ATE269402T1 - Ikk-beta proteine, nukleinsäuren und verfahren - Google Patents

Ikk-beta proteine, nukleinsäuren und verfahren

Info

Publication number
ATE269402T1
ATE269402T1 AT98933095T AT98933095T ATE269402T1 AT E269402 T1 ATE269402 T1 AT E269402T1 AT 98933095 T AT98933095 T AT 98933095T AT 98933095 T AT98933095 T AT 98933095T AT E269402 T1 ATE269402 T1 AT E269402T1
Authority
AT
Austria
Prior art keywords
ikk
beta
nucleic acids
methods
disclosed
Prior art date
Application number
AT98933095T
Other languages
English (en)
Inventor
David V Goeddel
John Woronicz
Original Assignee
Tularik Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tularik Inc filed Critical Tularik Inc
Application granted granted Critical
Publication of ATE269402T1 publication Critical patent/ATE269402T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AT98933095T 1997-07-01 1998-07-01 Ikk-beta proteine, nukleinsäuren und verfahren ATE269402T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US88711497A 1997-07-01 1997-07-01
US08/890,853 US5851812A (en) 1997-07-01 1997-07-10 IKK-β proteins, nucleic acids and methods
PCT/US1998/013783 WO1999001542A1 (en) 1997-07-01 1998-07-01 IKK-β PROTEINS, NUCLEIC ACIDS AND METHODS

Publications (1)

Publication Number Publication Date
ATE269402T1 true ATE269402T1 (de) 2004-07-15

Family

ID=27128822

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98933095T ATE269402T1 (de) 1997-07-01 1998-07-01 Ikk-beta proteine, nukleinsäuren und verfahren

Country Status (10)

Country Link
US (3) US5851812A (de)
EP (1) EP1005540B1 (de)
JP (2) JP3472584B2 (de)
AT (1) ATE269402T1 (de)
AU (1) AU725477B2 (de)
CA (1) CA2294516C (de)
DE (1) DE69824597T2 (de)
DK (1) DK1005540T3 (de)
ES (1) ES2218839T3 (de)
WO (1) WO1999001542A1 (de)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0920518A1 (de) * 1996-08-26 1999-06-09 Signal Pharmaceuticals, Inc. Von einem stimulus induzierbarer i(kappa)b kinase komplex
US5972674A (en) * 1996-08-26 1999-10-26 Signal Pharmaceuticals, Inc. Stimulus-inducible protein kinase complex and methods of use therefor
JP4125379B2 (ja) * 1997-02-25 2008-07-30 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア ＩκＢキナーゼ、そのサブユニット、およびこれらを使用する方法
US6235512B1 (en) * 1997-07-01 2001-05-22 Tularik Inc. IKK-α proteins, nucleic acids and methods
EP0897009A3 (de) * 1997-08-04 1999-06-09 Smithkline Beecham Plc HKABY60 Polypeptide
US6087169A (en) * 1997-08-04 2000-07-11 Smithkline Beecham Plc HKABY60: polynucleotide encoding a helix-loop-helix ubiquitous kinase family polypeptide
US6242253B1 (en) * 1997-10-09 2001-06-05 Regents Of The University Of California IkB kinase, subunits thereof, and methods of using same
US6030834A (en) * 1997-12-30 2000-02-29 Chiron Corporation Human IKK-beta DNA constructs and cells
JP2003526608A (ja) * 1998-10-15 2003-09-09 バイオイメージ エイ／エス 再分布及び／又は標的化での干渉によって得られる特異的治療の介入
ES2361660T3 (es) * 1998-12-10 2011-06-21 Signal Pharmaceuticals Llc Ubicutina-ligasa e3 humana para la modulación de nk-kappa b.
UA73492C2 (en) * 1999-01-19 2005-08-15 Aromatic heterocyclic compounds as antiinflammatory agents
MXPA01008440A (es) 1999-02-22 2002-04-24 Boehringer Ingelheim Pharma Derivados heterociclicos policiclos como agentes anti-inflamatorios..
NZ528846A (en) 1999-03-12 2005-05-27 Boehringer Ingelheim Pharma Compounds useful as anti-inflammatory agents
WO2000055152A1 (en) 1999-03-12 2000-09-21 Boehringer Ingelheim Pharmaceuticals, Inc. Aromatic heterocyclic compounds as anti-inflammatory agents
ATE312823T1 (de) * 1999-07-09 2005-12-15 Boehringer Ingelheim Pharma Verfahren zur herstellung heteroarylsubstituierter ureaverbindungen
US6468755B1 (en) 1999-08-10 2002-10-22 Joslin Diabetes Center, Inc. Method for identifying compounds for treatment of insulin resistance
US6630312B2 (en) 1999-08-10 2003-10-07 Joslin Diabetes Center, Inc. Method for identifying compounds for treatment of insulin resistance
AU2007202315B2 (en) * 1999-09-30 2009-11-19 Yale University Anti-inflammatory compounds and uses thereof
US6864355B1 (en) * 2000-05-02 2005-03-08 Yale University Inhibition of NF-κB activation by blockade of IKKβ-NEMO interactions at the NEMO binding domain
WO2001040503A2 (en) * 1999-12-06 2001-06-07 Axxima Pharmaceuticals Ag Method for identification and quantification of kinase inhibitors
EP1248856A2 (de) * 1999-12-23 2002-10-16 Xantos Biomedicine AG Screening-verfahren für nukleinsäuren
US6525046B1 (en) 2000-01-18 2003-02-25 Boehringer Ingelheim Pharmaceuticals, Inc. Aromatic heterocyclic compounds as antiinflammatory agents
US6608052B2 (en) 2000-02-16 2003-08-19 Boehringer Ingelheim Pharmaceuticals, Inc. Compounds useful as anti-inflammatory agents
US7049395B2 (en) * 2000-05-02 2006-05-23 Yale University Anti-inflammatory compounds and uses thereof
US20030044852A1 (en) * 2000-08-10 2003-03-06 Joslin Diabetes Center, Inc., A Massachusetts Corporation Methods for treatment of insulin resistance
US6869956B2 (en) * 2000-10-03 2005-03-22 Bristol-Myers Squibb Company Methods of treating inflammatory and immune diseases using inhibitors of IκB kinase (IKK)
MXPA03006817A (es) * 2001-02-01 2003-11-13 Bristol Myers Squibb Co Metodo de tratamiento de enfermedades inflamatorias e inmunes usando inhibidores de la ikb cinasa (ikk).
DE10115073A1 (de) * 2001-03-27 2002-10-10 Procorde Gmbh Verwendung von Inhibitoren von IKK-ß und Verfahren zum Auffinden solcher Inhibitoren
WO2002082082A2 (en) * 2001-04-09 2002-10-17 Boehringer Ingelheim Pharmaceuticals, Inc. Fluorescence polarization assay
WO2003041640A2 (en) * 2001-11-09 2003-05-22 The General Hospital Corporation METHODS FOR TREATING ISCHEMIC REPERFUSION INJURY USING IkB KINASE-BETA INHIBITORS
EP1455791A1 (de) * 2001-12-11 2004-09-15 Boehringer Ingelheim Pharmaceuticals Inc. Methode zur verabreichung von birb 796 bs
ATE386030T1 (de) * 2002-02-25 2008-03-15 Boehringer Ingelheim Pharma 1,4-disubstituierte benzokondensierte cycloalkyl- harnstoffverbindungen zur behandlung von zytokinvermittelten erkrankungen
US8053243B2 (en) * 2004-04-12 2011-11-08 The University Of Vermont And State Agricultural College Detection of nitrosylated proteins
US8426355B2 (en) * 2006-03-15 2013-04-23 Theralogics, Inc. Methods of treating muscular wasting diseases using NF-κB activation inhibitors
EP2584051B1 (de) 2006-05-22 2014-07-16 Alnylam Pharmaceuticals Inc. Zusammensetzungen und Verfahren zur Hemmung von IKK-B-Genexpressionen
JP5780521B2 (ja) 2008-05-28 2015-09-16 リベラジェン・バイオファーマ・インコーポレイテッドＲｅｖｅｒａＧｅｎ ＢｉｏＰｈａｒｍａ，Ｉｎｃ． 疾患を治療するための、ＮＦ−κＢの非ホルモン性ステロイド調節因子
WO2017004205A1 (en) 2015-06-29 2017-01-05 Reveragen Biopharma, Inc. NON-HORMONAL STEROID MODULATORS OF NF-κB FOR TREATMENT OF DISEASE
US11382922B2 (en) 2019-03-07 2022-07-12 Reveragen Biopharma, Inc. Aqueous oral pharmaceutical suspension compositions

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0920518A1 (de) * 1996-08-26 1999-06-09 Signal Pharmaceuticals, Inc. Von einem stimulus induzierbarer i(kappa)b kinase komplex
JP4125379B2 (ja) * 1997-02-25 2008-07-30 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア ＩκＢキナーゼ、そのサブユニット、およびこれらを使用する方法
US5843721A (en) * 1997-07-03 1998-12-01 Tularik Inc. Nucleic acids encoding human NIK protein
EP0897009A3 (de) * 1997-08-04 1999-06-09 Smithkline Beecham Plc HKABY60 Polypeptide
US6030834A (en) * 1997-12-30 2000-02-29 Chiron Corporation Human IKK-beta DNA constructs and cells

Also Published As

Publication number Publication date
JP2001510347A (ja) 2001-07-31
JP3472584B2 (ja) 2003-12-02
JP2003274984A (ja) 2003-09-30
DE69824597T2 (de) 2005-06-09
US5851812A (en) 1998-12-22
CA2294516A1 (en) 1999-01-14
EP1005540B1 (de) 2004-06-16
EP1005540A4 (de) 2003-04-02
CA2294516C (en) 2003-10-21
US5916760A (en) 1999-06-29
ES2218839T3 (es) 2004-11-16
AU725477B2 (en) 2000-10-12
DE69824597D1 (de) 2004-07-22
DK1005540T3 (da) 2004-10-18
EP1005540A1 (de) 2000-06-07
AU8283798A (en) 1999-01-25
WO1999001542A1 (en) 1999-01-14
US5939302A (en) 1999-08-17

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