ATE272833T1 - Verfahren zur erstellung von arrays hoher dichte - Google Patents

Verfahren zur erstellung von arrays hoher dichte

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Publication number
ATE272833T1
ATE272833T1 AT01203717T AT01203717T ATE272833T1 AT E272833 T1 ATE272833 T1 AT E272833T1 AT 01203717 T AT01203717 T AT 01203717T AT 01203717 T AT01203717 T AT 01203717T AT E272833 T1 ATE272833 T1 AT E272833T1
Authority
AT
Austria
Prior art keywords
high density
target
density arrays
strands
creating high
Prior art date
Application number
AT01203717T
Other languages
English (en)
Inventor
James R Hudson Jr
Elliot P Dawson
Original Assignee
Bioventures Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bioventures Inc filed Critical Bioventures Inc
Application granted granted Critical
Publication of ATE272833T1 publication Critical patent/ATE272833T1/de

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/36—Embedding or analogous mounting of samples
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/1031—Investigating individual particles by measuring electrical or magnetic effects
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
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Families Citing this family (116)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020155495A1 (en) * 2000-04-17 2002-10-24 Millstein Larry S. Method for producing arrays and devices relating thereto
ES2272057T3 (es) * 1998-02-25 2007-04-16 The United States Government As Represented By The Department Of Health And Human Services Metodo y aparato para realizar una disposicion para la determinacion rapida de perfiles moleculares.
JP3562968B2 (ja) 1998-08-14 2004-09-08 富士写真フイルム株式会社 試験片、その製造方法および装置並びにその読取方法および装置
JP3445501B2 (ja) 1998-09-04 2003-09-08 日立ソフトウエアエンジニアリング株式会社 シート状部材積層体及びシート状プローブ保持体の製造方法
US7122378B1 (en) 1999-03-05 2006-10-17 Mitsubishi Rayon Co., Ltd. Carriers having biological substance
US6713309B1 (en) * 1999-07-30 2004-03-30 Large Scale Proteomics Corporation Microarrays and their manufacture
WO2001026799A1 (en) * 1999-10-08 2001-04-19 Bio-Informatics Group, Inc. Biochip defining a channeled capillary array and associated methods
US6406840B1 (en) * 1999-12-17 2002-06-18 Biomosaic Systems, Inc. Cell arrays and the uses thereof
DE10001136C2 (de) 2000-01-13 2003-09-04 Michael Mengel Verfahren zur Herstellung von Materialblöcken mit multiplen Untersuchungsproben
WO2001053831A1 (en) * 2000-01-17 2001-07-26 Unitec Co., Ltd. Integrated support, integrated micro-container and permeable membrane, and method for production thereof and use thereof
WO2004034012A2 (en) * 2001-10-18 2004-04-22 Virtual Arrays, Inc. Coded particles for multiplexed analysis of biological samples
EP1296139A4 (de) * 2000-06-20 2005-07-13 Mitsubishi Rayon Co Micro-array von mit organismen assoziierten substanzen
DE10034570A1 (de) * 2000-07-14 2002-01-31 Max Delbrueck Centrum Verfahren zur Herstellung von Mikroarray-Chips mit Nukleinsäuren, Proteinen oder anderen Testsubstanzen
DE10042871A1 (de) * 2000-08-31 2002-05-16 Hte Ag The High Throughput Exp Dreidimensionale Materialbibliothek und Verfahren zur Herstellung einer dreidimensionalen Materialbibliothek
JP2004537712A (ja) 2000-10-18 2004-12-16 バーチャル・アレイズ・インコーポレーテッド 多重細胞分析システム
US6905816B2 (en) 2000-11-27 2005-06-14 Intelligent Medical Devices, Inc. Clinically intelligent diagnostic devices and methods
DE10110511C1 (de) * 2001-02-28 2002-10-10 Attomol Gmbh Molekulare Diagno Verfahren zur Herstellung eines Arrays zur Detektion von Komponenten aus einer biologischen Probe
DE10117135A1 (de) * 2001-04-05 2002-10-17 Biotechnolog Forschung Gmbh Verfahren zur Herstellung einer Vielzahl identischer Kopien einer planaren Testanordnung von Sondenmolekülen
US20030113714A1 (en) * 2001-09-28 2003-06-19 Belcher Angela M. Biological control of nanoparticles
US20030148380A1 (en) 2001-06-05 2003-08-07 Belcher Angela M. Molecular recognition of materials
GB0124338D0 (en) 2001-10-10 2001-11-28 Randox Lab Ltd Biochips
US7439346B2 (en) 2001-10-12 2008-10-21 Perkinelmer Las Inc. Nucleic acids arrays and methods of use therefor
AU2002367886B8 (en) 2001-10-12 2008-08-14 Perkinelmer Las, Inc. Compilations of nucleic acids and arrays and methods of using them
US6924107B2 (en) 2002-01-28 2005-08-02 Bio-Informatics Group, Inc. Four dimensional biochip design for high throughput applications and methods of using the four dimensional biochip
DE10208952B4 (de) 2002-02-28 2004-04-08 Bayer Ag Screeningverfahren zur Herstellung und Charakterisierung von Polyurethan-Schaumstoffen
EP1497418B1 (de) 2002-04-19 2012-10-17 Verenium Corporation Phospholipasen, diese codierende nukleinsäuren sowie verfahren zu ihrer herstellung und verwendung
US7226771B2 (en) 2002-04-19 2007-06-05 Diversa Corporation Phospholipases, nucleic acids encoding them and methods for making and using them
CA2503905A1 (en) * 2002-09-16 2004-03-25 Plexxikon, Inc. Crystal structure of pim-1 kinase
US20050064508A1 (en) 2003-09-22 2005-03-24 Semzyme Peptide mediated synthesis of metallic and magnetic materials
WO2004078923A2 (en) * 2003-02-28 2004-09-16 Plexxikon, Inc. Pyk2 crystal structure and uses
EP2194133B1 (de) 2003-03-06 2015-12-02 BASF Enzymes LLC Amylasen, Nukleinsäuren, die diese codieren, und Verfahren zu deren Herstellung und Verwendung
CA2889013C (en) 2003-03-07 2018-07-17 Dsm Ip Assets B.V. Hydrolases, nucleic acids encoding them and methods for making and using them
WO2004090099A2 (en) 2003-04-04 2004-10-21 Diversa Corporation Pectate lyases, nucleic acids encoding them and methods for making and using them
DE10316689A1 (de) * 2003-04-10 2004-10-28 Dimitrij Dr. Plachov Dreidimensionaler Chip
CN101370819A (zh) 2003-07-02 2009-02-18 维莱尼姆公司 葡聚糖酶,编码它们的核酸以及制备和使用它们的方法
US20050079548A1 (en) * 2003-07-07 2005-04-14 Plexxikon, Inc. Ligand development using PDE4B crystal structures
WO2005021714A2 (en) 2003-08-11 2005-03-10 Diversa Corporation Laccases, nucleic acids encoding them and methods for making and using them
US7488451B2 (en) 2003-09-15 2009-02-10 Millipore Corporation Systems for particle manipulation
WO2005028624A2 (en) * 2003-09-15 2005-03-31 Plexxikon, Inc. Molecular scaffolds for kinase ligand development
GB2408331A (en) * 2003-11-24 2005-05-25 Asahi Chemical Ind Arrays for screening polymeric materials
CN1925855B (zh) 2003-12-19 2010-06-16 普莱希科公司 开发Ret调节剂的化合物和方法
US20070066641A1 (en) * 2003-12-19 2007-03-22 Prabha Ibrahim Compounds and methods for development of RET modulators
US8168142B2 (en) 2004-04-20 2012-05-01 Universal Bio Research Co., Ltd. Cassette for stacking specimen, spotting device, and specimen stacking device
CA2565965A1 (en) 2004-05-06 2006-07-27 Plexxikon, Inc. Pde4b inhibitors and uses therefor
EP1766061B1 (de) * 2004-05-20 2013-07-17 Quest Diagnostics Investments Incorporated Vergleichende einfachmarkierung-hybridisierung
BRPI0510939A (pt) 2004-06-16 2007-07-17 Diversa Corp composições e métodos para descoloração enzimática de clorofila
US7498342B2 (en) 2004-06-17 2009-03-03 Plexxikon, Inc. Compounds modulating c-kit activity
CA2570817A1 (en) * 2004-06-17 2006-01-26 Plexxikon, Inc. Azaindoles modulating c-kit activity and uses therefor
DE102004031167A1 (de) * 2004-06-28 2006-01-12 Infineon Technologies Ag Verfahren zur Herstellung von Biochips aus porösen Substraten
EP1786813A2 (de) * 2004-09-03 2007-05-23 Plexxikon, Inc. Bizyklische heteroaryl-pde4b-inhibitoren
EP1846760B1 (de) * 2005-01-27 2010-12-15 Quest Diagnostics Investments Incorporated Schnelle komparative genomhybridisierung
EP1869174B1 (de) 2005-03-10 2015-02-18 BASF Enzymes LLC Lyase-enzyme, nukleinsäuren zu deren kodierung und verfahren zu deren herstellung und verwendung
EP1861506B1 (de) 2005-03-15 2015-04-15 BP Corporation North America Inc. Cellulasen, dafür codierende nukleinsäuren und verfahren zur herstellung und verwendung davon
MX2007014377A (es) 2005-05-17 2008-02-06 Plexxikon Inc Inhibidores de proteina cinasa de derivados de pirrol (2,3-b) piridina.
PL2395004T3 (pl) * 2005-06-22 2016-08-31 Plexxikon Inc Pochodne pirolo[2,3-b]pirydyny jako inhibitory kinazy białkowej
US8076074B2 (en) 2005-11-29 2011-12-13 Quest Diagnostics Investments Incorporated Balanced translocation in comparative hybridization
EP2216403A3 (de) 2006-02-02 2010-11-24 Verenium Corporation Esterasen und dazugehörige Nukleinsäuren und Verfahren
EP2444489B1 (de) 2006-02-10 2014-02-12 Verenium Corporation Cellulose abbauende Enzyme, Nukleinsäuren, die diese codieren, und Verfahren zu deren Herstellung und Verwendung
BRPI0707784B1 (pt) 2006-02-14 2018-05-22 Verenium Corporation Ácido nucléico isolado, sintético ou recombinante, cassete de expressão, vetor ou veículo de clonagem, célula hospedeira isolada transformada, e método para produção de um polipeptídeo recombinante
CA2643416C (en) 2006-03-07 2016-07-26 Cargill, Incorporated Aldolases, nucleic acids encoding them and methods for making and using them
CN102690833B (zh) 2006-03-07 2015-09-09 巴斯夫酶有限责任公司 醛缩酶、编码它们的核酸及制备和使用它们的方法
US20070232556A1 (en) * 2006-03-31 2007-10-04 Montine Thomas J Methods and compositions for the treatment of neurological diseases and disorders
WO2007140294A2 (en) * 2006-05-30 2007-12-06 Pall Corporation Analysis device
JPWO2007145228A1 (ja) * 2006-06-13 2009-11-05 独立行政法人産業技術総合研究所 マイクロアレイの作製方法
CN103397043A (zh) 2006-08-04 2013-11-20 维莱尼姆公司 葡聚糖酶、编码它们的核酸及制备和使用它们的方法
EP2617822A3 (de) 2006-09-21 2013-10-16 Verenium Corporation Phytasen, dafür kodierende Nukleinsäuren sowie Verfahren zu deren Herstellung und Verwendung
ES2451266T3 (es) 2006-09-21 2014-03-26 Dsm Ip Assets B.V. Fosfolipasas, ácidos nucleicos que las codifican, y métodos para obtenerlas y usarlas
US8618248B2 (en) 2006-10-31 2013-12-31 President And Fellows Of Harvard College Phosphopeptide compositions and anti-phosphopeptide antibody compositions and methods of detecting phosphorylated peptides
WO2008063888A2 (en) 2006-11-22 2008-05-29 Plexxikon, Inc. Compounds modulating c-fms and/or c-kit activity and uses therefor
PE20081581A1 (es) * 2006-12-21 2008-11-12 Plexxikon Inc COMPUESTOS PIRROLO[2,3-b]PIRIDINAS COMO MODULADORES DE QUINASA
WO2008079909A1 (en) * 2006-12-21 2008-07-03 Plexxikon, Inc. Pyrrolo [2,3-b] pyridines as kinase modulators
US7872018B2 (en) 2006-12-21 2011-01-18 Plexxikon, Inc. Compounds and methods for kinase modulation, and indications therefor
MX2009006782A (es) 2006-12-21 2009-09-21 Verenium Corp Amilasas y glucoamilasas, acidos nucleicos que las codifican y metodos para formarlas y usarlas.
JP2010516296A (ja) 2007-01-30 2010-05-20 ヴェレニウム コーポレイション リグノセルロース性物質を処理する酵素、前記をコードする核酸並びに前記を製造及び使用する方法
JP4625909B2 (ja) * 2007-03-07 2011-02-02 国立大学法人富山大学 組織アレイブロック作製方法、組織アレイシート作製方法、組織アレイブロック、組織アレイチップ、組織アレイブロック作製装置、及び、組織アレイシート作製装置
EP3196310B1 (de) 2007-04-27 2020-07-08 The Regents of The University of California Co2-pflanzensensoren, dafür kodierende nukleinsäuren sowie verfahren zu ihrer herstellung und verwendung
MX2010000617A (es) 2007-07-17 2010-05-17 Plexxikon Inc Compuestos y metodos para modulacion de cinasa, e indicaciones de estos.
US7507539B2 (en) * 2007-07-30 2009-03-24 Quest Diagnostics Investments Incorporated Substractive single label comparative hybridization
DK2708602T3 (da) 2007-10-03 2019-06-03 Bp Corp North America Inc Xylanaser, nukleinsyrer der koder for dem og fremgangsmåder til fremstilling og anvendelse af dem
CA2710683A1 (en) 2008-01-03 2009-07-16 Verenium Corporation Transferases and oxidoreductases, nucleic acids encoding them and methods for making and using them
US8153391B2 (en) 2008-08-29 2012-04-10 Bunge Oils, Inc. Hydrolases, nucleic acids encoding them and methods for making and using them
US8357503B2 (en) 2008-08-29 2013-01-22 Bunge Oils, Inc. Hydrolases, nucleic acids encoding them and methods for making and using them
US8198062B2 (en) 2008-08-29 2012-06-12 Dsm Ip Assets B.V. Hydrolases, nucleic acids encoding them and methods for making and using them
JP4793707B2 (ja) * 2008-09-03 2011-10-12 国立大学法人富山大学 組織片成形装置及び組織片成形方法
EP2334692B1 (de) * 2008-09-05 2016-04-13 The Royal Institution for the Advancement of Learning/McGill University Rna-monomere mit o-acetal-levulinylestergruppen und ihre verwendung für rna-mikroarrays
CN105132395A (zh) 2009-03-09 2015-12-09 生物蛋白有限公司 Mirac蛋白
EA031116B1 (ru) 2009-04-03 2018-11-30 Ф. Хоффманн-Ля Рош Аг КРИСТАЛЛИЧЕСКИЕ ПОЛИМОРФНЫЕ ФОРМЫ {3-[5-(4-ХЛОРФЕНИЛ)-1H-ПИРРОЛО[2,3-b]ПИРИДИН-3-КАРБОНИЛ]-2,4-ДИФТОРФЕНИЛ}АМИДА ПРОПАН-1-СУЛЬФОНОВОЙ КИСЛОТЫ
ES2608690T3 (es) 2009-05-21 2017-04-12 Basf Enzymes Llc Fitasas, ácidos nucleicos que las codifican y métodos para su producción y uso
US8329724B2 (en) 2009-08-03 2012-12-11 Hoffmann-La Roche Inc. Process for the manufacture of pharmaceutically active compounds
EP2480684A1 (de) * 2009-09-25 2012-08-01 Signature Genomic Laboratories, Llc Mehrfach (+/-)-strängige arrays und tests für den nachweis von chromosomalen anomalien im zusammenhang mit krebs und anderen erkrankungen
UA111708C2 (uk) 2009-10-16 2016-06-10 Бандж Ойлз, Інк. Спосіб рафінування олії
UA109884C2 (uk) 2009-10-16 2015-10-26 Поліпептид, що має активність ферменту фосфатидилінозитол-специфічної фосфоліпази с, нуклеїнова кислота, що його кодує, та спосіб його виробництва і застосування
UA105813C2 (uk) 2009-11-06 2014-06-25 Плексікон, Інк. Сполуки-інгібітори кіназ та фармацевтична композиція (варіанти)
JP5761732B2 (ja) * 2010-07-29 2015-08-12 サクラ精機株式会社 組織アレイの組織片形成方法及び組織アレイの組織片形成装置
AR083354A1 (es) 2010-10-06 2013-02-21 Bp Corp North America Inc Polipeptidos variantes cbh i (celobiohidrolasas i) con reducida inhibicion de producto
PL2672967T3 (pl) 2011-02-07 2019-04-30 Plexxikon Inc Związki i sposoby modulacji kinaz i wskazania ku temu
TWI558702B (zh) 2011-02-21 2016-11-21 普雷辛肯公司 醫藥活性物質的固態形式
JP5660468B2 (ja) * 2011-03-15 2015-01-28 三菱レイヨン株式会社 生体関連物質検出用ゲルマイクロアレイの製造方法
US9150570B2 (en) 2012-05-31 2015-10-06 Plexxikon Inc. Synthesis of heterocyclic compounds
US9267171B2 (en) 2013-02-28 2016-02-23 New York University DNA photolithography with cinnamate crosslinkers
EP2999967B1 (de) 2013-05-21 2020-05-20 NX Pharmagen Verwendung von tenascin-c als extrazellulärer marker für aus tumoren gewonnenen mikropartikeln
WO2015175375A1 (en) 2014-05-13 2015-11-19 Short Jay M Conditionally active biological proteins
US11111288B2 (en) 2014-08-28 2021-09-07 Bioatla, Inc. Conditionally active chimeric antigen receptors for modified t-cells
ES3034398T3 (en) 2014-08-28 2025-08-18 Bioatla Inc Conditionally active chimeric antigen receptors for modified t-cells
KR20170044115A (ko) 2014-09-03 2017-04-24 바이오아트라, 엘엘씨 동일한 진핵생물 세포 생산 숙주 내 조건부 활성 생체 단백질의 발견 및 제조
EP2995703B1 (de) * 2014-09-09 2019-08-28 Christian-Albrechts-Universität zu Kiel Verfahren zur Herstellung von Flächenableitelektroden und Halbzeug zur Durchführung des Verfahrens
AU2016222830B2 (en) 2015-02-24 2021-02-25 Bioatla Llc Conditionally active biological proteins
JP6367741B2 (ja) * 2015-03-12 2018-08-01 学校法人北里研究所 生体組織標本アレイ切片、生体組織標本アレイ、シート状生体組織標本アレイ、生体組織標本ブロック及びそれらの製造方法
US10829484B2 (en) 2015-07-28 2020-11-10 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
MX2018006856A (es) 2015-12-07 2018-08-01 Plexxikon Inc Compuestos y metodos para modulacion de la quinasa, e indicaciones de los mismos.
EP3455261B1 (de) 2016-05-13 2022-08-03 BioAtla, Inc. Anti-ror2-antikörper, antikörperfragmente, deren immunkonjugate und verwendungen davon
TW201815766A (zh) 2016-09-22 2018-05-01 美商普雷辛肯公司 用於ｉｄｏ及ｔｄｏ調節之化合物及方法以及其適應症
KR20180061979A (ko) * 2016-11-30 2018-06-08 한국전자통신연구원 표적물질 검출용 키트 및 이를 이용한 검출방법
WO2018136202A2 (en) 2016-12-23 2018-07-26 Plexxikon Inc. Compounds and methods for cdk8 modulation and indications therefor
US10428067B2 (en) 2017-06-07 2019-10-01 Plexxikon Inc. Compounds and methods for kinase modulation
CN110898672A (zh) * 2019-10-22 2020-03-24 浙江省北大信息技术高等研究院 多孔薄膜、多孔薄膜的制作方法及电渗微泵装置

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4084308A (en) * 1976-11-22 1978-04-18 Bell Telephone Laboratories, Incorporated Slicing method in fiber end preparation
US4382074A (en) * 1978-03-27 1983-05-03 Hiram Hart Scintillation proximity assay
US4271139A (en) * 1978-03-27 1981-06-02 Hiram Hart Scintillation proximity assay
US4568649A (en) * 1983-02-22 1986-02-04 Immunex Corporation Immediate ligand detection assay
US4673657A (en) * 1983-08-26 1987-06-16 The Regents Of The University Of California Multiple assay card and system
US4689310A (en) * 1984-09-21 1987-08-25 Ortho Diagnostic Systems Inc. Methods for attaching ligands or anti-ligands to a solid phase
US4948442A (en) * 1985-06-18 1990-08-14 Polyfiltronics, Inc. Method of making a multiwell test plate
US4820504A (en) * 1986-02-12 1989-04-11 City Of Hope Multi-specimen tissue blocks and slides
US5001048A (en) * 1987-06-05 1991-03-19 Aurthur D. Little, Inc. Electrical biosensor containing a biological receptor immobilized and stabilized in a protein film
US5192507A (en) * 1987-06-05 1993-03-09 Arthur D. Little, Inc. Receptor-based biosensors
US4914022A (en) * 1987-10-21 1990-04-03 Amc Cancer Research Center Method for preparing multiple tissue samples for microscopic investigation and testing
US5002377A (en) * 1988-07-07 1991-03-26 City Of Hope Multi-specimen slides for immunohistologic procedures
GB8822228D0 (en) * 1988-09-21 1988-10-26 Southern E M Support-bound oligonucleotides
FI82144C (fi) * 1989-03-22 1991-01-10 Wallac Oy Foerfarande foer samtidig bestaemning av flera ligander.
US5527681A (en) * 1989-06-07 1996-06-18 Affymax Technologies N.V. Immobilized molecular synthesis of systematically substituted compounds
US5143854A (en) * 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US5474796A (en) * 1991-09-04 1995-12-12 Protogene Laboratories, Inc. Method and apparatus for conducting an array of chemical reactions on a support surface
US5605662A (en) * 1993-11-01 1997-02-25 Nanogen, Inc. Active programmable electronic devices for molecular biological analysis and diagnostics
US5326691A (en) * 1991-11-21 1994-07-05 John Hozier Micro-libraries and methods of making and manipulating them methods for generating and analyzing micro-libraries
US5384261A (en) * 1991-11-22 1995-01-24 Affymax Technologies N.V. Very large scale immobilized polymer synthesis using mechanically directed flow paths
DE69233087T2 (de) * 1991-11-22 2003-12-24 Affymetrix, Inc. (N.D.Ges.D.Staates Delaware) Verfahren zur Herstellung von Polymerarrays
US5541061A (en) * 1992-04-29 1996-07-30 Affymax Technologies N.V. Methods for screening factorial chemical libraries
AU5997194A (en) * 1993-02-03 1994-08-29 A. James Farmilo Automated histo-cytochemistry apparatus and encapsulation system for processing biological materials
US5429807A (en) * 1993-10-28 1995-07-04 Beckman Instruments, Inc. Method and apparatus for creating biopolymer arrays on a solid support surface
US5985356A (en) * 1994-10-18 1999-11-16 The Regents Of The University Of California Combinatorial synthesis of novel materials
US5556752A (en) * 1994-10-24 1996-09-17 Affymetrix, Inc. Surface-bound, unimolecular, double-stranded DNA
US5585069A (en) * 1994-11-10 1996-12-17 David Sarnoff Research Center, Inc. Partitioned microelectronic and fluidic device array for clinical diagnostics and chemical synthesis
SE9404166D0 (sv) * 1994-11-30 1994-11-30 Pharmacia Biotech Ab Multifunctional surfaces
US5688696A (en) * 1994-12-12 1997-11-18 Selectide Corporation Combinatorial libraries having a predetermined frequency of each species of test compound
US5787572A (en) * 1995-02-14 1998-08-04 Schott Fibre Optics (Uk) Limited Apparatus for terminating a fibre optic bundle
US5690894A (en) * 1995-05-23 1997-11-25 The Regents Of The University Of California High density array fabrication and readout method for a fiber optic biosensor
US6037186A (en) * 1997-07-16 2000-03-14 Stimpson; Don Parallel production of high density arrays
US6521485B2 (en) * 2001-01-17 2003-02-18 Walsin Advanced Electronics Ltd Method for manufacturing wafer level chip size package

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US20010019827A1 (en) 2001-09-06
CN1249418C (zh) 2006-04-05
CN100367024C (zh) 2008-02-06
ES2190591T3 (es) 2003-08-01
IL134702A (en) 2004-03-28
US20030096292A1 (en) 2003-05-22
DE69833698D1 (de) 2006-05-04
DE69825496T2 (de) 2005-07-28
CA2301539C (en) 2003-06-17
ATE235682T1 (de) 2003-04-15
EP1176413B1 (de) 2004-08-04
EP1176413A3 (de) 2002-09-04
CN1677077A (zh) 2005-10-05
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DE69833698T2 (de) 2006-11-16
ES2260157T3 (es) 2006-11-01
EP1012564A1 (de) 2000-06-28
CN1677079A (zh) 2005-10-05
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ATE319986T1 (de) 2006-03-15
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