ATE264852T1 - Chinolinderivate als antibakterielle mittel - Google Patents
Chinolinderivate als antibakterielle mittelInfo
- Publication number
- ATE264852T1 ATE264852T1 AT00942068T AT00942068T ATE264852T1 AT E264852 T1 ATE264852 T1 AT E264852T1 AT 00942068 T AT00942068 T AT 00942068T AT 00942068 T AT00942068 T AT 00942068T AT E264852 T1 ATE264852 T1 AT E264852T1
- Authority
- AT
- Austria
- Prior art keywords
- antibacterial agents
- quinoline derivatives
- oxide
- compound
- formula
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/50—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- Oncology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Quinoline Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9914486.7A GB9914486D0 (en) | 1999-06-21 | 1999-06-21 | Medicaments |
| PCT/EP2000/005466 WO2000078748A1 (en) | 1999-06-21 | 2000-06-13 | Quinoline derivatives as antibacterials |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE264852T1 true ATE264852T1 (de) | 2004-05-15 |
Family
ID=10855774
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00942068T ATE264852T1 (de) | 1999-06-21 | 2000-06-13 | Chinolinderivate als antibakterielle mittel |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6911442B1 (de) |
| EP (1) | EP1187828B1 (de) |
| JP (1) | JP2003502419A (de) |
| AT (1) | ATE264852T1 (de) |
| AU (1) | AU5681800A (de) |
| DE (1) | DE60010076T2 (de) |
| ES (1) | ES2218175T3 (de) |
| GB (1) | GB9914486D0 (de) |
| WO (1) | WO2000078748A1 (de) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2321042T3 (es) | 1997-09-15 | 2009-06-01 | THE PROCTER & GAMBLE COMPANY | Quinolonas antimicrobianas, composiciones y usos de las mismas. |
| GB9917408D0 (en) * | 1999-07-23 | 1999-09-22 | Smithkline Beecham Plc | Compounds |
| US6803369B1 (en) | 2000-07-25 | 2004-10-12 | Smithkline Beecham Corporation | Compounds and methods for the treatment of neoplastic disease |
| NZ523749A (en) * | 2000-07-26 | 2005-03-24 | Smithkline Beecham P | Aminopiperidine quinolines and their azaisosteric analogues with antibacterial activity |
| EP1719770A3 (de) * | 2000-09-21 | 2008-03-05 | Smithkline Beecham Plc | Chinolinderivate als antibakterielle Mittel |
| GB0031088D0 (en) * | 2000-12-20 | 2001-01-31 | Smithkline Beecham Plc | Medicaments |
| GB0031086D0 (en) * | 2000-12-20 | 2001-01-31 | Smithkline Beecham Plc | Medicaments |
| GB0101577D0 (en) * | 2001-01-22 | 2001-03-07 | Smithkline Beecham Plc | Compounds |
| GB0112834D0 (en) | 2001-05-25 | 2001-07-18 | Smithkline Beecham Plc | Medicaments |
| GB0112836D0 (en) | 2001-05-25 | 2001-07-18 | Smithkline Beecham Plc | Medicaments |
| GB0118238D0 (en) * | 2001-07-26 | 2001-09-19 | Smithkline Beecham Plc | Medicaments |
| US7312212B2 (en) * | 2002-01-29 | 2007-12-25 | Glaxo Group Limited | Aminopiperidine derivatives |
| WO2003064431A2 (en) * | 2002-01-29 | 2003-08-07 | Glaxo Group Limited | Aminopiperidine compounds, process for their preparation, and pharmaceutical compositions containing them |
| TW200406413A (en) * | 2002-06-26 | 2004-05-01 | Glaxo Group Ltd | Compounds |
| TW200409637A (en) * | 2002-06-26 | 2004-06-16 | Glaxo Group Ltd | Compounds |
| GB0217294D0 (en) * | 2002-07-25 | 2002-09-04 | Glaxo Group Ltd | Medicaments |
| US6900224B2 (en) | 2002-07-31 | 2005-05-31 | The Procter & Gamble Company | Antimicrobial quinolones, their compositions and uses |
| EP1551829B1 (de) * | 2002-10-10 | 2010-04-07 | Morphochem Aktiengesellschaft Für Kombinatorische Chemie | Neue verbindungen mit antibakterieller aktivität |
| ES2340484T3 (es) * | 2002-11-05 | 2010-06-04 | Glaxo Group Limited | Agentes antibacterianos. |
| AU2003291227A1 (en) | 2002-11-05 | 2004-06-07 | Smithkline Beecham Corporation | Antibacterial agents |
| ATE411312T1 (de) | 2002-12-04 | 2008-10-15 | Glaxo Group Ltd | Chinoline und stickstoffhaltige derivatedavon und deren verwendung als antibakterielle mittel |
| ATE444068T1 (de) | 2004-01-23 | 2009-10-15 | Janssen Pharmaceutica Nv | Chinolinderivate und ihre verwendung als mycobakterielle inhibitoren |
| EP1773831A1 (de) * | 2004-07-08 | 2007-04-18 | Glaxo Group Limited | Antibakterielle mittel |
| JP2008528588A (ja) | 2005-01-25 | 2008-07-31 | グラクソ グループ リミテッド | 抗菌剤 |
| EP1846411A4 (de) | 2005-01-25 | 2010-08-04 | Glaxo Group Ltd | Antibakterielle wirkstoffe |
| EP1846416A4 (de) | 2005-01-25 | 2009-07-01 | Glaxo Group Ltd | Antibakterielle wirkstoffe |
| EP1845995A4 (de) | 2005-01-25 | 2010-03-03 | Glaxo Group Ltd | Antibakterielle wirkstoffe |
| WO2006081264A1 (en) | 2005-01-25 | 2006-08-03 | Glaxo Group Limited | Antibacterial agents |
| MY150958A (en) | 2005-06-16 | 2014-03-31 | Astrazeneca Ab | Compounds for the treatment of multi-drug resistant bacterial infections |
| JO2952B1 (en) * | 2005-08-03 | 2016-03-15 | جانسين فارماسوتيكا ان. في | Quinoline derivatives acting as antibacterial agents |
| CN101374831B (zh) | 2006-01-26 | 2011-04-27 | 埃科特莱茵药品有限公司 | 四氢吡喃抗生素 |
| US7973022B2 (en) * | 2006-02-17 | 2011-07-05 | Idexx Laboratories, Inc. | Fluoroquinolone carboxylic acid salt compositions |
| AU2007221049A1 (en) * | 2006-02-28 | 2007-09-07 | Amgen Inc. | Cinnoline and quinazoline derivates as phosphodiesterase 10 inhibitors |
| PL2001862T3 (pl) | 2006-03-28 | 2011-09-30 | Warner Chilcott Co Llc | Jabłczany oraz odmiany polimorficzne kwasu (3S,5S)-7-[3-amino-5-metylo-piperydynylo]-1-cyklopropylo-1,4-dihydro-8-metoksy-4-okso-3-chinolinokarboksylowego |
| WO2007110835A2 (en) | 2006-03-28 | 2007-10-04 | The Procter & Gamble Company | A coupling process for preparing quinolone intermediates |
| WO2007118130A2 (en) | 2006-04-06 | 2007-10-18 | Glaxo Group Limited | Antibacterial agents |
| TW200819457A (en) | 2006-08-30 | 2008-05-01 | Actelion Pharmaceuticals Ltd | Spiro antibiotic derivatives |
| CL2008001003A1 (es) | 2007-04-11 | 2008-10-17 | Actelion Pharmaceuticals Ltd | Compuestos derivados de oxazolidinona; composicion farmaceutica que comprende a dichos compuestos; y su uso para preparar un medicamento para tratar una infeccion bacteriana. |
| EP2785721A1 (de) | 2011-11-30 | 2014-10-08 | Actelion Pharmaceuticals Ltd. | 3,7-disubstituierte octahydro-2h-pyrido [4,3-e] [1,3] oxazin-2-on-antibiotika |
| WO2016138988A1 (en) * | 2015-03-02 | 2016-09-09 | University Of Copenhagen | Piperazine inhibitors of bacterial gyrase and topoisomerase iv |
| CN110117278B (zh) * | 2018-02-07 | 2022-07-19 | 石家庄以岭药业股份有限公司 | 烷氧基苯并五元(六元)杂环胺类化合物及其药物用途 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR86513E (fr) | 1963-03-25 | 1966-02-25 | Rhone Poulenc Sa | Nouveaux dérivés de la quinoléine et leur préparation |
| GB1496371A (en) | 1975-08-18 | 1977-12-30 | Serdex | 4-amino-quinoline derivatives process for their preparation and therapeutic applications thereof |
| US4925877A (en) | 1986-02-25 | 1990-05-15 | Zaidanhojin Biseibutsu Kagaku Kenkyukai | Physiologically active erbstatin analogue compounds and compositions |
| US4971996A (en) | 1987-03-11 | 1990-11-20 | Kanegafuchi Kagaku Kogyo Kabushiki Kaisha | Hydroxystyrene compounds which are useful as tyrosine kinase inhibitors |
| FI95572C (fi) | 1987-06-22 | 1996-02-26 | Eisai Co Ltd | Menetelmä lääkeaineena käyttökelpoisen piperidiinijohdannaisten tai sen farmaseuttisen suolan valmistamiseksi |
| ZA899436B (en) | 1988-12-12 | 1990-08-29 | Ciba Geigy | Piperidine derivatives |
| ES2188584T3 (es) | 1991-03-28 | 2003-07-01 | Eisai Co Ltd | Derivados heterociclicos de amina. |
| US5721237A (en) | 1991-05-10 | 1998-02-24 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Protein tyrosine kinase aryl and heteroaryl quinazoline compounds having selective inhibition of HER-2 autophosphorylation properties |
| EP0541486A1 (de) | 1991-11-07 | 1993-05-12 | Ciba-Geigy Ag | Polycyclische Konjugate |
| US5728708A (en) | 1993-10-01 | 1998-03-17 | Novartis Corporation | Pharmacologically active pyridine derivatives and processes for the preparation thereof |
| JPH07179407A (ja) | 1993-11-12 | 1995-07-18 | Green Cross Corp:The | 新規縮合環系化合物またはその塩、およびその医薬用途 |
| MX9702245A (es) | 1994-11-14 | 1997-06-28 | Warner Lambert Co | Seis-aril-pirido(2,3-d)pirimidinas y naftiridinas para inhibir la proliferacion celular mediada por la proteina cinasa tirosina. |
| ES2149468T3 (es) | 1995-04-26 | 2000-11-01 | Kyowa Hakko Kogyo Kk | Derivados de radicicol. |
| GB9514265D0 (en) | 1995-07-13 | 1995-09-13 | Wellcome Found | Hetrocyclic compounds |
| EP0869793A4 (de) | 1995-11-13 | 1999-02-03 | Smithkline Beecham Corp | Hämoregulatorische verbindungen |
| US5707990A (en) | 1996-01-30 | 1998-01-13 | Ortho Pharmaceutical Corporation | 2-substituted amino and thio alkyl benzoxazine antimicrobial agents |
| HRP970371A2 (en) | 1996-07-13 | 1998-08-31 | Kathryn Jane Smith | Heterocyclic compounds |
| ZA986594B (en) | 1997-07-25 | 1999-01-27 | Abbott Lab | Urokinase inhibitors |
| DE69908555T2 (de) | 1998-01-26 | 2004-05-06 | Smithkline Beecham P.L.C., Brentford | Chinolinderivate als antibakterielles arzneimittel |
| GB9822440D0 (en) | 1998-10-14 | 1998-12-09 | Smithkline Beecham Plc | Medicaments |
| GB9822450D0 (en) | 1998-10-14 | 1998-12-09 | Smithkline Beecham Plc | Medicaments |
| JP2002535323A (ja) | 1999-01-20 | 2002-10-22 | スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー | プロテインキナーゼ阻害剤としてのピペリジニルキノリン |
| US6403610B1 (en) | 1999-09-17 | 2002-06-11 | Aventis Pharma S.A. | Quinolylpropylpiperidine derivatives, their preparation and the compositions which comprise them |
-
1999
- 1999-06-21 GB GBGB9914486.7A patent/GB9914486D0/en not_active Ceased
-
2000
- 2000-06-13 AU AU56818/00A patent/AU5681800A/en not_active Abandoned
- 2000-06-13 JP JP2001504914A patent/JP2003502419A/ja active Pending
- 2000-06-13 WO PCT/EP2000/005466 patent/WO2000078748A1/en not_active Ceased
- 2000-06-13 ES ES00942068T patent/ES2218175T3/es not_active Expired - Lifetime
- 2000-06-13 AT AT00942068T patent/ATE264852T1/de not_active IP Right Cessation
- 2000-06-13 DE DE60010076T patent/DE60010076T2/de not_active Expired - Fee Related
- 2000-06-13 US US10/018,900 patent/US6911442B1/en not_active Expired - Fee Related
- 2000-06-13 EP EP00942068A patent/EP1187828B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| ES2218175T3 (es) | 2004-11-16 |
| DE60010076D1 (de) | 2004-05-27 |
| US6911442B1 (en) | 2005-06-28 |
| AU5681800A (en) | 2001-01-09 |
| WO2000078748A1 (en) | 2000-12-28 |
| JP2003502419A (ja) | 2003-01-21 |
| EP1187828A1 (de) | 2002-03-20 |
| GB9914486D0 (en) | 1999-08-18 |
| EP1187828B1 (de) | 2004-04-21 |
| DE60010076T2 (de) | 2005-04-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |