ATE264717T1 - Mikrofluidisches system und verfahren zu dessen betrieb - Google Patents

Mikrofluidisches system und verfahren zu dessen betrieb

Info

Publication number
ATE264717T1
ATE264717T1 AT98921307T AT98921307T ATE264717T1 AT E264717 T1 ATE264717 T1 AT E264717T1 AT 98921307 T AT98921307 T AT 98921307T AT 98921307 T AT98921307 T AT 98921307T AT E264717 T1 ATE264717 T1 AT E264717T1
Authority
AT
Austria
Prior art keywords
microfluidic system
operating
compounds
effects
relates
Prior art date
Application number
AT98921307T
Other languages
English (en)
Inventor
Daniel Jed Harrison
Per Andersson
Paul C H Li
Roderick Szarka
Richard Smith
Hossein Salimi-Moosavi
Original Assignee
Alberta Res Council
Univ Alberta
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26724544&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE264717(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US08/858,087 external-priority patent/US6632619B1/en
Application filed by Alberta Res Council, Univ Alberta filed Critical Alberta Res Council
Application granted granted Critical
Publication of ATE264717T1 publication Critical patent/ATE264717T1/de

Links

Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads or physically stretching molecules
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0093Microreactors, e.g. miniaturised or microfabricated reactors
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B81MICROSTRUCTURAL TECHNOLOGY
    • B81BMICROSTRUCTURAL DEVICES OR SYSTEMS, e.g. MICROMECHANICAL DEVICES
    • B81B1/00Devices without movable or flexible elements, e.g. microcapillary devices
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30Micromixers
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06Fluid handling related problems
    • B01L2200/0647Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0668Trapping microscopic beads
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0809Geometry, shape and general structure rectangular shaped
    • B01L2300/0816Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0861Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0864Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0861Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0867Multiple inlets and one sample wells, e.g. mixing, dilution
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/04Moving fluids with specific forces or mechanical means
    • B01L2400/0403Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/04Moving fluids with specific forces or mechanical means
    • B01L2400/0475Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/11Automated chemical analysis
    • Y10T436/117497Automated chemical analysis with a continuously flowing sample or carrier stream

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Dispersion Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Fluid Mechanics (AREA)
  • Engineering & Computer Science (AREA)
  • Computer Hardware Design (AREA)
  • Microelectronics & Electronic Packaging (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Saccharide Compounds (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
AT98921307T 1997-05-16 1998-05-15 Mikrofluidisches system und verfahren zu dessen betrieb ATE264717T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/858,087 US6632619B1 (en) 1997-05-16 1997-05-16 Microfluidic system and methods of use
US4702497P 1997-05-19 1997-05-19
PCT/CA1998/000481 WO1998052691A1 (en) 1997-05-16 1998-05-15 Microfluidic system and methods of use

Publications (1)

Publication Number Publication Date
ATE264717T1 true ATE264717T1 (de) 2004-05-15

Family

ID=26724544

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98921307T ATE264717T1 (de) 1997-05-16 1998-05-15 Mikrofluidisches system und verfahren zu dessen betrieb

Country Status (8)

Country Link
US (1) US6900021B1 (de)
EP (1) EP0981408B1 (de)
JP (1) JP2002503336A (de)
AT (1) ATE264717T1 (de)
AU (1) AU734957B2 (de)
CA (1) CA2286601A1 (de)
DE (1) DE69823347T2 (de)
WO (1) WO1998052691A1 (de)

Families Citing this family (250)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6168948B1 (en) 1995-06-29 2001-01-02 Affymetrix, Inc. Miniaturized genetic analysis systems and methods
US5856174A (en) 1995-06-29 1999-01-05 Affymetrix, Inc. Integrated nucleic acid diagnostic device
US6132580A (en) 1995-09-28 2000-10-17 The Regents Of The University Of California Miniature reaction chamber and devices incorporating same
US6221654B1 (en) 1996-09-25 2001-04-24 California Institute Of Technology Method and apparatus for analysis and sorting of polynucleotides based on size
US6833242B2 (en) 1997-09-23 2004-12-21 California Institute Of Technology Methods for detecting and sorting polynucleotides based on size
US6540895B1 (en) 1997-09-23 2003-04-01 California Institute Of Technology Microfabricated cell sorter for chemical and biological materials
US6143152A (en) * 1997-11-07 2000-11-07 The Regents Of The University Of California Microfabricated capillary array electrophoresis device and method
GB9808836D0 (en) 1998-04-27 1998-06-24 Amersham Pharm Biotech Uk Ltd Microfabricated apparatus for cell based assays
US6149882A (en) 1998-06-09 2000-11-21 Symyx Technologies, Inc. Parallel fixed bed reactor and fluid contacting apparatus
SE0001779D0 (sv) * 2000-05-12 2000-05-12 Gyros Ab Microanalysis device
US6416642B1 (en) * 1999-01-21 2002-07-09 Caliper Technologies Corp. Method and apparatus for continuous liquid flow in microscale channels using pressure injection, wicking, and electrokinetic injection
US20030235920A1 (en) * 2000-02-28 2003-12-25 James Wyatt Diagnostic device and method
AU5405100A (en) * 1999-06-16 2001-01-02 Gesellschaft Zur Forderung Der Spektrochemie Und Angewandten Spektroskopie E.V. Device for preparing samples
DE19927534B4 (de) * 1999-06-16 2008-01-31 Merck Patent Gmbh Vorrichtung zur Probenaufgabe
FR2798867A1 (fr) * 1999-09-23 2001-03-30 Commissariat Energie Atomique Dispositif de distribution de fluides dans un microsysteme fluidique
CA2290731A1 (en) 1999-11-26 2001-05-26 D. Jed Harrison Apparatus and method for trapping bead based reagents within microfluidic analysis system
US6432290B1 (en) 1999-11-26 2002-08-13 The Governors Of The University Of Alberta Apparatus and method for trapping bead based reagents within microfluidic analysis systems
US6589729B2 (en) * 2000-02-04 2003-07-08 Caliper Technologies Corp. Methods, devices, and systems for monitoring time dependent reactions
JP3442338B2 (ja) 2000-03-17 2003-09-02 株式会社日立製作所 Dna分析装置、dna塩基配列決定装置、dna塩基配列決定方法、および反応モジュール
DE10017791A1 (de) * 2000-04-10 2001-10-11 Basf Ag Verfahren und Vorrichtung zur Mikrodosierung kleinster Flüssigkeitsmengen für Biopolymerarrays
JP4606543B2 (ja) * 2000-04-13 2011-01-05 パナソニック株式会社 光学特性計測装置における被検溶液量確認方法および計測系制御方法
US7351376B1 (en) 2000-06-05 2008-04-01 California Institute Of Technology Integrated active flux microfluidic devices and methods
AU2001273057A1 (en) 2000-06-27 2002-01-08 Fluidigm Corporation A microfluidic design automation method and system
GB2366793B (en) * 2000-09-13 2005-03-09 Imperial College Chemical processing system and method
WO2002023163A1 (en) 2000-09-15 2002-03-21 California Institute Of Technology Microfabricated crossflow devices and methods
EP1336097A4 (de) 2000-10-13 2006-02-01 Fluidigm Corp Probeninjektionssystem auf der basis einer mikrofluidischen einrichtung für analytische einrichtungen
US7326563B2 (en) 2000-11-08 2008-02-05 Surface Logix, Inc. Device and method for monitoring leukocyte migration
US7374906B2 (en) 2000-11-08 2008-05-20 Surface Logix, Inc. Biological assays using gradients formed in microfluidic systems
EP1377821A2 (de) * 2001-04-03 2004-01-07 Micronics, Inc. Pneumatische ventilanpassung für mikrofluide schaltkreise
EP1384022A4 (de) 2001-04-06 2004-08-04 California Inst Of Techn Nukleinsäure-amplifikation verwendende mikrofluidvorrichtungen
US9678038B2 (en) 2001-07-25 2017-06-13 The Trustees Of Princeton University Nanochannel arrays and their preparation and use for high throughput macromolecular analysis
WO2003010289A2 (en) * 2001-07-25 2003-02-06 The Trustees Of Princeton University Nanochannel arrays and their preparation and use for high throughput macromolecular analysis
US8440093B1 (en) 2001-10-26 2013-05-14 Fuidigm Corporation Methods and devices for electronic and magnetic sensing of the contents of microfluidic flow channels
CA2468674A1 (en) * 2001-12-05 2003-06-12 University Of Washington Microfluidic device and surface decoration process for solid phase affinity binding assays
US7312085B2 (en) 2002-04-01 2007-12-25 Fluidigm Corporation Microfluidic particle-analysis systems
WO2003085379A2 (en) 2002-04-01 2003-10-16 Fluidigm Corporation Microfluidic particle-analysis systems
AU2003269813A1 (en) * 2002-04-16 2003-12-31 Princeton University Gradient structures interfacing microfluidics and nanofluidics, methods for fabrication and uses thereof
US6808075B2 (en) 2002-04-17 2004-10-26 Cytonome, Inc. Method and apparatus for sorting particles
US9943847B2 (en) 2002-04-17 2018-04-17 Cytonome/St, Llc Microfluidic system including a bubble valve for regulating fluid flow through a microchannel
US6976590B2 (en) 2002-06-24 2005-12-20 Cytonome, Inc. Method and apparatus for sorting particles
AU2003223722A1 (en) * 2002-04-24 2003-11-10 Surface Logix, Inc. Device and method for monitoring leukocyte migration
US7129091B2 (en) 2002-05-09 2006-10-31 University Of Chicago Device and method for pressure-driven plug transport and reaction
US7901939B2 (en) 2002-05-09 2011-03-08 University Of Chicago Method for performing crystallization and reactions in pressure-driven fluid plugs
JP4106977B2 (ja) 2002-06-21 2008-06-25 株式会社日立製作所 分析チップ及び分析装置
BR0314268A (pt) * 2002-09-16 2005-07-26 Cytonome Inc Método e aparelho para separação de partìculas
CA2500283A1 (en) 2002-09-25 2004-04-08 California Institute Of Technology Microfluidic large scale integration
US8871446B2 (en) 2002-10-02 2014-10-28 California Institute Of Technology Microfluidic nucleic acid analysis
EP1558076A4 (de) * 2002-10-22 2007-03-21 Surface Logix Inc Vorrichtung und verfahren zur berwachung der leukozytenwanderung
WO2004061085A2 (en) 2002-12-30 2004-07-22 The Regents Of The University Of California Methods and apparatus for pathogen detection and analysis
US7041481B2 (en) 2003-03-14 2006-05-09 The Regents Of The University Of California Chemical amplification based on fluid partitioning
US20060078893A1 (en) 2004-10-12 2006-04-13 Medical Research Council Compartmentalised combinatorial chemistry by microfluidic control
GB0307403D0 (en) 2003-03-31 2003-05-07 Medical Res Council Selection by compartmentalised screening
GB0307428D0 (en) 2003-03-31 2003-05-07 Medical Res Council Compartmentalised combinatorial chemistry
JP2004305076A (ja) * 2003-04-04 2004-11-04 Canon Inc 対象物に対する修飾装置
TW200506364A (en) 2003-04-09 2005-02-16 Effector Cell Inst Inc Apparatus for detecting cell chemo-taxis
EP3023140B1 (de) 2003-04-10 2019-10-09 President and Fellows of Harvard College Erzeugung und kontrolle von fluiden
WO2004092322A2 (en) * 2003-04-14 2004-10-28 Surface Logix, Inc. Devices and assays for monitoring/measuring cellular dynamics to create subject profiles from primary cells
WO2004101743A2 (en) * 2003-05-06 2004-11-25 Bellbrook Labs, Llc Three dimensional cell cultures in a microscale fluid handling system
US7169282B2 (en) * 2003-05-13 2007-01-30 Aura Biosystems Inc. Dielectrophoresis apparatus
JP4276891B2 (ja) * 2003-05-15 2009-06-10 東芝機械株式会社 微細流路およびこれを含むマイクロ化学チップ
CA2468014C (en) * 2003-06-04 2016-03-22 Abbott Rapid Diagnostics International Unlimited Company Flow sensing for determination of assay results
JP2005027659A (ja) * 2003-06-20 2005-02-03 Nitto Denko Corp 細胞マイクロチップ
US20060147898A1 (en) * 2003-06-20 2006-07-06 Nitto Denko Corporation Cell microchip
US7413712B2 (en) 2003-08-11 2008-08-19 California Institute Of Technology Microfluidic rotary flow reactor matrix
CN104069784B (zh) 2003-08-27 2017-01-11 哈佛大学 流体物种的电子控制
JP3959436B2 (ja) * 2003-08-29 2007-08-15 独立行政法人物質・材料研究機構 流れ変動構造及びマイクロミキサ
AU2004284461A1 (en) 2003-10-23 2005-05-06 Georgetown University Method for two- and three-dimensional microassembly of patterns and structures
JP4341372B2 (ja) 2003-10-30 2009-10-07 コニカミノルタホールディングス株式会社 液体の混合方法および混合装置ならびに混合システム
DE102004005193B4 (de) * 2004-02-02 2006-08-24 Medion Diagnostics Gmbh Vorrichtung zur Separation einzelner Partikel von Partikel-Agglutinationen
JP2005233802A (ja) * 2004-02-20 2005-09-02 Yokogawa Electric Corp 物理量計測装置およびその装置を用いて行う物理量校正方法
US8058056B2 (en) 2004-03-12 2011-11-15 The Regents Of The University Of California Method and apparatus for integrated cell handling and measurements
US20050221339A1 (en) 2004-03-31 2005-10-06 Medical Research Council Harvard University Compartmentalised screening by microfluidic control
US20050227350A1 (en) * 2004-04-13 2005-10-13 Agency For Science, Technology And Research Device and method for studying cell migration and deformation
US7799553B2 (en) 2004-06-01 2010-09-21 The Regents Of The University Of California Microfabricated integrated DNA analysis system
US7655470B2 (en) 2004-10-29 2010-02-02 University Of Chicago Method for manipulating a plurality of plugs and performing reactions therein in microfluidic systems
US9477233B2 (en) 2004-07-02 2016-10-25 The University Of Chicago Microfluidic system with a plurality of sequential T-junctions for performing reactions in microdroplets
CN101194157B (zh) * 2004-07-16 2013-03-20 西蒙·弗雷瑟大学 微观流体装置和使用该装置的方法
JP4735119B2 (ja) * 2004-08-09 2011-07-27 日本精工株式会社 反応器及びその製造方法
CN102759466A (zh) 2004-09-15 2012-10-31 英特基因有限公司 微流体装置
JP2006087336A (ja) * 2004-09-22 2006-04-06 Shimadzu Corp 細胞分析装置
US7968287B2 (en) 2004-10-08 2011-06-28 Medical Research Council Harvard University In vitro evolution in microfluidic systems
JP4185904B2 (ja) * 2004-10-27 2008-11-26 株式会社日立ハイテクノロジーズ 液体搬送基板、分析システム、分析方法
US9260693B2 (en) 2004-12-03 2016-02-16 Cytonome/St, Llc Actuation of parallel microfluidic arrays
US8399205B2 (en) * 2005-01-21 2013-03-19 The University Of Rochester Device and method for separation, concentration, and/or purification of cells
ATE474663T1 (de) * 2005-06-15 2010-08-15 Rhodia Operations Mikrofluidikzirkulationsvorrichtung zur bestimmung von parametern einer physikalischen und/oder chemischen transformation und verwendung davon
US20060285999A1 (en) * 2005-06-21 2006-12-21 West Virginia University Research Corporation Apparatus and method for coupling microfluidic systems with electrospray ionization mass spectrometry utilizing a hydrodynamic flow restrictor
EP1741487B1 (de) * 2005-07-05 2011-03-09 ibidi GmbH Mikrofluid-Vorrichtung und Verfahren zur Erzeugung diffusiv aufgebauter Gradienten
EP1945793A4 (de) * 2005-08-11 2015-11-25 Eksigent Technologies Llc Verfahren zur messung biochemischer reaktionen
EP1936383A4 (de) * 2005-10-13 2009-04-29 Nissui Pharm Co Ltd Testeinrichtung
US20070107780A1 (en) * 2005-11-07 2007-05-17 Bristol-Myers Squibb Company Fluid handling device
EP2363205A3 (de) 2006-01-11 2014-06-04 Raindance Technologies, Inc. Mikrofluidische Vorrichtungen Und Verfahren Zur Verwendung Bei Der Bildung Und Kontrolle Von Nanoreaktoren
US7749365B2 (en) 2006-02-01 2010-07-06 IntegenX, Inc. Optimized sample injection structures in microfluidic separations
WO2008030631A2 (en) 2006-02-03 2008-03-13 Microchip Biotechnologies, Inc. Microfluidic devices
US7766033B2 (en) 2006-03-22 2010-08-03 The Regents Of The University Of California Multiplexed latching valves for microfluidic devices and processors
CN100392316C (zh) 2006-03-27 2008-06-04 博奥生物有限公司 控制液体在微管路中连续流动的流路结构
US8293524B2 (en) 2006-03-31 2012-10-23 Fluxion Biosciences Inc. Methods and apparatus for the manipulation of particle suspensions and testing thereof
US9562837B2 (en) 2006-05-11 2017-02-07 Raindance Technologies, Inc. Systems for handling microfludic droplets
EP2530168B1 (de) 2006-05-11 2015-09-16 Raindance Technologies, Inc. Mikrofluidische Vorrichtungen
DE102006024355B4 (de) * 2006-05-19 2008-04-03 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Mikrofluidische Anordnung zur Detektion von in Proben enthaltenen chemischen, biochemischen Molekülen und/oder Partikeln
JP4821466B2 (ja) * 2006-07-03 2011-11-24 富士ゼロックス株式会社 液滴吐出ヘッド
EP2077912B1 (de) 2006-08-07 2019-03-27 The President and Fellows of Harvard College Fluorkohlenstoffemulsionsstabilisierende tenside
US8841116B2 (en) 2006-10-25 2014-09-23 The Regents Of The University Of California Inline-injection microdevice and microfabricated integrated DNA analysis system using same
US20080245740A1 (en) * 2007-01-29 2008-10-09 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Fluidic methods
KR20100028526A (ko) 2007-02-05 2010-03-12 마이크로칩 바이오테크놀로지스, 인크. 마이크로유체 및 나노유체 장치, 시스템 및 응용
US8772046B2 (en) 2007-02-06 2014-07-08 Brandeis University Manipulation of fluids and reactions in microfluidic systems
CA2964611C (en) 2007-03-28 2021-06-01 Bionano Genomics, Inc. Methods of macromolecular analysis using nanochannel arrays
US20090034359A1 (en) * 2007-04-04 2009-02-05 The Regents Of The University Of California Stopped flow, quenched flow and continuous flow reaction method and apparatus
WO2008130623A1 (en) 2007-04-19 2008-10-30 Brandeis University Manipulation of fluids, fluid components and reactions in microfluidic systems
US8454906B2 (en) 2007-07-24 2013-06-04 The Regents Of The University Of California Microfabricated droplet generator for single molecule/cell genetic analysis in engineered monodispersed emulsions
WO2009048673A2 (en) 2007-07-26 2009-04-16 University Of Chicago Stochastic confinement to detect, manipulate, and utilize molecules and organisms
EP2200931B1 (de) * 2007-09-19 2017-06-07 The Charles Stark Draper Laboratory, Inc. Mikrofluidstrukturen mit kreisförmigem querschnitt
EP2040073A1 (de) * 2007-09-20 2009-03-25 Iline Microsystems, S.L. Mikrofluidische Vorrichtung und Verfahren zur Flüssigkeitsgerinnungs-Zeitbestimmung
JP5251882B2 (ja) 2007-10-26 2013-07-31 凸版印刷株式会社 反応チップ及び反応方法、遺伝子処理装置用温度調節機構及び遺伝子処理装置
JP2009106169A (ja) * 2007-10-26 2009-05-21 Univ Soka マイクロチャンバーアレイを用いた細胞培養方法及び該方法に用いられる細胞培養装置
WO2009108260A2 (en) 2008-01-22 2009-09-03 Microchip Biotechnologies, Inc. Universal sample preparation system and use in an integrated analysis system
WO2009131722A2 (en) 2008-01-24 2009-10-29 Sandia National Laboratories Methods and devices for immobilization of single particles
US20090234332A1 (en) * 2008-03-17 2009-09-17 The Charles Stark Draper Laboratory, Inc Artificial microvascular device and methods for manufacturing and using the same
WO2009149257A1 (en) 2008-06-04 2009-12-10 The University Of Chicago The chemistrode: a plug-based microfluidic device and method for stimulation and sampling with high temporal, spatial, and chemical resolution
US12038438B2 (en) 2008-07-18 2024-07-16 Bio-Rad Laboratories, Inc. Enzyme quantification
WO2010009365A1 (en) 2008-07-18 2010-01-21 Raindance Technologies, Inc. Droplet libraries
KR101390717B1 (ko) * 2008-09-02 2014-04-30 삼성전자주식회사 미세유동장치 및 미세유동장치에의 시료주입방법
US8951939B2 (en) 2011-07-12 2015-02-10 Bio-Rad Laboratories, Inc. Digital assays with multiplexed detection of two or more targets in the same optical channel
US12162008B2 (en) 2008-09-23 2024-12-10 Bio-Rad Laboratories, Inc. Partition-based method of analysis
US9764322B2 (en) 2008-09-23 2017-09-19 Bio-Rad Laboratories, Inc. System for generating droplets with pressure monitoring
US8633015B2 (en) * 2008-09-23 2014-01-21 Bio-Rad Laboratories, Inc. Flow-based thermocycling system with thermoelectric cooler
US8709762B2 (en) 2010-03-02 2014-04-29 Bio-Rad Laboratories, Inc. System for hot-start amplification via a multiple emulsion
US10512910B2 (en) 2008-09-23 2019-12-24 Bio-Rad Laboratories, Inc. Droplet-based analysis method
CA2738578C (en) 2008-09-23 2021-05-04 Quantalife, Inc. Droplet-based assay system
US9156010B2 (en) 2008-09-23 2015-10-13 Bio-Rad Laboratories, Inc. Droplet-based assay system
US11130128B2 (en) 2008-09-23 2021-09-28 Bio-Rad Laboratories, Inc. Detection method for a target nucleic acid
US9417190B2 (en) 2008-09-23 2016-08-16 Bio-Rad Laboratories, Inc. Calibrations and controls for droplet-based assays
US9132394B2 (en) 2008-09-23 2015-09-15 Bio-Rad Laboratories, Inc. System for detection of spaced droplets
US12090480B2 (en) 2008-09-23 2024-09-17 Bio-Rad Laboratories, Inc. Partition-based method of analysis
US9492797B2 (en) 2008-09-23 2016-11-15 Bio-Rad Laboratories, Inc. System for detection of spaced droplets
US9598725B2 (en) 2010-03-02 2017-03-21 Bio-Rad Laboratories, Inc. Emulsion chemistry for encapsulated droplets
EP2384429A1 (de) 2008-12-31 2011-11-09 Integenx Inc. Instrument mit mikrofluidischem chip
US8528589B2 (en) 2009-03-23 2013-09-10 Raindance Technologies, Inc. Manipulation of microfluidic droplets
US9464319B2 (en) 2009-03-24 2016-10-11 California Institute Of Technology Multivolume devices, kits and related methods for quantification of nucleic acids and other analytes
US10196700B2 (en) 2009-03-24 2019-02-05 University Of Chicago Multivolume devices, kits and related methods for quantification and detection of nucleic acids and other analytes
US9447461B2 (en) 2009-03-24 2016-09-20 California Institute Of Technology Analysis devices, kits, and related methods for digital quantification of nucleic acids and other analytes
CA2756463C (en) 2009-03-24 2019-01-22 University Of Chicago Slip chip device and methods
EP2438154A1 (de) 2009-06-02 2012-04-11 Integenx Inc. Fluidische vorrichtung mit membranventilen
CA2764678C (en) 2009-06-04 2017-12-12 Lockheed Martin Corporation Multiple-sample microfluidic chip for dna analysis
AU2010256429B2 (en) 2009-06-05 2015-09-17 Integenx Inc. Universal sample preparation system and use in an integrated analysis system
US20110001963A1 (en) * 2009-07-02 2011-01-06 Durack Gary P System and method for the measurement of multiple emissions from multiple parallel flow channels in a flow cytometry system
WO2011005760A1 (en) * 2009-07-06 2011-01-13 Sony Corporation Microfluidic device having onboard tissue or cell sample handling
US20110003330A1 (en) * 2009-07-06 2011-01-06 Durack Gary P Microfluidic device
US8778279B2 (en) * 2009-07-06 2014-07-15 Sony Corporation Microfluidic device
CN103335931A (zh) * 2009-07-07 2013-10-02 索尼公司 微流体装置
CN102482631A (zh) 2009-07-07 2012-05-30 索尼公司 适于在离心处理后选择性地提取样品的微流体装置及其使用方法
WO2011005754A1 (en) * 2009-07-08 2011-01-13 Sony Corporation Microfluidic device having a flow channel within a gain medium
WO2011011350A2 (en) 2009-07-20 2011-01-27 Siloam Biosciences, Inc. Microfluidic assay platforms
CA2767056C (en) 2009-09-02 2018-12-04 Bio-Rad Laboratories, Inc. System for mixing fluids by coalescence of multiple emulsions
US20110186165A1 (en) * 2009-10-05 2011-08-04 Borenstein Jeffrey T Three-dimensional microfluidic platforms and methods of use and manufacture thereof
US20110082563A1 (en) * 2009-10-05 2011-04-07 The Charles Stark Draper Laboratory, Inc. Microscale multiple-fluid-stream bioreactor for cell culture
US10520500B2 (en) 2009-10-09 2019-12-31 Abdeslam El Harrak Labelled silica-based nanomaterial with enhanced properties and uses thereof
US8940494B2 (en) * 2009-11-04 2015-01-27 Cfd Research Corporation Microfluidic assay in idealized microvascular network for characterization of leukocyte adhesion cascade
US8584703B2 (en) 2009-12-01 2013-11-19 Integenx Inc. Device with diaphragm valve
EP2517025B1 (de) 2009-12-23 2019-11-27 Bio-Rad Laboratories, Inc. Verfahren zur reduzierung des austauschs von molekülen zwischen tröpfchen
US10351905B2 (en) 2010-02-12 2019-07-16 Bio-Rad Laboratories, Inc. Digital analyte analysis
US9399797B2 (en) 2010-02-12 2016-07-26 Raindance Technologies, Inc. Digital analyte analysis
US9366632B2 (en) 2010-02-12 2016-06-14 Raindance Technologies, Inc. Digital analyte analysis
JP5934657B2 (ja) 2010-02-12 2016-06-15 レインダンス テクノロジーズ, インコーポレイテッド デジタル検体分析
CA2767113A1 (en) 2010-03-25 2011-09-29 Bio-Rad Laboratories, Inc. Detection system for droplet-based assays
CA2767182C (en) 2010-03-25 2020-03-24 Bio-Rad Laboratories, Inc. Droplet generation for droplet-based assays
EP2556170A4 (de) 2010-03-25 2014-01-01 Quantalife Inc Tröpfchentransport- und erkennungssystem
US8512538B2 (en) 2010-05-28 2013-08-20 Integenx Inc. Capillary electrophoresis device
EP2596347B1 (de) 2010-07-22 2017-09-06 Hach Company Alkalinitätsanalyse mittels lab-on-chip
EP2606242B1 (de) 2010-08-20 2026-04-01 Integenx Inc. Mikrofluidikvorrichtungen mit mechanisch abgedichteten membranventilen
EP2606154B1 (de) 2010-08-20 2019-09-25 Integenx Inc. Integriertes analysesystem
WO2012045012A2 (en) 2010-09-30 2012-04-05 Raindance Technologies, Inc. Sandwich assays in droplets
AU2011315951B2 (en) 2010-10-15 2015-03-19 Lockheed Martin Corporation Micro fluidic optic design
SG190074A1 (en) 2010-11-01 2013-06-28 Bio Rad Laboratories System for forming emulsions
EP3859011A1 (de) 2011-02-11 2021-08-04 Bio-Rad Laboratories, Inc. Verfahren zur bildung gemischter tröpfchen
US12097495B2 (en) 2011-02-18 2024-09-24 Bio-Rad Laboratories, Inc. Methods and compositions for detecting genetic material
EP2675819B1 (de) 2011-02-18 2020-04-08 Bio-Rad Laboratories, Inc. Zusammensetzungen und verfahren für molekulare etikettierung
AU2012231098B2 (en) 2011-03-18 2016-09-29 Bio-Rad Laboratories, Inc. Multiplexed digital assays with combinatorial use of signals
WO2012149042A2 (en) 2011-04-25 2012-11-01 Bio-Rad Laboratories, Inc. Methods and compositions for nucleic acid analysis
DE202012013668U1 (de) 2011-06-02 2019-04-18 Raindance Technologies, Inc. Enzymquantifizierung
US8841071B2 (en) 2011-06-02 2014-09-23 Raindance Technologies, Inc. Sample multiplexing
CN102242055B (zh) * 2011-06-03 2013-08-14 博奥生物有限公司 一种精子活力评价及筛选的方法及其专用微流控芯片装置
US8658430B2 (en) 2011-07-20 2014-02-25 Raindance Technologies, Inc. Manipulating droplet size
WO2013019751A1 (en) 2011-07-29 2013-02-07 Bio-Rad Laboratories, Inc., Library characterization by digital assay
US9449296B2 (en) 2011-08-02 2016-09-20 Kit Check, Inc. Management of pharmacy kits using multiple acceptance criteria for pharmacy kit segments
US8990099B2 (en) 2011-08-02 2015-03-24 Kit Check, Inc. Management of pharmacy kits
US10209241B2 (en) 2011-08-12 2019-02-19 Rutgers, The State University Of New Jersey High throughput sensitization detection devices and methods
KR101911435B1 (ko) * 2011-09-26 2018-10-25 삼성전자주식회사 유체 제어 장치, 이를 포함하는 필터 및 바이오칩
US10865440B2 (en) 2011-10-21 2020-12-15 IntegenX, Inc. Sample preparation, processing and analysis systems
US20150136604A1 (en) 2011-10-21 2015-05-21 Integenx Inc. Sample preparation, processing and analysis systems
US9322054B2 (en) 2012-02-22 2016-04-26 Lockheed Martin Corporation Microfluidic cartridge
WO2013155531A2 (en) 2012-04-13 2013-10-17 Bio-Rad Laboratories, Inc. Sample holder with a well having a wicking promoter
US9180449B2 (en) 2012-06-12 2015-11-10 Hach Company Mobile water analysis
US10221442B2 (en) 2012-08-14 2019-03-05 10X Genomics, Inc. Compositions and methods for sample processing
US10323279B2 (en) 2012-08-14 2019-06-18 10X Genomics, Inc. Methods and systems for processing polynucleotides
US11591637B2 (en) 2012-08-14 2023-02-28 10X Genomics, Inc. Compositions and methods for sample processing
US10752949B2 (en) 2012-08-14 2020-08-25 10X Genomics, Inc. Methods and systems for processing polynucleotides
US9701998B2 (en) 2012-12-14 2017-07-11 10X Genomics, Inc. Methods and systems for processing polynucleotides
JP6367196B2 (ja) 2012-08-14 2018-08-01 テンエックス・ジェノミクス・インコーポレイテッド マイクロカプセル組成物および方法
US10584381B2 (en) 2012-08-14 2020-03-10 10X Genomics, Inc. Methods and systems for processing polynucleotides
US9951386B2 (en) 2014-06-26 2018-04-24 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10273541B2 (en) 2012-08-14 2019-04-30 10X Genomics, Inc. Methods and systems for processing polynucleotides
USD768872S1 (en) 2012-12-12 2016-10-11 Hach Company Cuvette for a water analysis instrument
EP3567116A1 (de) 2012-12-14 2019-11-13 10X Genomics, Inc. Verfahren und systeme zur verarbeitung von polynukleotiden
US10533221B2 (en) 2012-12-14 2020-01-14 10X Genomics, Inc. Methods and systems for processing polynucleotides
KR102190198B1 (ko) 2013-02-08 2020-12-14 10엑스 제노믹스, 인크. 폴리뉴클레오티드 바코드 생성
US11901041B2 (en) 2013-10-04 2024-02-13 Bio-Rad Laboratories, Inc. Digital analysis of nucleic acid modification
CN105873681B (zh) 2013-11-18 2019-10-11 尹特根埃克斯有限公司 用于样本分析的卡盒和仪器
US9171280B2 (en) 2013-12-08 2015-10-27 Kit Check, Inc. Medication tracking
US9944977B2 (en) 2013-12-12 2018-04-17 Raindance Technologies, Inc. Distinguishing rare variations in a nucleic acid sequence from a sample
US11193176B2 (en) 2013-12-31 2021-12-07 Bio-Rad Laboratories, Inc. Method for detecting and quantifying latent retroviral RNA species
CA2943624A1 (en) 2014-04-10 2015-10-15 10X Genomics, Inc. Fluidic devices, systems, and methods for encapsulating and partitioning reagents, and applications of same
US10208332B2 (en) 2014-05-21 2019-02-19 Integenx Inc. Fluidic cartridge with valve mechanism
US12312640B2 (en) 2014-06-26 2025-05-27 10X Genomics, Inc. Analysis of nucleic acid sequences
WO2015200869A1 (en) 2014-06-26 2015-12-30 10X Genomics, Inc. Analysis of nucleic acid sequences
EP4574974A3 (de) 2014-06-26 2025-10-08 10x Genomics, Inc. Verfahren zur analyse von nukleinsäuren aus einzelnen zellen oder zellpopulationen
WO2016065073A1 (en) 2014-10-22 2016-04-28 Integenx Inc. Systems and methods for sample preparation, processing and analysis
WO2016069939A1 (en) 2014-10-29 2016-05-06 10X Genomics, Inc. Methods and compositions for targeted nucleic acid sequencing
US9975122B2 (en) 2014-11-05 2018-05-22 10X Genomics, Inc. Instrument systems for integrated sample processing
KR20160081022A (ko) * 2014-12-30 2016-07-08 삼성전자주식회사 미세유동장치 및 이에 공급된 시료의 검출방법
CN107427808B (zh) 2015-01-12 2020-10-23 10X基因组学有限公司 用于制备核酸测序文库的方法和系统以及用其制备的文库
EP3262407B1 (de) 2015-02-24 2023-08-30 10X Genomics, Inc. Partitionsverarbeitungsverfahren und -systeme
CN107532202A (zh) 2015-02-24 2018-01-02 10X 基因组学有限公司 用于靶向核酸序列覆盖的方法
WO2016161081A1 (en) 2015-04-03 2016-10-06 Fluxion Biosciences, Inc. Molecular characterization of single cells and cell populations for non-invasive diagnostics
US10647981B1 (en) 2015-09-08 2020-05-12 Bio-Rad Laboratories, Inc. Nucleic acid library generation methods and compositions
SG10202108763UA (en) 2015-12-04 2021-09-29 10X Genomics Inc Methods and compositions for nucleic acid analysis
TWI808934B (zh) 2015-12-31 2023-07-21 美商伯克利之光生命科技公司 經工程化以表現促發炎多肽之腫瘤浸潤細胞
WO2017131216A1 (ja) * 2016-01-28 2017-08-03 国立大学法人京都大学 生体高分子分画用チップ、それを用いた生体高分子の分画方法、および生体高分子の分析方法
CN109922885B (zh) * 2016-03-16 2022-05-10 伯克利之光生命科技公司 用于基因组编辑克隆的选择和传代的方法、系统和装置
WO2017197343A2 (en) 2016-05-12 2017-11-16 10X Genomics, Inc. Microfluidic on-chip filters
WO2017197338A1 (en) 2016-05-13 2017-11-16 10X Genomics, Inc. Microfluidic systems and methods of use
US10482292B2 (en) 2016-10-03 2019-11-19 Gary L. Sharpe RFID scanning device
US10692316B2 (en) 2016-10-03 2020-06-23 Gary L. Sharpe RFID scanning device
US10677661B2 (en) * 2016-11-09 2020-06-09 Northeastern University Stop-start method in a microfluidic calorimeter
US10011872B1 (en) 2016-12-22 2018-07-03 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10550429B2 (en) 2016-12-22 2020-02-04 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10815525B2 (en) 2016-12-22 2020-10-27 10X Genomics, Inc. Methods and systems for processing polynucleotides
AU2017388874A1 (en) 2016-12-30 2019-07-18 Berkeley Lights, Inc. Methods for selection and generation of genome edited T cells
EP4310183B1 (de) 2017-01-30 2025-07-09 10X Genomics, Inc. Verfahren und systeme zur tröpfchenbasierten einzelzellenbarcodierung
US12264411B2 (en) 2017-01-30 2025-04-01 10X Genomics, Inc. Methods and systems for analysis
US10844372B2 (en) 2017-05-26 2020-11-24 10X Genomics, Inc. Single cell analysis of transposase accessible chromatin
CN109526228B (zh) 2017-05-26 2022-11-25 10X基因组学有限公司 转座酶可接近性染色质的单细胞分析
US20190088354A1 (en) 2017-09-01 2019-03-21 Kit Check, Inc. Identifying discrepancies between events from disparate systems
CN111051523B (zh) 2017-11-15 2024-03-19 10X基因组学有限公司 功能化凝胶珠
US10829815B2 (en) 2017-11-17 2020-11-10 10X Genomics, Inc. Methods and systems for associating physical and genetic properties of biological particles
WO2019195166A1 (en) 2018-04-06 2019-10-10 10X Genomics, Inc. Systems and methods for quality control in single cell processing
CA3053995A1 (en) * 2019-01-08 2020-07-08 Interface Fluidics Ltd. Microfluidic devices and systems, and methods for operating microfluidic devices and systems
CN112138622B (zh) * 2019-06-27 2025-03-21 天津联力化工有限公司 一种填料组件和包含它的管道式反应器
US11551797B2 (en) 2019-08-06 2023-01-10 Kit Check, Inc. Selective distribution of pharmacy item data from pharmacy item tracking system
US20230266230A1 (en) * 2022-02-24 2023-08-24 Kyungpook National University Industry-Academic Cooperation Foundation Disease diagnosis kit, disease diagnosis method using the disease diagnosis kit and method for manufacturing the disease diagnosis kit
CN115739221B (zh) * 2022-11-30 2024-07-23 重庆大学 一种具有尖角结构和蜗牛形通道的芯片装置

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE418017B (sv) 1978-06-14 1981-04-27 Bifok Ab Sett att kontinuerligt bestemma olika langsamt reagerande substanser kvantitativt med anvendning av en enda metcell
US5310674A (en) 1982-05-10 1994-05-10 Bar-Ilan University Apertured cell carrier
IL68507A (en) 1982-05-10 1986-01-31 Univ Bar Ilan System and methods for cell selection
SE455537B (sv) 1985-01-31 1988-07-18 Bifok Ab Sett for kemisk analys vid vilken provet och/eller dess reaktionsprodukter bringas att passera en genomstromningscell, samt en apparatur for utovande av settet
US4676274A (en) * 1985-02-28 1987-06-30 Brown James F Capillary flow control
US5180662A (en) * 1988-01-05 1993-01-19 The United States Of America As Represented By The Department Of Health And Human Services Cytotoxic T lymphocyte activation assay
WO1990004645A1 (en) * 1988-10-21 1990-05-03 Molecular Devices Corporation Methods and apparatus for detecting the effect of cell affecting agents on living cells
US4987084A (en) 1989-02-21 1991-01-22 Dana Farber Cancer Institute Method of testing the effect of a molecule on B lymphocyte function
US5149972A (en) 1990-01-18 1992-09-22 University Of Massachusetts Medical Center Two excitation wavelength video imaging microscope
US5750015A (en) 1990-02-28 1998-05-12 Soane Biosciences Method and device for moving molecules by the application of a plurality of electrical fields
US5770029A (en) * 1996-07-30 1998-06-23 Soane Biosciences Integrated electrophoretic microdevices
WO1992003734A1 (en) * 1990-08-20 1992-03-05 Alain De Weck A method for measuring t-lymphocyte responses by chemiluminescent assays
US5460945A (en) * 1991-05-30 1995-10-24 Center For Blood Research, Inc. Device and method for analysis of blood components and identifying inhibitors and promoters of the inflammatory response
ATE166578T1 (de) * 1991-07-25 1998-06-15 Idec Pharma Corp Anregung von antworten zytotoxischer t- lymphozyten
US5587128A (en) 1992-05-01 1996-12-24 The Trustees Of The University Of Pennsylvania Mesoscale polynucleotide amplification devices
DE69319427T2 (de) 1992-05-01 1998-12-10 Univ Pennsylvania Analyse bei messung des durchflusswiderstandes
JPH08501392A (ja) * 1992-09-14 1996-02-13 パーデュー リサーチ ファウンデーション 電気泳動法による化学分析
JPH06265447A (ja) * 1993-03-16 1994-09-22 Hitachi Ltd 微量反応装置およびこれを使用する微量成分測定装置
US5776748A (en) 1993-10-04 1998-07-07 President And Fellows Of Harvard College Method of formation of microstamped patterns on plates for adhesion of cells and other biological materials, devices and uses therefor
DE4411268C2 (de) * 1994-03-31 2001-02-01 Danfoss As Analyseverfahren und Analysevorrichtung
US6001229A (en) 1994-08-01 1999-12-14 Lockheed Martin Energy Systems, Inc. Apparatus and method for performing microfluidic manipulations for chemical analysis
CN1145704C (zh) 1994-11-14 2004-04-14 宾夕法尼亚州大学信托人 中型多核苷酸扩增装置
WO1996014934A1 (en) 1994-11-14 1996-05-23 Trustees Of The University Of Pennsylvania Mesoscale sample preparation device and systems for determination and processing of analytes
AU5143096A (en) 1995-03-31 1996-10-16 Novo Nordisk A/S Method for identifying biologically active substances by the ir effect on living cells
US5840254A (en) * 1995-06-02 1998-11-24 Cdc Technologies, Inc. Apparatus for mixing fluids for analysis
TW293783B (de) * 1995-06-16 1996-12-21 Ciba Geigy Ag
US5872010A (en) * 1995-07-21 1999-02-16 Northeastern University Microscale fluid handling system
US5942443A (en) 1996-06-28 1999-08-24 Caliper Technologies Corporation High throughput screening assay systems in microscale fluidic devices
US5726404A (en) * 1996-05-31 1998-03-10 University Of Washington Valveless liquid microswitch
US5804436A (en) 1996-08-02 1998-09-08 Axiom Biotechnologies, Inc. Apparatus and method for real-time measurement of cellular response
US5858648A (en) 1996-11-04 1999-01-12 Sienna Biotech, Inc. Assays using reference microparticles

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DE69823347D1 (de) 2004-05-27
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