ATE268766T1 - Stickstoff enthaltende heterobicyclen als factor xa inhibitoren - Google Patents

Stickstoff enthaltende heterobicyclen als factor xa inhibitoren

Info

Publication number
ATE268766T1
ATE268766T1 AT00982716T AT00982716T ATE268766T1 AT E268766 T1 ATE268766 T1 AT E268766T1 AT 00982716 T AT00982716 T AT 00982716T AT 00982716 T AT00982716 T AT 00982716T AT E268766 T1 ATE268766 T1 AT E268766T1
Authority
AT
Austria
Prior art keywords
inhibitors
nitrogen containing
factor
heterobicycles
same
Prior art date
Application number
AT00982716T
Other languages
English (en)
Inventor
Irina C Jacobson
Mimi L Quan
Original Assignee
Bristol Myers Squibb Pharma Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Pharma Co filed Critical Bristol Myers Squibb Pharma Co
Application granted granted Critical
Publication of ATE268766T1 publication Critical patent/ATE268766T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT00982716T 1999-07-16 2000-07-12 Stickstoff enthaltende heterobicyclen als factor xa inhibitoren ATE268766T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14434499P 1999-07-16 1999-07-16
PCT/US2000/018903 WO2001005784A1 (en) 1999-07-16 2000-07-12 NITROGEN CONTAINING HETEROBICYCLES AS FACTOR Xa INHIBITORS

Publications (1)

Publication Number Publication Date
ATE268766T1 true ATE268766T1 (de) 2004-06-15

Family

ID=22508178

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00982716T ATE268766T1 (de) 1999-07-16 2000-07-12 Stickstoff enthaltende heterobicyclen als factor xa inhibitoren

Country Status (18)

Country Link
US (2) US6429205B1 (de)
EP (1) EP1196412B1 (de)
JP (1) JP2004507439A (de)
KR (1) KR20030011268A (de)
CN (1) CN1454211A (de)
AT (1) ATE268766T1 (de)
AU (1) AU2481501A (de)
BR (1) BR0013200A (de)
CA (1) CA2380727A1 (de)
DE (1) DE60011430T2 (de)
ES (1) ES2222257T3 (de)
HK (1) HK1045502B (de)
IL (1) IL147317A0 (de)
MX (1) MXPA02000537A (de)
NO (1) NO20020217L (de)
PL (1) PL357108A1 (de)
WO (1) WO2001005784A1 (de)
ZA (1) ZA200200094B (de)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6339099B1 (en) * 1997-06-20 2002-01-15 Dupont Pharmaceuticals Company Guanidine mimics as factor Xa inhibitors
CA2375920A1 (en) 1999-06-14 2000-12-21 Eli Lilly And Company Compounds
AU2001234690A1 (en) 2000-02-01 2001-08-14 Cor Therapeutics, Inc. 2-(1h)-quinolone and 2-(1h)-quinoxalone inhibitors of factor xa
EP1255743A1 (de) * 2000-02-01 2002-11-13 Millenium Pharmaceuticals, Inc. 3,4-dihydro-2h-benzo[1,4]oxazine als faktor xa inhibitoren
EP1283199A4 (de) * 2000-05-16 2003-12-17 Takeda Chemical Industries Ltd Antagonisten des melanin-konzentrierenden hormons
AU2001268712A1 (en) 2000-06-23 2002-01-08 Bristol-Myers Squibb Company 1 - (heteroaryl-phenyl) - condensed pyrazol derivatives as factor Xa inhibitors
AU2001268711A1 (en) 2000-06-23 2002-01-08 Bristol-Myers Squibb Pharma Company Heteroaryl-phenyl substituted factor xa inhibitors
AU2002341693B2 (en) 2001-09-21 2008-05-29 Bristol-Myers Squibb Holdings Ireland Unlimited Company Lactam-containing compounds and derivatives thereof as factor Xa inhibitors
TWI320039B (en) 2001-09-21 2010-02-01 Lactam-containing compounds and derivatives thereof as factor xa inhibitors
WO2003048081A2 (en) 2001-12-04 2003-06-12 Bristol-Myers Squibb Company Glycinamides as factor xa inhibitors
TW200302225A (en) 2001-12-04 2003-08-01 Bristol Myers Squibb Co Substituted amino methyl factor Xa inhibitors
KR101011837B1 (ko) * 2002-01-22 2011-01-31 이 아이 듀폰 디 네모아 앤드 캄파니 무척추 해충 방제를 위한 퀴나졸린(디)온
JP4324480B2 (ja) 2002-03-26 2009-09-02 ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド グルココルチコイドミメティクス、その製法、医薬組成物、及び使用
WO2003099276A1 (en) 2002-05-10 2003-12-04 Bristol-Myers Squibb Company 1,1-disubstituted cycloalkyl derivatives as factor xa inhibitors
CA2496175A1 (en) 2002-08-21 2004-03-04 Boehringer Ingelheim Pharmaceuticals, Inc. Substituted hihydroquinolines as glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
CN100513398C (zh) 2002-12-03 2009-07-15 Axys药物公司 作为因子viia抑制剂的2-(2-羟基联苯-3-基)-1h-苯并咪唑-5-甲脒衍生物
AU2003292218A1 (en) * 2002-12-23 2004-07-14 Sanofi-Aventis Deutschland Gmbh PYRAZOLE-DERIVATIVES AS FACTOR Xa INHIBITORS
EP1479678A1 (de) * 2003-05-19 2004-11-24 Aventis Pharma Deutschland GmbH Pyrazolderivate als Faktor-Xa-Inhibitoren
US7429581B2 (en) 2002-12-23 2008-09-30 Sanofi-Aventis Deutschland Gmbh Pyrazole-derivatives as factor Xa inhibitors
US7122557B2 (en) 2003-03-18 2006-10-17 Bristol-Myers Squibb Company Sulfonyl-amidino-containing and tetrahydropyrimidino-containing compounds as factor Xa inhibitors
US7129264B2 (en) * 2003-04-16 2006-10-31 Bristol-Myers Squibb Company Biarylmethyl indolines and indoles as antithromboembolic agents
UY28526A1 (es) 2003-09-24 2005-04-29 Boehringer Ingelheim Pharma Miméticos de glucocorticoides, métodos de preparación composiciones farmacéuticas y usos de los mismos
US20050124664A1 (en) * 2003-10-30 2005-06-09 Eric Sartori Urea thiadiazole inhibitors of plasminogen activator inhibior-1
US7795272B2 (en) 2004-03-13 2010-09-14 Boehringer Ingelheim Pharmaceutical, Inc. Glucocorticoid mimetics, methods of making them, pharmaceutical compositions and uses thereof
US7446210B2 (en) * 2004-10-26 2008-11-04 Janssen Pharmaceutica N.V. Factor Xa compounds
PE20060776A1 (es) 2004-12-27 2006-09-26 Boehringer Ingelheim Pharma Mimeticos de glucocorticoides, metodos para prepararlos y composiciones farmaceuticas
GT200600042A (es) * 2005-02-10 2006-09-27 Aventis Pharma Inc Compuestos de bis arilo y heteroarilo sustituido como antagonistas selectivos de 5ht2a
DE102005038947A1 (de) * 2005-05-18 2006-11-30 Grünenthal GmbH Substituierte Benzo[d]isoxazol-3-yl-amin-Verbindungen und deren Verwendung in Arzneimitteln
MX2009005264A (es) 2006-12-06 2009-05-28 Boehringer Ingelheim Int Mimeticos de glucocorticoides, metodos para su fabricacion, composiciones farmaceuticas y usos de los mismos.
BRPI0811204A8 (pt) * 2007-05-10 2015-09-22 Bristol Myers Squibb Co Tetra-hidroibenzo-1,4-diazepinas substituídas por arila e heteroarila e uso das mesmas para bloquear a recaptação de norepinefrina, dopamina e serotonina
DK2300472T3 (da) 2008-06-06 2012-04-10 Boehringer Ingelheim Int Glucocorticoidmimetika, fremgangsmåder til disses fremstilling, farmaceutiske sammensætninger samt anvendelser deraf
EP2865671B1 (de) * 2012-06-22 2017-11-01 Sumitomo Chemical Company, Ltd Kondensierte heterocyclische verbindung
CA3025810A1 (en) * 2016-05-23 2017-11-30 Manish P. PONDA Aminoacylindazole immunomodulators for treatment of autoimmune diseases

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU1335897A (en) 1995-12-21 1997-07-17 Du Pont Merck Pharmaceutical Company, The Isoxazoline, isothiazoline and pyrazoline factor xa inhibitors
CA2275796A1 (en) * 1996-12-23 1998-07-02 Donald Joseph Phillip Pinto Nitrogen containing heteroaromatics as factor xa inhibitors
CA2276034A1 (en) 1996-12-23 1998-07-02 Mimi Lifen Quan Oxygen or sulfur containing 5-membered heteroaromatics as factor xa inhibitors
HRP980334A2 (en) 1997-06-19 1999-04-30 Mimi Lifen Quan INHIBITORS OF FACTOR Xa WITH A NEUTRAL P1 SPECIFICITY GROUP
ZA985247B (en) * 1997-06-19 1999-12-17 Du Pont Merck Pharma Guanidine mimics as factor Xa inhibitors.
CA2314401A1 (en) 1997-12-22 1999-07-01 Du Pont Pharmaceuticals Company Nitrogen containing heteroaromatics with ortho-substituted p1's as factor xa inhibitors

Also Published As

Publication number Publication date
MXPA02000537A (es) 2004-09-10
NO20020217D0 (no) 2002-01-15
KR20030011268A (ko) 2003-02-07
US6716841B2 (en) 2004-04-06
WO2001005784A1 (en) 2001-01-25
HK1045502B (en) 2004-12-10
IL147317A0 (en) 2002-08-14
CN1454211A (zh) 2003-11-05
BR0013200A (pt) 2002-05-07
NO20020217L (no) 2002-03-15
PL357108A1 (en) 2004-07-12
US20030096820A1 (en) 2003-05-22
EP1196412A1 (de) 2002-04-17
ZA200200094B (en) 2003-04-30
DE60011430D1 (de) 2004-07-15
JP2004507439A (ja) 2004-03-11
CA2380727A1 (en) 2001-01-25
ES2222257T3 (es) 2005-02-01
US6429205B1 (en) 2002-08-06
HK1045502A1 (en) 2002-11-29
AU2481501A (en) 2001-02-05
EP1196412B1 (de) 2004-06-09
DE60011430T2 (de) 2005-07-07

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