierte therapeutische mittel
KR100878980B1 (ko) 2005-12-31 2009-01-14 성균관대학교산학협력단 Ｄｎａ에 결합된 염료 수용체와 ｑｄ 공여체로 구성된신규한 ｆｒｅｔ 시스템
JPWO2007125822A1 (ja) * 2006-04-28 2009-09-10 国立大学法人東京工業大学 薬剤スクリーニングのための複合体
EP2064348B1 (de) * 2006-09-18 2012-02-08 Ensemble Therapeutics Corporation Profilierung einer rezeptorfamilie
CN101809433A (zh) * 2007-07-09 2010-08-18 Fio公司 用于增强试样中靶分子荧光检测的系统和方法
WO2009021026A1 (en) * 2007-08-06 2009-02-12 University Of Kentucky Research Foundation Semi-synthetic antibodies as recognition elements
EA201000836A1 (ru) * 2007-11-21 2010-12-30 Эразмус Юниверсити Медикал Сентер Роттердам Улучшенные зонды для fret и их применение
US8180421B2 (en) * 2007-12-12 2012-05-15 Kimberly-Clark Worldwide, Inc. Resonance energy transfer based detection of nosocomial infection
US8431356B2 (en) 2009-01-22 2013-04-30 Regents Of The University Of Minnesota Fluorescence resonance energy transfer assays for sarco/endoplasmic reticulum calcium atpase and phospholamban
EP2211178A1 (de) * 2009-01-22 2010-07-28 Universität Potsdam Verfahren zur Detektion eines Analyts in einer Probe mittels Multiplex-FRET-Analyse und Kit
CN101638579B (zh) * 2009-08-21 2013-03-06 天津城市建设学院 量子点-花菁染料-叶酸生物探针及其制备方法
DE102010010052A1 (de) * 2010-03-03 2011-09-08 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Signalgebende Bindemoleküle, Vorrichtungen und Verfahren zu deren Verwendung
JP5877155B2 (ja) * 2010-07-26 2016-03-02 オリンパス株式会社 発光プローブを用いて溶液中の希薄粒子を検出する方法
CN103097878B (zh) 2010-09-10 2015-07-22 奥林巴斯株式会社 使用单个发光颗粒的光强度的光学分析方法
CN103221806B (zh) 2010-09-10 2015-11-25 奥林巴斯株式会社 使用两个以上的波长带的光的测量的光学分析方法
CN103210302B (zh) 2010-10-19 2015-05-27 奥林巴斯株式会社 观测单个发光粒子的偏振特性的光分析装置、光分析方法
WO2012070414A1 (ja) 2010-11-25 2012-05-31 オリンパス株式会社 単一発光粒子の光の波長特性を用いた光分析装置及び光分析方法
US8569254B2 (en) 2010-12-10 2013-10-29 National Yang Ming University Methods for modulating the expression and aggregation of CAG-expanded gene product in cells and methods for identifying agents useful for doing the same
JP5856983B2 (ja) 2011-01-20 2016-02-10 オリンパス株式会社 単一発光粒子からの光の検出を用いた光分析方法及び光分析装置
EP2669663B1 (de) 2011-01-26 2017-09-27 Olympus Corporation Verfahren zur identifizierung von polymorphismen von nukleinsäuremolekülen
EP2669376B1 (de) 2011-01-26 2017-08-16 Olympus Corporation Verfahren zur identifizierung von polymorphismen von nukleinsäuremolekülen
WO2012133292A1 (ja) 2011-03-29 2012-10-04 オリンパス株式会社 単一発光粒子検出を用いた光分析装置、光分析方法並びに光分析用コンピュータプログラム
JP5885738B2 (ja) 2011-04-13 2016-03-15 オリンパス株式会社 単一発光粒子検出を用いた光分析装置、光分析方法及び光分析用コンピュータプログラム
JP6013328B2 (ja) 2011-04-18 2016-10-25 オリンパス株式会社 標的粒子の定量方法
JP6013335B2 (ja) 2011-08-11 2016-10-25 オリンパス株式会社 標的粒子の計数方法
CN103733049B (zh) 2011-08-15 2016-01-20 奥林巴斯株式会社 利用单个发光粒子检测的光分析装置、光分析方法以及光分析用计算机程序
WO2013031439A1 (ja) 2011-08-26 2013-03-07 オリンパス株式会社 単一発光粒子検出を用いた光分析装置、光分析方法及び光分析用コンピュータプログラム
WO2013031309A1 (ja) 2011-08-26 2013-03-07 オリンパス株式会社 光分析を用いた単一粒子検出装置、単一粒子検出方法及び単一粒子検出用コンピュータプログラム
EP2752655A4 (de) 2011-08-30 2015-06-17 Olympus Corp Verfahren zum nachweis von zielpartikeln
JP6010035B2 (ja) 2011-08-30 2016-10-19 オリンパス株式会社 単一発光粒子検出を用いた光分析装置、光分析方法及び光分析用コンピュータプログラム
CN103930768B (zh) 2011-11-10 2016-05-18 奥林巴斯株式会社 利用单个发光粒子检测的光分析装置、光分析方法以及光分析用计算机程序
MX359411B (es) 2012-01-13 2018-09-27 Univ Wuerzburg J Maximilians Complementación funcional bipartita inducida por antígenos, dual.
WO2013121905A1 (ja) 2012-02-17 2013-08-22 オリンパス株式会社 単一粒子検出を用いた光分析装置、光分析方法及び光分析用コンピュータプログラム
JP5940644B2 (ja) 2012-02-22 2016-06-29 オリンパス株式会社 標的粒子の検出方法
EP2829614A4 (de) 2012-03-21 2016-03-16 Olympus Corp Verfahren zur detektion eines zielnucleinsäuremoleküls
WO2013157283A1 (ja) 2012-04-18 2013-10-24 オリンパス株式会社 標的粒子の検出方法
EP2840380A4 (de) 2012-04-18 2015-11-25 Olympus Corp Einzelpartikeldetektor mit photoanalysis, einzelpartikelnachweisverfahren und computerprogramm für einzelpartikelnachweis
JP6450381B2 (ja) 2013-07-05 2019-01-09 ユニバーシティ オブ ワシントン スルー イッツ センター フォー コマーシャリゼーション がんを処置するための可溶性ｍｉｃ中和モノクローナル抗体
WO2015015951A1 (ja) 2013-07-31 2015-02-05 オリンパス株式会社 単一発光粒子検出技術を用いた光学顕微鏡装置、顕微鏡観察法及び顕微鏡観察のためのコンピュータプログラム
CN105593667A (zh) 2013-10-07 2016-05-18 奥林巴斯株式会社 利用单个发光粒子检测的光分析装置、光分析方法以及光分析用计算机程序
US10281476B2 (en) 2013-12-10 2019-05-07 Regents Of The University Of Minnesota Methods to identify modulators of RyR calcium channels
US10794898B2 (en) 2014-01-17 2020-10-06 Regents Of The University Of Minnesota High-throughput, high-precision methods for detecting protein structural changes in living cells
CN104592396A (zh) * 2015-02-26 2015-05-06 南京大学 基于荧光共振能量转移技术的Caspase-8活性检测荧光探针
US10900070B2 (en) 2015-05-01 2021-01-26 The General Hospital Corporation Multiplex analysis of gene expression in individual living cells
EP3297672B1 (de) 2015-05-21 2021-09-01 Harpoon Therapeutics, Inc. Trispezifische bindungsproteine und verfahren zur verwendung
JPWO2017098597A1 (ja) 2015-12-09 2018-10-11 オリンパス株式会社 単一発光粒子検出を用いた光分析方法及び光分析装置
US20190062846A1 (en) * 2016-01-29 2019-02-28 Dana-Farber Cancer Institute, Inc. Compositions and methods for screening pediatric gliomas and methods of treatment thereof
US11623958B2 (en) 2016-05-20 2023-04-11 Harpoon Therapeutics, Inc. Single chain variable fragment CD3 binding proteins
HRP20251020T1 (hr) 2016-05-20 2025-10-24 Harpoon Therapeutics, Inc. Proteini s jednolančanim varijabilnim fragmentom koji vežu cd3
KR102530742B1 (ko) 2016-05-20 2023-05-09 하푼 테라퓨틱스, 인크. 단일 도메인 혈청 알부민 결합 단백질
JP7215997B2 (ja) 2016-11-23 2023-01-31 ハープーン セラピューティクス，インク． 前立腺特異的膜抗原（ｐｓｍａ）を標的とする三重特異性タンパク質と使用方法
KR102275008B1 (ko) 2016-11-23 2021-07-13 하푼 테라퓨틱스, 인크. 전립선 특이 막 항원 결합 단백질
EP3351926A1 (de) * 2017-01-18 2018-07-25 Hifibio Verfahren zur analyse und auswahl eines spezifischen tröpfchens unter einer vielzahl von tröpfchen und zugehörige vorrichtung
WO2018160754A2 (en) 2017-02-28 2018-09-07 Harpoon Therapeutics, Inc. Inducible monovalent antigen binding protein
US20210003570A1 (en) 2017-05-10 2021-01-07 Rowan University Diagnostic biomarkers for detecting, subtyping, and/or assessing progression of multiple sclerosis
US10730954B2 (en) 2017-05-12 2020-08-04 Harpoon Therapeutics, Inc. MSLN targeting trispecific proteins and methods of use
SG10202107880XA (en) 2017-05-12 2021-09-29 Harpoon Therapeutics Inc Mesothelin binding proteins
IL315737A (en) 2017-10-13 2024-11-01 Harpoon Therapeutics Inc B-cell maturation antigen-binding proteins
CA3078969A1 (en) 2017-10-13 2019-04-18 Harpoon Therapeutics, Inc. Trispecific proteins and methods of use
MX2020012217A (es) 2018-05-14 2021-03-02 Harpoon Therapeutics Inc Porción de unión para activación condicional de moléculas de inmunoglobulina.
US12195544B2 (en) 2018-09-21 2025-01-14 Harpoon Therapeutics, Inc. EGFR binding proteins and methods of use
CN119306844A (zh) 2018-09-25 2025-01-14 哈普恩治疗公司 Dll3结合蛋白及使用方法
US11604186B2 (en) * 2018-10-17 2023-03-14 Molecular Devices (Austria) GmbH Real time western blot assays utilizing fluorescence resonance energy transfer (FRET)
US11726081B2 (en) 2019-02-15 2023-08-15 Regents Of The University Of Minnesota Methods to identify modulators of tau protein structure
WO2020232303A1 (en) 2019-05-14 2020-11-19 Harpoon Therapeutics, Inc. EpCAM BINDING PROTEINS AND METHODS OF USE
US11656221B2 (en) 2019-06-11 2023-05-23 Regents Of The University Of Minnesota Methods to identify modulators of actin-binding proteins
CN110243792A (zh) * 2019-06-11 2019-09-17 山东师范大学 一种基于量子点和四面体dna结构的荧光化学传感器及其检测方法和应用
BR112022016550A2 (pt) 2020-02-21 2022-11-16 Harpoon Therapeutics Inc Proteínas de ligação a flt3 e métodos de uso
CN119354855A (zh) 2020-09-23 2025-01-24 深圳迈瑞生物医疗电子股份有限公司 样本检测方法和样本分析仪
CN116087069B (zh) * 2023-04-10 2023-08-08 苏州药明康德新药开发有限公司 一种基于流式细胞术检测特定细胞群体组蛋白甲基化和乙酰化修饰水平的方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI102922B (fi) * 1996-06-28 1999-03-15 Valtion Teknillinen Fluoresenssiin perustuva immunomääritysmenetelmä
CA2305711A1 (en) * 1997-10-07 1999-04-15 Merck & Co., Inc. Assays for nuclear receptor ligands using fret
JP4425470B2 (ja) * 1998-09-18 2010-03-03 マサチューセッツ インスティテュート オブ テクノロジー 半導体ナノ結晶の生物学的用途
US6140054A (en) * 1998-09-30 2000-10-31 University Of Utah Research Foundation Multiplex genotyping using fluorescent hybridization probes
GB9926336D0 (en) * 1999-11-05 2000-01-12 Isis Innovation Universal flourescent sensors
JP2001204497A (ja) * 2000-01-20 2001-07-31 Japan Science & Technology Corp 蛍光共鳴エネルギー移動を利用した、ｄｎａハイブリダイゼーション法によるｄｎａ検出方法
US20020081617A1 (en) * 2000-11-08 2002-06-27 Tione Buranda Fluorescence and FRET based assays for biomolecules on beads
EP1382965B1 (de) 2001-04-23 2005-11-30 Eiken Kagaku Kabushiki Kaisha Analyseverfahren mit intermolekularer wechselwirkung eines reporters (markers)
WO2002103321A2 (en) * 2001-06-14 2002-12-27 Anadys Pharmaceuticals, Inc. Methods of screening for ligands of target molecules
JP4537053B2 (ja) * 2001-06-25 2010-09-01 ジョージア テック リサーチ コーポレーション 二重共鳴エネルギー転移核酸プローブ
US20030228603A1 (en) * 2002-04-05 2003-12-11 Cload Sharon T. Compositions selective for caffeine or aspartame and methods of using same
EP1561114B1 (de) 2002-11-07 2008-05-07 Erasmus Universiteit Rotterdam Fret proben und verfahren zur erkennung aufeinander einwirkeneden moleküle

Also Published As

Publication number Publication date
EP1561114B1 (de) 2008-05-07
ES2306900T3 (es) 2008-11-16
NZ540219A (en) 2008-08-29
JP2006505775A (ja) 2006-02-16
JP4511363B2 (ja) 2010-07-28
EP1561114A1 (de) 2005-08-10
US7413862B2 (en) 2008-08-19
US20050260660A1 (en) 2005-11-24
AU2003283860A1 (en) 2004-06-07
CA2505515C (en) 2013-08-27
WO2004042404A1 (en) 2004-05-21
DE60320828D1 (de) 2008-06-19
AU2003283860B2 (en) 2009-09-17
CA2505515A1 (en) 2004-05-21
CN1735808A (zh) 2006-02-15

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