ES2190591T3 - Metodo de producir disposiciones ordenadas de alta densidad. - Google Patents
Metodo de producir disposiciones ordenadas de alta densidad.Info
- Publication number
- ES2190591T3 ES2190591T3 ES98922436T ES98922436T ES2190591T3 ES 2190591 T3 ES2190591 T3 ES 2190591T3 ES 98922436 T ES98922436 T ES 98922436T ES 98922436 T ES98922436 T ES 98922436T ES 2190591 T3 ES2190591 T3 ES 2190591T3
- Authority
- ES
- Spain
- Prior art keywords
- high density
- provisions
- target
- producing ordered
- ordered
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/36—Embedding or analogous mounting of samples
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/1031—Investigating individual particles by measuring electrical or magnetic effects
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00497—Features relating to the solid phase supports
- B01J2219/00513—Essentially linear supports
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00497—Features relating to the solid phase supports
- B01J2219/00513—Essentially linear supports
- B01J2219/00515—Essentially linear supports in the shape of strings
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00497—Features relating to the solid phase supports
- B01J2219/00513—Essentially linear supports
- B01J2219/00518—Essentially linear supports in the shape of tapes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00497—Features relating to the solid phase supports
- B01J2219/00513—Essentially linear supports
- B01J2219/0052—Essentially linear supports in the shape of elongated tubes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00497—Features relating to the solid phase supports
- B01J2219/00513—Essentially linear supports
- B01J2219/0052—Essentially linear supports in the shape of elongated tubes
- B01J2219/00522—Essentially linear supports in the shape of elongated tubes in a multiple parallel arrangement
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00497—Features relating to the solid phase supports
- B01J2219/00513—Essentially linear supports
- B01J2219/00524—Essentially linear supports in the shape of fiber bundles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00497—Features relating to the solid phase supports
- B01J2219/00527—Sheets
- B01J2219/00533—Sheets essentially rectangular
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00497—Features relating to the solid phase supports
- B01J2219/00527—Sheets
- B01J2219/00536—Sheets in the shape of disks
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00497—Features relating to the solid phase supports
- B01J2219/00527—Sheets
- B01J2219/00538—Sheets in the shape of cylinders
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00585—Parallel processes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00596—Solid-phase processes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
- B01J2219/0061—The surface being organic
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
- B01J2219/00612—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports the surface being inorganic
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
- B01J2219/00614—Delimitation of the attachment areas
- B01J2219/00617—Delimitation of the attachment areas by chemical means
- B01J2219/00619—Delimitation of the attachment areas by chemical means using hydrophilic or hydrophobic regions
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
- B01J2219/00614—Delimitation of the attachment areas
- B01J2219/00621—Delimitation of the attachment areas by physical means, e.g. trenches, raised areas
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
- B01J2219/00623—Immobilisation or binding
- B01J2219/00626—Covalent
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
- B01J2219/00623—Immobilisation or binding
- B01J2219/00628—Ionic
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
- B01J2219/00623—Immobilisation or binding
- B01J2219/0063—Other, e.g. van der Waals forces, hydrogen bonding
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
- B01J2219/00632—Introduction of reactive groups to the surface
- B01J2219/00637—Introduction of reactive groups to the surface by coating it with another layer
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00639—Making arrays on substantially continuous surfaces the compounds being trapped in or bound to a porous medium
- B01J2219/00641—Making arrays on substantially continuous surfaces the compounds being trapped in or bound to a porous medium the porous medium being continuous, e.g. porous oxide substrates
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00639—Making arrays on substantially continuous surfaces the compounds being trapped in or bound to a porous medium
- B01J2219/00644—Making arrays on substantially continuous surfaces the compounds being trapped in or bound to a porous medium the porous medium being present in discrete locations, e.g. gel pads
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00657—One-dimensional arrays
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00659—Two-dimensional arrays
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00664—Three-dimensional arrays
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00673—Slice arrays
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00718—Type of compounds synthesised
- B01J2219/0072—Organic compounds
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00718—Type of compounds synthesised
- B01J2219/0072—Organic compounds
- B01J2219/00722—Nucleotides
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00718—Type of compounds synthesised
- B01J2219/0072—Organic compounds
- B01J2219/00725—Peptides
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00718—Type of compounds synthesised
- B01J2219/00745—Inorganic compounds
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00718—Type of compounds synthesised
- B01J2219/00745—Inorganic compounds
- B01J2219/0075—Metal based compounds
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00718—Type of compounds synthesised
- B01J2219/00745—Inorganic compounds
- B01J2219/0075—Metal based compounds
- B01J2219/00754—Metal oxides
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/04—Libraries containing only organic compounds
- C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/04—Libraries containing only organic compounds
- C40B40/10—Libraries containing peptides or polypeptides, or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/04—Libraries containing only organic compounds
- C40B40/14—Libraries containing macromolecular compounds and not covered by groups C40B40/06 - C40B40/12
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/18—Libraries containing only inorganic compounds or inorganic materials
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/01—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells
Landscapes
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pathology (AREA)
- Organic Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Manufacture Or Reproduction Of Printing Formes (AREA)
- Particle Accelerators (AREA)
- Electron Beam Exposure (AREA)
- Silver Salt Photography Or Processing Solution Therefor (AREA)
- Inorganic Insulating Materials (AREA)
- Crystals, And After-Treatments Of Crystals (AREA)
- Image Processing (AREA)
- Physical Deposition Of Substances That Are Components Of Semiconductor Devices (AREA)
- Sampling And Sample Adjustment (AREA)
- Seasonings (AREA)
- Mechanical Treatment Of Semiconductor (AREA)
- Non-Silver Salt Photosensitive Materials And Non-Silver Salt Photography (AREA)
- Luminescent Compositions (AREA)
- Facsimile Heads (AREA)
Abstract
Un método para producir disposiciones ordenadas de alta densidad de sustancias dianas que comprende la etapa de cortar en sentido transversal un haz de hebras dianas, en el que las hebras dianas comprenden las sustancias dianas, caracterizado porque el corte en sentido transversal da como resultado una disposición ordenada de alta densidad que tiene un espesor mayor que 50 m.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US92797497A | 1997-09-11 | 1997-09-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2190591T3 true ES2190591T3 (es) | 2003-08-01 |
Family
ID=25455526
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES98922436T Expired - Lifetime ES2190591T3 (es) | 1997-09-11 | 1998-05-19 | Metodo de producir disposiciones ordenadas de alta densidad. |
| ES01203717T Expired - Lifetime ES2225407T3 (es) | 1997-09-11 | 1998-05-19 | Metodo para producir disposiciones ordenadas de alta densidad. |
| ES01203716T Expired - Lifetime ES2260157T3 (es) | 1997-09-11 | 1998-05-19 | Metodo para ser dispositivos de alta densidad. |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES01203717T Expired - Lifetime ES2225407T3 (es) | 1997-09-11 | 1998-05-19 | Metodo para producir disposiciones ordenadas de alta densidad. |
| ES01203716T Expired - Lifetime ES2260157T3 (es) | 1997-09-11 | 1998-05-19 | Metodo para ser dispositivos de alta densidad. |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US20010019827A1 (es) |
| EP (3) | EP1176413B1 (es) |
| JP (2) | JP2001515735A (es) |
| CN (5) | CN1677076A (es) |
| AT (3) | ATE235682T1 (es) |
| AU (1) | AU733589B2 (es) |
| CA (1) | CA2301539C (es) |
| DE (3) | DE69812655T2 (es) |
| DK (1) | DK1012564T3 (es) |
| ES (3) | ES2190591T3 (es) |
| IL (1) | IL134702A (es) |
| PT (1) | PT1012564E (es) |
| WO (1) | WO1999013313A1 (es) |
Families Citing this family (116)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020155495A1 (en) * | 2000-04-17 | 2002-10-24 | Millstein Larry S. | Method for producing arrays and devices relating thereto |
| AU754047B2 (en) * | 1998-02-25 | 2002-10-31 | United States Of America, Represented By The Secretary, Department Of Health And Human Services, The | Tumor tissue microarrays for rapid molecular profiling |
| JP3562968B2 (ja) | 1998-08-14 | 2004-09-08 | 富士写真フイルム株式会社 | 試験片、その製造方法および装置並びにその読取方法および装置 |
| JP3445501B2 (ja) | 1998-09-04 | 2003-09-08 | 日立ソフトウエアエンジニアリング株式会社 | シート状部材積層体及びシート状プローブ保持体の製造方法 |
| EP1158047B1 (en) | 1999-03-05 | 2009-05-20 | Mitsubishi Rayon Co., Ltd. | Microarrays having biological substance |
| US6713309B1 (en) * | 1999-07-30 | 2004-03-30 | Large Scale Proteomics Corporation | Microarrays and their manufacture |
| WO2001026799A1 (en) * | 1999-10-08 | 2001-04-19 | Bio-Informatics Group, Inc. | Biochip defining a channeled capillary array and associated methods |
| US6406840B1 (en) | 1999-12-17 | 2002-06-18 | Biomosaic Systems, Inc. | Cell arrays and the uses thereof |
| DE10001136C2 (de) * | 2000-01-13 | 2003-09-04 | Michael Mengel | Verfahren zur Herstellung von Materialblöcken mit multiplen Untersuchungsproben |
| CA2397656A1 (en) * | 2000-01-17 | 2001-07-26 | Unitec Co. Ltd. | Integrated support, integrated minute vessels and permeable membrane, and method of making and using the same |
| WO2001098781A1 (en) * | 2000-06-20 | 2001-12-27 | Mitsubishi Rayon Co., Ltd. | Micro-array of organism-associated substance |
| DE10034570A1 (de) * | 2000-07-14 | 2002-01-31 | Max Delbrueck Centrum | Verfahren zur Herstellung von Mikroarray-Chips mit Nukleinsäuren, Proteinen oder anderen Testsubstanzen |
| DE10042871A1 (de) * | 2000-08-31 | 2002-05-16 | Hte Ag The High Throughput Exp | Dreidimensionale Materialbibliothek und Verfahren zur Herstellung einer dreidimensionalen Materialbibliothek |
| JP2004537712A (ja) | 2000-10-18 | 2004-12-16 | バーチャル・アレイズ・インコーポレーテッド | 多重細胞分析システム |
| US6905816B2 (en) | 2000-11-27 | 2005-06-14 | Intelligent Medical Devices, Inc. | Clinically intelligent diagnostic devices and methods |
| DE10110511C1 (de) * | 2001-02-28 | 2002-10-10 | Attomol Gmbh Molekulare Diagno | Verfahren zur Herstellung eines Arrays zur Detektion von Komponenten aus einer biologischen Probe |
| DE10117135A1 (de) * | 2001-04-05 | 2002-10-17 | Biotechnolog Forschung Gmbh | Verfahren zur Herstellung einer Vielzahl identischer Kopien einer planaren Testanordnung von Sondenmolekülen |
| US20030148380A1 (en) | 2001-06-05 | 2003-08-07 | Belcher Angela M. | Molecular recognition of materials |
| US20030113714A1 (en) * | 2001-09-28 | 2003-06-19 | Belcher Angela M. | Biological control of nanoparticles |
| GB0124338D0 (en) | 2001-10-10 | 2001-11-28 | Randox Lab Ltd | Biochips |
| EP1451318A4 (en) | 2001-10-12 | 2007-06-27 | Perkinelmer Las Inc | COMPOSITIONS OF NUCLEIC ACIDS AND ARRAYS AND METHOD FOR THEIR USE |
| US7439346B2 (en) | 2001-10-12 | 2008-10-21 | Perkinelmer Las Inc. | Nucleic acids arrays and methods of use therefor |
| EP1585958A4 (en) * | 2001-10-18 | 2007-07-25 | Millipore Corp | CODED PARTICLES FOR THE MULTIPLEX ANALYSIS OF BIOLOGICAL SAMPLES |
| US6924107B2 (en) | 2002-01-28 | 2005-08-02 | Bio-Informatics Group, Inc. | Four dimensional biochip design for high throughput applications and methods of using the four dimensional biochip |
| DE10208952B4 (de) | 2002-02-28 | 2004-04-08 | Bayer Ag | Screeningverfahren zur Herstellung und Charakterisierung von Polyurethan-Schaumstoffen |
| US7226771B2 (en) | 2002-04-19 | 2007-06-05 | Diversa Corporation | Phospholipases, nucleic acids encoding them and methods for making and using them |
| PT1497418E (pt) | 2002-04-19 | 2013-01-25 | Dsm Ip Assets Bv | Fosfolípases, ácidos nucleicos que as codificam e métodos para as preparar e utilizar |
| CA2503905A1 (en) * | 2002-09-16 | 2004-03-25 | Plexxikon, Inc. | Crystal structure of pim-1 kinase |
| US20050064508A1 (en) | 2003-09-22 | 2005-03-24 | Semzyme | Peptide mediated synthesis of metallic and magnetic materials |
| JP2007524374A (ja) * | 2003-02-28 | 2007-08-30 | プレキシコン,インコーポレーテッド | Pyk2結晶構造および使用 |
| EP3508578A1 (en) | 2003-03-06 | 2019-07-10 | BASF Enzymes, LLC | Amylases, nucleic acids encoding them and methods for making and using them |
| EP2853593B1 (en) | 2003-03-07 | 2017-10-04 | DSM IP Assets B.V. | Hydrolases, nucleic acids encoding them and mehods for making and using them |
| DK2341136T3 (en) | 2003-04-04 | 2016-09-12 | Basf Enzymes Llc | Pectate lyases, nucleic acids encoding them, and methods of making and using them |
| DE10316689A1 (de) * | 2003-04-10 | 2004-10-28 | Dimitrij Dr. Plachov | Dreidimensionaler Chip |
| BRPI0412279A (pt) | 2003-07-02 | 2006-09-19 | Diversa Corp | glucanases, ácidos nucléicos codificando as mesmas e métodos para preparar e aplicar os mesmos |
| US20050079548A1 (en) * | 2003-07-07 | 2005-04-14 | Plexxikon, Inc. | Ligand development using PDE4B crystal structures |
| CA2535526C (en) | 2003-08-11 | 2015-09-29 | Diversa Corporation | Laccases, nucleic acids encoding them and methods for making and using them |
| US7488451B2 (en) | 2003-09-15 | 2009-02-10 | Millipore Corporation | Systems for particle manipulation |
| WO2005028624A2 (en) * | 2003-09-15 | 2005-03-31 | Plexxikon, Inc. | Molecular scaffolds for kinase ligand development |
| GB2408331A (en) * | 2003-11-24 | 2005-05-25 | Asahi Chemical Ind | Arrays for screening polymeric materials |
| US20070066641A1 (en) * | 2003-12-19 | 2007-03-22 | Prabha Ibrahim | Compounds and methods for development of RET modulators |
| PL1696920T3 (pl) | 2003-12-19 | 2015-03-31 | Plexxikon Inc | Związki i sposoby opracowywania modulatorów Ret |
| EP1739433B1 (en) * | 2004-04-20 | 2013-08-21 | Universal Bio Research Co., Ltd. | Cassette for stacking specimen, spotting device, and specimen stacking device |
| JP2008503446A (ja) | 2004-05-06 | 2008-02-07 | プレキシコン,インコーポレーテッド | Pde4b阻害剤及びその使用 |
| US8911942B2 (en) * | 2004-05-20 | 2014-12-16 | Quest Diagnostics Investments Incorporated | Single label comparative hybridization |
| ES2461857T3 (es) | 2004-06-16 | 2014-05-21 | Dsm Ip Assets B.V. | Composiciones y métodos para la decoloración enzimática de clorofila |
| JP2008503473A (ja) * | 2004-06-17 | 2008-02-07 | プレキシコン,インコーポレーテッド | C−kit活性を調節する化合物 |
| US7498342B2 (en) * | 2004-06-17 | 2009-03-03 | Plexxikon, Inc. | Compounds modulating c-kit activity |
| DE102004031167A1 (de) * | 2004-06-28 | 2006-01-12 | Infineon Technologies Ag | Verfahren zur Herstellung von Biochips aus porösen Substraten |
| EP1786813A2 (en) * | 2004-09-03 | 2007-05-23 | Plexxikon, Inc. | Bicyclic heteroaryl pde4b inhibitors |
| WO2006081353A2 (en) * | 2005-01-27 | 2006-08-03 | Quest Diagnostics Investments Incorporated | Rapid comparative genome hybridization |
| EP2886658A1 (en) | 2005-03-10 | 2015-06-24 | BASF Enzymes LLC | Lyase enzymes, nucleic acids encoding them and methods for making and using them |
| NZ594810A (en) | 2005-03-15 | 2012-12-21 | Verenium Corp | Cellulases, nucleic acids encoding them and methods for making and using them |
| CA2608733A1 (en) * | 2005-05-17 | 2007-02-01 | Plexxikon, Inc. | Pyrrol (2,3-b) pyridine derivatives protein kinase inhibitors |
| DK2395004T3 (en) * | 2005-06-22 | 2016-03-21 | Plexxikon Inc | Pyrrolo [2,3-b] pyridine derivatives as protein kinase inhibitors |
| US8076074B2 (en) | 2005-11-29 | 2011-12-13 | Quest Diagnostics Investments Incorporated | Balanced translocation in comparative hybridization |
| EP2216403A3 (en) | 2006-02-02 | 2010-11-24 | Verenium Corporation | Esterases and related nucleic acids and methods |
| NZ595501A (en) | 2006-02-10 | 2013-05-31 | Verenium Corp | Cellulolytic enzymes, nucleic acids encoding them and methods for making and using them |
| TR201809912T4 (tr) | 2006-02-14 | 2018-07-23 | Bp Corp North America Inc | Ksilanazlar, bunları kodlayan nükleik asitler ve bunları yapmak ve kullanmak için yöntemler. |
| EP2112227B1 (en) | 2006-03-07 | 2013-05-15 | Cargill, Incorporated | Aldolases, nucleic acids encoding them and methods for making and using them |
| EA029538B1 (ru) | 2006-03-07 | 2018-04-30 | Басф Энзаймс Ллк | Полипептид, обладающий активностью альдолазы, полинуклеотид, кодирующий этот полипептид, и способы получения и применения полинуклеотида и полипептида |
| US20070232556A1 (en) * | 2006-03-31 | 2007-10-04 | Montine Thomas J | Methods and compositions for the treatment of neurological diseases and disorders |
| WO2007140294A2 (en) * | 2006-05-30 | 2007-12-06 | Pall Corporation | Analysis device |
| JPWO2007145228A1 (ja) * | 2006-06-13 | 2009-11-05 | 独立行政法人産業技術総合研究所 | マイクロアレイの作製方法 |
| DK2069389T3 (en) | 2006-08-04 | 2015-01-12 | Bp Corp North America Inc | Glucanases, nucleic acids encoding them, and processes for their preparation and use |
| HUE029140T2 (hu) | 2006-09-21 | 2017-02-28 | Basf Enzymes Llc | Fitázok, ezeket kódoló nukleinsavak, valamint eljárások az elõállításukra és alkalmazásuk |
| CA2663001A1 (en) | 2006-09-21 | 2008-03-27 | Verenium Corporation | Phospholipases, nucleic acids encoding them and methods for making and using them |
| US8618248B2 (en) | 2006-10-31 | 2013-12-31 | President And Fellows Of Harvard College | Phosphopeptide compositions and anti-phosphopeptide antibody compositions and methods of detecting phosphorylated peptides |
| WO2008063888A2 (en) | 2006-11-22 | 2008-05-29 | Plexxikon, Inc. | Compounds modulating c-fms and/or c-kit activity and uses therefor |
| BRPI0719449A2 (pt) | 2006-12-21 | 2017-06-20 | Syngenta Participations Ag | molécula de ácido nucléico isolada, sintética ou recombinante, polipeptídeo isolado, planta ou parte de planta, eículo de clonagem que compreende um ácido nucléico, cassete de expressão que compreende uma molécula de ácido nucléico e método para hidrolisar um polissacarídeo, oligossacarídeo ou amido |
| WO2008079909A1 (en) * | 2006-12-21 | 2008-07-03 | Plexxikon, Inc. | Pyrrolo [2,3-b] pyridines as kinase modulators |
| WO2008080015A2 (en) | 2006-12-21 | 2008-07-03 | Plexxikon, Inc. | Compounds and methods for kinase modulation, and indications therefor |
| PE20081581A1 (es) * | 2006-12-21 | 2008-11-12 | Plexxikon Inc | COMPUESTOS PIRROLO[2,3-b]PIRIDINAS COMO MODULADORES DE QUINASA |
| NZ578309A (en) | 2007-01-30 | 2012-06-29 | Verenium Corp | Enzymes for the treatment of lignocellulosics, nucleic acids encoding them and methods for making and using them |
| EP2116610B1 (en) * | 2007-03-07 | 2011-10-26 | National University Corporation University of Toyama | Method and system of producing a tissue array block |
| MX347887B (es) | 2007-04-27 | 2017-05-16 | The Regents Of The Univ Of California At San Diego | Sensores de co2 de planta, acidos nucleicos que los codifican y metodos para hacerlos y usarlos. |
| US20100190777A1 (en) | 2007-07-17 | 2010-07-29 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
| US7507539B2 (en) * | 2007-07-30 | 2009-03-24 | Quest Diagnostics Investments Incorporated | Substractive single label comparative hybridization |
| CN110577945A (zh) | 2007-10-03 | 2019-12-17 | 维莱尼姆公司 | 木聚糖酶、编码它们的核酸以及其制备和应用方法 |
| EP2238242B9 (en) | 2008-01-03 | 2015-06-10 | BASF Enzymes LLC | Transferases and oxidoreductases, nucleic acids encoding them and methods for making and using them |
| US8198062B2 (en) | 2008-08-29 | 2012-06-12 | Dsm Ip Assets B.V. | Hydrolases, nucleic acids encoding them and methods for making and using them |
| US8153391B2 (en) | 2008-08-29 | 2012-04-10 | Bunge Oils, Inc. | Hydrolases, nucleic acids encoding them and methods for making and using them |
| US8357503B2 (en) | 2008-08-29 | 2013-01-22 | Bunge Oils, Inc. | Hydrolases, nucleic acids encoding them and methods for making and using them |
| JP4793707B2 (ja) * | 2008-09-03 | 2011-10-12 | 国立大学法人富山大学 | 組織片成形装置及び組織片成形方法 |
| US9249175B2 (en) * | 2008-09-05 | 2016-02-02 | The Royal Institute For The Advancement Of Learning/Mcgill University | RNA monomers containing O-acetal levulinyl ester groups and their use in RNA microarrays |
| US20100260739A1 (en) * | 2009-03-09 | 2010-10-14 | Bioatla, Llc | Mirac Proteins |
| HUE027598T2 (en) * | 2009-04-03 | 2016-10-28 | Hoffmann La Roche | Propane-1-sulfonic acid {3- [5- (4-chlorophenyl) -1H-pyrrolo [2,3-B] pyridine-3-carbonyl] -2,4-difluorophenyl} amide compositions and their uses |
| CN106011159A (zh) | 2009-05-21 | 2016-10-12 | 巴斯夫酶有限责任公司 | 肌醇六磷酸酶、编码它们的核酸及制备和使用它们的方法 |
| US8329724B2 (en) | 2009-08-03 | 2012-12-11 | Hoffmann-La Roche Inc. | Process for the manufacture of pharmaceutically active compounds |
| CN102630250A (zh) * | 2009-09-25 | 2012-08-08 | 基因诊断测试公司 | 用于检测与癌症和其他疾病相关的染色体异常的多重(+/-)链阵列和测试 |
| UA111708C2 (uk) | 2009-10-16 | 2016-06-10 | Бандж Ойлз, Інк. | Спосіб рафінування олії |
| UA109884C2 (uk) | 2009-10-16 | 2015-10-26 | Поліпептид, що має активність ферменту фосфатидилінозитол-специфічної фосфоліпази с, нуклеїнова кислота, що його кодує, та спосіб його виробництва і застосування | |
| ES2633317T3 (es) | 2009-11-06 | 2017-09-20 | Plexxikon, Inc. | Compuestos y métodos para la modulación de quinasas, e indicaciones para ello |
| JP5761732B2 (ja) * | 2010-07-29 | 2015-08-12 | サクラ精機株式会社 | 組織アレイの組織片形成方法及び組織アレイの組織片形成装置 |
| BR112013008347A2 (pt) | 2010-10-06 | 2016-06-14 | Bp Corp North America Inc | polipeptídeos de variantes cbh i |
| MA34948B1 (fr) | 2011-02-07 | 2014-03-01 | Plexxikon Inc | Composes et procedes de modulation de kinase, et leurs indications |
| TWI558702B (zh) | 2011-02-21 | 2016-11-21 | 普雷辛肯公司 | 醫藥活性物質的固態形式 |
| JP5660468B2 (ja) * | 2011-03-15 | 2015-01-28 | 三菱レイヨン株式会社 | 生体関連物質検出用ゲルマイクロアレイの製造方法 |
| US9150570B2 (en) | 2012-05-31 | 2015-10-06 | Plexxikon Inc. | Synthesis of heterocyclic compounds |
| US9267171B2 (en) | 2013-02-28 | 2016-02-23 | New York University | DNA photolithography with cinnamate crosslinkers |
| EP2999967B1 (en) | 2013-05-21 | 2020-05-20 | NX Pharmagen | Use of tenascin-c as an extracellular marker of tumor-derived microparticles |
| ES2913205T3 (es) | 2014-05-13 | 2022-06-01 | Bioatla Inc | Proteínas biológicas activas condicionalmente |
| ES3034398T3 (en) | 2014-08-28 | 2025-08-18 | Bioatla Inc | Conditionally active chimeric antigen receptors for modified t-cells |
| US11111288B2 (en) | 2014-08-28 | 2021-09-07 | Bioatla, Inc. | Conditionally active chimeric antigen receptors for modified t-cells |
| EP3189152A4 (en) | 2014-09-03 | 2018-04-04 | BioAtla LLC | Discovering and producing conditionally active biologic proteins in the same eukaryotic cell production hosts |
| EP2995703B1 (de) * | 2014-09-09 | 2019-08-28 | Christian-Albrechts-Universität zu Kiel | Verfahren zur Herstellung von Flächenableitelektroden und Halbzeug zur Durchführung des Verfahrens |
| CA2977687C (en) | 2015-02-24 | 2024-02-13 | Hwai Wen Chang | Conditionally active proteins |
| JP6367741B2 (ja) * | 2015-03-12 | 2018-08-01 | 学校法人北里研究所 | 生体組織標本アレイ切片、生体組織標本アレイ、シート状生体組織標本アレイ、生体組織標本ブロック及びそれらの製造方法 |
| WO2017019804A2 (en) | 2015-07-28 | 2017-02-02 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
| CN108368110A (zh) | 2015-12-07 | 2018-08-03 | 普莱希科公司 | 用于激酶调节的化合物和方法以及其适应症 |
| TWI851939B (zh) | 2016-05-13 | 2024-08-11 | 美商拜奧亞特拉公司 | 抗-ror2抗體、抗體片段、其免疫結合物及其用途 |
| TW201815766A (zh) | 2016-09-22 | 2018-05-01 | 美商普雷辛肯公司 | 用於ido及tdo調節之化合物及方法以及其適應症 |
| KR20180061979A (ko) * | 2016-11-30 | 2018-06-08 | 한국전자통신연구원 | 표적물질 검출용 키트 및 이를 이용한 검출방법 |
| AU2017395023B2 (en) | 2016-12-23 | 2022-04-07 | Plexxikon Inc. | Compounds and methods for CDK8 modulation and indications therefor |
| WO2018226846A1 (en) | 2017-06-07 | 2018-12-13 | Plexxikon Inc. | Compounds and methods for kinase modulation |
| CN110898672A (zh) * | 2019-10-22 | 2020-03-24 | 浙江省北大信息技术高等研究院 | 多孔薄膜、多孔薄膜的制作方法及电渗微泵装置 |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4084308A (en) * | 1976-11-22 | 1978-04-18 | Bell Telephone Laboratories, Incorporated | Slicing method in fiber end preparation |
| US4382074A (en) * | 1978-03-27 | 1983-05-03 | Hiram Hart | Scintillation proximity assay |
| US4271139A (en) * | 1978-03-27 | 1981-06-02 | Hiram Hart | Scintillation proximity assay |
| US4568649A (en) * | 1983-02-22 | 1986-02-04 | Immunex Corporation | Immediate ligand detection assay |
| US4673657A (en) * | 1983-08-26 | 1987-06-16 | The Regents Of The University Of California | Multiple assay card and system |
| US4689310A (en) * | 1984-09-21 | 1987-08-25 | Ortho Diagnostic Systems Inc. | Methods for attaching ligands or anti-ligands to a solid phase |
| US4948442A (en) * | 1985-06-18 | 1990-08-14 | Polyfiltronics, Inc. | Method of making a multiwell test plate |
| US4820504A (en) * | 1986-02-12 | 1989-04-11 | City Of Hope | Multi-specimen tissue blocks and slides |
| US5001048A (en) * | 1987-06-05 | 1991-03-19 | Aurthur D. Little, Inc. | Electrical biosensor containing a biological receptor immobilized and stabilized in a protein film |
| US5192507A (en) * | 1987-06-05 | 1993-03-09 | Arthur D. Little, Inc. | Receptor-based biosensors |
| US4914022A (en) * | 1987-10-21 | 1990-04-03 | Amc Cancer Research Center | Method for preparing multiple tissue samples for microscopic investigation and testing |
| US5002377A (en) * | 1988-07-07 | 1991-03-26 | City Of Hope | Multi-specimen slides for immunohistologic procedures |
| GB8822228D0 (en) * | 1988-09-21 | 1988-10-26 | Southern E M | Support-bound oligonucleotides |
| FI82144C (fi) * | 1989-03-22 | 1991-01-10 | Wallac Oy | Foerfarande foer samtidig bestaemning av flera ligander. |
| US5143854A (en) * | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
| US5527681A (en) * | 1989-06-07 | 1996-06-18 | Affymax Technologies N.V. | Immobilized molecular synthesis of systematically substituted compounds |
| US5474796A (en) * | 1991-09-04 | 1995-12-12 | Protogene Laboratories, Inc. | Method and apparatus for conducting an array of chemical reactions on a support surface |
| US5605662A (en) * | 1993-11-01 | 1997-02-25 | Nanogen, Inc. | Active programmable electronic devices for molecular biological analysis and diagnostics |
| US5326691A (en) * | 1991-11-21 | 1994-07-05 | John Hozier | Micro-libraries and methods of making and manipulating them methods for generating and analyzing micro-libraries |
| US5677195A (en) * | 1991-11-22 | 1997-10-14 | Affymax Technologies N.V. | Combinatorial strategies for polymer synthesis |
| US5384261A (en) * | 1991-11-22 | 1995-01-24 | Affymax Technologies N.V. | Very large scale immobilized polymer synthesis using mechanically directed flow paths |
| US5541061A (en) * | 1992-04-29 | 1996-07-30 | Affymax Technologies N.V. | Methods for screening factorial chemical libraries |
| ES2176588T3 (es) * | 1993-02-03 | 2002-12-01 | Histaggen Inc | Procedimiento para almacenar un ligando dentro de un medio contencion liberable y procedimiento para liberar un ligando del mismo. |
| US5429807A (en) * | 1993-10-28 | 1995-07-04 | Beckman Instruments, Inc. | Method and apparatus for creating biopolymer arrays on a solid support surface |
| US5985356A (en) * | 1994-10-18 | 1999-11-16 | The Regents Of The University Of California | Combinatorial synthesis of novel materials |
| US5556752A (en) * | 1994-10-24 | 1996-09-17 | Affymetrix, Inc. | Surface-bound, unimolecular, double-stranded DNA |
| US5585069A (en) * | 1994-11-10 | 1996-12-17 | David Sarnoff Research Center, Inc. | Partitioned microelectronic and fluidic device array for clinical diagnostics and chemical synthesis |
| SE9404166D0 (sv) * | 1994-11-30 | 1994-11-30 | Pharmacia Biotech Ab | Multifunctional surfaces |
| US5688696A (en) * | 1994-12-12 | 1997-11-18 | Selectide Corporation | Combinatorial libraries having a predetermined frequency of each species of test compound |
| US5787572A (en) * | 1995-02-14 | 1998-08-04 | Schott Fibre Optics (Uk) Limited | Apparatus for terminating a fibre optic bundle |
| US5690894A (en) * | 1995-05-23 | 1997-11-25 | The Regents Of The University Of California | High density array fabrication and readout method for a fiber optic biosensor |
| US6037186A (en) * | 1997-07-16 | 2000-03-14 | Stimpson; Don | Parallel production of high density arrays |
| US6521485B2 (en) * | 2001-01-17 | 2003-02-18 | Walsin Advanced Electronics Ltd | Method for manufacturing wafer level chip size package |
-
1998
- 1998-05-19 IL IL13470298A patent/IL134702A/en not_active IP Right Cessation
- 1998-05-19 CN CNA2005100688281A patent/CN1677076A/zh active Pending
- 1998-05-19 CN CNB2005100688309A patent/CN100367023C/zh not_active Expired - Fee Related
- 1998-05-19 EP EP01203717A patent/EP1176413B1/en not_active Expired - Lifetime
- 1998-05-19 DE DE69812655T patent/DE69812655T2/de not_active Expired - Fee Related
- 1998-05-19 CN CNB2005100688313A patent/CN100367024C/zh not_active Expired - Fee Related
- 1998-05-19 DK DK98922436T patent/DK1012564T3/da active
- 1998-05-19 WO PCT/US1998/010243 patent/WO1999013313A1/en not_active Ceased
- 1998-05-19 CN CNB988090244A patent/CN1249418C/zh not_active Expired - Fee Related
- 1998-05-19 JP JP2000511049A patent/JP2001515735A/ja active Pending
- 1998-05-19 AT AT98922436T patent/ATE235682T1/de not_active IP Right Cessation
- 1998-05-19 AU AU74985/98A patent/AU733589B2/en not_active Ceased
- 1998-05-19 DE DE69825496T patent/DE69825496T2/de not_active Expired - Fee Related
- 1998-05-19 ES ES98922436T patent/ES2190591T3/es not_active Expired - Lifetime
- 1998-05-19 CN CNB2005100688296A patent/CN100337106C/zh not_active Expired - Fee Related
- 1998-05-19 PT PT98922436T patent/PT1012564E/pt unknown
- 1998-05-19 DE DE69833698T patent/DE69833698T2/de not_active Expired - Fee Related
- 1998-05-19 ES ES01203717T patent/ES2225407T3/es not_active Expired - Lifetime
- 1998-05-19 AT AT01203717T patent/ATE272833T1/de not_active IP Right Cessation
- 1998-05-19 CA CA002301539A patent/CA2301539C/en not_active Expired - Fee Related
- 1998-05-19 EP EP98922436A patent/EP1012564B1/en not_active Expired - Lifetime
- 1998-05-19 ES ES01203716T patent/ES2260157T3/es not_active Expired - Lifetime
- 1998-05-19 EP EP01203716A patent/EP1207383B1/en not_active Expired - Lifetime
- 1998-05-19 AT AT01203716T patent/ATE319986T1/de not_active IP Right Cessation
-
2001
- 2001-04-06 US US09/827,505 patent/US20010019827A1/en not_active Abandoned
-
2002
- 2002-12-11 US US10/317,927 patent/US20030096292A1/en not_active Abandoned
-
2005
- 2005-07-06 JP JP2005198156A patent/JP2005351903A/ja active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ITBO970740A0 (it) | Macchina sezionatrice per il taglio di pannelli e relativo metodo di taglio. | |
| PT858440E (pt) | Processo para a preparacao de 1,1,1,3,3-pentafluoropropano | |
| BR8902681A (pt) | Quadro para casco de trabalho,notadamente para fuselagem de aeronave e processo de fabricacao do mesmo | |
| ATE235682T1 (de) | Verfahren zum erstellen von arrays hoher dichte | |
| FI982518A0 (fi) | Menetelmä ja laite hiljaisen keilan aikaansaamiseksi tietoliikennejärjestelmässä | |
| BR9911845B1 (pt) | mÉtodo para produzir um produto de madeira composta. | |
| BR9709048B1 (pt) | método e sistema para exibição de um guia de programa eletrÈnico e artigo de manufatura. | |
| BR9711418B1 (pt) | folha fotovoltaica, e, processo para a fabricação de uma folha fotovoltaica. | |
| EP0750684A4 (en) | COMPOSITE PART, ALLOY AND METHOD | |
| DE69729832D1 (de) | Vorrichtung mit durch die Umhüllung gepumptem faseroptischen Laser | |
| MX9203116A (es) | Articulo compuesto que comprende microestructuras orientadas y metodo para su fabricacion. | |
| DE69626878D1 (de) | Gasturbinenschaufeln mit Laserschock behandelte Kanten | |
| BR9711672B1 (pt) | mÉtodo para visualizar um desenho. | |
| BR9609841B1 (pt) | aparelho e mÉtodo para gerar raÍzes quadradas espectrais de linha de codificaÇço. | |
| DE69402315D1 (de) | Laserstrahlschneidverfahren | |
| FR2698302B1 (fr) | Méthode de découpage par laser. | |
| BR9605585A (pt) | Máquina para o seccionamento de componenetes | |
| FI945695A7 (fi) | Menetelmä sellukuitujen valmistamiseksi, joiden fibrilloitumistaipumus on vähentynyt | |
| TR199500953A1 (tr) | Sac büyümesini saglayan yöntem. | |
| DE69626175D1 (de) | Laservorrichtung, insbesondere zum optischen Pumpen | |
| ITBO940156A0 (it) | Metodo e dispositivo per la formazione di gruppi di articoli appiatti-ti disposti di taglio. | |
| CA2174986A1 (en) | Method of using a web cutting device | |
| BR9609197A (pt) | Um tanque de combustível e um processo para a produção do tanque de combustível | |
| BR9700713A (pt) | Processo e aparelho para tratamento de um tronco de arvore através do corte | |
| DE69605492D1 (de) | Schneidmaschine für Rund- oder Vierkantrohre |