ATE268908T1 - Verfahren zur diagnose und behandlung von diabetes - Google Patents

Verfahren zur diagnose und behandlung von diabetes

Info

Publication number
ATE268908T1
ATE268908T1 AT91918181T AT91918181T ATE268908T1 AT E268908 T1 ATE268908 T1 AT E268908T1 AT 91918181 T AT91918181 T AT 91918181T AT 91918181 T AT91918181 T AT 91918181T AT E268908 T1 ATE268908 T1 AT E268908T1
Authority
AT
Austria
Prior art keywords
gad
assays
purified
ligand
diabetes
Prior art date
Application number
AT91918181T
Other languages
English (en)
Inventor
Steinunn Baekkeskov
Henk-Jan Aanstoot
Pietro Decamilli
Franco Folli
Michele Solimena
Original Assignee
Univ California
Univ Yale
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24315208&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE268908(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Univ California, Univ Yale filed Critical Univ California
Application granted granted Critical
Publication of ATE268908T1 publication Critical patent/ATE268908T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/04—Endocrine or metabolic disorders
    • G01N2800/042—Disorders of carbohydrate metabolism, e.g. diabetes, glucose metabolism
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/811—Test for named disease, body condition or organ function

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Organic Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Rheumatology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rehabilitation Therapy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT91918181T 1990-09-07 1991-09-06 Verfahren zur diagnose und behandlung von diabetes ATE268908T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US57900790A 1990-09-07 1990-09-07
PCT/US1991/006438 WO1992004632A1 (en) 1990-09-07 1991-09-06 Methods for the diagnosis and treatment of diabetes

Publications (1)

Publication Number Publication Date
ATE268908T1 true ATE268908T1 (de) 2004-06-15

Family

ID=24315208

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91918181T ATE268908T1 (de) 1990-09-07 1991-09-06 Verfahren zur diagnose und behandlung von diabetes

Country Status (9)

Country Link
US (2) US7718386B1 (de)
EP (1) EP0547164B1 (de)
JP (1) JP2727377B2 (de)
AT (1) ATE268908T1 (de)
AU (1) AU8721991A (de)
DE (1) DE69133393T2 (de)
DK (1) DK0547164T3 (de)
ES (1) ES2223039T3 (de)
WO (1) WO1992004632A1 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU727683B2 (en) * 1990-09-21 2000-12-21 Regents Of The University Of California, The Cloned glutamic acid decarboxylase
US6682906B1 (en) * 1990-09-21 2004-01-27 The Regents Of The University Of California Cloned glutamic acid decarboxylase
EP0572478B1 (de) * 1991-02-22 2005-09-07 The Walter And Eliza Hall Institute Of Medical Research Hbgad und higad polypeptide und nukleinsäuren und deren verwendung zur diagnose und behandlung von gad autoantigen assoziierten krankheiten
WO1992019972A1 (en) * 1991-05-03 1992-11-12 Novo Nordisk A/S Islet cell autoantigen (gad) for the detection of preclinical diabetes
WO1992020811A2 (en) * 1991-05-15 1992-11-26 Zymogenetics, Inc. Cloning and expression of human islet glutamic acid decarboxylase autoantigen
AU661684B2 (en) * 1991-06-18 1995-08-03 Regents Of The University Of California, The Cloned glutamic acid decarboxylase
US5200318A (en) * 1992-05-13 1993-04-06 Miles Inc. Diagnosis of IDDM with a panel of immunoreagents
DE4237244A1 (de) * 1992-11-04 1994-05-05 Elias Entwicklungslabor Fuer I Verfahren zur Herstellung hochreiner humaner GAD-1- und GAD-2- Proteine
DE69334246D1 (de) * 1992-12-03 2008-12-24 Univ California Verbesserte reagentien und methoden zur diagnose und behandlung von diabetes und stiff man syndrome
EP0693183B1 (de) * 1993-04-16 2002-07-24 The Regents of the University of California Verfahren zur bestimmung der diabetesanfälligkeit bei asymptomatischen patienten
WO1994027634A1 (en) * 1993-06-02 1994-12-08 Institute For Child Health Research Cryptic peptides for use in inducing immunologic tolerance
DK88093D0 (da) * 1993-07-28 1993-07-28 Novo Nordisk As Stabilt praeparat
DE4418223A1 (de) 1994-05-25 1995-11-30 Boehringer Mannheim Gmbh Verfahren zum Nachweis des Vorliegens eines Insulin-abhängigen Diabetes mellitus
KR19990063648A (ko) * 1995-09-21 1999-07-26 프레드한 아룬디프 에스 글루타민산 데카복실라제에 대한 항체와 폴리(에틸렌 글리콜)공액물을 섬세포에 제공하는 방법
US5763591A (en) * 1996-03-25 1998-06-09 Cedars-Sinai Medical Center Polynucleic acid sequences that are functionally associated with the development of autoimmune disease
AU3958999A (en) * 1999-06-01 2000-12-18 Kyokuto Pharmaceutical Industrial Co., Ltd. Method for assaying anti-gad antibody and kit
WO2010057647A2 (en) * 2008-11-21 2010-05-27 Universita' Degli Studi Di Milano Methods and compositions for the diagnosis and treatment of diabetes
IN2014DN09410A (de) 2012-04-13 2015-07-17 Diabetomics Llc
US12605432B2 (en) 2014-06-04 2026-04-21 Diamyd Medical Ab Combinations for antigen based therapy
JP7619556B2 (ja) * 2020-10-08 2025-01-22 藤倉化成株式会社 動脈病変を検出し、並びに、脳心臓血管障害、糖尿病、慢性腎臓病、又は固形癌を検出する、体液抗体バイオマーカー
CN114924079A (zh) * 2022-03-29 2022-08-19 北京世纪沃德生物科技有限公司 一种抗谷氨酸脱羧酶抗体测定试剂盒及检测方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2548963C3 (de) * 1975-11-03 1982-03-11 Merck Patent Gmbh, 6100 Darmstadt Verfahren und Mittel zur Bestimmung der Aktivität von Creatinkinase-MB
US4086142A (en) 1976-12-06 1978-04-25 The Dow Chemical Company Decarboxylation of endogenous serum glutamate in transaminase assays
DE3526096A1 (de) 1985-07-22 1987-01-22 Basf Ag Verfahren zur reinigung von htnf
US4855242A (en) 1986-04-14 1989-08-08 Joslin Diabetes Center, Inc. Method of detecting antibodies
US5258498A (en) 1987-05-21 1993-11-02 Creative Biomolecules, Inc. Polypeptide linkers for production of biosynthetic proteins
US5645998A (en) * 1988-12-13 1997-07-08 University Of Florida Research Foundation Methods and compositions for the early detection and treatment of insulin dependent diabetes mellitus
US6001360A (en) 1988-12-13 1999-12-14 University Of Florida Method and compositions for early detection and treatment of insulin dependent diabetes mellitus
US5762937A (en) 1988-12-13 1998-06-09 University Of Florida Research Foundation, Inc. Methods and compositions for the early detection and treatment of insulin dependent diabetes mellitus
AU4815890A (en) 1988-12-13 1990-07-10 University Of Florida Methods and compositions for the early detection and treatment of insulin dependent diabetes mellitus
NO306996B1 (no) 1989-02-17 2000-01-24 Bayer Ag Isolert bukspyttkjerteloey-celle-(ICA)-antigen for in vitro- bruk
US5114844A (en) * 1989-03-14 1992-05-19 Yeda Research And Development Co., Ltd. Diagnosis and treatment of insulin dependent diabetes mellitus
AU661828B2 (en) * 1990-08-17 1995-08-10 University Of Florida Methods and compositions for early detection and treatment of insulin dependent diabetes mellitus
US5512447A (en) * 1990-09-07 1996-04-30 The Regents Of The University Of California Methods for the diagnosis and treatment of diabetes
US5674978A (en) 1990-09-21 1997-10-07 The Regents Of The University Of California Peptides derived from glutamic acid decarboxylase
US5998366A (en) 1990-09-21 1999-12-07 The Regents Of The University Of California Method for ameliorating glutamic acid decarboxylase associated autoimmune disorders
US6682906B1 (en) * 1990-09-21 2004-01-27 The Regents Of The University Of California Cloned glutamic acid decarboxylase

Also Published As

Publication number Publication date
US7718386B1 (en) 2010-05-18
JP2727377B2 (ja) 1998-03-11
DE69133393T2 (de) 2005-06-16
DK0547164T3 (da) 2004-10-25
EP0547164A4 (de) 1994-01-26
US20020131963A1 (en) 2002-09-19
DE69133393D1 (de) 2004-07-15
WO1992004632A1 (en) 1992-03-19
ES2223039T3 (es) 2005-02-16
JPH06502916A (ja) 1994-03-31
EP0547164B1 (de) 2004-06-09
AU8721991A (en) 1992-03-30
EP0547164A1 (de) 1993-06-23

Similar Documents

Publication Publication Date Title
DE69133393D1 (de) Verfahren zur diagnose und behandlung von diabetes
Sher et al. Specificity of calcium channel autoantibodies in Lambert-Eaton myasthenic syndrome
JP5711449B2 (ja) 膵島細胞抗原分子及び又はインスリンに反応する自己抗体の検出
Thivolet et al. Glutamic acid decarboxylase (GAD) autoantibodies are additional predictive markers of type 1 (insulin-dependent) diabetes mellitus in high risk individuals
Hawa et al. Value of Antibodies to Islet Protein Tyrosine Phosphatase–Like Molecule in Predicting Type 1 Diabetes
Marder et al. Low molecular weight C1q-precipitins in hypocomplementemic vasculitis-urticaria syndrome: partial purification and characterization as immunoglobulin
EP0367788A1 (de) Biosensoren mit rezeptoren
US5710009A (en) Receptor:release ligand (reland) complexes and release assays using said reland and methods and kits based thereon
Klein et al. Anti-M4 antibodies in primary biliary cirrhosis react with sulphite oxidase, an enzyme of the mitochondrial inter-membrane space
US5674692A (en) Methods for diabetes susceptibility assessment in asymptomatic patients
US6960448B2 (en) Methods for diabetes susceptibility assessment in asymptomatic patients
Richter et al. Human monoclonal islet specific autoantibodies share features of islet cell and 64 kDa antibodies
Souan et al. Detection of anti-acetylcholine antibodies in myasthenic patients
Yokokawa et al. Presence of anti-DNA antibody in diabetes mellitus: its relation to the duration of diabetes and diabetic complications
Adams et al. Study of procainamide hapten-specific antibodies in rabbits and humans
Shoenfeld et al. Increased presence of common systemic lupus erythematosus (SLE) anti-DNA idiotypes (16/6 Id, 32/15 Id) is induced by procainamide
EP0296171A4 (de) Bewertungsverfahren für nephrotoxizität.
JP3510889B2 (ja) 糖尿病及び前糖尿症状の診断のための方法
Heilbronn et al. Acetylcholine receptor antibodies in the diagnosis of human and experimental myasthenia gravis
Ali et al. Anti-DNA antibodies in autoimmune disorders by ELISA using nylon as the solid phase
De Lazzari et al. Gastric cell c-AMP stimulating autoantibodies in duodenal ulcer disease.
Kohno et al. A highly sensitive enzyme immunoassay of anti-insulin antibodies in human serum
JPH07506049A (ja) 神経症および精神病の診断用免疫吸着剤およびその実際的用途
AU739280B2 (en) Receptor: release ligand (reland) complexes and assays and kits based thereon
TSAI et al. Improved sensitivity of a microassay for allo-and xenoantibodies to mouse erythrocytes

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 0547164

Country of ref document: EP

EELA Cancelled due to lapse of time