ATE266660T1 - Piperidin-derivate und ihre verwendung als serotonin rezeptor antagonisten - Google Patents
Piperidin-derivate und ihre verwendung als serotonin rezeptor antagonistenInfo
- Publication number
- ATE266660T1 ATE266660T1 AT00986241T AT00986241T ATE266660T1 AT E266660 T1 ATE266660 T1 AT E266660T1 AT 00986241 T AT00986241 T AT 00986241T AT 00986241 T AT00986241 T AT 00986241T AT E266660 T1 ATE266660 T1 AT E266660T1
- Authority
- AT
- Austria
- Prior art keywords
- receptor antagonists
- serotonin receptor
- piperidine derivatives
- withdrawal
- nicotine
- Prior art date
Links
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical class C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 title 1
- 229940121356 serotonin receptor antagonist Drugs 0.000 title 1
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 abstract 1
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- 241000208125 Nicotiana Species 0.000 abstract 1
- 235000002637 Nicotiana tabacum Nutrition 0.000 abstract 1
- 230000036506 anxiety Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229960002715 nicotine Drugs 0.000 abstract 1
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 abstract 1
- 208000024891 symptom Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17272399P | 1999-12-20 | 1999-12-20 | |
| PCT/US2000/032426 WO2001046179A1 (en) | 1999-12-20 | 2000-12-06 | Piperidine derivatives and their use as serotonin receptor antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE266660T1 true ATE266660T1 (de) | 2004-05-15 |
Family
ID=22628938
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00986241T ATE266660T1 (de) | 1999-12-20 | 2000-12-06 | Piperidin-derivate und ihre verwendung als serotonin rezeptor antagonisten |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US6784180B2 (de) |
| EP (1) | EP1250336B1 (de) |
| AT (1) | ATE266660T1 (de) |
| AU (1) | AU2251801A (de) |
| DE (1) | DE60010758T2 (de) |
| ES (1) | ES2220582T3 (de) |
| WO (1) | WO2001046179A1 (de) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040110691A1 (en) * | 2001-11-13 | 2004-06-10 | Stamler Jonathan S. | Thiol reactive agents as a therapeutic modality |
| WO2004082686A2 (en) * | 2003-03-13 | 2004-09-30 | Dynogen Pharmaceuticals, Inc. | Use of compounds with combined 5-ht1a and ssri activities to treat sexual dysfunction |
| US20040223912A1 (en) * | 2003-05-07 | 2004-11-11 | Montalto Michael Christopher | Compositions and methods for non-invasive imaging of soluble beta-amyloid |
| WO2004100998A2 (en) * | 2003-05-07 | 2004-11-25 | General Electric Company | Compositions and methods for non-invasive imaging of soluble beta-amyloid |
| JP5070042B2 (ja) * | 2004-05-03 | 2012-11-07 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 選択的アンドローゲン受容体モジュレーター（ｓａｒｍｓ）としての新規インドール化合物 |
| TWI320783B (en) | 2005-04-14 | 2010-02-21 | Otsuka Pharma Co Ltd | Heterocyclic compound |
| US20140206667A1 (en) | 2012-11-14 | 2014-07-24 | Michela Gallagher | Methods and compositions for treating schizophrenia |
| DK2948143T3 (da) * | 2013-01-24 | 2021-07-26 | Minerva Neurosciences Inc | Anvendelse af phenoxypropylaminforbindelser til behandling af depression |
| CN112955145A (zh) | 2018-09-04 | 2021-06-11 | 密涅瓦神经科学有限公司 | 使用苯氧丙胺化合物治疗疼痛的方法 |
| CN119059962A (zh) * | 2024-09-09 | 2024-12-03 | 郑州药领医药科技有限公司 | 一种n保护的2,2-二甲基哌啶-4-酮的制备方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA954689B (en) * | 1994-06-08 | 1996-01-29 | Lundbeck & Co As H | 4-Aryl-1-(indanmethyl dihydrobenzofuranmethyl or dihydrobenzothiophenemethyl) piperidines tetrahydropyridines or piperazines |
| US5741789A (en) * | 1995-01-17 | 1998-04-21 | Eli Lilly And Company | Compounds having effects on serotonin-related systems |
| US5846982A (en) * | 1996-06-14 | 1998-12-08 | Eli Lilly And Company | Inhibition of serotonin reuptake |
| US5912256A (en) | 1996-06-20 | 1999-06-15 | Eli Lilly And Company | Compounds having effects on serotonin-related systems |
| AU4977899A (en) * | 1998-07-27 | 2000-02-21 | Eli Lilly And Company | Treatment of anxiety disorders |
-
2000
- 2000-12-06 ES ES00986241T patent/ES2220582T3/es not_active Expired - Lifetime
- 2000-12-06 US US10/148,655 patent/US6784180B2/en not_active Expired - Fee Related
- 2000-12-06 WO PCT/US2000/032426 patent/WO2001046179A1/en not_active Ceased
- 2000-12-06 AU AU22518/01A patent/AU2251801A/en not_active Abandoned
- 2000-12-06 DE DE60010758T patent/DE60010758T2/de not_active Expired - Fee Related
- 2000-12-06 EP EP00986241A patent/EP1250336B1/de not_active Expired - Lifetime
- 2000-12-06 AT AT00986241T patent/ATE266660T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE60010758D1 (de) | 2004-06-17 |
| US6784180B2 (en) | 2004-08-31 |
| EP1250336A1 (de) | 2002-10-23 |
| WO2001046179A1 (en) | 2001-06-28 |
| DE60010758T2 (de) | 2005-05-12 |
| AU2251801A (en) | 2001-07-03 |
| EP1250336B1 (de) | 2004-05-12 |
| US20030225281A1 (en) | 2003-12-04 |
| ES2220582T3 (es) | 2004-12-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |