ATE270268T1 - 2,4-diamino-3-hydroxycarboxylsäurederivate als proteasome inhibitoren - Google Patents

2,4-diamino-3-hydroxycarboxylsäurederivate als proteasome inhibitoren

Info

Publication number
ATE270268T1
ATE270268T1 AT00927038T AT00927038T ATE270268T1 AT E270268 T1 ATE270268 T1 AT E270268T1 AT 00927038 T AT00927038 T AT 00927038T AT 00927038 T AT00927038 T AT 00927038T AT E270268 T1 ATE270268 T1 AT E270268T1
Authority
AT
Austria
Prior art keywords
substituted
alkyl
unsubstituted
arylalkyl
formula
Prior art date
Application number
AT00927038T
Other languages
English (en)
Inventor
Dennis France
Peter Fuerst
Johann Zimmermann
Carlos Garcia-Echeverria
Dieter Scholz
Pascal Furet
Patricia Imbach
Original Assignee
Novartis Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Pharma Gmbh filed Critical Novartis Pharma Gmbh
Application granted granted Critical
Publication of ATE270268T1 publication Critical patent/ATE270268T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Detergent Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AT00927038T 1999-04-27 2000-04-25 2,4-diamino-3-hydroxycarboxylsäurederivate als proteasome inhibitoren ATE270268T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US30077999A 1999-04-27 1999-04-27
US38870099A 1999-09-02 1999-09-02
PCT/EP2000/003688 WO2000064863A1 (en) 1999-04-27 2000-04-25 Use of 2,4-diamino-3-hydroxycarboxylic acid derivatives as proteasome inhibitors

Publications (1)

Publication Number Publication Date
ATE270268T1 true ATE270268T1 (de) 2004-07-15

Family

ID=26971977

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00927038T ATE270268T1 (de) 1999-04-27 2000-04-25 2,4-diamino-3-hydroxycarboxylsäurederivate als proteasome inhibitoren

Country Status (12)

Country Link
US (1) US20050026994A1 (de)
EP (1) EP1173413B1 (de)
JP (1) JP2002543058A (de)
CN (1) CN100357267C (de)
AT (1) ATE270268T1 (de)
AU (1) AU4555800A (de)
BR (1) BR0010134A (de)
CA (1) CA2370830C (de)
DE (1) DE60011889T2 (de)
ES (1) ES2223512T3 (de)
PT (1) PT1173413E (de)
WO (1) WO2000064863A1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
YU49055B (sh) 1996-04-25 2003-08-29 Milenko dipl.ing. Pupović Sto za nameštanje kičme
GB0012795D0 (en) * 2000-05-25 2000-07-19 Novartis Ag Organic compounds
US6872382B1 (en) 2001-05-21 2005-03-29 Alcon, Inc. Use of selective PDE IV inhibitors to treat dry eye disorders
US7112588B2 (en) 2001-05-21 2006-09-26 Alcon, Inc. Use of proteasome inhibitors to treat dry eye disorders
BR0209965A (pt) 2001-05-21 2004-04-06 Alcon Inc Uso de inibidores de nf-kappab para tratar distúrbios do olho seco
ES2278049T3 (es) 2001-05-21 2007-08-01 Alcon, Inc. Uso de inhibidores de proteasoma para tratar trastornos de ojo seco.
US6645994B1 (en) 2001-06-01 2003-11-11 Alcon, Inc. Method of treating dry eye disorders
US7223745B2 (en) 2003-08-14 2007-05-29 Cephalon, Inc. Proteasome inhibitors and methods of using the same
US7576206B2 (en) 2003-08-14 2009-08-18 Cephalon, Inc. Proteasome inhibitors and methods of using the same
EP1637529A1 (de) 2004-09-20 2006-03-22 4Sc Ag Neue Piperidin-4-yl-Thiazol-Carboxamid-Analog als Inhibitoren für die Vermehrung von T-Zellen und ihre Verwendung
US7468383B2 (en) 2005-02-11 2008-12-23 Cephalon, Inc. Proteasome inhibitors and methods of using the same
US8459852B2 (en) 2007-10-05 2013-06-11 Dental Equipment, Llc LED-based dental exam lamp
AU2010341530B2 (en) 2009-12-22 2016-03-10 Cephalon, Inc. Proteasome inhibitors and processes for their preparation, purification and use
US12391971B2 (en) * 2017-01-31 2025-08-19 Chugai Seiyaku Kabushiki Kaisha Method for synthesizing peptides in cell-free translation system

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5344634A (en) * 1976-10-01 1978-04-21 Kyowa Hakko Kogyo Co Ltd Carcinostatic agent
CA2109326A1 (en) * 1991-07-02 1993-01-03 Andreas Billich 4-amino-3-hydroxycarboxylic acid derivatives
US5538997A (en) * 1993-03-12 1996-07-23 Sandoz Ltd. 2,4-diamino-3-hydroxycarboxylic acid derivatives
DE4331135A1 (de) * 1993-09-14 1995-03-16 Bayer Ag Neue antiviral wirksame valinhaltige Pseudopeptide

Also Published As

Publication number Publication date
WO2000064863A1 (en) 2000-11-02
HK1044931A1 (en) 2002-11-08
US20050026994A1 (en) 2005-02-03
PT1173413E (pt) 2004-10-29
CA2370830C (en) 2009-10-13
EP1173413A1 (de) 2002-01-23
EP1173413B1 (de) 2004-06-30
ES2223512T3 (es) 2005-03-01
JP2002543058A (ja) 2002-12-17
DE60011889T2 (de) 2005-07-14
BR0010134A (pt) 2002-01-15
CN100357267C (zh) 2007-12-26
AU4555800A (en) 2000-11-10
DE60011889D1 (en) 2004-08-05
CA2370830A1 (en) 2000-11-02
CN1351587A (zh) 2002-05-29

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