ATE272647T1 - Auftrennung von isomeren von n-(n-(3,3- dimethylbutyl)-l- alpha-aspartyl)-l-phenylalanin- 1-methylester durch verwendung mittels metallischer ionen - Google Patents
Auftrennung von isomeren von n-(n-(3,3- dimethylbutyl)-l- alpha-aspartyl)-l-phenylalanin- 1-methylester durch verwendung mittels metallischer ionenInfo
- Publication number
- ATE272647T1 ATE272647T1 AT01914499T AT01914499T ATE272647T1 AT E272647 T1 ATE272647 T1 AT E272647T1 AT 01914499 T AT01914499 T AT 01914499T AT 01914499 T AT01914499 T AT 01914499T AT E272647 T1 ATE272647 T1 AT E272647T1
- Authority
- AT
- Austria
- Prior art keywords
- alpha
- aspartyl
- dimethylbutyl
- phenylalanine
- methyl ester
- Prior art date
Links
- HLIAVLHNDJUHFG-HOTGVXAUSA-N neotame Chemical class CC(C)(C)CCN[C@@H](CC(O)=O)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 HLIAVLHNDJUHFG-HOTGVXAUSA-N 0.000 title abstract 3
- 150000001455 metallic ions Chemical class 0.000 title 1
- SYSQUGFVNFXIIT-UHFFFAOYSA-N n-[4-(1,3-benzoxazol-2-yl)phenyl]-4-nitrobenzenesulfonamide Chemical compound C1=CC([N+](=O)[O-])=CC=C1S(=O)(=O)NC1=CC=C(C=2OC3=CC=CC=C3N=2)C=C1 SYSQUGFVNFXIIT-UHFFFAOYSA-N 0.000 title 1
- 108010070257 neotame Proteins 0.000 title 1
- 238000000926 separation method Methods 0.000 title 1
- 229910021645 metal ion Inorganic materials 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06104—Dipeptides with the first amino acid being acidic
- C07K5/06113—Asp- or Asn-amino acid
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Life Sciences & Earth Sciences (AREA)
- Peptides Or Proteins (AREA)
- Seasonings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/641,976 US6225493B1 (en) | 2000-08-21 | 2000-08-21 | Metal ion assisted N-[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester isomer resolution |
| PCT/US2001/006105 WO2002016406A1 (en) | 2000-08-21 | 2001-02-27 | METAL ION ASSISTED N-[N-(3,3-DIMETHYLBUTYL)-L-α-ASPARTYL]-L-PHENYLALANINE 1-METHYL ESTER ISOMER RESOLUTION |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE272647T1 true ATE272647T1 (de) | 2004-08-15 |
Family
ID=24574626
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01914499T ATE272647T1 (de) | 2000-08-21 | 2001-02-27 | Auftrennung von isomeren von n-(n-(3,3- dimethylbutyl)-l- alpha-aspartyl)-l-phenylalanin- 1-methylester durch verwendung mittels metallischer ionen |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US6225493B1 (de) |
| EP (1) | EP1311535B1 (de) |
| AT (1) | ATE272647T1 (de) |
| AU (1) | AU2001239882A1 (de) |
| DE (1) | DE60104702T2 (de) |
| ES (1) | ES2222351T3 (de) |
| WO (1) | WO2002016406A1 (de) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6692778B2 (en) * | 1998-06-05 | 2004-02-17 | Wm. Wrigley Jr. Company | Method of controlling release of N-substituted derivatives of aspartame in chewing gum |
| US8222232B2 (en) * | 2001-02-16 | 2012-07-17 | Cargill, Incorporated | Glucosamine and N-acetylglucosamine compositions and methods of making the same fungal biomass |
| US7923437B2 (en) * | 2001-02-16 | 2011-04-12 | Cargill, Incorporated | Water soluble β-glucan, glucosamine, and N-acetylglucosamine compositions and methods for making the same |
| US7816514B2 (en) | 2001-02-16 | 2010-10-19 | Cargill, Incorporated | Glucosamine and method of making glucosamine from microbial biomass |
| AU2003290567B2 (en) * | 2002-11-01 | 2008-12-04 | Cargill, Incorporated | Heat pasteurized liquids containing glucosamine |
| US20060058263A1 (en) * | 2002-11-01 | 2006-03-16 | Rogers Brent D | Heat pasturized liquids containing glucosamine |
| US20060003965A1 (en) * | 2002-11-01 | 2006-01-05 | Fosdick Lawrence D | N-acetyl-d-glucosamine (nag) supplemented food products and beverages |
| CN103664670A (zh) * | 2012-09-06 | 2014-03-26 | 济南大学 | 利用n-烷基-l-苯丙氨酸甲酯萃取拆分苯丙氨酸的方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5591886A (en) * | 1990-11-05 | 1997-01-07 | Mitsui Toatsu Chemicals, Incorporated | Process for the crystallizing L-α-aspartyl-L-phenylalanine methyl ester from the solution |
| JPH05178889A (ja) * | 1991-10-30 | 1993-07-20 | Ajinomoto Co Inc | α−Ｌ−アスパルチル−Ｌ−フェニルアラニンメチルエステルの晶析方法 |
| JPH05194587A (ja) * | 1992-01-14 | 1993-08-03 | Ajinomoto Co Inc | α−Ｌ−アスパルチル−Ｌ−フェニルアラニンメチルエステルの精製法 |
| DE69613305T2 (de) * | 1995-10-11 | 2002-05-02 | Holland Sweetener Co. V.O.F., Maastricht | Verbesserte enzymatische Kupplungsreaktion von N-geschützte L-Asparaginsäure und Phenylalaninmethylester |
| FR2753966B1 (fr) * | 1996-09-27 | 2003-10-31 | Tosoh Corp | Procede pour preparer un acide amine optiquement actif ou son derive ayant une haute purete optique |
| US5728862A (en) * | 1997-01-29 | 1998-03-17 | The Nutrasweet Company | Method for preparing and purifying an N-alkylated aspartame derivative |
| US6146680A (en) * | 1997-09-11 | 2000-11-14 | The Nutrasweet Company | Metal complexes of N-[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester |
| US6077962A (en) * | 1998-12-24 | 2000-06-20 | The Nutrasweet Company | N-3, 3-dimethylbutyl-L-aspartic acid and esters thereof, the process of preparing the same, and the process for preparing N-(N-(3,3-dimethylbutyl) -α L-aspartyl)-L- phenylalanine 1-methyl ester therefrom |
-
2000
- 2000-08-21 US US09/641,976 patent/US6225493B1/en not_active Expired - Lifetime
-
2001
- 2001-02-27 EP EP01914499A patent/EP1311535B1/de not_active Expired - Lifetime
- 2001-02-27 DE DE60104702T patent/DE60104702T2/de not_active Expired - Lifetime
- 2001-02-27 ES ES01914499T patent/ES2222351T3/es not_active Expired - Lifetime
- 2001-02-27 AU AU2001239882A patent/AU2001239882A1/en not_active Abandoned
- 2001-02-27 WO PCT/US2001/006105 patent/WO2002016406A1/en not_active Ceased
- 2001-02-27 AT AT01914499T patent/ATE272647T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| AU2001239882A1 (en) | 2002-03-04 |
| EP1311535B1 (de) | 2004-08-04 |
| DE60104702D1 (de) | 2004-09-09 |
| EP1311535A1 (de) | 2003-05-21 |
| US6225493B1 (en) | 2001-05-01 |
| DE60104702T2 (de) | 2005-09-01 |
| ES2222351T3 (es) | 2005-02-01 |
| WO2002016406A1 (en) | 2002-02-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |