ATE266398T1 - Pharmazeutische zusammensetzungen enthaltend tyrphostine - Google Patents

Pharmazeutische zusammensetzungen enthaltend tyrphostine

Info

Publication number
ATE266398T1
ATE266398T1 AT97934696T AT97934696T ATE266398T1 AT E266398 T1 ATE266398 T1 AT E266398T1 AT 97934696 T AT97934696 T AT 97934696T AT 97934696 T AT97934696 T AT 97934696T AT E266398 T1 ATE266398 T1 AT E266398T1
Authority
AT
Austria
Prior art keywords
tyrphostines
pharmaceutical compositions
compositions containing
formulae
phenyl
Prior art date
Application number
AT97934696T
Other languages
English (en)
Inventor
Abraham Novogrodsky
Alexander Levitzki
Aviv Gazit
Original Assignee
Notox Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Notox Ltd filed Critical Notox Ltd
Application granted granted Critical
Publication of ATE266398T1 publication Critical patent/ATE266398T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4406—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 3, e.g. zimeldine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT97934696T 1996-08-14 1997-08-14 Pharmazeutische zusammensetzungen enthaltend tyrphostine ATE266398T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IL11906996A IL119069A0 (en) 1996-08-14 1996-08-14 Pharmaceutical composition comprising tyrphostins
PCT/IL1997/000276 WO1998006391A1 (en) 1996-08-14 1997-08-14 Pharmaceutical compositions comprising tyrphostins

Publications (1)

Publication Number Publication Date
ATE266398T1 true ATE266398T1 (de) 2004-05-15

Family

ID=11069189

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97934696T ATE266398T1 (de) 1996-08-14 1997-08-14 Pharmazeutische zusammensetzungen enthaltend tyrphostine

Country Status (11)

Country Link
US (2) US6426366B1 (de)
EP (1) EP0923371B1 (de)
JP (1) JP2001504085A (de)
CN (1) CN1232392A (de)
AT (1) ATE266398T1 (de)
AU (1) AU728672B2 (de)
BR (1) BR9711160A (de)
CA (1) CA2263325A1 (de)
DE (1) DE69729104D1 (de)
IL (1) IL119069A0 (de)
WO (1) WO1998006391A1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1146869A2 (de) * 1999-01-27 2001-10-24 University Of South Florida Inhibierung der stat3 signaltransduktion für krebsbehandlung
WO2001026645A1 (en) * 1999-10-12 2001-04-19 Temple University-Of The Commonwealth System Of Higher Education Method for protecting normal cells from cytotoxicity of chemotherapeutic agents
US20040052762A1 (en) * 2001-09-10 2004-03-18 Hua Yu Stat3 agonists and antagonists and therapeutic uses thereof
IL159270A0 (en) * 2001-06-14 2004-06-01 Yissum Res Dev Co Non-myeloablative tolerogenic treatment with tyrphostins
US6433018B1 (en) * 2001-08-31 2002-08-13 The Research Foundation Of State University Of New York Method for reducing hypertrophy and ischemia
US7638122B2 (en) * 2003-03-07 2009-12-29 University Of South Florida Stat3 antagonists and their use as vaccines against cancer
PT1701941E (pt) * 2003-12-11 2012-08-03 Univ Texas Compostos para o tratamento de doenças proliferativas celulares
ES2368741T3 (es) 2004-02-25 2011-11-21 Dana-Farber Cancer Institute, Inc. Inhibidores del receptor 1 del factor de crecimiento de tipo insulina para inhibir el crecimiento de células tumorales.
PL2514742T3 (pl) 2006-03-31 2015-07-31 Univ Texas Leki przeciwnowotworowe będące pochodnymi kwasu kawowego dostępnymi biologicznie po podaniu doustnym
US20100292229A1 (en) * 2006-06-30 2010-11-18 The Board Of Regents Of The University Of Texas System Tryphostin-analogs for the treatment of cell proliferative diseases
CA2722992A1 (en) * 2008-05-05 2009-11-12 Schering Corporation Sequential administration of chemotherapeutic agents for treatment of cancer
JP5675606B2 (ja) 2008-07-08 2015-02-25 ボード・オブ・リージエンツ，ザ・ユニバーシテイ・オブ・テキサス・システム シグナル伝達性転写因子（ｓｔａｔ）の増殖及び活性化の新規の抑制剤
WO2011080261A1 (en) 2009-12-28 2011-07-07 INSERM (Institut National de la Santé et de la Recherche Médicale) Method for improved cardiomyogenic differentiation of pluripotent cells
TWI846678B (zh) 2017-11-10 2024-07-01 美國德州系統大學評議委員會 咖啡酸衍生物及其用途

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH484603A (de) 1966-03-21 1970-01-31 Ciba Geigy Schädlingsbekämpfungsmittel, enthaltend bestimmte Malodinitrile
US3551573A (en) 1967-11-08 1970-12-29 Monsanto Co Insecticidal composition and method containing anilinomethylene malonitriles
US3726662A (en) 1970-01-14 1973-04-10 Monsanto Co Herbicidal anilinomethylene-malononitriles
IT7819093A0 (it) * 1977-01-10 1978-01-06 Ciba Geigy Prodotti antielmintici e loro impiego.
AU632992B2 (en) * 1987-12-24 1993-01-21 Yissum Research Development Company Of The Hebrew University Of Jerusalem Pharmaceutical compositions comprising benzylidene- and cinnamylidene-malononitrile derivatives for the inhibition of proliferative processes in mammalian cells, certain such novel compounds and their preparation
RU2024514C1 (ru) 1991-10-01 1994-12-15 Иркутский институт органической химии СО РАН Комплекс 1-этилимидазола с аскорбатом цинка, повышающий устойчивость организма к действию диоксида азота и обладающий цитопротекторным и антигипоксическим действием
US5284868A (en) 1991-10-09 1994-02-08 Eli Lilly And Company Pharmaceutical compounds
US5972598A (en) 1992-09-17 1999-10-26 Board Of Trustess Of The University Of Illinois Methods for preventing multidrug resistance in cancer cells
WO1995002420A2 (en) 1993-07-15 1995-01-26 Cancer Research Campaign Technology Ltd. Prodrugs of protein tyrosine kinase inhibitors
IL107736A (en) 1993-11-24 2001-01-11 Yissum Res Dev Co Pharmaceutical composition for the prevention of septic shock and for the treatment of chronic inflammatory diseases
US5700823A (en) 1994-01-07 1997-12-23 Sugen, Inc. Treatment of platelet derived growth factor related disorders such as cancers
WO1995024190A2 (en) * 1994-03-07 1995-09-14 Sugen, Inc. Receptor tyrosine kinase inhibitors for inhibiting cell proliferative disorders and compositions thereof
WO1997011692A2 (en) * 1995-09-11 1997-04-03 Osteoarthritis Sciences, Inc. Protein tyrosine kinase inhibitors for treating osteoarthritis

Also Published As

Publication number Publication date
EP0923371B1 (de) 2004-05-12
IL119069A0 (en) 1996-11-14
JP2001504085A (ja) 2001-03-27
CN1232392A (zh) 1999-10-20
US6426366B1 (en) 2002-07-30
AU728672B2 (en) 2001-01-18
US20030013748A1 (en) 2003-01-16
WO1998006391A1 (en) 1998-02-19
BR9711160A (pt) 2000-01-11
CA2263325A1 (en) 1998-02-19
AU3782297A (en) 1998-03-06
DE69729104D1 (de) 2004-06-17
EP0923371A1 (de) 1999-06-23

Similar Documents

Publication Publication Date Title
PT97888A (pt) Processo para a preparacao de compostos heterociclicos derivados de indol e de composicoes farmaceuticas que os contem
DE69729104D1 (de) Pharmazeutische zusammensetzungen enthaltend tyrphostine
ATE5258T1 (de) (piperidinylalkyl)chinazolin-derivate, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zusammensetzungen.
CA2113229A1 (en) Anti-fibrotic quinazolinone-containing compositions and methods for the use thereof
YU11997A (sh) Laktamski derivati i njihove farmaceutske kompozicije
DE69310602D1 (de) 3',5'-Ditertbutyl-4'-Hydroxyflavone, Verfahren zu ihrer Herstellung und pharmazeutische Zusammensetzung mit Antioxidations- und Antivasokonstriktionsaktivität
ATE101120T1 (de) N-substituierte lauramide, ihre herstellung und sie enthaltende zusammensetzungen.
KR970707108A (ko) 항염증제로 유용한, 복소환부를 갖는 디-t-부틸페놀 화합물(DI-TERT-BUTYLPHENOL COMPOUNDS WITH HETEROCYCLIC MOIETY, USEFUL AS ANTI-INFLAMMATORY AGENTS)
EP0765865A4 (de) 2-acylaminopropanolverbindungen und medizinische zusammensetzungen
ATE273281T1 (de) Heterozyklische cytotoxische wirkstoffe
DE3575554D1 (de) Aminosaeurederivate mit antitumoraktivitaet sowie diese derivate enthaltende zusammensetzungen.
BG104717A (en) Water soluble azoles as broad-spectrum antifungals
NO952180L (no) Insekticide 5-substituerte 2,4-diaminopyrimidiner
AR007052A1 (es) Un derivado de carbohidrato, su uso y una composicion farmaceutica que lo comprende
KR910004557A (ko) 2,4,6-치환 페놀 유도체
AU8383691A (en) Amelinic compounds and use thereof in self-extinguishing polymeric compositions
MX9206930A (es) Nuevos compuestos
DE68927554D1 (de) Cephalosporinverbindungen und Verfahren zu ihrer Herstellung
KR890009890A (ko) 하이드록시 피리미딘의 아실 유도체
SE9701912D0 (sv) Pharmaceutical composition and use thereof
NO964735L (no) Adenosin-derivater
NO303817B1 (no) Tiokarbamatsulfoksydsammensetning for avholdenhet fra inntakelse av etanol
DE69523640D1 (de) Substituierte 6-r-1,3,4-thiadiazin-2-amine, deren verwendung als anaesthetische, cardiovaskulare und hypometabolische mittel, und eine sie enthaltende pharmazeutische zubereitung
JPS55104266A (en) Novel pyridone derivative
ATE126504T1 (de) 1-phenoxycarbonyl-2-pyrrolidon-derivate und nootrope wirkstoffe.

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties