ATE272646T1 - Herstellung von kristallinen form ii von clarithromycin - Google Patents

Herstellung von kristallinen form ii von clarithromycin

Info

Publication number: ATE272646T1
Authority: AT; Austria
Prior art keywords: methylerythromycin; alkyl; solvent; halo; nitro
Prior art date: 1996-07-29

Application number

AT97934319T

Other languages

English (en)

Inventor

Jih-Hua Liu

David A Riley

Original Assignee

Abbott Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-07-29

Filing date

1997-07-28

Publication date

2004-08-15

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27102712&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE272646(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1996-07-29 Priority claimed from US08/681,695 external-priority patent/US5844105A/en

1997-07-28 Application filed by Abbott Lab filed Critical Abbott Lab

2004-08-15 Application granted granted Critical

2004-08-15 Publication of ATE272646T1 publication Critical patent/ATE272646T1/de

Links

AGOYDEPGAOXOCK-KCBOHYOISA-N clarithromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@](C)([C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)OC)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 AGOYDEPGAOXOCK-KCBOHYOISA-N 0.000 title abstract 5
229960002626 clarithromycin Drugs 0.000 title abstract 4
UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 abstract 9
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 6
125000000217 alkyl group Chemical group 0.000 abstract 4
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 4
239000004215 Carbon black (E152) Substances 0.000 abstract 3
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
125000003545 alkoxy group Chemical group 0.000 abstract 3
125000001475 halogen functional group Chemical group 0.000 abstract 3
229930195733 hydrocarbon Natural products 0.000 abstract 3
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 3
239000002904 solvent Substances 0.000 abstract 3
125000001424 substituent group Chemical group 0.000 abstract 3
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 abstract 2
239000013078 crystal Substances 0.000 abstract 2
239000003880 polar aprotic solvent Substances 0.000 abstract 2
ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 abstract 1
229930006677 Erythromycin A Natural products 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
229960003276 erythromycin Drugs 0.000 abstract 1
JMMWKPVZQRWMSS-UHFFFAOYSA-N isopropanol acetate Natural products CC(C)OC(C)=O JMMWKPVZQRWMSS-UHFFFAOYSA-N 0.000 abstract 1
229940011051 isopropyl acetate Drugs 0.000 abstract 1
GWYFCOCPABKNJV-UHFFFAOYSA-M isovalerate Chemical compound CC(C)CC([O-])=O GWYFCOCPABKNJV-UHFFFAOYSA-M 0.000 abstract 1
239000003960 organic solvent Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Medicinal Chemistry (AREA)
Biotechnology (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Molecular Biology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Genetics & Genomics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biochemistry (AREA)
Pulmonology (AREA)
Bioinformatics & Cheminformatics (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT97934319T 1996-07-29 1997-07-28 Herstellung von kristallinen form ii von clarithromycin ATE272646T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US08/681,695 US5844105A (en)	1996-07-29	1996-07-29	Preparation of crystal form II of clarithromycin
US90027197A	1997-07-25	1997-07-25
PCT/US1997/013166 WO1998004574A1 (en)	1996-07-29	1997-07-28	Preparation of crystal form ii of clarithromycin

Publications (1)

Publication Number	Publication Date
ATE272646T1 true ATE272646T1 (de)	2004-08-15

Family

ID=27102712

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT97934319T ATE272646T1 (de)	1996-07-29	1997-07-28	Herstellung von kristallinen form ii von clarithromycin

Country Status (12)

Country	Link
EP (1)	EP0915899B1 (de)
JP (4)	JP4104660B2 (de)
KR (1)	KR100524214B1 (de)
AT (1)	ATE272646T1 (de)
AU (1)	AU733646B2 (de)
CA (1)	CA2261732C (de)
DE (3)	DE69730138T2 (de)
DK (1)	DK0915899T3 (de)
ES (1)	ES2173057T3 (de)
IL (1)	IL127833A (de)
PT (1)	PT915899E (de)
WO (1)	WO1998004574A1 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5945405A (en) *	1997-01-17	1999-08-31	Abbott Laboratories	Crystal form O of clarithromycin
CA2245398C (en)	1998-08-21	2002-01-29	Apotex Inc.	Azithromycin monohydrate isopropanol clathrate and methods for the manufacture thereof
KR100377159B1 (ko) *	1998-09-09	2003-08-19	한미약품공업 주식회사	잔류 용매가 없는 클라리스로마이신의 결정형 2의 제조 방법
GB9827355D0 (en) *	1998-12-11	1999-02-03	Biochemie Sa	Organic compounds
KR20010008496A (ko) *	1999-07-01	2001-02-05	유충식	6-오-메틸 에리트로마이신의 제조방법
KR100322313B1 (ko) *	1999-10-21	2002-02-06	민경윤	클라리스로마이신 결정형 2의 제조방법 및 이에 사용되는 클라리스로마이신 포르메이트
US6627743B1 (en)	1999-12-03	2003-09-30	Abbott Laboratories	6-O-methylerythromycin A crystal form III
WO2001044262A1 (en)	1999-12-16	2001-06-21	Teva Pharmaceutical Industries Ltd.	Processes for preparing clarithromycin polymorphs and novel polymorph iv
AU2261901A (en)	2000-01-11	2001-07-24	Teva Pharma	Processes for preparing clarithromycin polymorphs
KR20030047873A (ko)	2000-02-29	2003-06-18	테바 파마슈티컬 인더스트리즈 리미티드	클라리트로마이신 및 클라리트로마이신 중간체의 제조방법, 실질적으로는 옥심이 제거된 클라리트로마이신 및이를 포함하는 약학적 조성물
KR100361397B1 (ko) *	2000-03-15	2002-11-23	한미약품공업 주식회사	에리스로마이신 에이 9-오-트로필옥심 유도체를 이용한클라리스로마이신의 제조방법
KR100367981B1 (ko) *	2000-11-23	2003-01-14	한미약품공업 주식회사	클라리스로마이신 결정형 2의 제조 방법 및 이 방법에사용되는 결정성 클라리스로마이신 메실레이트 삼수화물
RU2230748C2 (ru) *	2000-03-15	2004-06-20	Ханми Фарм. Ко., Лтд.	Способ получения кларитромицина в виде кристаллов формы ii
KR100408848B1 (ko) *	2001-03-12	2003-12-06	주식회사 씨트리	클래리스로마이신의 정제방법
SI1390377T1 (sl) *	2001-05-22	2006-06-30	Pfizer Prod Inc	Nova kristalna oblika azitromicina
ES2258142T3 (es)	2001-05-22	2006-08-16	Pfizer Products Inc.	Nueva forma cristalina.
US6861413B2 (en)	2001-05-22	2005-03-01	Pfizer Inc.	Stable non-dihydrate azithromycin oral suspensions
KR100372254B1 (en) *	2002-07-15	2003-02-19	Korea United Pharm Inc	Erythromycin a 9-o-pseudosaccharinyl oxime derivative and process for preparing clarithromycin using the same
EP1435359A1 (de) *	2002-12-31	2004-07-07	Alembic Limited	Verfahren zur Reinigung von Roxithromycin
US7384921B2 (en) *	2004-02-20	2008-06-10	Enanta Pharmaceuticals, Inc.	Polymorphic forms of 6-11 bicyclic ketolide derivatives
CA2670482C (en) *	2006-12-05	2011-10-11	Pfizer Inc.	Motilide polymorphs
DE102007016367A1 (de) *	2007-04-03	2008-10-09	Grünenthal GmbH	Polymorph von Clarithromycin (Form V)
CN103087130B (zh) *	2013-02-06	2015-12-23	浙江国邦药业有限公司	一种克拉霉素晶型转换方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5782400A (en)	1980-11-12	1982-05-22	Taisho Pharmaceut Co Ltd	Erythromycin derivative
US4331803A (en)	1980-06-04	1982-05-25	Taisho Pharmaceutical Co., Ltd.	Novel erythromycin compounds
JPS572298A (en) *	1980-06-04	1982-01-07	Taisho Pharmaceut Co Ltd	Erythromycin derivative
JPS60214796A (ja) *	1984-04-06	1985-10-28	Taisho Pharmaceut Co Ltd	６−０−メチルエリスロマイシン類の製法
JPS61103890A (ja)	1984-10-26	1986-05-22	Taisho Pharmaceut Co Ltd	６−０−メチルエリスロマイシンａ誘導体
US4670549A (en) *	1985-03-18	1987-06-02	Taisho Pharmaceutical Co., Ltd.	Method for selective methylation of erythromycin a derivatives
EP0260938B1 (de)	1986-09-18	1992-12-09	Taisho Pharmaceutical Co. Ltd	Erythromycin-A-Derivate und Verfahren zu ihrer Herstellung
JPH0755958B2 (ja) *	1986-10-03	1995-06-14	大正製薬株式会社	エリスロマイシンａ誘導体の製造方法
KR960000434B1 (ko) *	1986-12-17	1996-01-06	다이쇼 세이야꾸 가부시끼가이샤	에리스로마이신 a유도체 및 그의 제조 방법
JP2526951B2 (ja) *	1986-12-17	1996-08-21	大正製薬株式会社	エリスロマイシンａ誘導体およびその製造方法
JP2782793B2 (ja) *	1988-06-15	1998-08-06	大正製薬株式会社	エリスロマイシンａ誘導体およびその製造方法
ZA922777B (en) *	1991-04-29	1993-10-15	Lilly Co Eli	Pharmaceutical formulation containing dirithromycin
US5872229A (en)	1995-11-21	1999-02-16	Abbott Laboratories	Process for 6-O-alkylation of erythromycin derivatives
US5719272A (en)	1996-04-02	1998-02-17	Abbott Laboratories	2'-protected 3'-dimethylamine, 9-etheroxime erythromycin A derivatives
US5837829A (en)	1996-04-02	1998-11-17	Abbott Laboratories	9-oximesilyl erythromycin a derivatives

1997
- 1997-07-28 DE DE69730138T patent/DE69730138T2/de not_active Revoked
- 1997-07-28 IL IL12783397A patent/IL127833A/en not_active IP Right Cessation
- 1997-07-28 EP EP97934319A patent/EP0915899B1/de not_active Revoked
- 1997-07-28 JP JP50903898A patent/JP4104660B2/ja not_active Expired - Lifetime
- 1997-07-28 KR KR10-1999-7000654A patent/KR100524214B1/ko not_active Expired - Lifetime
- 1997-07-28 DE DE0000915899T patent/DE97934319T1/de active Pending
- 1997-07-28 PT PT97934319T patent/PT915899E/pt unknown
- 1997-07-28 AU AU37405/97A patent/AU733646B2/en not_active Expired
- 1997-07-28 CA CA002261732A patent/CA2261732C/en not_active Expired - Lifetime
- 1997-07-28 DK DK97934319T patent/DK0915899T3/da active
- 1997-07-28 DE DE29724846U patent/DE29724846U1/de not_active Expired - Lifetime
- 1997-07-28 AT AT97934319T patent/ATE272646T1/de active
- 1997-07-28 ES ES97934319T patent/ES2173057T3/es not_active Expired - Lifetime
- 1997-07-28 WO PCT/US1997/013166 patent/WO1998004574A1/en not_active Ceased
2005
- 2005-12-12 JP JP2005357782A patent/JP2006137765A/ja active Pending
2009
- 2009-06-15 JP JP2009141790A patent/JP2009242411A/ja not_active Withdrawn
2013
- 2013-04-03 JP JP2013077418A patent/JP2013151542A/ja active Pending

Also Published As

Publication number	Publication date
AU733646B2 (en)	2001-05-17
CA2261732C (en)	2001-07-24
JP2013151542A (ja)	2013-08-08
DK0915899T3 (da)	2004-11-29
AU3740597A (en)	1998-02-20
PT915899E (pt)	2004-11-30
CA2261732A1 (en)	1998-02-05
IL127833A0 (en)	1999-10-28
KR20000029591A (ko)	2000-05-25
JP2006137765A (ja)	2006-06-01
JP4104660B2 (ja)	2008-06-18
DE97934319T1 (de)	2004-08-26
EP0915899A1 (de)	1999-05-19
ES2173057T1 (es)	2002-10-16
JP2009242411A (ja)	2009-10-22
JP2002514171A (ja)	2002-05-14
DE69730138D1 (de)	2004-09-30
KR100524214B1 (ko)	2005-11-01
EP0915899B1 (de)	2004-08-04
DE29724846U1 (de)	2004-12-16
WO1998004574A1 (en)	1998-02-05
DE69730138T2 (de)	2005-03-03
ES2173057T3 (es)	2004-11-16
IL127833A (en)	2004-06-20

Legal Events

Date

Code

Title

Description

2006-08-15

UEP

Publication of translation of european patent specification

Ref document number: 0915899

Country of ref document: EP

Publication	Publication Date	Title
ATE272646T1 (de)	2004-08-15	Herstellung von kristallinen form ii von clarithromycin
ES8609267A1 (es)	1986-07-16	Un procedimiento para preparar un derivado de pirazol
KR850007434A (ko)	1985-12-04	에리트로마이신a 유도체의 선택적 메틸화 방법
AU526571B2 (en)	1983-01-20	Alkyl derivatives of c-076 compounds
ATE119905T1 (de)	1995-04-15	Makrolide antibiotika und verfahren zu deren herstellung.
AU3172893A (en)	1993-07-28	5-O-desosaminylerythronolide derivatives
KR930021654A (ko)	1993-11-22	전립선 이상비대 치료용 스테로이드 유도체, 그의 제조방법 및 용도
DE69413393D1 (de)	1998-10-22	In 15-stellung substituierte 4-azasteroide
KR910019994A (ko)	1991-12-19	시클로헥센온 옥심 에테르, 이들의 제조방법, 이들의 제조를 위한 중간체 및 이들의 제초제로서의 용도
MX9501622A (es)	1997-03-29	Derivados de milbemicina 13-sustituidos, su preparacion y su uso.
MX9301721A (es)	1993-09-01	Derivados, composiciones de carbinol de bis-arilo sin puente, y metodos de uso.
DK264281A (da)	1981-12-19	Fremgangsmaade til fremtilling af indol- og indolindrivater
ES8506011A1 (es)	1985-06-16	Procedimiento para la obtencion de un derivado de tetrahidrobenzotiazol
KR960700258A (ko)	1996-01-19	5-0-데소사미닐에리쓰로노라이드 유도체
HRP980496B1 (en)	2007-03-31	New thilozine hydroxy derivatives and a process for the preparation thereof
KR930010014A (ko)	1993-06-21	기론다론 화합물 및 그의 제조방법
KR950026860A (ko)	1995-10-16	4-히드록시 피라졸을 함유한 프로페노익 에스테르 유도체
SE8004621L (sv)	1980-12-26	Bensimidazolderivat
IE801888L (en)	1981-03-19	Trans-fused decahydroquinolinol derivatives
JPS54154739A (en)	1979-12-06	Reducing agents
KR970074771A (ko)	1997-12-10	지네로부터 추출한 신규한 퀴놀론계 화합물 및 그 유도체
KR970014569A (ko)	1997-04-28	치환된 아미노기를 갖는 신규 티아졸에톡시퀴나졸린 유도체, 그의 제조방법 및 그를 유효성분으로 하는 식물 병원균 퇴치용 농약 조성물
JPS5517343A (en)	1980-02-06	Repellent against wild animal
DE69808673D1 (de)	2002-11-14	Zinn-polyoxaalkancarboxylaten, und diese enthaltende zusammensetzungen
DE69716944D1 (de)	2002-12-12	Borkenkäfer anlockendes mittel