ATE277171T1 - Ikk-alpha proteine, nukleinsäuren und verfahren - Google Patents

Ikk-alpha proteine, nukleinsäuren und verfahren

Info

Publication number
ATE277171T1
ATE277171T1 AT98933094T AT98933094T ATE277171T1 AT E277171 T1 ATE277171 T1 AT E277171T1 AT 98933094 T AT98933094 T AT 98933094T AT 98933094 T AT98933094 T AT 98933094T AT E277171 T1 ATE277171 T1 AT E277171T1
Authority
AT
Austria
Prior art keywords
ikk
alpha
nucleic acids
methods
disclosed
Prior art date
Application number
AT98933094T
Other languages
English (en)
Inventor
Mike Rothe
Zhaodan Cao
Catherine Regnier
Original Assignee
Tularik Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tularik Inc filed Critical Tularik Inc
Application granted granted Critical
Publication of ATE277171T1 publication Critical patent/ATE277171T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6842—Proteomic analysis of subsets of protein mixtures with reduced complexity, e.g. membrane proteins, phosphoproteins, organelle proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/91—Transferases (2.)
    • G01N2333/912—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • G01N2333/91205—Phosphotransferases in general
    • G01N2333/9121—Phosphotransferases in general with an alcohol group as acceptor (2.7.1), e.g. general tyrosine, serine or threonine kinases

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Organic Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AT98933094T 1997-07-01 1998-07-01 Ikk-alpha proteine, nukleinsäuren und verfahren ATE277171T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US88711597A 1997-07-01 1997-07-01
US08/890,854 US6235512B1 (en) 1997-07-01 1997-07-10 IKK-α proteins, nucleic acids and methods
PCT/US1998/013782 WO1999001541A1 (en) 1997-07-01 1998-07-01 IKK-α PROTEINS, NUCLEIC ACIDS AND METHODS

Publications (1)

Publication Number Publication Date
ATE277171T1 true ATE277171T1 (de) 2004-10-15

Family

ID=27128823

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98933094T ATE277171T1 (de) 1997-07-01 1998-07-01 Ikk-alpha proteine, nukleinsäuren und verfahren

Country Status (9)

Country Link
US (6) US6235512B1 (de)
EP (1) EP1005539B1 (de)
JP (2) JP3549899B2 (de)
AT (1) ATE277171T1 (de)
AU (1) AU726294B2 (de)
CA (1) CA2294566C (de)
DE (1) DE69826493T2 (de)
ES (1) ES2224414T3 (de)
WO (1) WO1999001541A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2263835C (en) * 1996-08-26 2012-02-21 Signal Pharmaceuticals, Inc. Stimulus-inducible i (kappa)b kinase [ikk] signalsome
US5972674A (en) * 1996-08-26 1999-10-26 Signal Pharmaceuticals, Inc. Stimulus-inducible protein kinase complex and methods of use therefor
EP0897009A3 (de) * 1997-08-04 1999-06-09 Smithkline Beecham Plc HKABY60 Polypeptide
US6087169A (en) 1997-08-04 2000-07-11 Smithkline Beecham Plc HKABY60: polynucleotide encoding a helix-loop-helix ubiquitous kinase family polypeptide
US6242253B1 (en) * 1997-10-09 2001-06-05 Regents Of The University Of California IkB kinase, subunits thereof, and methods of using same
DE69943222D1 (de) * 1998-12-10 2011-04-07 Signal Pharm Llc Menschliche ubiqutin ligase e3. verwendung für die modulation von nf-kappa b
WO2000055332A2 (en) * 1999-03-18 2000-09-21 Incyte Pharmaceuticals, Inc. Human regulators of intracellular phosphorylation
AU6898700A (en) 1999-08-10 2001-03-05 Joslin Diabetes Center Inc. Method for identifying compounds for treatment of insulin resistance
US6630312B2 (en) 1999-08-10 2003-10-07 Joslin Diabetes Center, Inc. Method for identifying compounds for treatment of insulin resistance
US6864355B1 (en) * 2000-05-02 2005-03-08 Yale University Inhibition of NF-κB activation by blockade of IKKβ-NEMO interactions at the NEMO binding domain
US6365366B1 (en) * 2000-03-13 2002-04-02 Tularik Inc. T2k kinase assays
JP4750999B2 (ja) * 2000-03-31 2011-08-17 アベンティス・ファーマスーティカルズ・インコーポレイテツド 核因子κＢ誘導因子
US7049395B2 (en) * 2000-05-02 2006-05-23 Yale University Anti-inflammatory compounds and uses thereof
WO2003099781A2 (en) * 2002-05-24 2003-12-04 Boehringer Ingelheim Pharmaceuticals, Inc. METHODS FOR THE IDENTIFICATION OF IKKα FUNCTION AND OTHER GENES USEFUL FOR TREATMENT OF INFLAMMATORY DISEASES
AU2003297700A1 (en) * 2002-12-09 2004-06-30 Boehringer Ingelheim Pharmaceuticals, Inc. METHODS FOR MODULATING IKKAlpha ACTIVITY
JP4659602B2 (ja) * 2005-11-30 2011-03-30 三井金属アクト株式会社 車両用ドアラッチの操作装置

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2263835C (en) * 1996-08-26 2012-02-21 Signal Pharmaceuticals, Inc. Stimulus-inducible i (kappa)b kinase [ikk] signalsome
WO1998037228A1 (en) * 1997-02-25 1998-08-27 The Regents Of The University Of California IλB KINASE, SUBUNITS THEREOF, AND METHODS OF USING SAME
US6268194B1 (en) * 1997-02-25 2001-07-31 The Regents Of The University Of California IKB kinase and methods of using same
WO1998045704A2 (en) * 1997-04-07 1998-10-15 Bioimage A/S A method for extracting quantitative information relating to an influence on a cellular response
US5851812A (en) * 1997-07-01 1998-12-22 Tularik Inc. IKK-β proteins, nucleic acids and methods
US5843721A (en) * 1997-07-03 1998-12-01 Tularik Inc. Nucleic acids encoding human NIK protein
US5962673A (en) 1998-11-20 1999-10-05 Isis Pharmaceuticals Inc. Antisense modulation of inhibitor-kappa B kinase-alpha expression

Also Published As

Publication number Publication date
US6235492B1 (en) 2001-05-22
US6479266B1 (en) 2002-11-12
AU8283698A (en) 1999-01-25
US6235512B1 (en) 2001-05-22
ES2224414T3 (es) 2005-03-01
JP2001510346A (ja) 2001-07-31
DE69826493D1 (de) 2004-10-28
US7045613B2 (en) 2006-05-16
US20030077683A1 (en) 2003-04-24
WO1999001541A1 (en) 1999-01-14
US20060019365A1 (en) 2006-01-26
JP2003265192A (ja) 2003-09-24
EP1005539A4 (de) 2003-04-02
AU726294B2 (en) 2000-11-02
EP1005539B1 (de) 2004-09-22
EP1005539A1 (de) 2000-06-07
JP3549899B2 (ja) 2004-08-04
CA2294566C (en) 2005-08-30
DE69826493T2 (de) 2005-12-01
CA2294566A1 (en) 1999-01-14
US6235513B1 (en) 2001-05-22

Similar Documents

Publication Publication Date Title
ATE269402T1 (de) Ikk-beta proteine, nukleinsäuren und verfahren
ATE418563T1 (de) Nik proteine, nukleinsäure sowie verfahren
ATE277171T1 (de) Ikk-alpha proteine, nukleinsäuren und verfahren
PT973794E (pt) Receptores de netrina
CA2281895A1 (en) Ikb kinases
ATE374247T1 (de) Thymidinkinase mutanten und fusionproteine mit thymidinkinase und guanylatekinase aktivitäten
DE69732535D1 (de) Oligonucleotidzusammenstellung und verfahren zur regulierung der protein b7 expression
ATE280226T1 (de) Genetische marker für brust und eierstockkrebs
ATE245190T1 (de) Robo: eine familie polypeptiden und nukleinesäuren wirksam in nervenzellleitung
WO1996015144A3 (en) Chromosome 21 gene marker, compositions and methods using same
WO2001014420A3 (en) Novel members of the plexin family and uses thereof
EP1757616A3 (de) Semaphorinrezeptoren
WO1994026891A3 (en) Purified mammalian flt3 ligands and agonists and antagonists thereof
DE69928395D1 (de) Cyclin-e2 proteine und dafür kodierende gene
WO1999047558A3 (en) T cell costimulatory proteins, sequences and uses thereof
CA2273855A1 (en) Novel feline fc epsilon receptor alpha chain nucleic acid molecules, proteins and uses thereof
WO2000018907A3 (de) Antisense-sequenzen für die hemmung der expression des adhäsionsmoleküls icam-1
WO2000031253A3 (fr) Mutations du gene de la parkine, compositions, methodes et utilisations
WO2002064827A3 (en) Nucleic acids of the human abca12 gene, vectors containing such nucleic acids, and uses thereof
WO2000006733A3 (en) T cell receptor proteins, nucleic acid molecules, and uses thereof
SE9604439D0 (sv) New receptor
WO2005054426A3 (en) Angiogenesis affecting polypeptides, proteins, and compositions, and methods of use thereof
DE69836226D1 (de) Ifn rezeptor 1 bindende proteine, dafür kodierende dna und verfahren zur regulierung der zellulären antwort auf interferone
ATE465248T1 (de) Humane cyclooxygenase-3 und ihre verwendung
WO2003044160A3 (en) Novel molecules of the card related protein family and uses thereof

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties