ATE270330T1 - Alpha untereinheit des humanen beta-2 integrins - Google Patents

Alpha untereinheit des humanen beta-2 integrins

Info

Publication number
ATE270330T1
ATE270330T1 AT95905459T AT95905459T ATE270330T1 AT E270330 T1 ATE270330 T1 AT E270330T1 AT 95905459 T AT95905459 T AT 95905459T AT 95905459 T AT95905459 T AT 95905459T AT E270330 T1 ATE270330 T1 AT E270330T1
Authority
AT
Austria
Prior art keywords
alpha
disclosed
integrin
human beta
human
Prior art date
Application number
AT95905459T
Other languages
English (en)
Inventor
W Michael Gallatin
Der Vieren Monica Van
Original Assignee
Icos Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/173,497 external-priority patent/US5437958A/en
Application filed by Icos Corp filed Critical Icos Corp
Application granted granted Critical
Publication of ATE270330T1 publication Critical patent/ATE270330T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70546Integrin superfamily
    • C07K14/70553Integrin beta2-subunit-containing molecules, e.g. CD11, CD18
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2839Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
    • C07K16/2845Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily against integrin beta2-subunit-containing molecules, e.g. CD11, CD18
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6816Hybridisation assays characterised by the detection means
    • C12Q1/6818Hybridisation assays characterised by the detection means involving interaction of two or more labels, e.g. resonant energy transfer
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00Genetically modified animals
    • A01K2217/05Animals comprising random inserted nucleic acids (transgenic)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/04Endocrine or metabolic disorders
    • G01N2800/042Disorders of carbohydrate metabolism, e.g. diabetes, glucose metabolism

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Percussion Or Vibration Massage (AREA)
  • Sorption Type Refrigeration Machines (AREA)
  • Physical Deposition Of Substances That Are Components Of Semiconductor Devices (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Eye Examination Apparatus (AREA)
  • Diaphragms For Electromechanical Transducers (AREA)
AT95905459T 1993-12-23 1994-12-21 Alpha untereinheit des humanen beta-2 integrins ATE270330T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/173,497 US5437958A (en) 1993-12-23 1993-12-23 Human β2 integrin α subunit
US08/286,889 US5470953A (en) 1993-12-23 1994-08-05 Human β2 integrin α subunit
PCT/US1994/014832 WO1995017412A1 (en) 1993-12-23 1994-12-21 NOVEL HUMAN β2 INTEGRIN ALPHA SUBUNIT

Publications (1)

Publication Number Publication Date
ATE270330T1 true ATE270330T1 (de) 2004-07-15

Family

ID=26869214

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95905459T ATE270330T1 (de) 1993-12-23 1994-12-21 Alpha untereinheit des humanen beta-2 integrins

Country Status (11)

Country Link
US (2) US5470953A (de)
EP (1) EP0686161B1 (de)
JP (1) JP3261383B2 (de)
AT (1) ATE270330T1 (de)
AU (1) AU1860395A (de)
CA (1) CA2156622A1 (de)
DE (1) DE69433869T2 (de)
DK (1) DK0686161T3 (de)
ES (1) ES2229234T3 (de)
PT (1) PT686161E (de)
WO (1) WO1995017412A1 (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5817515A (en) * 1993-12-23 1998-10-06 Icos Corporation Human B2 integrin alpha subunit antibodies
US5837478A (en) * 1993-12-23 1998-11-17 Icos Corporation Method of identifying modulators of binding between and VCAM-1
US6620915B2 (en) * 1993-12-23 2003-09-16 Icos Corporation Monoclonal antibodies specific for integrin α-d subunit
CN1195374A (zh) * 1996-04-15 1998-10-07 艾科斯有限公司 整合素调节/信号传递的细胞质调节剂
US6075004A (en) * 1996-04-26 2000-06-13 The University Of Kansas Peptide compositions which induce immune tolerance and methods of use
WO1998032771A1 (en) * 1997-01-29 1998-07-30 Toray Industries, Inc. Chimeric proteins, heterodimer complexes thereof and substitute for platelet
US6080910A (en) * 1997-02-20 2000-06-27 Case Western Reserve University Transgenic knockout animals lacking IgG3
EP1053347B1 (de) * 1998-01-09 2007-02-28 Phylogica Limited Nachweisverfahren für peptide
EP2182008A3 (de) * 1998-11-16 2010-07-14 ICOS Corporation Monoklonaler anti alpha-D (ITGAD) Antikörper zur Behandlung von Inflammation
ATE320486T1 (de) * 1999-05-05 2006-04-15 Phylogica Ltd Isolierung von biologischen modulatoren aus bibiotheken mit biologisch vielfältigen genfragmenten
US7270969B2 (en) 1999-05-05 2007-09-18 Phylogica Limited Methods of constructing and screening diverse expression libraries
US7803765B2 (en) 1999-05-05 2010-09-28 Phylogica Limited Methods of constructing biodiverse gene fragment libraries and biological modulators isolated therefrom
WO2001017544A1 (en) * 1999-09-03 2001-03-15 The Brigham And Women's Hospital, Inc. Peptides that bind to urokinase receptor
US6951927B2 (en) 2000-07-07 2005-10-04 California Institute Of Technology Proteins with integrin-like activity
ATE448306T1 (de) 2000-09-01 2009-11-15 Blood Res Center Veränderte, in gewünschter konformation stabilisierte polypeptide und verfahren zu deren herstellung
WO2002059114A1 (en) * 2000-11-28 2002-08-01 Genentech, Inc. Lfa-1 antagonist compounds
CA2544678C (en) 2003-11-05 2013-12-31 Sunesis Pharmaceuticals, Inc. Modulators of cellular adhesion
DK2444079T3 (en) 2005-05-17 2017-01-30 Sarcode Bioscience Inc Compositions and Methods for the Treatment of Eye Diseases
US8575070B2 (en) 2006-02-20 2013-11-05 Phylogica Limited Methods of constructing and screening libraries of peptide structures
CA2663545A1 (en) 2006-09-19 2008-03-27 Phylogica Limited Neuroprotective peptide inhibitors of ap-1 signaling and uses thereof
US8822409B2 (en) 2007-06-20 2014-09-02 Phylogica Limited Compositions and uses thereof for the treatment of acute respiratory distress syndrome (ARDS) and clinical disorders associated with therewith
ES2830024T3 (es) 2007-10-19 2021-06-02 Novartis Ag Composiciones y métodos para el tratamiento del edema macular
WO2009128932A1 (en) * 2008-04-15 2009-10-22 Sarcode Corporation Delivery of lfa-1 antagonists to the gastrointestinal system
US20090257957A1 (en) * 2008-04-15 2009-10-15 John Burnier Aerosolized LFA-1 antagonists for use in localized treatment of immune related disorders
WO2009128934A1 (en) * 2008-04-15 2009-10-22 Sarcode Corporation Topical lfa-1 antagonists for use in localized treatment of immune related disorders
WO2009139817A2 (en) 2008-04-15 2009-11-19 Sarcode Corporation Crystalline pharmaceutical and methods of preparation and use thereof
WO2011050175A1 (en) 2009-10-21 2011-04-28 Sarcode Corporation Crystalline pharmaceutical and methods of preparation and use thereof
KR20200108932A (ko) 2012-07-25 2020-09-21 에스에이알코드 바이오사이언스 인코포레이티드 Lfa-1 저해제 및 그의 다형체

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4271139A (en) * 1978-03-27 1981-06-02 Hiram Hart Scintillation proximity assay
US4568649A (en) * 1983-02-22 1986-02-04 Immunex Corporation Immediate ligand detection assay
EP0643728A4 (de) * 1993-01-22 1995-07-19 Icos Corp Dem interzellulär-adhäsions-molekül (icam) ähnliche proteine.

Also Published As

Publication number Publication date
EP0686161B1 (de) 2004-06-30
PT686161E (pt) 2004-11-30
AU1860395A (en) 1995-07-10
US5766850A (en) 1998-06-16
WO1995017412A1 (en) 1995-06-29
ES2229234T3 (es) 2005-04-16
DK0686161T3 (da) 2004-11-15
JP3261383B2 (ja) 2002-02-25
EP0686161A1 (de) 1995-12-13
DE69433869T2 (de) 2005-08-25
EP0686161A4 (de) 1997-07-16
JPH08507933A (ja) 1996-08-27
US5470953A (en) 1995-11-28
HK1011999A1 (en) 1999-07-23
CA2156622A1 (en) 1995-06-29
DE69433869D1 (de) 2004-08-05

Similar Documents

Publication Publication Date Title
ATE270330T1 (de) Alpha untereinheit des humanen beta-2 integrins
DE69534588D1 (de) Protocadherin-proteine und verwendungen davon
DK0539530T3 (da) Rensningsstyret kloning af peptider
WO2001021631A3 (en) Secreted proteins and uses thereof
ATE393222T1 (de) Dcr3 polypeptid, ein tnfr homolog
EP0259475A4 (de) Rekombinanter menschlicher endothelzellenwachstumsfaktor.
BR9507618A (pt) Frações polipeptidicas solúveis da proteína lag-3 processo de produção composição terapêutica anticorpos anti-idiotipo
DE68926888D1 (de) Verfahren zur Herstellung von sekretierten Rezeptoranalogen
ATE279947T1 (de) Immunglobulinähnliche domäne mit erhöhten halbwertszeiten
DK150992A (da) Fremgangsmaade til fremstilling af et polypeptidfragment af faktor viii:c, dna-sekvens og ekstrachromosomalt element indeholdende en saadan dna-sekvens, som koder herfor
ATE365744T1 (de) Nukleinsäuremoleküle, proteine und peptide, die im zusammenhang stehen mit dickdarmzellen und dickdarm-krebszellen
ATE380867T1 (de) Lactoferrinrezeptorgen von moraxella
ATE135371T1 (de) Mit akuter pankreatitis assoziiertes protein, mittel zur diagnose von akuter pankreatitis
DK1137773T3 (da) Væsktfaktorhomolog ZVEGF3
ATE153069T1 (de) Vektoren und zusammensetzungen zur expression von glykosilationsmutanten des menschlichen proteins- c
ATE196775T1 (de) Gereinigte flt3 liganden von saeugentieren, agonisten und antagonisten davon
NO930428L (no) Proteinstrukturen til plantetoksingelonin
CA2218755A1 (en) Monoclonal antibody to human beta 2 integrin alpha subunit
ATE346919T1 (de) Nebenhoden-spezifisches rezeptorprotein und dessen verwendung
MX9708107A (es) Subunidad alfa de integrina beta 2 humana.
DE69832299D1 (de) Einkettigen polypeptiden enthalten troponin i und troponin c
DK0708831T3 (da) Celletæthedsforstærkende proteintyrosinphosphataser
ATE260339T1 (de) Antikörper gegen menschliches restrictin
DE50015410D1 (de) Nukleinsäuremolekül, umfassend eine für ein hämocyanin kodierende nukleinsäuresequenz und mindestens eine intronsequenz
DE59914878D1 (de) Neuer spannungsabhängiger kaliumkanal und seine verwendung zur entwicklung von therapeutika

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 0686161

Country of ref document: EP

REN Ceased due to non-payment of the annual fee