ATE266201T1 - Verbundnanopartikel sowie deren konjugate mit biomolekülen - Google Patents

Verbundnanopartikel sowie deren konjugate mit biomolekülen

Info

Publication number
ATE266201T1
ATE266201T1 AT00974662T AT00974662T ATE266201T1 AT E266201 T1 ATE266201 T1 AT E266201T1 AT 00974662 T AT00974662 T AT 00974662T AT 00974662 T AT00974662 T AT 00974662T AT E266201 T1 ATE266201 T1 AT E266201T1
Authority
AT
Austria
Prior art keywords
minus
plus
conjugates
composite
dnanoparticles
Prior art date
Application number
AT00974662T
Other languages
English (en)
Inventor
Abdelhamid Elaissari
Eric Bosc
Christian Pichot
Bernard Mandrand
Jerome Bibette
Olivier Mondain-Monval
Original Assignee
Bio Merieux
Centre Nat Rech Scient
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bio Merieux, Centre Nat Rech Scient filed Critical Bio Merieux
Application granted granted Critical
Publication of ATE266201T1 publication Critical patent/ATE266201T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles
    • G01N33/5434—Magnetic particles using magnetic particle immunoreagent carriers which constitute new materials per se
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2446/00—Magnetic particle immunoreagent carriers
    • G01N2446/20—Magnetic particle immunoreagent carriers the magnetic material being present in the particle core
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2446/00—Magnetic particle immunoreagent carriers
    • G01N2446/60—Magnetic particle immunoreagent carriers the magnetic material being dispersed in a medium other than the main solvent prior to incorporation into the polymer particle
    • G01N2446/64—Magnetic material dispersed in oil drop
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2446/00—Magnetic particle immunoreagent carriers
    • G01N2446/60—Magnetic particle immunoreagent carriers the magnetic material being dispersed in a medium other than the main solvent prior to incorporation into the polymer particle
    • G01N2446/66—Magnetic material dispersed in surfactant
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2984—Microcapsule with fluid core [includes liposome]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2984—Microcapsule with fluid core [includes liposome]
    • Y10T428/2985—Solid-walled microcapsule from synthetic polymer
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2984—Microcapsule with fluid core [includes liposome]
    • Y10T428/2985—Solid-walled microcapsule from synthetic polymer
    • Y10T428/2987—Addition polymer from unsaturated monomers only

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Inks, Pencil-Leads, Or Crayons (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Polymerisation Methods In General (AREA)
  • Peptides Or Proteins (AREA)
AT00974662T 1999-11-05 2000-11-06 Verbundnanopartikel sowie deren konjugate mit biomolekülen ATE266201T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9914194A FR2800635B1 (fr) 1999-11-05 1999-11-05 Nanospheres composites, conjugues derives, procede de preparation et leurs utilisations
PCT/FR2000/003085 WO2001033223A1 (fr) 1999-11-05 2000-11-06 Nanospheres composites et leurs conjugues avec des biomolecules

Publications (1)

Publication Number Publication Date
ATE266201T1 true ATE266201T1 (de) 2004-05-15

Family

ID=9552017

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00974662T ATE266201T1 (de) 1999-11-05 2000-11-06 Verbundnanopartikel sowie deren konjugate mit biomolekülen

Country Status (10)

Country Link
US (2) US6866838B1 (de)
EP (1) EP1226438B1 (de)
JP (2) JP4980532B2 (de)
AT (1) ATE266201T1 (de)
AU (1) AU1288201A (de)
CA (1) CA2390077A1 (de)
DE (1) DE60010500T2 (de)
ES (1) ES2220560T3 (de)
FR (1) FR2800635B1 (de)
WO (1) WO2001033223A1 (de)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2804117B1 (fr) * 2000-01-21 2004-08-20 Bio Merieux Procede d'isolement de proteines et/ou d'acides nucleiques, complexes de particules et de proteines et/ou d'acides nucleiques, reactif et applications
US6689338B2 (en) 2000-06-01 2004-02-10 The Board Of Regents For Oklahoma State University Bioconjugates of nanoparticles as radiopharmaceuticals
FR2824563B1 (fr) * 2001-05-10 2004-12-03 Bio Merieux Particules composites, conjugues derives, procede de preparation et applications
EP1306128A1 (de) * 2001-10-29 2003-05-02 Tenaxis Gmbh Sorptionsfähige Kompositmaterialen
US7939170B2 (en) 2002-08-15 2011-05-10 The Rockefeller University Water soluble metal and semiconductor nanoparticle complexes
JP2004175922A (ja) * 2002-11-27 2004-06-24 Toppan Forms Co Ltd ヌクレオチド重合体マイクロカプセルインキ
JP2004331832A (ja) * 2003-05-08 2004-11-25 Ricoh Co Ltd Ｄｎａインク組成物とそれを用いた識別画像印刷体、及びインクジェット記録装置
CN1312479C (zh) * 2003-08-08 2007-04-25 清华大学 一种纳米荧光磁粒及其制备方法
FR2860717B1 (fr) * 2003-10-13 2006-02-03 Ethypharm Sa Compositions de particules lipidiques solides monodisperses
CA2553647A1 (en) * 2004-01-20 2005-08-04 Alnis Biosciences, Inc. Articles comprising magnetic material and bioactive agents
US7964380B2 (en) * 2005-01-21 2011-06-21 Argylia Technologies Nanoparticles for manipulation of biopolymers and methods of thereof
EP1721603A1 (de) * 2005-05-11 2006-11-15 Albert-Ludwigs-Universität Freiburg Nanopartikel geeignet für Biokonjugation
WO2007014445A1 (en) * 2005-08-02 2007-02-08 Miv Therapeutics Inc. Microdevices comprising nanocapsules for controlled delivery of drugs and method of manufacturing same
US7564245B2 (en) 2005-08-31 2009-07-21 T2 Biosystems, Inc. NMR device for detection of analytes
USH2257H1 (en) * 2005-09-28 2011-06-07 The United States Of America As Represented By The Secretary Of The Navy Microtags for detection and identification of materials
DE102005047786A1 (de) * 2005-10-05 2007-04-19 Urs Isler Verfahren zur Behandlung von Gamen zur Authentifizierung und Vorrichtung zum Nachweis der Authentizität
ES2761937T3 (es) * 2005-10-24 2020-05-21 Magsense Life Sciences Inc Método para preparar micropartículas recubiertas con polímero
FR2894970B1 (fr) * 2005-12-15 2008-01-25 Biomerieux Sa Procede de preparation de particules composites, particules composites obtenues et leur utilisation dans un test diagnostic
WO2007110917A1 (ja) 2006-03-27 2007-10-04 Tokyo Institute Of Technology ポリマー被覆強磁性粒子の製造方法及びポリマー被覆強磁性粒子
AU2007317787B2 (en) * 2006-11-08 2012-07-12 T2 Biosystems, Inc. NMR systems for in vivo detection of analytes
US7981688B2 (en) 2007-03-08 2011-07-19 University Of Washington Stimuli-responsive magnetic nanoparticles and related methods
KR100860506B1 (ko) 2007-08-28 2008-09-26 연세대학교 산학협력단 금속 나노입자를 포함하는 고분자 복합재 및 그의 합성방법
US8421458B2 (en) 2007-09-28 2013-04-16 T2 Biosystems, Inc. NMR diagnostics by means of a plastic sample container
WO2009061481A1 (en) 2007-11-06 2009-05-14 T2 Biosystems, Inc. Small magnet and rf coil for magnetic resonance relaxometry
WO2010005741A1 (en) * 2008-06-16 2010-01-14 Georgia Tech Research Corporation Nanogels for cellular delivery of therapeutics
WO2010035258A2 (en) * 2008-09-25 2010-04-01 Nanoready Ltd. Discrete metallic copper nanoparticles
WO2010051362A1 (en) 2008-10-29 2010-05-06 T2 Biosystems, Inc. Nmr detection of coagulation time
EP2396373B1 (de) 2009-02-12 2014-06-18 Bayer Intellectual Property GmbH Antireflex- / antifog-beschichtungen
WO2010117458A1 (en) * 2009-04-10 2010-10-14 President And Fellows Of Harvard College Manipulation of particles in channels
US8426214B2 (en) * 2009-06-12 2013-04-23 University Of Washington System and method for magnetically concentrating and detecting biomarkers
GB0913258D0 (en) 2009-07-29 2009-09-02 Dynex Technologies Inc Reagent dispenser
US9523701B2 (en) 2009-07-29 2016-12-20 Dynex Technologies, Inc. Sample plate systems and methods
US9080933B2 (en) 2009-11-09 2015-07-14 University Of Washington Through Its Center For Commercialization Stimuli-responsive polymer diagnostic assay comprising magnetic nanoparticles and capture conjugates
US20110117668A1 (en) * 2009-11-09 2011-05-19 University Of Washington Through Its Center For Commercialization Self-powered smart diagnostic devices
CA2780562A1 (en) * 2009-11-11 2011-05-19 Basf Se Method of increasing the efficiency in an ore separation process by means of hydrophobic magnetic particles by targeted input of mechanical energy
US8563298B2 (en) 2010-10-22 2013-10-22 T2 Biosystems, Inc. NMR systems and methods for the rapid detection of analytes
US8409807B2 (en) 2010-10-22 2013-04-02 T2 Biosystems, Inc. NMR systems and methods for the rapid detection of analytes
WO2012054639A2 (en) 2010-10-22 2012-04-26 T2 Biosystems, Inc. Nmr systems and methods for the rapid detection of analytes
EP2732046B1 (de) 2011-07-13 2017-09-06 T2 Biosystems, Inc. Kernspinresonanzverfahren zur überwachung der bildung von blutgerinnseln
US8728501B2 (en) * 2011-08-31 2014-05-20 Shanghai World-Prospect Chemtech Co., Ltd. Composite material of inorganic nonmetallic mineral loaded with titania layer, preparation process and use thereof
EP2748651B1 (de) 2011-09-21 2017-08-30 T2 Biosystems, Inc. Nmr-verfahren für endotoxinanalyse
EP2839038B1 (de) 2012-04-20 2019-01-16 T2 Biosystems, Inc. Zusammensetzungen und verfahren für den nachweis einer candida-spezies
KR101382530B1 (ko) * 2012-06-07 2014-04-07 한양대학교 에리카산학협력단 팔라듐이 담지된 유기화학 반응 촉매 및 이를 이용하여 바이아릴 화합물을 제조하는 방법
EP2929047A4 (de) 2012-12-07 2016-08-03 T2 Biosystems Inc Verfahren zur überwachung der formierung von dichten gerinnseln
RU2533824C1 (ru) * 2013-10-11 2014-11-20 Федеральное государственное бюджетное учреждение науки Институт элементоорганических соединений им. А.Н. Несмеянова Российской академии наук (ИНЭОС РАН) Способ получения магнитовосприимчивых водорастворимых гидрофобно модифицированных полиакриламидов и магнитная жидкость на их основе
CA2909415C (en) 2014-03-27 2019-03-19 Innosense Llc Hydrophilic anti-fog coatings
WO2017127731A1 (en) 2016-01-21 2017-07-27 T2 Biosystems, Inc. Nmr methods and systems for the rapid detection of bacteria
US11237162B2 (en) 2016-05-24 2022-02-01 Jsr Corporation Composite particles, coated particles, method for producing composite particles, ligand-containing solid phase carrier and method for detecting or separating target substance in sample
CN111589388A (zh) * 2020-04-21 2020-08-28 同济大学 一种阻燃微胶囊及其制备方法
CN111589387A (zh) * 2020-04-21 2020-08-28 同济大学 一种微胶囊复合材料及其制备方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4157323A (en) * 1976-06-09 1979-06-05 California Institute Of Technology Metal containing polymeric functional microspheres
US4342739A (en) * 1979-01-09 1982-08-03 Fuji Photo Film Co., Ltd. Novel material for immunological assay of biochemical components and a process for the determination of said components
FR2480764B1 (fr) * 1980-04-18 1985-10-04 Rhone Poulenc Spec Chim Latex de polymeres magnetiques et procede de preparation
PT71309A (en) * 1980-05-27 1980-06-01 Hovione Sociedade Quimica Lda Process of selective
JPS6119103A (ja) * 1984-07-06 1986-01-28 Japan Synthetic Rubber Co Ltd 磁性粒子
JPS6186941A (ja) * 1984-10-03 1986-05-02 Japan Synthetic Rubber Co Ltd 含油マイクロカプセルの製造方法
EP0180384B1 (de) * 1984-11-01 1991-04-24 TECHNICON INSTRUMENTS CORPORATION(a Delaware corporation) Magnetisch empfindlicher Reagensträger und Verfahren zur Herstellung
FR2645160B1 (de) * 1989-03-31 1992-10-02 Rhone Poulenc Chimie
US5922304A (en) * 1989-12-22 1999-07-13 Imarx Pharmaceutical Corp. Gaseous precursor filled microspheres as magnetic resonance imaging contrast agents
JPH05165248A (ja) * 1991-12-17 1993-07-02 Brother Ind Ltd マイクロカプセルの製造方法および画像形成装置
ATE231875T1 (de) 1996-03-20 2003-02-15 Bio Merieux Isolierung von nukleinsäure
JP2884069B2 (ja) * 1996-09-10 1999-04-19 工業技術院長 ｐＨ感応性、感熱性マイクロビーズ及びその製造方法
US6416740B1 (en) * 1997-05-13 2002-07-09 Bristol-Myers Squibb Medical Imaging, Inc. Acoustically active drug delivery systems
WO1999019000A1 (en) * 1997-10-11 1999-04-22 The Research Foundation Of State University Of New York Controlled size polymeric microspheres with superparamagnetic cores
FR2773416B1 (fr) 1998-01-06 2000-02-11 Bio Merieux Particules magnetiques perfectionnees, leurs procedes d'obtention et leurs utilisations dans la separation de molecules

Also Published As

Publication number Publication date
US6866838B1 (en) 2005-03-15
DE60010500D1 (de) 2004-06-09
EP1226438A1 (de) 2002-07-31
US20050137334A1 (en) 2005-06-23
DE60010500T2 (de) 2005-05-12
JP4980532B2 (ja) 2012-07-18
JP2003513093A (ja) 2003-04-08
FR2800635B1 (fr) 2002-07-26
ES2220560T3 (es) 2004-12-16
US7001589B2 (en) 2006-02-21
WO2001033223A1 (fr) 2001-05-10
EP1226438B1 (de) 2004-05-06
CA2390077A1 (fr) 2001-05-10
FR2800635A1 (fr) 2001-05-11
AU1288201A (en) 2001-05-14
JP2012017332A (ja) 2012-01-26

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