ATE266034T1 - Gastro-spezifische prodrugs - Google Patents

Gastro-spezifische prodrugs

Info

Publication number
ATE266034T1
ATE266034T1 AT01909258T AT01909258T ATE266034T1 AT E266034 T1 ATE266034 T1 AT E266034T1 AT 01909258 T AT01909258 T AT 01909258T AT 01909258 T AT01909258 T AT 01909258T AT E266034 T1 ATE266034 T1 AT E266034T1
Authority
AT
Austria
Prior art keywords
disclosed
hydrophilic group
gastro
awh
drug
Prior art date
Application number
AT01909258T
Other languages
English (en)
Inventor
Samuel J Tremont
Paul W Collins
Ricky L Fenton
Original Assignee
Pharmacia Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Corp filed Critical Pharmacia Corp
Application granted granted Critical
Publication of ATE266034T1 publication Critical patent/ATE266034T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AT01909258T 2000-02-28 2001-02-16 Gastro-spezifische prodrugs ATE266034T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/514,819 US6413945B1 (en) 1997-04-04 2000-02-28 Gastro-specific prodrugs
PCT/US2001/004960 WO2001064690A1 (en) 2000-02-28 2001-02-16 Gastro-specific prodrugs

Publications (1)

Publication Number Publication Date
ATE266034T1 true ATE266034T1 (de) 2004-05-15

Family

ID=24048822

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01909258T ATE266034T1 (de) 2000-02-28 2001-02-16 Gastro-spezifische prodrugs

Country Status (11)

Country Link
US (1) US6413945B1 (de)
EP (1) EP1261613B1 (de)
JP (1) JP2003525301A (de)
AT (1) ATE266034T1 (de)
AU (1) AU2001237033A1 (de)
DE (1) DE60103134T2 (de)
DK (1) DK1261613T3 (de)
ES (1) ES2215880T3 (de)
PT (1) PT1261613E (de)
TR (1) TR200401012T4 (de)
WO (1) WO2001064690A1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005105153A1 (en) * 2004-04-30 2005-11-10 Kopran Research Laboratories Limited Hydroxyalkyl derivatives of biologically active compounds
CN102112118A (zh) * 2008-04-25 2011-06-29 北卡罗来纳-查佩尔山大学 特别用于非湿润模型的颗粒复制的可降解化合物及其使用方法
US20110212986A1 (en) * 2008-08-21 2011-09-01 Health Research, Inc. Anti-flavivirus therapeutic
EP2616103A1 (de) 2010-09-16 2013-07-24 The University of North Carolina At Chapel Hill Bifunktionelle asymmetrische silylmonomere und teilchen daraus als prodrugs und freisetzungsvehikel für pharmazeutische, chemische und biologische wirkstoffe
WO2016057828A1 (en) 2014-10-08 2016-04-14 Epigenetics Pharma Llc Silylated pyrimidine prodrugs and methods of their use

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5055604A (en) * 1990-04-17 1991-10-08 G. D. Searle & Co. Process for preparing prostaglandin analogs using organozirconium compounds
ES2084825T3 (es) * 1990-07-26 1996-05-16 Monsanto Co Procedimiento de preparacion de poliamidas entrecruzadas.
JPH08165301A (ja) * 1994-12-15 1996-06-25 Mitsubishi Chem Corp 環状イヌロオリゴ糖のシリル化誘導体およびその製造方法
US5618959A (en) * 1995-03-10 1997-04-08 Vivus Incorporated Process for preparing prostaglandin E1, E2 and analogs thereof using furylcopper reagents
US6030959A (en) * 1997-04-04 2000-02-29 Monsanto Company Gastro-specific prodrugs

Also Published As

Publication number Publication date
US6413945B1 (en) 2002-07-02
TR200401012T4 (tr) 2004-10-21
AU2001237033A1 (en) 2001-09-12
WO2001064690A1 (en) 2001-09-07
DE60103134T2 (de) 2005-04-28
DK1261613T3 (da) 2004-08-09
PT1261613E (pt) 2004-08-31
EP1261613A1 (de) 2002-12-04
EP1261613B1 (de) 2004-05-06
ES2215880T3 (es) 2004-10-16
DE60103134D1 (de) 2004-06-09
JP2003525301A (ja) 2003-08-26

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