ATE267519T1 - Fläschchen und verfahren zur cryokonservierung - Google Patents

Fläschchen und verfahren zur cryokonservierung

Info

Publication number
ATE267519T1
ATE267519T1 AT01942276T AT01942276T ATE267519T1 AT E267519 T1 ATE267519 T1 AT E267519T1 AT 01942276 T AT01942276 T AT 01942276T AT 01942276 T AT01942276 T AT 01942276T AT E267519 T1 ATE267519 T1 AT E267519T1
Authority
AT
Austria
Prior art keywords
cryopreservation
biopharmaceutical
compartment
biopharmaceutical product
vials
Prior art date
Application number
AT01942276T
Other languages
English (en)
Inventor
Richard Wisniewski
Original Assignee
Integrated Biosystems Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Integrated Biosystems Inc filed Critical Integrated Biosystems Inc
Application granted granted Critical
Publication of ATE267519T1 publication Critical patent/ATE267519T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
    • A23G9/00—Frozen sweets, e.g. ice confectionery, ice-cream; Mixtures therefor
    • A23G9/04—Production of frozen sweets, e.g. ice-cream
    • A23G9/06—Production of frozen sweets, e.g. ice-cream characterised by using carbon dioxide or carbon dioxide snow or other cryogenic agents as cooling medium
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A01N1/14—Mechanical aspects of preservation; Apparatus or containers therefor
    • A01N1/142—Apparatus
    • A01N1/144—Apparatus for temperature control, e.g. refrigerators or freeze-drying apparatus
    • A01N1/145—Stationary or portable vessels generating cryogenic temperatures, e.g. liquid nitrogen baths
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A01N1/14—Mechanical aspects of preservation; Apparatus or containers therefor
    • A01N1/146—Non-refrigerated containers specially adapted for transporting or storing living parts whilst preserving
    • A01N1/147—Carriers for immersion in cryogenic fluid for slow freezing or vitrification
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23B—PRESERVATION OF FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES; CHEMICAL RIPENING OF FRUIT OR VEGETABLES
    • A23B2/00—Preservation of foods or foodstuffs, in general
    • A23B2/80—Freezing; Subsequent thawing; Cooling
    • A23B2/805—Materials not being transported through or in the apparatus with or without shaping, e.g. in the form of powders, granules or flakes
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23B—PRESERVATION OF FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES; CHEMICAL RIPENING OF FRUIT OR VEGETABLES
    • A23B2/00—Preservation of foods or foodstuffs, in general
    • A23B2/80—Freezing; Subsequent thawing; Cooling
    • A23B2/85—Freezing; Subsequent thawing; Cooling with addition of or treatment with chemicals
    • A23B2/88—Freezing; Subsequent thawing; Cooling with addition of or treatment with chemicals with direct contact between the food and the chemical, e.g. liquid N2 at cryogenic temperature
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/04—Preserving or maintaining viable microorganisms
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
    • F25D—REFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
    • F25D3/00—Devices using other cold materials; Devices using cold-storage bodies
    • F25D3/10—Devices using other cold materials; Devices using cold-storage bodies using liquefied gases, e.g. liquid air
    • F25D3/11—Devices using other cold materials; Devices using cold-storage bodies using liquefied gases, e.g. liquid air with conveyors carrying articles to be cooled through the cooling space

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Dentistry (AREA)
  • Environmental Sciences (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Combustion & Propulsion (AREA)
  • Virology (AREA)
  • Microbiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Mechanical Engineering (AREA)
  • Thermal Sciences (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Packages (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
AT01942276T 2000-01-14 2001-01-12 Fläschchen und verfahren zur cryokonservierung ATE267519T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/483,191 US6337205B1 (en) 1998-01-06 2000-01-14 Cryopreservation vial apparatus and methods
PCT/US2001/000940 WO2001050852A2 (en) 2000-01-14 2001-01-12 Cryopreservation vial apparatus and methods

Publications (1)

Publication Number Publication Date
ATE267519T1 true ATE267519T1 (de) 2004-06-15

Family

ID=23919040

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01942276T ATE267519T1 (de) 2000-01-14 2001-01-12 Fläschchen und verfahren zur cryokonservierung

Country Status (9)

Country Link
US (2) US6337205B1 (de)
EP (1) EP1246524B1 (de)
JP (1) JP2003519513A (de)
AT (1) ATE267519T1 (de)
CA (1) CA2390917A1 (de)
DE (1) DE60103498T2 (de)
DK (1) DK1246524T3 (de)
ES (1) ES2220778T3 (de)
WO (1) WO2001050852A2 (de)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12650394B2 (en) 2022-05-17 2026-06-09 Sartorius Stedim North America Inc. Small volume system and methods of evaluating the stability of biopharmaceutical compositions

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6681581B2 (en) * 2001-11-20 2004-01-27 Supachill Technologies Pty. Ltd. Pre-conditioned solute for use in cryogenic processes
US7331186B2 (en) * 2002-06-27 2008-02-19 I.M.T. Interface Multigrad Technology Ltd Changing the temperature of a liquid sample and a receptacle useful therefor
EP1569509A1 (de) * 2002-11-06 2005-09-07 Pfizer Products Inc. Kryogenisch konservierte virale abgabesysteme und deren herstellung und verwendung
WO2004055456A1 (en) * 2002-12-13 2004-07-01 Integrated Biosystems, Inc. Scaled down freezing and thawing system for bioparmaceuticals and biologics
GB0319601D0 (en) * 2003-08-20 2003-09-24 Sandoz Ag Production process
US20070077237A1 (en) * 2003-10-09 2007-04-05 Udi Damari Method for freezing, thawing and transplantation of viable cartilage
US20050241333A1 (en) * 2003-12-03 2005-11-03 Hamilton Robert W Rate-controlled freezer and cooling methods thereof
EP1711214A1 (de) * 2004-02-02 2006-10-18 Interface Multigrad Technology (IMT) Ltd. Vorrichtung zum gerichteten kühlen von biomasse
WO2005072523A2 (en) * 2004-02-02 2005-08-11 I.M.T. Interface Multigrad Technology Ltd. Biological material and methods and solutions for preservation thereof
US7892726B2 (en) * 2004-06-07 2011-02-22 Core Dynamics Limited Method for sterilizing lyophilized eukaryotic anuclear cells with gamma irradiation
EP1778007A1 (de) * 2004-08-12 2007-05-02 I.M.T. Interface Multigrad Technology Ltd. Verfahren und gerät zum einfrieren bzw. auftauen von biologischem material
EP1850661A2 (de) * 2005-02-22 2007-11-07 Interface Multigrad Technology (IMT) Ltd. Konservierter lebensfähiger knorpel, verfahren zu seiner konservierung, sowie hierfür verwendete(s) system und geräte
EP1909565A2 (de) * 2005-08-03 2008-04-16 Interface Multigrad Technology (IMT) Ltd. Somatische zellen für die zelltherapie
DE102005047438A1 (de) * 2005-09-30 2007-04-05 "Stiftung Caesar" (Center Of Advanced European Studies And Research) Zahn-Einfrier-Behälter
JP5011810B2 (ja) * 2006-05-08 2012-08-29 ニプロ株式会社 凍結保存容器及び凍結保存方法
ES2969987T3 (es) * 2006-06-20 2024-05-23 Erik John Woods Dispositivo de criopreservación
US8709797B2 (en) 2006-06-20 2014-04-29 Cook General Biotechnology Llc Systems and methods for cryopreservation of cells
US8222027B2 (en) 2006-06-20 2012-07-17 Cook General Biotechnolgy, LLC Systems and methods for cryopreservation of cells
WO2009091971A2 (en) * 2008-01-17 2009-07-23 Vance Products Incorporated, D/B/A Cook Urological Incorporated Rapid chilling device for vitrification
US20090202978A1 (en) * 2008-02-13 2009-08-13 Ginadi Shaham Method and apparatus for freezing of a biological material
US20090272138A1 (en) * 2008-05-01 2009-11-05 Kim Brian S Condensate Evaporation Device
US9700038B2 (en) 2009-02-25 2017-07-11 Genea Limited Cryopreservation of biological cells and tissues
ES2743693T3 (es) * 2009-04-29 2020-02-20 Biolife Solutions Inc Aparatos y composiciones para crioconservación de monocapas celulares
WO2011098996A2 (en) 2010-02-09 2011-08-18 Core Dynamics Ltd. Improved method for changing the temperature of a biological specimen
AU2011257909B2 (en) 2010-05-28 2015-06-18 Genea Ip Holdings Pty Limited Improved micromanipulation and storage apparatus and methods
WO2012061779A1 (en) * 2010-11-04 2012-05-10 Abbott Gmbh & Co. Kg Drug formulations
CN102533555B (zh) * 2010-12-23 2015-11-18 王一鸿 接种物及其制备方法
US20120210734A1 (en) * 2011-02-22 2012-08-23 Hoffman Gary A Production and use of high pressure for cryopreservation and cryofixation
DE102011115467A1 (de) * 2011-10-10 2013-04-11 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Vorrichtung und Verfahren zur Druck-Kryokonservierung einer biologischen Probe
US9518898B2 (en) 2012-12-06 2016-12-13 Cook Medical Technologies Llc Cryogenic storage container with sealing closure and methods of using the same
US9297499B2 (en) 2012-12-06 2016-03-29 Cook Medical Technologies Llc Cryogenic storage container, storage device, and methods of using the same
US20150048085A1 (en) 2013-08-16 2015-02-19 Corning Incorporated Vessels and methods for cryopreservation
US10765111B1 (en) * 2014-03-05 2020-09-08 Akron Biotechnology, Llc Cryosolutions and uses thereof
WO2016040063A1 (en) * 2014-09-08 2016-03-17 The Research Institute At Nationwide Children's Hospital Cryopreservation instrument and method of using same
US20160174545A1 (en) * 2014-12-19 2016-06-23 Biotech Incorporated Closed System Cryopreservation Device
CN108430217B (zh) 2015-11-16 2021-10-22 康宁股份有限公司 低温用瓶组件
WO2017099865A1 (en) 2015-12-07 2017-06-15 Coopersurgical, Inc. Low temperature specimen carriers and related methods
US10638748B2 (en) 2015-12-22 2020-05-05 Corning Incorporated Break away/tear away cryopreservation vial and methods for manufacturing and using same
WO2018211437A1 (en) 2017-05-16 2018-11-22 Smartfreez Lda System for scale-down the processes of freezing and thawing aqueous solutions of thermo-sensitive pharmaceuticals
US11116206B2 (en) 2018-10-01 2021-09-14 Cook Medical Technologies Llc Cryocontainer
JP7379374B2 (ja) 2018-12-12 2023-11-14 武田薬品工業株式会社 複素環化合物
US11882824B2 (en) 2019-03-08 2024-01-30 Fisher Bioservices Inc. Cryogenic vial sleeve and related systems and methods
KR20220146614A (ko) * 2020-02-28 2022-11-01 업카라 인코포레이티드 모세관 보조 유리화 방법 및 생물학적 시료의 보존을 위한 물질
EP4247159A4 (de) * 2020-11-19 2024-11-13 Upkara, Inc. Verfahren zur stabilen vitrifizierung
US12239127B2 (en) 2021-07-28 2025-03-04 Sartorius Stedim North America Inc. Thermal capacitors, systems, and methods for rapid freezing or heating of biological materials
CN114796658A (zh) * 2022-04-25 2022-07-29 上海理工大学 一种血液低温保存袋及其快速且均匀的降温和复温方法
WO2023223243A1 (en) * 2022-05-17 2023-11-23 Sartorius Stedim North America Inc. Small volume system and methods of evaluating the stability of biopharmaceutical compositions
CN119724014B (zh) * 2024-12-17 2026-04-21 上海药明生物技术有限公司 一种生物制剂冻融工艺开发和表征用缩小模型及其应用

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2879005A (en) 1954-12-29 1959-03-24 Melvin Sobel Method of refining scrap plastic and apparatus therefor
US3214928A (en) 1963-03-22 1965-11-02 Oberdorfer Karl Method and apparatus for freezing food products
US4314451A (en) 1980-10-27 1982-02-09 Airco, Inc. Controlling temperature of a cryogenically refrigerated product
US4476686A (en) 1982-09-29 1984-10-16 The Boc Group, Inc. Methods and apparatus for chilling a product
DE3238535A1 (de) * 1982-10-18 1984-04-19 Planer Products Ltd., Sunbury-on-Thames, Middlesex Verfahren und apparat zum gesteuerten kuehlen eines produktes
CA1238225A (en) 1983-11-07 1988-06-21 Air Liquide, Societe Anonyme Pour L'etude Et L'exploitation Des Procedes Georges Claude (L') Food processing method and apparatus
CA1273498A (en) 1986-02-25 1990-09-04 Peter Harrold Gibson Freezing apparatus
SE453554B (sv) 1986-06-16 1988-02-15 Frigoscandia Contracting Ab Forfarande och anordning for frysning av flytande eller halvflytande livsmedel i form av vesentligen likformiga pellets
CH672834A5 (de) * 1987-01-19 1989-12-29 Agrogen Stiftung
DE3833753A1 (de) 1988-03-31 1989-08-03 Edwin Schmidt Verfahren und vorrichtungen zum tiefkuehlen von kohlendioxidgasfoermig und stickstoff-gasfoermig aus druckbehaeltern, beziehungsweise luft aus druckflaschen oder -erzeugern und deren tiefkalte anwendung
EP0366818A1 (de) * 1988-11-02 1990-05-09 Leybold Aktiengesellschaft Kryostat mit einem Flüssig-Stickstoff (LN2)-Bad
US5059399A (en) * 1989-12-22 1991-10-22 Schilling Dean W Cryogenic self-seeding vial
CA2041341A1 (en) 1991-04-26 1992-10-27 Frank C. Hume Method of treating materials at low temperatures
MX9300947A (es) 1992-02-26 1994-08-31 Unilever Nv Metodo para preparar un producto alimenticio.
US5205129A (en) 1992-04-30 1993-04-27 Specialty Equipment Companies, Inc. Apparatus for freezing and dispensing semi-frozen food products having dual freezing chambers and method
CA2130517C (en) * 1993-09-10 1999-10-05 Walter Fassbind Array of reaction containers for an apparatus for automatic performance of temperature cycles
JP2673415B2 (ja) 1994-04-22 1997-11-05 岩谷産業株式会社 凍結処理方法及び凍結処理装置
US5743097A (en) 1996-01-23 1998-04-28 Frank; Jimmy I. Apparatus and method for controlling the flow rate of refrigerant to a refrigeration device
US5689961A (en) * 1996-01-30 1997-11-25 Organogenesis Inc. Ice seeding apparatus for cryopreservation systems
US5732559A (en) 1996-06-17 1998-03-31 Blentech Corporation Rotational resistance cryogenic control system for chilling in a vacuum tumbler or agitator blender
US5728417A (en) 1996-06-17 1998-03-17 Blentech Corporation Method for controlling cryogenic flow in a food mixing machine
US6196296B1 (en) * 1997-02-04 2001-03-06 Integrated Biosystems, Inc. Freezing and thawing vessel with thermal bridge formed between container and heat exchange member
DE69832261T2 (de) * 1997-02-04 2006-08-03 Integrated Biosystems Inc., Napa Einfrier- und auftaubehälter mit thermischen brücken
CA2301023C (en) * 1997-08-20 2007-05-01 Biopore, Inc. Cassette device and system to facilitate cryopreservation
US5964100A (en) * 1998-01-06 1999-10-12 Integrated Biosystems, Inc. System for freeze granulation
US6079215A (en) * 1998-01-06 2000-06-27 Integrated Biosystems, Inc. Method for freeze granulation

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12650394B2 (en) 2022-05-17 2026-06-09 Sartorius Stedim North America Inc. Small volume system and methods of evaluating the stability of biopharmaceutical compositions

Also Published As

Publication number Publication date
EP1246524A2 (de) 2002-10-09
DE60103498D1 (de) 2004-07-01
DE60103498T2 (de) 2005-06-30
JP2003519513A (ja) 2003-06-24
US20020110907A1 (en) 2002-08-15
US6337205B1 (en) 2002-01-08
CA2390917A1 (en) 2001-07-19
WO2001050852A2 (en) 2001-07-19
DK1246524T3 (da) 2004-09-27
EP1246524B1 (de) 2004-05-26
WO2001050852A3 (en) 2002-02-14
ES2220778T3 (es) 2004-12-16
US6858424B2 (en) 2005-02-22

Similar Documents

Publication Publication Date Title
DE60103498D1 (de) Fläschchen und verfahren zur cryokonservierung
BR0209777A (pt) Formulações lìquidas estáveis
MX2022013264A (es) Vacuna contra el coronavirus.
DE69925936D1 (de) Vorrichtung zur lokalen verabreichung einer arznei in einer körperhöhle
WO2002069810A3 (en) Sealing access canula system
EP1661886A4 (de) Insektizid zur verwendung in der landwirtschaft bzw. im gartenbau und verfahren zu dessen anwendung
GEP20022804B (en) Erythropoietin Derivatives
BR0215052A (pt) Composições acaricidas e métodos
ES2160716T3 (es) Procedimiento para estabilizar la respuesta de un biosensor.
ES2187798T3 (es) Procedimiento de conservacion de virus recombinantes infecciosos, suspension acuosa viral y su utilizacion como medicamento.
ATE357186T1 (de) Verfahren zur befestigung eines weichen gewebes auf einem knochen
EA200100154A1 (ru) Бензоциклогептены, способ их получения, содержащие их фармацевтические препараты и их применение для получения лекарственных средств
DE60143718D1 (de) Vektorkonstruktionen
BR0005549A (pt) Ampola para o acondicionamento de um lìquido de uso médico
WO2001059459A3 (en) Compositions and methods for screening therapeutic agents
ATE389451T1 (de) Verfahren zur immobilisierung eines homogenkatalysators, und katalytisches material
BR0014577A (pt) Método e sistema para refrigerar e efetuar mudança no estado de uma mistura lìquida
WO2003057129A1 (en) Blood bag system and method of inactivating pathogenic microorganisms
ATE183740T1 (de) Alpha-substituierte 1-benzyl-naphthyl-derivate
FR2720407B1 (fr) Véhicule aqueux pour micro-organismes non autonomes du règne animal à maintenir vivants hors de leur milieu naturel, notamment spermatozoïdes de bovin.
KR960006920A (ko) 혈액 항응고제에 대한 해독제로서 사용하기에 적합한 약제 및 이의 용도
López-Béjar et al. In vitro and in vivo survival of vitrified rabbit embryos
DE60127948D1 (de) Verfahren zur herstellung von avermectinderivaten
DE60013583D1 (de) Verfahren zur herstellung von arzneimitteln eines basischen hydrophoben wirkstoffs
Kusuma Trehalose preincubation increases mesenchymal (CD271+) stem cells post-cryopreservation viability

Legal Events

Date Code Title Description
REN Ceased due to non-payment of the annual fee
UEP Publication of translation of european patent specification

Ref document number: 1246524

Country of ref document: EP