ATE267799T1 - Ein verfahren zur herstellung von (2s,2'r,3'r)-2- (2,3-dicarboxycyclopropyl)-glycin - Google Patents
Ein verfahren zur herstellung von (2s,2'r,3'r)-2- (2,3-dicarboxycyclopropyl)-glycinInfo
- Publication number
- ATE267799T1 ATE267799T1 AT99915658T AT99915658T ATE267799T1 AT E267799 T1 ATE267799 T1 AT E267799T1 AT 99915658 T AT99915658 T AT 99915658T AT 99915658 T AT99915658 T AT 99915658T AT E267799 T1 ATE267799 T1 AT E267799T1
- Authority
- AT
- Austria
- Prior art keywords
- glycine
- dicarboxycyclopropyl
- producing
- mglur
- dicarboxyl
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title 1
- 102000016193 Metabotropic glutamate receptors Human genes 0.000 abstract 2
- 108010010914 Metabotropic glutamate receptors Proteins 0.000 abstract 2
- 239000004471 Glycine Substances 0.000 abstract 1
- YZCKVEUIGOORGS-NJFSPNSNSA-N Tritium Chemical group [3H] YZCKVEUIGOORGS-NJFSPNSNSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 229910052722 tritium Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C253/00—Preparation of carboxylic acid nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/46—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/09—Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid esters or lactones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
- C07C51/363—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
- C07C67/31—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by introduction of functional groups containing oxygen only in singly bound form
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
- C07C67/317—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by splitting-off hydrogen or functional groups; by hydrogenolysis of functional groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Furan Compounds (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP98104992 | 1998-03-19 | ||
| PCT/EP1999/001803 WO1999047489A1 (en) | 1998-03-19 | 1999-03-18 | A process for the manufacture of (2s,2'r,3'r)-2-(2,3-dicarboxylcyclopropyl)-glycine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE267799T1 true ATE267799T1 (de) | 2004-06-15 |
Family
ID=8231618
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99915658T ATE267799T1 (de) | 1998-03-19 | 1999-03-18 | Ein verfahren zur herstellung von (2s,2'r,3'r)-2- (2,3-dicarboxycyclopropyl)-glycin |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US6020525A (de) |
| EP (1) | EP1064255B1 (de) |
| JP (1) | JP3486170B2 (de) |
| AT (1) | ATE267799T1 (de) |
| AU (1) | AU749579B2 (de) |
| CA (1) | CA2323203A1 (de) |
| DE (1) | DE69917615T2 (de) |
| WO (1) | WO1999047489A1 (de) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL1013789C2 (nl) * | 1999-12-08 | 2001-06-12 | Dsm Nv | Werkwijze voor de bereiding van enantiomeer verrijkte verbindingen. |
| US6794542B2 (en) | 1999-12-08 | 2004-09-21 | Dsm N.V. | Method for the preparation of enantiomerically enriched compounds |
| CN101768035B (zh) * | 2009-01-05 | 2013-11-27 | 浙江华海药业股份有限公司 | 一种制备以及回收芳香甲基联苯化合物的方法 |
| US9499586B2 (en) * | 2012-10-16 | 2016-11-22 | Hong Kong Baptist University | Anticancer and anti-obesity cyclic peptide agents |
| US9963485B2 (en) | 2012-10-16 | 2018-05-08 | Hong Kong Baptist University | Cycloheptapeptide agents for treatment of cancer and obesity diseases |
| WO2018068757A1 (en) * | 2016-10-14 | 2018-04-19 | Hong Kong Baptist University | Cycloheptapeptide agents for treatment of cancer and obesity diseases |
| AR111295A1 (es) | 2017-03-20 | 2019-06-26 | Forma Therapeutics Inc | Composiciones de pirrolopirrol como activadores de piruvato quinasa (pkr) |
| WO2020061255A1 (en) | 2018-09-19 | 2020-03-26 | Forma Therapeutics, Inc. | Activating pyruvate kinase r |
| US20200129485A1 (en) | 2018-09-19 | 2020-04-30 | Forma Therapeutics, Inc. | Treating sickle cell disease with a pyruvate kinase r activating compound |
| MX2022003025A (es) | 2019-09-19 | 2022-04-07 | Forma Therapeutics Inc | Activacion de la piruvato cinasa r. |
| US12128035B2 (en) | 2021-03-19 | 2024-10-29 | Novo Nordisk Health Care Ag | Activating pyruvate kinase R |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5186868A (en) * | 1990-04-05 | 1993-02-16 | The Regents Of The University Of California | Methods for tritium labeling |
| DE69210214T2 (de) * | 1991-10-18 | 1996-10-02 | Suntory Ltd | 2-(2,3-dicarboxycyclopropyl)-glycin und ein verfahren zu ihrer herstellung |
-
1999
- 1999-02-23 US US09/256,047 patent/US6020525A/en not_active Expired - Fee Related
- 1999-03-18 AT AT99915658T patent/ATE267799T1/de not_active IP Right Cessation
- 1999-03-18 CA CA002323203A patent/CA2323203A1/en not_active Abandoned
- 1999-03-18 JP JP2000536686A patent/JP3486170B2/ja not_active Expired - Fee Related
- 1999-03-18 WO PCT/EP1999/001803 patent/WO1999047489A1/en not_active Ceased
- 1999-03-18 DE DE69917615T patent/DE69917615T2/de not_active Expired - Fee Related
- 1999-03-18 AU AU34149/99A patent/AU749579B2/en not_active Ceased
- 1999-03-18 EP EP99915658A patent/EP1064255B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| AU3414999A (en) | 1999-10-11 |
| CA2323203A1 (en) | 1999-09-23 |
| EP1064255A1 (de) | 2001-01-03 |
| WO1999047489A1 (en) | 1999-09-23 |
| AU749579B2 (en) | 2002-06-27 |
| EP1064255B1 (de) | 2004-05-26 |
| JP3486170B2 (ja) | 2004-01-13 |
| US6020525A (en) | 2000-02-01 |
| JP2002506846A (ja) | 2002-03-05 |
| DE69917615D1 (de) | 2004-07-01 |
| DE69917615T2 (de) | 2005-06-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1064255 Country of ref document: EP |
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| REN | Ceased due to non-payment of the annual fee |