ATE271544T1 - 2-amino-6-(2-substituierte-4-phenoxy)- substituierte-pyridine - Google Patents

2-amino-6-(2-substituierte-4-phenoxy)- substituierte-pyridine

Info

Publication number
ATE271544T1
ATE271544T1 AT98900635T AT98900635T ATE271544T1 AT E271544 T1 ATE271544 T1 AT E271544T1 AT 98900635 T AT98900635 T AT 98900635T AT 98900635 T AT98900635 T AT 98900635T AT E271544 T1 ATE271544 T1 AT E271544T1
Authority
AT
Austria
Prior art keywords
substituted
pyridines
phenoxy
amino
Prior art date
Application number
AT98900635T
Other languages
English (en)
Inventor
John Adams Lowe Iii
Jolanta Nowakowski
Robert Alfred Volkmann
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Application granted granted Critical
Publication of ATE271544T1 publication Critical patent/ATE271544T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/73—Unsubstituted amino or imino radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Addiction (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT98900635T 1997-02-10 1998-01-29 2-amino-6-(2-substituierte-4-phenoxy)- substituierte-pyridine ATE271544T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3753397P 1997-02-10 1997-02-10
PCT/IB1998/000112 WO1998034919A1 (en) 1997-02-10 1998-01-29 2-amino-6-(2-substituted-4-phenoxy)-substituted-pyridines

Publications (1)

Publication Number Publication Date
ATE271544T1 true ATE271544T1 (de) 2004-08-15

Family

ID=21894849

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98900635T ATE271544T1 (de) 1997-02-10 1998-01-29 2-amino-6-(2-substituierte-4-phenoxy)- substituierte-pyridine

Country Status (44)

Country Link
US (2) US20010007873A1 (de)
EP (1) EP0958282B1 (de)
JP (1) JP3505189B2 (de)
KR (1) KR100460399B1 (de)
CN (3) CN1523015A (de)
AP (1) AP833A (de)
AR (1) AR011117A1 (de)
AT (1) ATE271544T1 (de)
AU (1) AU744313B2 (de)
BG (1) BG103633A (de)
BR (1) BR9811093A (de)
CA (1) CA2277990C (de)
CO (1) CO4920225A1 (de)
CZ (1) CZ292135B6 (de)
DE (1) DE69825147T2 (de)
DK (1) DK0958282T3 (de)
DZ (1) DZ2414A1 (de)
EA (1) EA003834B1 (de)
ES (1) ES2224354T3 (de)
GT (1) GT199800032A (de)
HN (1) HN1998000030A (de)
HR (1) HRP980069A2 (de)
HU (1) HUP0000762A3 (de)
IL (1) IL130898A0 (de)
IS (1) IS5118A (de)
MA (1) MA27676A1 (de)
MY (1) MY120976A (de)
NO (1) NO314803B1 (de)
NZ (2) NZ518345A (de)
OA (1) OA11084A (de)
PA (1) PA8446301A1 (de)
PE (1) PE58599A1 (de)
PL (1) PL335161A1 (de)
PT (1) PT958282E (de)
SI (1) SI0958282T1 (de)
SK (1) SK101199A3 (de)
TN (1) TNSN98024A1 (de)
TR (1) TR199901917T2 (de)
TW (1) TW458969B (de)
UA (1) UA64740C2 (de)
UY (1) UY24881A1 (de)
WO (1) WO1998034919A1 (de)
YU (1) YU35699A (de)
ZA (1) ZA981017B (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20010049379A1 (en) 1997-08-27 2001-12-06 Lowe John Adams 2-aminopyridines containing fused ring substituents
CN1303379A (zh) * 1998-06-03 2001-07-11 辉瑞产品公司 作为氧化氮合酶抑制剂的含稠环取代基的2-氨基吡啶
HUP0103113A3 (en) * 1998-08-11 2002-02-28 Pfizer Prod Inc New pharmaceutical compositions uses for nos inhibitors
US7115557B2 (en) 1998-09-25 2006-10-03 Sciaticon Ab Use of certain drugs for treating nerve root injury
SE9803710L (sv) 1998-09-25 2000-03-26 A & Science Invest Ab Användning av vissa substanser för behandling av nervrotsskador
CA2364719C (en) 1999-02-25 2006-07-04 Pfizer Products Inc. 2-aminopyridines containing fused ring substituents
FR2812635B1 (fr) * 2000-08-01 2002-10-11 Aventis Pharma Sa Nouveaux composes heterocycliques, preparation et utilisation comme medicaments notamment comme anti- bacteriens
GB0019006D0 (en) * 2000-08-04 2000-09-20 Astrazeneca Ab Novel compounds
US20030232739A1 (en) * 2001-08-15 2003-12-18 Pfizer Inc. Pharmaceutical combinations comprising a NOS inhibitor and an NMDA receptor antagonist
US20030045449A1 (en) * 2001-08-15 2003-03-06 Pfizer, Inc. Pharmaceutical combinations for the treatment of neurodegenerative diseases
US6803470B2 (en) 2001-10-10 2004-10-12 Pfizer Inc 2-amino-6-(2,4,5-substituted-phenyl)-pyridines
DOP2002000467A (es) * 2001-10-10 2003-04-15 Pfizer Prod Inc 2-amino-6 (fenilo sustituido en las posiciones 2,4,5)-piridinas
US7045652B2 (en) 2002-07-03 2006-05-16 Pfizer Inc Processes for preparing substituted aryl boronic acids
US20040092741A1 (en) * 2002-11-08 2004-05-13 Pfizer Inc Substituted pyridines via boronic acid coupling
WO2005007627A1 (ja) * 2003-07-18 2005-01-27 Nihon Nohyaku Co., Ltd. フェニルピリジン誘導体、その中間体及びこれを有効成分とする除草剤
US20080070952A1 (en) * 2005-02-21 2008-03-20 Proximagen Ltd., Inhibition or Treatment of Dyskinesia
GB0607196D0 (en) * 2006-04-11 2006-05-17 Prosidion Ltd G-protein coupled receptor agonists
WO2008080938A1 (en) * 2006-12-28 2008-07-10 Basf Se Use 2-substituted pyridines for cancer treatment
UA105182C2 (ru) 2008-07-03 2014-04-25 Ньюрексон, Інк. Бензоксазины, бензотиазины и родственные соединения, которые имеют ингибирующую nos активность
AU2014221489B2 (en) 2013-02-28 2018-03-08 Tiumbio Co., Ltd. Tricyclic compound and use thereof
EP3066072B1 (de) * 2013-11-07 2021-11-03 The University of Kansas Biphenylamidderivate als hsp90-inhibitoren
WO2016024602A1 (ja) * 2014-08-13 2016-02-18 Meiji Seikaファルマ株式会社 結晶性抗白癬菌薬およびその製造方法
CN106265640B (zh) * 2016-08-11 2019-05-14 吉林大学 Appa在制备治疗糖尿病肾病药物中的应用
CN108069831B (zh) * 2018-01-25 2020-11-24 上海恩氟佳科技有限公司 一种合成2,3-二甲基-4-氟苯酚的方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0674627A1 (de) * 1992-12-18 1995-10-04 The Wellcome Foundation Limited Pyrimidin-, pyridin-, pteridinon- und indazolderivate als enzyminhibitoren
AU688811B2 (en) * 1993-10-21 1998-03-19 G.D. Searle & Co. Amidino derivatives useful as nitric oxide synthase inhibitors
AU4515696A (en) * 1994-12-12 1996-07-03 Merck & Co., Inc. Substituted 2-aminopyridines as inhibitors of nitric oxide synthase
NZ326874A (en) * 1996-03-29 2000-01-28 Pfizer 6-phenylpyridyl-2-amine derivatives

Also Published As

Publication number Publication date
SI0958282T1 (en) 2005-02-28
WO1998034919A1 (en) 1998-08-13
GT199800032A (es) 1998-02-11
EP0958282A1 (de) 1999-11-24
CN1515554A (zh) 2004-07-28
CZ292135B6 (cs) 2003-08-13
PE58599A1 (es) 1999-06-12
ES2224354T3 (es) 2005-03-01
HUP0000762A3 (en) 2000-10-30
AR011117A1 (es) 2000-08-02
NO993823L (no) 1999-08-09
UA64740C2 (uk) 2004-03-15
TW458969B (en) 2001-10-11
US20030162765A1 (en) 2003-08-28
YU35699A (sh) 2002-06-19
HN1998000030A (es) 1998-10-22
KR100460399B1 (ko) 2004-12-08
IL130898A0 (en) 2001-01-28
BR9811093A (pt) 2000-07-18
CN1523015A (zh) 2004-08-25
CA2277990C (en) 2006-08-01
DE69825147D1 (de) 2004-08-26
TNSN98024A1 (fr) 2005-03-15
CO4920225A1 (es) 2000-05-29
UY24881A1 (es) 2000-12-29
PL335161A1 (en) 2000-04-10
MA27676A1 (fr) 2006-01-02
EA003834B1 (ru) 2003-10-30
DE69825147T2 (de) 2005-08-04
SK101199A3 (en) 2000-10-09
ZA981017B (en) 1999-08-10
AP833A (en) 2000-05-10
CZ276999A3 (cs) 2000-05-17
HUP0000762A2 (hu) 2000-09-28
KR20000070803A (ko) 2000-11-25
CA2277990A1 (en) 1998-08-13
HRP980069A2 (en) 1998-12-31
NO314803B1 (no) 2003-05-26
JP3505189B2 (ja) 2004-03-08
DK0958282T3 (da) 2004-11-29
NO993823D0 (no) 1999-08-09
JP2000509408A (ja) 2000-07-25
CN1246848A (zh) 2000-03-08
PT958282E (pt) 2004-11-30
PA8446301A1 (es) 2000-05-24
AU744313B2 (en) 2002-02-21
IS5118A (is) 1999-07-29
DZ2414A1 (fr) 2003-01-04
MY120976A (en) 2005-12-30
NZ518345A (en) 2005-02-25
OA11084A (en) 2002-03-15
US20010007873A1 (en) 2001-07-12
BG103633A (bg) 2000-11-30
EA199900632A1 (ru) 2000-02-28
TR199901917T2 (xx) 1999-12-21
EP0958282B1 (de) 2004-07-21
NZ336623A (en) 2000-11-24
AU5572798A (en) 1998-08-26

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