ATE268776T1 - Benzodiazepinderivate als gaba-a- rezeptormodulatoren - Google Patents

Benzodiazepinderivate als gaba-a- rezeptormodulatoren

Info

Publication number
ATE268776T1
ATE268776T1 AT01996541T AT01996541T ATE268776T1 AT E268776 T1 ATE268776 T1 AT E268776T1 AT 01996541 T AT01996541 T AT 01996541T AT 01996541 T AT01996541 T AT 01996541T AT E268776 T1 ATE268776 T1 AT E268776T1
Authority
AT
Austria
Prior art keywords
gaba
receptor modulators
benzodiazepine derivatives
benzodiazepine
derivatives
Prior art date
Application number
AT01996541T
Other languages
English (en)
Inventor
Raffaello Masciadri
Andrew William Thomas
Juergen Wichmann
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of ATE268776T1 publication Critical patent/ATE268776T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT01996541T 2000-11-16 2001-11-08 Benzodiazepinderivate als gaba-a- rezeptormodulatoren ATE268776T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP00124332 2000-11-16
PCT/EP2001/012887 WO2002040487A2 (en) 2000-11-16 2001-11-08 Benzodiazepine derivatives as gaba a receptor modulators

Publications (1)

Publication Number Publication Date
ATE268776T1 true ATE268776T1 (de) 2004-06-15

Family

ID=8170315

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01996541T ATE268776T1 (de) 2000-11-16 2001-11-08 Benzodiazepinderivate als gaba-a- rezeptormodulatoren

Country Status (40)

Country Link
US (1) US6743789B2 (de)
EP (1) EP1337535B1 (de)
JP (1) JP4088151B2 (de)
KR (1) KR100504300B1 (de)
CN (1) CN1191255C (de)
AR (1) AR031345A1 (de)
AT (1) ATE268776T1 (de)
AU (2) AU1700702A (de)
BG (1) BG107817A (de)
BR (1) BR0115393A (de)
CA (1) CA2427576C (de)
CZ (1) CZ295256B6 (de)
DE (1) DE60103776T2 (de)
DK (1) DK1337535T3 (de)
EC (1) ECSP034607A (de)
ES (1) ES2220831T3 (de)
GC (1) GC0000375A (de)
GT (1) GT200100230A (de)
HR (1) HRP20030360A2 (de)
HU (1) HUP0303281A3 (de)
IL (1) IL155813A0 (de)
JO (1) JO2359B1 (de)
MA (1) MA26962A1 (de)
MX (1) MXPA03004251A (de)
MY (1) MY141675A (de)
NO (1) NO324706B1 (de)
NZ (1) NZ525413A (de)
PA (1) PA8532401A1 (de)
PE (1) PE20020583A1 (de)
PL (1) PL362925A1 (de)
PT (1) PT1337535E (de)
RU (1) RU2278865C2 (de)
SI (1) SI1337535T1 (de)
SK (1) SK7232003A3 (de)
TR (1) TR200402073T4 (de)
TW (1) TWI239333B (de)
UY (1) UY27026A1 (de)
WO (1) WO2002040487A2 (de)
YU (1) YU35603A (de)
ZA (1) ZA200303435B (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6686352B2 (en) 2001-05-18 2004-02-03 Hoffmann-La Roche Inc. Substituted imidazo [1,5-a] pyrimido [5,4-d] [1] benzazepine derivatives
EP1634879A4 (de) * 2003-06-19 2007-09-05 Daiichi Seiyaku Co Verfahren zur selektiven einführung eines aminosubstituenten
PL1691811T3 (pl) 2003-12-11 2014-12-31 Sunovion Pharmaceuticals Inc Skojarzenie leku uspokajającego i modulatora neuroprzekaźnikowego oraz sposoby poprawy jakości snu i leczenia depresji
AU2005272627A1 (en) 2004-08-13 2006-02-23 Amgen Inc. Substituted benzofused heterocycles
ATE402707T1 (de) 2004-10-12 2008-08-15 Hoffmann La Roche Imidazoä1,5aütriazoloä1,5dübenzodiazepin- derivative zur behandlung kognitiver störungen
NZ554439A (en) * 2004-10-20 2009-09-25 Hoffmann La Roche Imidazo-benzodiazepine derivatives
JP4751398B2 (ja) * 2004-10-20 2011-08-17 エフ．ホフマン−ラ ロシュ アーゲー ハロゲン置換ベンゾジアゼピン誘導体
MX2007007115A (es) 2004-12-14 2007-07-11 Hoffmann La Roche Imidazo-benzodiazepinas tetraciclicas como moduladoras del receptor del acido gamma-aminobutirico (gaba).
US8510055B2 (en) 2005-08-03 2013-08-13 The Johns Hopkins University Methods for characterizing and treating cognitive impairment in aging and disease
EP2682481A3 (de) * 2005-08-03 2014-09-17 The Johns-Hopkins University Verfahren zur Charakterisierung und Behandlung einer kognitiven Beeinträchtigung bei Alterung und Krankheit
AU2006301377B2 (en) * 2005-10-11 2012-03-08 F. Hoffmann-La Roche Ag Imidazo benzodiazepine derivatives
EP2314289A1 (de) 2005-10-31 2011-04-27 Braincells, Inc. Gaba-rezeptor-vermittelte modulation von neurogenese
US9156836B2 (en) * 2008-05-16 2015-10-13 Synta Pharmaceuticals Corp. Tricyclic triazole compounds that modulate HSP90 activity
PL2358714T3 (pl) * 2008-11-18 2012-12-31 Hoffmann La Roche Etery alkilocykloheksylowe dihydrotetraazabenzoazulenu
BRPI0922303B1 (pt) * 2008-11-28 2019-11-12 Hoffmann La Roche arilciclo-hexiléteres de di-hidrotetra-azabenzoazulenos, seu processo de preparação, composição farmacêutica que os compreende e uso
CU20090172A7 (es) 2009-10-09 2011-10-05 Ct De Investigación Y Desarrollo De Medicamentos Sistemas tricíclicos y tetracíclicos con actividad sobre el sistema nervioso central y vascular
JP5916746B2 (ja) 2010-11-15 2016-05-11 エージンバイオ， インコーポレイテッド 認知障害を処置するためのピリダジン誘導体、組成物、および方法
US20150374705A1 (en) 2012-02-14 2015-12-31 Shanghai Institues for Biological Sciences Substances for treatment or relief of pain
CA2885148A1 (en) * 2012-09-21 2014-03-27 Uwm Research Foundation, Inc. Novel gabaa agonists and methods of using to control airway hyperresponsiveness and inflammation in asthma
AU2014368961B2 (en) * 2013-12-20 2019-10-17 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
EP3310785B1 (de) * 2015-06-19 2024-11-20 Agenebio, Inc. Benzodiazepinderivate, zusammensetzungen und verfahren zur behandlung kognitiver beeinträchtigung
US10059718B2 (en) 2016-01-04 2018-08-28 Tabomedex Biosciences, LLC Fused quadracyclic compounds, compositions and uses thereof
US10973479B2 (en) 2016-05-16 2021-04-13 Canon Medical Systems Corporation X-ray diagnosis apparatus, X-ray diagnosis apparatus controlling method, and X-ray diagnosis system
US20180170941A1 (en) * 2016-12-19 2018-06-21 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
US11505555B2 (en) 2016-12-19 2022-11-22 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
KR102512548B1 (ko) 2017-12-22 2023-03-22 삼성디스플레이 주식회사 유기 전계 발광 소자 및 유기 전계 발광 소자용 함질소 화합물
MX2020013927A (es) 2018-06-19 2021-03-02 Agenebio Inc Derivados de benzodiazepina, composiciones y metodos para tratar el deterioro cognitivo.
KR102151969B1 (ko) * 2019-12-11 2020-09-04 주식회사 지투비 투과도 가변창의 제조방법 및 그에 의해 제조된 투과도 가변창
CN112979658B (zh) * 2021-02-22 2022-05-31 南湖实验室 一种氟马西尼的制备方法
WO2024039886A1 (en) 2022-08-19 2024-02-22 Agenebio, Inc. Benzazepine derivatives, compositions, and methods for treating cognitive impairment

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK174086D0 (da) 1986-04-16 1986-04-16 Ferrosan As Nye benzodiazepinderivater samt fremgangsmaade til fremstilling af samme
TW201311B (de) 1991-06-17 1993-03-01 Hoffmann La Roche

Also Published As

Publication number Publication date
HUP0303281A2 (hu) 2004-01-28
DE60103776T2 (de) 2005-07-14
CA2427576A1 (en) 2002-05-23
CN1474820A (zh) 2004-02-11
US6743789B2 (en) 2004-06-01
CA2427576C (en) 2007-11-06
GT200100230A (es) 2002-07-04
HUP0303281A3 (en) 2005-05-30
KR20030045192A (ko) 2003-06-09
BG107817A (bg) 2004-07-30
WO2002040487A3 (en) 2002-09-26
NO20032208L (no) 2003-05-15
PE20020583A1 (es) 2002-07-06
WO2002040487A2 (en) 2002-05-23
AU2002217007B2 (en) 2006-11-30
AU1700702A (en) 2002-05-27
CN1191255C (zh) 2005-03-02
CZ20031597A3 (cs) 2003-11-12
NZ525413A (en) 2005-02-25
TR200402073T4 (tr) 2004-10-21
JP2004517070A (ja) 2004-06-10
RU2278865C2 (ru) 2006-06-27
RU2003116895A (ru) 2005-02-20
YU35603A (sh) 2006-05-25
PL362925A1 (en) 2004-11-02
US20020103371A1 (en) 2002-08-01
DE60103776D1 (de) 2004-07-15
ECSP034607A (es) 2003-06-25
HK1062442A1 (en) 2004-11-05
MY141675A (en) 2010-06-15
GC0000375A (en) 2007-03-31
JP4088151B2 (ja) 2008-05-21
SI1337535T1 (en) 2004-10-31
MA26962A1 (fr) 2004-12-20
IL155813A0 (en) 2003-12-23
ES2220831T3 (es) 2004-12-16
HRP20030360A2 (en) 2005-04-30
BR0115393A (pt) 2004-07-06
EP1337535A2 (de) 2003-08-27
ZA200303435B (en) 2004-08-05
UY27026A1 (es) 2002-06-20
NO324706B1 (no) 2007-12-03
DK1337535T3 (da) 2004-10-25
MXPA03004251A (es) 2003-09-22
PT1337535E (pt) 2004-09-30
JO2359B1 (en) 2006-12-12
PA8532401A1 (es) 2002-08-26
KR100504300B1 (ko) 2005-07-28
TWI239333B (en) 2005-09-11
EP1337535B1 (de) 2004-06-09
NO20032208D0 (no) 2003-05-15
AR031345A1 (es) 2003-09-17
CZ295256B6 (cs) 2005-06-15
SK7232003A3 (en) 2004-03-02

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