ATE272116T1 - Polypeptide mit der möglichkeit rhesus d antigenspezifische bindungsstrukturen aus zu bilden, dafür kodierende dna und deren prozess der herstellung und anwendung - Google Patents

Polypeptide mit der möglichkeit rhesus d antigenspezifische bindungsstrukturen aus zu bilden, dafür kodierende dna und deren prozess der herstellung und anwendung

Info

Publication number
ATE272116T1
ATE272116T1 AT97929244T AT97929244T ATE272116T1 AT E272116 T1 ATE272116 T1 AT E272116T1 AT 97929244 T AT97929244 T AT 97929244T AT 97929244 T AT97929244 T AT 97929244T AT E272116 T1 ATE272116 T1 AT E272116T1
Authority
AT
Austria
Prior art keywords
rhesus
polypeptides
forming
antigen
possibility
Prior art date
Application number
AT97929244T
Other languages
English (en)
Inventor
Sylvia Miescher
Monique Vogel
Beda Stadler
Andreas Morell
Martin Imboden
Hanspeter Amstutz
Original Assignee
Zlb Bioplasma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zlb Bioplasma Ag filed Critical Zlb Bioplasma Ag
Application granted granted Critical
Publication of ATE272116T1 publication Critical patent/ATE272116T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/80—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood groups or blood types or red blood cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/34—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood group antigens
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S424/00—Drug, bio-affecting and body treating compositions
    • Y10S424/80—Antibody or fragment thereof whose amino acid sequence is disclosed in whole or in part
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S424/00—Drug, bio-affecting and body treating compositions
    • Y10S424/81—Drug, bio-affecting and body treating compositions involving autoimmunity, allergy, immediate hypersensitivity, delayed hypersensitivity, immunosuppression, immunotolerance, or anergy
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/868—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof involving autoimmunity, allergy, immediate hypersensitivity, delayed hypersensitivity, immunosuppression, or immunotolerance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Urology & Nephrology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Food Science & Technology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Mycology (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Epidemiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Plant Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
AT97929244T 1996-06-24 1997-06-20 Polypeptide mit der möglichkeit rhesus d antigenspezifische bindungsstrukturen aus zu bilden, dafür kodierende dna und deren prozess der herstellung und anwendung ATE272116T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP96810421 1996-06-24
PCT/EP1997/003253 WO1997049809A1 (en) 1996-06-24 1997-06-20 Polypeptides capable of forming antigen binding structures with specificity for the rhesus d antigens, the dna encoding them and the process for their preparation and use

Publications (1)

Publication Number Publication Date
ATE272116T1 true ATE272116T1 (de) 2004-08-15

Family

ID=8225636

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97929244T ATE272116T1 (de) 1996-06-24 1997-06-20 Polypeptide mit der möglichkeit rhesus d antigenspezifische bindungsstrukturen aus zu bilden, dafür kodierende dna und deren prozess der herstellung und anwendung

Country Status (23)

Country Link
US (3) US7038020B1 (de)
EP (1) EP0920509B1 (de)
JP (1) JP3841360B2 (de)
KR (1) KR100361449B1 (de)
AT (1) ATE272116T1 (de)
AU (1) AU722127B2 (de)
BG (1) BG64534B1 (de)
BR (1) BR9709958A (de)
CA (1) CA2258494C (de)
CZ (1) CZ296807B6 (de)
DE (1) DE69730031T2 (de)
DK (1) DK0920509T3 (de)
ES (1) ES2224255T3 (de)
HU (1) HUP9902605A3 (de)
IL (1) IL127595A (de)
IS (1) IS2220B (de)
NO (1) NO327947B1 (de)
NZ (1) NZ333329A (de)
PL (1) PL186019B1 (de)
RU (1) RU2204602C2 (de)
SK (1) SK284879B6 (de)
TR (1) TR199802692T2 (de)
WO (1) WO1997049809A1 (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU1631000A (en) * 1998-11-19 2000-06-05 Incyte Pharmaceuticals, Inc. Immunoglobulin superfamily proteins
EP1106625A1 (de) * 1999-11-17 2001-06-13 ZLB Bioplasma AG Rhesus D-spezifische Peptidsequenzen
FR2807767B1 (fr) 2000-04-12 2005-01-14 Lab Francais Du Fractionnement Anticorps monoclonaux anti-d
US8288322B2 (en) 2000-04-17 2012-10-16 Dyax Corp. Methods of constructing libraries comprising displayed and/or expressed members of a diverse family of peptides, polypeptides or proteins and the novel libraries
CA2798625C (en) 2000-04-17 2017-01-24 Dyax Corp. Novel methods of constructing libraries of genetic packages that collectively display the members of a diverse family of peptides, polypeptides or proteins
US20030049731A1 (en) * 2000-12-05 2003-03-13 Bowdish Katherine S. Engineered plasmids and their use for in situ production of genes
WO2002061071A2 (en) 2000-12-18 2002-08-08 Dyax Corp. Focused libraries of genetic packages
AU2016225923B2 (en) * 2001-04-17 2018-07-05 Takeda Pharmaceutical Company Limited Novel Methods of Constructing Libraries Comprising Displayed and/or Expressed Members of a Diverse Family of Peptides, Polypeptides or Proteins and the Novel Libraries
RU2209434C1 (ru) * 2001-11-15 2003-07-27 Российский центр судебно-медицинской экспертизы Министерства здравоохранения Российской Федерации Способ получения резус-пептидов анти-d, специфически выявляющих антиген rhd в следах крови и выделений
US20040067532A1 (en) 2002-08-12 2004-04-08 Genetastix Corporation High throughput generation and affinity maturation of humanized antibody
US8288109B2 (en) 2004-07-20 2012-10-16 Symphogen A/S Procedure for structural characterization of a recombinant polyclonal protein or a polyclonal cell line
EA014182B1 (ru) * 2004-07-20 2010-10-29 Симфоген А/С КОМПОЗИЦИЯ ПОЛИКЛОНАЛЬНЫХ АНТИ-RhD АНТИТЕЛ, СПОСОБ ЕЁ ПОЛУЧЕНИЯ И ПРИМЕНЕНИЕ КОМПОЗИЦИИ
GB0706558D0 (en) * 2007-04-03 2007-05-09 Common Services Agency For The Diagnostic assay
EP3124497B1 (de) 2007-09-14 2020-04-15 Adimab, LLC Synthetische antikörperbibliotheken mit rationalem design und verwendungen davon
US8877688B2 (en) 2007-09-14 2014-11-04 Adimab, Llc Rationally designed, synthetic antibody libraries and uses therefor
US12529164B2 (en) 2007-09-14 2026-01-20 Adimab, Llc Rationally designed, synthetic antibody libraries and uses therefor
US20090093004A1 (en) 2007-10-04 2009-04-09 Symphogen A/S Potency assay
WO2009114815A1 (en) 2008-03-13 2009-09-17 Dyax Corp Libraries of genetic packages comprising novel hc cdr3 designs
JP5780951B2 (ja) 2008-04-24 2015-09-16 ダイアックス コーポレーション 新規のｈｃｃｄｒ１、ｃｄｒ２、およびｃｄｒ３設計、ならびに新規のｌｃｃｄｒ１、ｃｄｒ２、およびｃｄｒ３設計を含む、遺伝子パッケージのライブラリ
KR102318383B1 (ko) 2010-07-16 2021-10-27 아디맵 엘엘씨 항체 라이브러리
BR112015010240A2 (pt) * 2012-11-06 2017-08-22 Medimmune Ltd Terapias de combinação através do uso de mo-léculas de ligação de psl e de pcrv anti-pseudomonas
JP7278270B2 (ja) * 2017-10-20 2023-05-19 シーエスエル、リミテッド 方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2127434A (en) 1982-09-17 1984-04-11 Univ London A human monoclonal antibody against Rhesus D antigen
GB8722018D0 (en) * 1987-09-18 1987-10-28 Central Blood Lab Authority Human anti-rh(d)monoclonal antibodies
GB8925590D0 (en) * 1989-11-13 1990-01-04 Central Blood Lab Authority Monoclonal antibodies

Also Published As

Publication number Publication date
IS2220B (is) 2007-03-15
US7038020B1 (en) 2006-05-02
EP0920509B1 (de) 2004-07-28
BG64534B1 (bg) 2005-06-30
CA2258494A1 (en) 1997-12-31
PL330794A1 (en) 1999-06-07
HUP9902605A2 (hu) 1999-11-29
ES2224255T3 (es) 2005-03-01
US20050266013A1 (en) 2005-12-01
WO1997049809A1 (en) 1997-12-31
HUP9902605A3 (en) 2001-11-28
DE69730031D1 (de) 2004-09-02
KR20000022530A (ko) 2000-04-25
SK284879B6 (sk) 2006-01-05
DE69730031T2 (de) 2005-06-16
IL127595A (en) 2005-09-25
DK0920509T3 (da) 2004-12-06
TR199802692T2 (xx) 1999-03-22
EP0920509A1 (de) 1999-06-09
BG103016A (en) 1999-08-31
JP2000515732A (ja) 2000-11-28
AU3342397A (en) 1998-01-14
SK176198A3 (en) 1999-07-12
CZ296807B6 (cs) 2006-06-14
IL127595A0 (en) 1999-10-28
NO986088L (no) 1999-02-24
IS4922A (is) 1998-12-11
US20060165694A1 (en) 2006-07-27
PL186019B1 (pl) 2003-09-30
CA2258494C (en) 2008-05-27
JP3841360B2 (ja) 2006-11-01
US7429647B2 (en) 2008-09-30
AU722127B2 (en) 2000-07-20
NO327947B1 (no) 2009-10-26
NZ333329A (en) 2000-07-28
US7399471B2 (en) 2008-07-15
CZ395998A3 (cs) 1999-05-12
BR9709958A (pt) 1999-08-10
NO986088D0 (no) 1998-12-23
RU2204602C2 (ru) 2003-05-20
KR100361449B1 (ko) 2003-01-24

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