ATE266653T1 - Verfahren zur entfernung einer silyloxy- schutzgruppe von 4-silyloxy-tetrahydropyran-2- onen - Google Patents

Verfahren zur entfernung einer silyloxy- schutzgruppe von 4-silyloxy-tetrahydropyran-2- onen

Info

Publication number: ATE266653T1
Authority: AT; Austria
Prior art keywords: silyloxy; tetrahydropyran; removal; protecting group; onenes
Prior art date: 1999-02-04

Application number

AT00901283T

Other languages

English (en)

Inventor

Marko Zlicar

Rudolf Rucman

Original Assignee

Lek Tovarna Farmacevtskih

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-02-04

Filing date

2000-02-02

Publication date

2004-05-15

2000-02-02 Application filed by Lek Tovarna Farmacevtskih filed Critical Lek Tovarna Farmacevtskih

2004-05-15 Application granted granted Critical

2004-05-15 Publication of ATE266653T1 publication Critical patent/ATE266653T1/de

Links

238000000034 method Methods 0.000 title abstract 4
-1 SILYLOXY PROTECTING GROUP Chemical group 0.000 title 1
OZJPLYNZGCXSJM-UHFFFAOYSA-N 5-valerolactone Chemical class O=C1CCCCO1 OZJPLYNZGCXSJM-UHFFFAOYSA-N 0.000 abstract 1
RYMZZMVNJRMUDD-UHFFFAOYSA-N SJ000286063 Natural products C12C(OC(=O)C(C)(C)CC)CC(C)C=C2C=CC(C)C1CCC1CC(O)CC(=O)O1 RYMZZMVNJRMUDD-UHFFFAOYSA-N 0.000 abstract 1
125000001181 organosilyl group Chemical group [SiH3]* 0.000 abstract 1
RYMZZMVNJRMUDD-HGQWONQESA-N simvastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)C(C)(C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 RYMZZMVNJRMUDD-HGQWONQESA-N 0.000 abstract 1
229960002855 simvastatin Drugs 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/30—Oxygen atoms, e.g. delta-lactones
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pyrane Compounds (AREA)

AT00901283T 1999-02-04 2000-02-02 Verfahren zur entfernung einer silyloxy- schutzgruppe von 4-silyloxy-tetrahydropyran-2- onen ATE266653T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
SI9900025A SI20159A (sl)	1999-02-04	1999-02-04	Nov postopek za odstranitev sililoksi zaščitne skupine iz 4-sililoksi tetrahidro-piran-2-on-ov
PCT/IB2000/000105 WO2000046217A1 (en)	1999-02-04	2000-02-02	Novel process for the removal of a silyloxy protecting group from 4-silyloxy-tetrahydro-pyran-2-ones

Publications (1)

Publication Number	Publication Date
ATE266653T1 true ATE266653T1 (de)	2004-05-15

Family

ID=20432398

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT00901283T ATE266653T1 (de)	1999-02-04	2000-02-02	Verfahren zur entfernung einer silyloxy- schutzgruppe von 4-silyloxy-tetrahydropyran-2- onen

Country Status (9)

Country	Link
US (1)	US6509479B1 (de)
EP (1)	EP1149086B1 (de)
JP (1)	JP2002536372A (de)
AT (1)	ATE266653T1 (de)
AU (1)	AU2124100A (de)
DE (1)	DE60010659T2 (de)
ES (1)	ES2216853T3 (de)
SI (1)	SI20159A (de)
WO (1)	WO2000046217A1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
KR100417841B1 (ko) *	2001-02-13	2004-02-05	주식회사종근당	심바스타틴의 개선된 제조방법
US6833461B2 (en) *	2001-02-27	2004-12-21	Chong Kun Dang Pharmaceutical Corp.	Process for preparing simvastatin
SI21187A (sl) *	2002-03-26	2003-10-31	Krka, Tovarna Zdravil D.D., Novo Mesto	Postopek za pripravo 4-oksitetrahidropiran-2-onov
AU2003289546A1 (en) *	2003-12-16	2005-07-05	Uk Chemipharm Co., Ltd.	Process for preparing simvastatin.

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4444784A (en)	1980-08-05	1984-04-24	Merck & Co., Inc.	Antihypercholesterolemic compounds
US5021453A (en) *	1988-03-02	1991-06-04	Merck & Co., Inc.	3-keto HMG-CoA reductase inhibitors
FI893004A7 (fi) *	1988-06-29	1989-12-30	Merck & Co Inc	5-oksygenoituja HMG-CoA-reduktaasi-inhibiittoreita
US5041562A (en) *	1989-06-09	1991-08-20	Merck & Co., Inc.	3-keto HMG-CoA reductase inhibitors

1999
- 1999-02-04 SI SI9900025A patent/SI20159A/sl not_active IP Right Cessation
2000
- 2000-02-02 JP JP2000597287A patent/JP2002536372A/ja not_active Withdrawn
- 2000-02-02 AT AT00901283T patent/ATE266653T1/de not_active IP Right Cessation
- 2000-02-02 WO PCT/IB2000/000105 patent/WO2000046217A1/en not_active Ceased
- 2000-02-02 DE DE60010659T patent/DE60010659T2/de not_active Expired - Fee Related
- 2000-02-02 ES ES00901283T patent/ES2216853T3/es not_active Expired - Lifetime
- 2000-02-02 EP EP00901283A patent/EP1149086B1/de not_active Expired - Lifetime
- 2000-02-02 US US09/869,372 patent/US6509479B1/en not_active Expired - Fee Related
- 2000-02-02 AU AU21241/00A patent/AU2124100A/en not_active Abandoned

Also Published As

Publication number	Publication date
WO2000046217A1 (en)	2000-08-10
US6509479B1 (en)	2003-01-21
AU2124100A (en)	2000-08-25
ES2216853T3 (es)	2004-11-01
EP1149086A1 (de)	2001-10-31
DE60010659T2 (de)	2005-05-19
EP1149086B1 (de)	2004-05-12
DE60010659D1 (de)	2004-06-17
JP2002536372A (ja)	2002-10-29
SI20159A (sl)	2000-08-31

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Legal Events

Date

Code

Title

Description

2004-12-15

UEP

Publication of translation of european patent specification

Ref document number: 1149086

Country of ref document: EP

2006-11-15

REN

Ceased due to non-payment of the annual fee