ATE394677T1 - Fret proben und verfahren zur erkennung aufeinander einwirkeneden moleküle - Google Patents

Fret proben und verfahren zur erkennung aufeinander einwirkeneden moleküle

Info

Publication number
ATE394677T1
ATE394677T1 AT03776064T AT03776064T ATE394677T1 AT E394677 T1 ATE394677 T1 AT E394677T1 AT 03776064 T AT03776064 T AT 03776064T AT 03776064 T AT03776064 T AT 03776064T AT E394677 T1 ATE394677 T1 AT E394677T1
Authority
AT
Austria
Prior art keywords
action
methods
probe
detecting molecules
detecting
Prior art date
Application number
AT03776064T
Other languages
English (en)
Inventor
Dongen Jacobus Van
Frank Staal
Original Assignee
Univ Erasmus
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Erasmus filed Critical Univ Erasmus
Application granted granted Critical
Publication of ATE394677T1 publication Critical patent/ATE394677T1/de

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Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6816Hybridisation assays characterised by the detection means
    • C12Q1/6818Hybridisation assays characterised by the detection means involving interaction of two or more labels, e.g. resonant energy transfer
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B82NANOTECHNOLOGY
    • B82YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B82NANOTECHNOLOGY
    • B82YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y10/00Nanotechnology for information processing, storage or transmission, e.g. quantum computing or single electron logic
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/542Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326Magnetic particles
    • G01N33/54333Modification of conditions of immunological binding reaction, e.g. use of more than one type of particle, use of chemical agents to improve binding, choice of incubation time or application of magnetic field during binding reaction

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Nanotechnology (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Pathology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Food Science & Technology (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Genetics & Genomics (AREA)
  • Theoretical Computer Science (AREA)
  • Mathematical Physics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medical Informatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
AT03776064T 2002-11-07 2003-11-06 Fret proben und verfahren zur erkennung aufeinander einwirkeneden moleküle ATE394677T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP02079667 2002-11-07

Publications (1)

Publication Number Publication Date
ATE394677T1 true ATE394677T1 (de) 2008-05-15

Family

ID=32309414

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03776064T ATE394677T1 (de) 2002-11-07 2003-11-06 Fret proben und verfahren zur erkennung aufeinander einwirkeneden moleküle

Country Status (11)

Country Link
US (1) US7413862B2 (de)
EP (1) EP1561114B1 (de)
JP (1) JP4511363B2 (de)
CN (1) CN1735808A (de)
AT (1) ATE394677T1 (de)
AU (1) AU2003283860B2 (de)
CA (1) CA2505515C (de)
DE (1) DE60320828D1 (de)
ES (1) ES2306900T3 (de)
NZ (1) NZ540219A (de)
WO (1) WO2004042404A1 (de)

Families Citing this family (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004042404A1 (en) 2002-11-07 2004-05-21 Erasmus Universiteit Rotterdam Fret probes and methods for detecting interacting molecules
EP1634603A1 (de) * 2004-08-26 2006-03-15 Eberhard-Karls-Universität Tübingen Universitätsklinikum Behandlung von transformierten oder infizierten biologischen Zellen
KR100704011B1 (ko) 2005-02-16 2007-04-04 한국과학기술원 금속나노입자와 양자점의 fret에 의한 생체분자특이결합 검출 방법
JP4639935B2 (ja) * 2005-05-09 2011-02-23 ソニー株式会社 物質間の相互作用を検出する表面、dnaチップその他のセンサーチップ、プローブ、並びにバックグラウンドノイズ蛍光の低減方法
WO2006126570A1 (ja) 2005-05-24 2006-11-30 National University Corporation Saitama University 生体反応又は生体内状態変化の複数同時解析法
JP5102772B2 (ja) * 2005-11-29 2012-12-19 ザ・ユニバーシティ・オブ・シドニー デミボディ:二量体化活性化治療剤
KR100878980B1 (ko) 2005-12-31 2009-01-14 성균관대학교산학협력단 Dna에 결합된 염료 수용체와 qd 공여체로 구성된신규한 fret 시스템
WO2007125822A1 (ja) * 2006-04-28 2007-11-08 Tokyo Institute Of Technology 薬剤スクリーニングのための複合体
WO2008036273A2 (en) * 2006-09-18 2008-03-27 Ensemble Discovery Corporation Receptor family profiling
WO2009006739A1 (en) * 2007-07-09 2009-01-15 Fio Corporation Systems and methods for enhancing fluorescent detection of target molecules in a test sample
US20110229415A1 (en) * 2007-08-06 2011-09-22 Sylvia Daunert Semi-synthetic antibodies as recognition elements
DK2210100T3 (da) * 2007-11-21 2011-09-05 Univ Erasmus Medical Ct Fprbedrede fret-prober og anvendelse deraf
US8180421B2 (en) * 2007-12-12 2012-05-15 Kimberly-Clark Worldwide, Inc. Resonance energy transfer based detection of nosocomial infection
EP2211178A1 (de) * 2009-01-22 2010-07-28 Universität Potsdam Verfahren zur Detektion eines Analyts in einer Probe mittels Multiplex-FRET-Analyse und Kit
US8431356B2 (en) 2009-01-22 2013-04-30 Regents Of The University Of Minnesota Fluorescence resonance energy transfer assays for sarco/endoplasmic reticulum calcium atpase and phospholamban
CN101638579B (zh) * 2009-08-21 2013-03-06 天津城市建设学院 量子点-花菁染料-叶酸生物探针及其制备方法
DE102010010052A1 (de) * 2010-03-03 2011-09-08 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Signalgebende Bindemoleküle, Vorrichtungen und Verfahren zu deren Verwendung
CN103026205B (zh) * 2010-07-26 2016-03-23 奥林巴斯株式会社 使用发光探针检测溶液中稀疏颗粒的方法
CN103097878B (zh) 2010-09-10 2015-07-22 奥林巴斯株式会社 使用单个发光颗粒的光强度的光学分析方法
EP2602612A4 (de) 2010-09-10 2018-05-16 Olympus Corporation Optisches analyseverfahren mit optischer messung in mehreren wellenlängenbändern
EP2620763A4 (de) 2010-10-19 2015-05-27 Olympus Corp Optische analyse zum beobachten von polarisationsdaten einzelner lichtemittierender teilchen, verfahren für optische analysen und computerprogramm für optische analysen
JP5945506B2 (ja) 2010-11-25 2016-07-05 オリンパス株式会社 単一発光粒子の光の波長特性を用いた光分析装置及び光分析方法
US8569254B2 (en) 2010-12-10 2013-10-29 National Yang Ming University Methods for modulating the expression and aggregation of CAG-expanded gene product in cells and methods for identifying agents useful for doing the same
JP5856983B2 (ja) 2011-01-20 2016-02-10 オリンパス株式会社 単一発光粒子からの光の検出を用いた光分析方法及び光分析装置
JP6009944B2 (ja) 2011-01-26 2016-10-19 オリンパス株式会社 核酸分子の多型識別方法
WO2012102260A1 (ja) 2011-01-26 2012-08-02 オリンパス株式会社 核酸分子の多型識別方法
WO2012133292A1 (ja) 2011-03-29 2012-10-04 オリンパス株式会社 単一発光粒子検出を用いた光分析装置、光分析方法並びに光分析用コンピュータプログラム
WO2012141019A1 (ja) 2011-04-13 2012-10-18 オリンパス株式会社 単一発光粒子検出を用いた光分析装置、光分析方法及び光分析用コンピュータプログラム
CN103620389B (zh) 2011-04-18 2016-08-17 奥林巴斯株式会社 目标粒子的定量方法、光分析装置以及光分析用计算机程序
WO2013021687A1 (ja) 2011-08-11 2013-02-14 オリンパス株式会社 標的粒子の検出方法
WO2013024650A1 (ja) 2011-08-15 2013-02-21 オリンパス株式会社 単一発光粒子検出を用いた光分析装置、光分析方法及び光分析用コンピュータプログラム
CN103765195B (zh) 2011-08-26 2018-06-01 奥林巴斯株式会社 利用光分析的单个粒子检测装置、单个粒子检测方法以及单个粒子检测用计算机程序
WO2013031439A1 (ja) 2011-08-26 2013-03-07 オリンパス株式会社 単一発光粒子検出を用いた光分析装置、光分析方法及び光分析用コンピュータプログラム
EP2752654A4 (de) 2011-08-30 2015-04-15 Olympus Corp Optisches analysegerät mit einzelnachweis lichtemittierender teilchen, optisches analyseverfahren und computerprogramm für optische analysen
EP2752655A4 (de) 2011-08-30 2015-06-17 Olympus Corp Verfahren zum nachweis von zielpartikeln
WO2013069504A1 (ja) 2011-11-10 2013-05-16 オリンパス株式会社 単一発光粒子検出を用いた光分析装置、光分析方法及び光分析用コンピュータプログラム
CN108034006A (zh) 2012-01-13 2018-05-15 乌利班-马克西姆利安大学 双抗原诱导的双功能互补作用
JP5996625B2 (ja) 2012-02-17 2016-09-21 オリンパス株式会社 単一粒子検出を用いた光分析装置、光分析方法及び光分析用コンピュータプログラム
EP2818850B1 (de) 2012-02-22 2016-08-03 Olympus Corporation Verfahren zum nachweis eines zielpartikels
JP6095645B2 (ja) 2012-03-21 2017-03-15 オリンパス株式会社 標的核酸分子の検出方法
WO2013157283A1 (ja) 2012-04-18 2013-10-24 オリンパス株式会社 標的粒子の検出方法
JP6010114B2 (ja) 2012-04-18 2016-10-19 オリンパス株式会社 光分析を用いた単一粒子検出装置、単一粒子検出方法及び単一粒子検出用コンピュータプログラム
US9803017B2 (en) 2013-07-05 2017-10-31 University Of Washington Through Its Center For Commercialization Soluble MIC neutralizing monoclonal antibody for treating cancer
JP6360481B2 (ja) 2013-07-31 2018-07-18 オリンパス株式会社 単一発光粒子検出技術を用いた光学顕微鏡装置、顕微鏡観察法及び顕微鏡観察のためのコンピュータプログラム
WO2015052965A1 (ja) 2013-10-07 2015-04-16 オリンパス株式会社 単一発光粒子検出を用いた光分析装置、光分析方法及び光分析用コンピュータプログラム
US10281476B2 (en) 2013-12-10 2019-05-07 Regents Of The University Of Minnesota Methods to identify modulators of RyR calcium channels
US10794898B2 (en) 2014-01-17 2020-10-06 Regents Of The University Of Minnesota High-throughput, high-precision methods for detecting protein structural changes in living cells
CN104592396A (zh) * 2015-02-26 2015-05-06 南京大学 基于荧光共振能量转移技术的Caspase-8活性检测荧光探针
US10900070B2 (en) 2015-05-01 2021-01-26 The General Hospital Corporation Multiplex analysis of gene expression in individual living cells
MX383614B (es) 2015-05-21 2025-03-14 Harpoon Therapeutics Inc Proteinas de union triespecificas y metodos de uso.
WO2017098597A1 (ja) 2015-12-09 2017-06-15 オリンパス株式会社 単一発光粒子検出を用いた光分析方法及び光分析装置
US20190062846A1 (en) * 2016-01-29 2019-02-28 Dana-Farber Cancer Institute, Inc. Compositions and methods for screening pediatric gliomas and methods of treatment thereof
AU2017267793B2 (en) 2016-05-20 2024-01-25 Harpoon Therapeutics, Inc. Single chain variable fragment CD3 binding proteins
US11623958B2 (en) 2016-05-20 2023-04-11 Harpoon Therapeutics, Inc. Single chain variable fragment CD3 binding proteins
US10100106B2 (en) 2016-05-20 2018-10-16 Harpoon Therapeutics, Inc. Single domain serum albumin binding protein
US10844134B2 (en) 2016-11-23 2020-11-24 Harpoon Therapeutics, Inc. PSMA targeting trispecific proteins and methods of use
KR102275008B1 (ko) 2016-11-23 2021-07-13 하푼 테라퓨틱스, 인크. 전립선 특이 막 항원 결합 단백질
EP3351926A1 (de) * 2017-01-18 2018-07-25 Hifibio Verfahren zur analyse und auswahl eines spezifischen tröpfchens unter einer vielzahl von tröpfchen und zugehörige vorrichtung
WO2018160754A2 (en) 2017-02-28 2018-09-07 Harpoon Therapeutics, Inc. Inducible monovalent antigen binding protein
CA3062763A1 (en) 2017-05-10 2018-11-15 Rowan University Diagnostic biomarkers for detecting, subtyping, and/or assessing progression of multiple sclerosis
AU2018265856B2 (en) 2017-05-12 2023-04-27 Harpoon Therapeutics, Inc. Mesothelin binding proteins
CA3063362A1 (en) 2017-05-12 2018-11-15 Harpoon Therapeutics, Inc. Msln targeting trispecific proteins and methods of use
SI3694529T1 (sl) 2017-10-13 2024-10-30 Harpoon Therapeutics, Inc. Trispecifične beljakovine in načini uporabe
IL315737A (en) 2017-10-13 2024-11-01 Harpoon Therapeutics Inc B-cell maturation antigen-binding proteins
BR112020023330A2 (pt) 2018-05-14 2021-04-20 Harpoon Therapeutics, Inc. porção de ligação para ativação condicional de moléculas de imunoglobulina
US12195544B2 (en) 2018-09-21 2025-01-14 Harpoon Therapeutics, Inc. EGFR binding proteins and methods of use
EP3856771A4 (de) 2018-09-25 2022-06-29 Harpoon Therapeutics, Inc. Dll3-bindende proteine und verfahren zur verwendung
US11604186B2 (en) * 2018-10-17 2023-03-14 Molecular Devices (Austria) GmbH Real time western blot assays utilizing fluorescence resonance energy transfer (FRET)
US11726081B2 (en) 2019-02-15 2023-08-15 Regents Of The University Of Minnesota Methods to identify modulators of tau protein structure
KR20220008866A (ko) 2019-05-14 2022-01-21 하푼 테라퓨틱스, 인크. EpCAM 결합 단백질 및 사용 방법
CN110243792A (zh) * 2019-06-11 2019-09-17 山东师范大学 一种基于量子点和四面体dna结构的荧光化学传感器及其检测方法和应用
US11656221B2 (en) 2019-06-11 2023-05-23 Regents Of The University Of Minnesota Methods to identify modulators of actin-binding proteins
CA3170833A1 (en) 2020-02-21 2021-08-26 Harpoon Therapeutics, Inc. Flt3 binding proteins and methods of use
CN114252386A (zh) * 2020-09-23 2022-03-29 深圳迈瑞生物医疗电子股份有限公司 样本检测方法和样本分析仪
CN116087069B (zh) * 2023-04-10 2023-08-08 苏州药明康德新药开发有限公司 一种基于流式细胞术检测特定细胞群体组蛋白甲基化和乙酰化修饰水平的方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI102922B1 (fi) * 1996-06-28 1999-03-15 Valtion Teknillinen Fluoresenssiin perustuva immunomääritysmenetelmä
WO1999018124A1 (en) * 1997-10-07 1999-04-15 Merck & Co., Inc. Assays for nuclear receptor ligands using fret
EP1116036B1 (de) * 1998-09-18 2004-08-11 Massachusetts Institute Of Technology Wasserlösliche fluoreszierende halbleiternanokristalle
US6140054A (en) * 1998-09-30 2000-10-31 University Of Utah Research Foundation Multiplex genotyping using fluorescent hybridization probes
GB9926336D0 (en) * 1999-11-05 2000-01-12 Isis Innovation Universal flourescent sensors
JP2001204497A (ja) * 2000-01-20 2001-07-31 Japan Science & Technology Corp 蛍光共鳴エネルギー移動を利用した、dnaハイブリダイゼーション法によるdna検出方法
US20020081617A1 (en) * 2000-11-08 2002-06-27 Tione Buranda Fluorescence and FRET based assays for biomolecules on beads
WO2002088733A1 (fr) 2001-04-23 2002-11-07 Eiken Kagaku Kabushiki Kaisha Methode d'analyse faisant intervenir une interaction intermoleculaire par rapporteur (marqueur)
AU2002315157A1 (en) * 2001-06-14 2003-01-02 Anadys Pharmaceuticals, Inc. Methods of screening for ligands of target molecules
CA2451614C (en) * 2001-06-25 2011-01-04 Georgia Tech Research Corporation Dual resonance energy transfer nucleic acid probes
US20030228603A1 (en) * 2002-04-05 2003-12-11 Cload Sharon T. Compositions selective for caffeine or aspartame and methods of using same
WO2004042404A1 (en) 2002-11-07 2004-05-21 Erasmus Universiteit Rotterdam Fret probes and methods for detecting interacting molecules

Also Published As

Publication number Publication date
CA2505515C (en) 2013-08-27
CA2505515A1 (en) 2004-05-21
DE60320828D1 (de) 2008-06-19
NZ540219A (en) 2008-08-29
ES2306900T3 (es) 2008-11-16
EP1561114B1 (de) 2008-05-07
US20050260660A1 (en) 2005-11-24
AU2003283860B2 (en) 2009-09-17
JP2006505775A (ja) 2006-02-16
JP4511363B2 (ja) 2010-07-28
US7413862B2 (en) 2008-08-19
EP1561114A1 (de) 2005-08-10
WO2004042404A1 (en) 2004-05-21
AU2003283860A1 (en) 2004-06-07
CN1735808A (zh) 2006-02-15

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