ATE264845T1 - Benzazepine mit vasopressin-antagonistischer wirkung - Google Patents
Benzazepine mit vasopressin-antagonistischer wirkungInfo
- Publication number
- ATE264845T1 ATE264845T1 AT96941870T AT96941870T ATE264845T1 AT E264845 T1 ATE264845 T1 AT E264845T1 AT 96941870 T AT96941870 T AT 96941870T AT 96941870 T AT96941870 T AT 96941870T AT E264845 T1 ATE264845 T1 AT E264845T1
- Authority
- AT
- Austria
- Prior art keywords
- benzazepines
- antagonistic effect
- vasopressin antagonistic
- vasopressin
- effect
- Prior art date
Links
- GXBMIBRIOWHPDT-UHFFFAOYSA-N Vasopressin Natural products N1C(=O)C(CC=2C=C(O)C=CC=2)NC(=O)C(N)CSSCC(C(=O)N2C(CCC2)C(=O)NC(CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(CCC(N)=O)NC(=O)C1CC1=CC=CC=C1 GXBMIBRIOWHPDT-UHFFFAOYSA-N 0.000 title 1
- 102000002852 Vasopressins Human genes 0.000 title 1
- 108010004977 Vasopressins Proteins 0.000 title 1
- 230000003042 antagnostic effect Effects 0.000 title 1
- KBZOIRJILGZLEJ-LGYYRGKSSA-N argipressin Chemical compound C([C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CSSC[C@@H](C(N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N1)=O)N)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)C1=CC=CC=C1 KBZOIRJILGZLEJ-LGYYRGKSSA-N 0.000 title 1
- 150000008038 benzoazepines Chemical class 0.000 title 1
- 229960003726 vasopressin Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/04—Drugs for genital or sexual disorders; Contraceptives for inducing labour or abortion; Uterotonics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pregnancy & Childbirth (AREA)
- Gynecology & Obstetrics (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP32613695 | 1995-12-15 | ||
| JP18950096 | 1996-07-18 | ||
| PCT/JP1996/003652 WO1997022591A1 (en) | 1995-12-15 | 1996-12-13 | Benzazepine derivatives with vasopressin agonistic activity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE264845T1 true ATE264845T1 (de) | 2004-05-15 |
Family
ID=26505504
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT96941870T ATE264845T1 (de) | 1995-12-15 | 1996-12-13 | Benzazepine mit vasopressin-antagonistischer wirkung |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US6096736A (de) |
| EP (1) | EP0877736B1 (de) |
| KR (1) | KR100493503B1 (de) |
| CN (1) | CN1104419C (de) |
| AR (1) | AR005044A1 (de) |
| AT (1) | ATE264845T1 (de) |
| BR (1) | BR9612126A (de) |
| DE (1) | DE69632268T2 (de) |
| DK (1) | DK0877736T3 (de) |
| ES (1) | ES2219703T3 (de) |
| MX (1) | MX9804849A (de) |
| PT (1) | PT877736E (de) |
| TW (1) | TW359669B (de) |
| WO (1) | WO1997022591A1 (de) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR9811585A (pt) * | 1997-07-30 | 2000-09-26 | American Home Prod | Agonistas de vasopressinas tricìclicas |
| US6511974B1 (en) | 1997-07-30 | 2003-01-28 | Wyeth | Tricyclic vasopressin agonists |
| AU8592598A (en) * | 1997-07-30 | 1999-02-22 | Wyeth | Tricyclic vasopressin agonists |
| US6194407B1 (en) | 1997-07-30 | 2001-02-27 | American Home Products Corporation | Tricyclic pyrido vasopressin agonists |
| US7138393B2 (en) | 1998-07-24 | 2006-11-21 | Wyeth | Biologically active vasopressin agonist metabolites |
| US6090803A (en) * | 1998-07-24 | 2000-07-18 | American Home Products Corporation | Tricyclic vasopressin agonists |
| EP1381370B1 (de) | 2001-04-12 | 2007-03-07 | Wyeth | N-biphenylcarbonyl- und n-phenylpyridylcarbonyl substituierte bi- and tricyclische azepine und diazepine als vasopressin-agonisten |
| CN1294134C (zh) | 2001-04-12 | 2007-01-10 | 惠氏公司 | 环己基苯基血管升压素激动剂 |
| HUP0402235A2 (hu) * | 2001-11-16 | 2005-02-28 | Yamanouchi Pharmaceutical Co., Ltd. | 4,4-Difluor-1,2,3,4-tetrahidro-5H-1-benzazepin-származékok és ezek sói és ezeket tartalmazó gyógyszerkészítmények |
| SI1619185T1 (sl) | 2003-04-28 | 2011-09-30 | Astellas Pharma Inc | 4,4-difluoro-1,2,3,4-tetrahidro-5H-1-benzazepinski derivat ali njegova sol |
| EP1802623A1 (de) * | 2004-10-12 | 2007-07-04 | Novo Nordisk A/S | 11beta-hydroxysteroid-dehydrogenase-typ-1-aktive spiroverbindungen |
| GT200500317A (es) * | 2004-11-05 | 2006-10-27 | Proceso para preparar compuestos de quinolina y productos obtenidos de los mismos | |
| TW200718692A (en) * | 2005-04-22 | 2007-05-16 | Wyeth Corp | Dihydrobenzofuran derivatives and uses thereof |
| US7368477B2 (en) * | 2005-04-22 | 2008-05-06 | Wyeth | Benzofuranyl alkanamine derivatives and uses thereof |
| AU2006239942A1 (en) * | 2005-04-22 | 2006-11-02 | Wyeth | Dihydrobenzofuran derivatives and uses thereof |
| EP1879875A1 (de) * | 2005-04-22 | 2008-01-23 | Wyeth | Kristallformen von {[(2r)-7-(2,6-dichlorophenyl)-5-fluoro-2,3-dihydro-1-benzofuran-2-yl]methyl}amin-hydrochlorid |
| US20060258712A1 (en) * | 2005-04-24 | 2006-11-16 | Wyeth | Methods for modulating bladder function |
| AR054849A1 (es) * | 2005-07-26 | 2007-07-18 | Wyeth Corp | Diazepinoquinolinas, sintesis de las mismas, e intermediarios para obtenerlas |
| EA200801243A1 (ru) * | 2005-11-01 | 2008-10-30 | Транстек Фарма | Фармацевтическое применение замещенных амидов |
| KR20080069189A (ko) * | 2005-11-01 | 2008-07-25 | 트랜스테크 파르마, 인크. | 치환된 아미드의 약학적 사용 |
| TW200734334A (en) * | 2006-01-13 | 2007-09-16 | Wyeth Corp | Treatment of substance abuse |
| JP2009530346A (ja) * | 2006-03-21 | 2009-08-27 | ハイ ポイント ファーマシューティカルズ，リミティド ライアビリティ カンパニー | メタボリックシンドロームの治療用のアダマンタン誘導体 |
| EP1998773A2 (de) * | 2006-03-24 | 2008-12-10 | Wyeth a Corporation of the State of Delaware | Neue therapeutische kombinationen zur behandlung von depression |
| AU2007230997A1 (en) * | 2006-03-24 | 2007-10-04 | Wyeth | Treatment of pain |
| KR20090014347A (ko) | 2006-04-07 | 2009-02-10 | 하이 포인트 파마슈티칼스, 엘엘씨 | 11β-히드록시스테로이드 탈수소효소 타입 1 활성 화합물 |
| EP2038255A2 (de) * | 2006-06-16 | 2009-03-25 | High Point Pharmaceuticals, LLC | Pharmazeutische verwendung substituierter piperidincarbonsäureamide |
| WO2008006702A1 (en) * | 2006-07-13 | 2008-01-17 | High Point Pharmaceuticals, Llc. | 11beta-hydroxysteroid dehydrogenase type 1 active compounds |
| EP1878721A1 (de) * | 2006-07-13 | 2008-01-16 | Novo Nordisk A/S | 4-Piperidylbenzamide als Inhibitoren der 11-beta-hydroxysteroiddehydrogenase Typ 1 |
| EP2129652A2 (de) * | 2007-02-23 | 2009-12-09 | High Point Pharmaceuticals, LLC | N-adamantylbenzamide als inhibitoren von 11-beta-hydroxysteroiddehydrogenase |
| EP2125704A1 (de) * | 2007-02-23 | 2009-12-02 | High Point Pharmaceuticals, LLC | N-adamantylbenzamide als inhibitoren von 11-beta-hydroxysteroiddehydrogenase |
| EP2150526B1 (de) | 2007-02-23 | 2017-09-20 | vTv Therapeutics LLC | N-adamantylbenzamide als inhibitoren von 11-beta-hydroxysteroid dehydrogenase |
| WO2008101885A1 (en) * | 2007-02-23 | 2008-08-28 | High Point Pharmaceuticals, Llc | N-adamantyl benzamides as inhibitors of 11-beta-hydroxysteroid dehydrogenase |
| WO2008110196A1 (en) * | 2007-03-09 | 2008-09-18 | High Point Pharmaceuticals, Llc | Indole- and benzimidazole amides as hydroxysteroid dehydrogenase inhibitors |
| US20100056600A1 (en) * | 2007-03-28 | 2010-03-04 | Soren Ebdrup | 11beta-hsd1 active compounds |
| CN101677562A (zh) * | 2007-04-11 | 2010-03-24 | 高点制药有限责任公司 | 新化合物 |
| ES2393230T3 (es) * | 2007-04-24 | 2012-12-19 | High Point Pharmaceuticals, Llc | Uso farmacéutico de amidas sustituidas |
| CL2008002777A1 (es) * | 2007-09-21 | 2010-01-22 | Wyeth Corp | Metodo de preparacion de compuestos diazepinoquinolinicos quirales por recristalizacion en un sistema de solvente ternario. |
| GB201005623D0 (en) | 2010-04-01 | 2010-05-19 | Vantia Ltd | New polymorph |
| JP5968466B2 (ja) | 2012-12-26 | 2016-08-10 | 株式会社三和化学研究所 | 新規ベンゾアゼピン誘導体及びその医薬用途 |
| TWI643847B (zh) * | 2014-06-11 | 2018-12-11 | 日商三和化學研究所股份有限公司 | Novel benzoazepine derivatives and their medical uses |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK0450097T3 (da) * | 1989-10-20 | 1996-05-20 | Otsuka Pharma Co Ltd | Benzoheterocykliske forbindelser |
| US5258510A (en) * | 1989-10-20 | 1993-11-02 | Otsuka Pharma Co Ltd | Benzoheterocyclic compounds |
| TW198715B (de) * | 1991-04-19 | 1993-01-21 | Dtsuka Seiyaku Kk | |
| JPH05320135A (ja) * | 1992-05-19 | 1993-12-03 | Yamanouchi Pharmaceut Co Ltd | テトラヒドロベンズアゼピン誘導体 |
| EP0602209A1 (de) * | 1992-07-02 | 1994-06-22 | Otsuka Pharmaceutical Co., Ltd. | Oxytocinantagonist |
| TW270927B (de) * | 1992-10-16 | 1996-02-21 | Otsuka Pharma Co Ltd | |
| WO1994020473A1 (fr) * | 1993-03-11 | 1994-09-15 | Yamanouchi Pharmaceutical Co., Ltd. | Compose avec action antagoniste de la vasopressine |
| GB9307527D0 (en) * | 1993-04-13 | 1993-06-02 | Fujisawa Pharmaceutical Co | New venzamide derivatives,processes for the preparation thereof and pharmaceutical composition comprising the same |
| FR2714378B1 (fr) * | 1993-12-24 | 1996-03-15 | Sanofi Sa | Dérivés de l'indol-2-one substitués en 3 par un groupe azoté, leur préparation, les compositions pharmaceutiques en contenant. |
| ES2284741T3 (es) * | 1994-06-15 | 2007-11-16 | Otsuka Pharmaceutical Company, Limited | Derivados de benzoheterociclicos utilizados como moduladores de vasoprsinao de oxitocina. |
-
1996
- 1996-11-25 TW TW085114489A patent/TW359669B/zh not_active IP Right Cessation
- 1996-12-12 AR ARP960105628A patent/AR005044A1/es active IP Right Grant
- 1996-12-13 PT PT96941870T patent/PT877736E/pt unknown
- 1996-12-13 CN CN96199950A patent/CN1104419C/zh not_active Expired - Fee Related
- 1996-12-13 DK DK96941870T patent/DK0877736T3/da active
- 1996-12-13 ES ES96941870T patent/ES2219703T3/es not_active Expired - Lifetime
- 1996-12-13 AT AT96941870T patent/ATE264845T1/de active
- 1996-12-13 WO PCT/JP1996/003652 patent/WO1997022591A1/en not_active Ceased
- 1996-12-13 US US09/091,295 patent/US6096736A/en not_active Expired - Lifetime
- 1996-12-13 EP EP96941870A patent/EP0877736B1/de not_active Expired - Lifetime
- 1996-12-13 DE DE69632268T patent/DE69632268T2/de not_active Expired - Lifetime
- 1996-12-13 BR BR9612126A patent/BR9612126A/pt not_active IP Right Cessation
- 1996-12-13 KR KR10-1998-0704489A patent/KR100493503B1/ko not_active Expired - Fee Related
-
1998
- 1998-06-15 MX MX9804849A patent/MX9804849A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO1997022591A1 (en) | 1997-06-26 |
| TW359669B (en) | 1999-06-01 |
| KR100493503B1 (ko) | 2005-09-30 |
| DE69632268D1 (de) | 2004-05-27 |
| CN1209121A (zh) | 1999-02-24 |
| DE69632268T2 (de) | 2005-04-21 |
| EP0877736A1 (de) | 1998-11-18 |
| EP0877736B1 (de) | 2004-04-21 |
| AR005044A1 (es) | 1999-04-07 |
| PT877736E (pt) | 2004-09-30 |
| KR20000064406A (ko) | 2000-11-06 |
| HK1016973A1 (en) | 1999-11-12 |
| MX9804849A (es) | 1998-09-30 |
| BR9612126A (pt) | 1999-02-17 |
| ES2219703T3 (es) | 2004-12-01 |
| CN1104419C (zh) | 2003-04-02 |
| DK0877736T3 (da) | 2004-08-16 |
| US6096736A (en) | 2000-08-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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