ATE266034T1 - Gastro-spezifische prodrugs - Google Patents

Gastro-spezifische prodrugs

Info

Publication number
ATE266034T1
ATE266034T1 AT01909258T AT01909258T ATE266034T1 AT E266034 T1 ATE266034 T1 AT E266034T1 AT 01909258 T AT01909258 T AT 01909258T AT 01909258 T AT01909258 T AT 01909258T AT E266034 T1 ATE266034 T1 AT E266034T1
Authority
AT
Austria
Prior art keywords
disclosed
hydrophilic group
gastro
awh
drug
Prior art date
Application number
AT01909258T
Other languages
English (en)
Inventor
Samuel J Tremont
Paul W Collins
Ricky L Fenton
Original Assignee
Pharmacia Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Corp filed Critical Pharmacia Corp
Application granted granted Critical
Publication of ATE266034T1 publication Critical patent/ATE266034T1/de

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02Silicon compounds
    • C07F7/08Compounds having one or more C—Si linkages
    • C07F7/18Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804Compounds having Si-O-C linkages

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AT01909258T 2000-02-28 2001-02-16 Gastro-spezifische prodrugs ATE266034T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/514,819 US6413945B1 (en) 1997-04-04 2000-02-28 Gastro-specific prodrugs
PCT/US2001/004960 WO2001064690A1 (en) 2000-02-28 2001-02-16 Gastro-specific prodrugs

Publications (1)

Publication Number Publication Date
ATE266034T1 true ATE266034T1 (de) 2004-05-15

Family

ID=24048822

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01909258T ATE266034T1 (de) 2000-02-28 2001-02-16 Gastro-spezifische prodrugs

Country Status (11)

Country Link
US (1) US6413945B1 (de)
EP (1) EP1261613B1 (de)
JP (1) JP2003525301A (de)
AT (1) ATE266034T1 (de)
AU (1) AU2001237033A1 (de)
DE (1) DE60103134T2 (de)
DK (1) DK1261613T3 (de)
ES (1) ES2215880T3 (de)
PT (1) PT1261613E (de)
TR (1) TR200401012T4 (de)
WO (1) WO2001064690A1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1744785A1 (de) * 2004-04-30 2007-01-24 Kopran Research Laboratories Limited Hydroxyalkylderivate von biologischen wirkstoffen
US8945527B2 (en) * 2008-04-25 2015-02-03 The University Of North Carolina At Chapel Hill Degradable compounds and methods of use thereof, particularly with particle replication in non-wetting templates
US20110212986A1 (en) * 2008-08-21 2011-09-01 Health Research, Inc. Anti-flavivirus therapeutic
US20130203675A1 (en) 2010-09-16 2013-08-08 Joseph M. DeSimone Asymmetric biofunctional silyl monomers and particles thereof as prodrugs and delivery vehicles for pharmaceutical, chemical and biological agents
EP3204121B1 (de) 2014-10-08 2019-06-19 Epigenetics Pharma LLC Silylierte 5-aza-pyrimidin- prodrugs als krebsmittel

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5055604A (en) * 1990-04-17 1991-10-08 G. D. Searle & Co. Process for preparing prostaglandin analogs using organozirconium compounds
WO1992001477A1 (en) * 1990-07-26 1992-02-06 G.D. Searle & Co. Polymeric drug delivery system
JPH08165301A (ja) * 1994-12-15 1996-06-25 Mitsubishi Chem Corp 環状イヌロオリゴ糖のシリル化誘導体およびその製造方法
US5618959A (en) * 1995-03-10 1997-04-08 Vivus Incorporated Process for preparing prostaglandin E1, E2 and analogs thereof using furylcopper reagents
US6030959A (en) * 1997-04-04 2000-02-29 Monsanto Company Gastro-specific prodrugs

Also Published As

Publication number Publication date
EP1261613A1 (de) 2002-12-04
AU2001237033A1 (en) 2001-09-12
DK1261613T3 (da) 2004-08-09
DE60103134T2 (de) 2005-04-28
JP2003525301A (ja) 2003-08-26
PT1261613E (pt) 2004-08-31
US6413945B1 (en) 2002-07-02
WO2001064690A1 (en) 2001-09-07
TR200401012T4 (tr) 2004-10-21
DE60103134D1 (de) 2004-06-09
ES2215880T3 (es) 2004-10-16
EP1261613B1 (de) 2004-05-06

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