ATE273307T1 - Benzo(5,6)cycloheptapyridin derivate anwendbar als farnesyl protein transferase inhibitoren - Google Patents

Benzo(5,6)cycloheptapyridin derivate anwendbar als farnesyl protein transferase inhibitoren

Info

Publication number: ATE273307T1
Authority: AT; Austria
Prior art keywords: cycloheptapyridine; benzo; protein transferase; transferase inhibitors; farnesyl protein
Prior art date: 1997-06-17

Application number

AT98932715T

Other languages

English (en)

Inventor

Dinanath F Rane

Stacy W Remiszewski

Ronald J Doll

Original Assignee

Schering Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-06-17

Filing date

1998-06-15

Publication date

2004-08-15

1998-06-15 Application filed by Schering Corp filed Critical Schering Corp

2004-08-15 Application granted granted Critical

2004-08-15 Publication of ATE273307T1 publication Critical patent/ATE273307T1/de

Links

OZVMEJXYSDZMDV-UHFFFAOYSA-N 11h-benzo[1,2]cyclohepta[3,4-b]pyridine Chemical class C1=CC2=NC=CC=C2CC2=CC=CC=C21 OZVMEJXYSDZMDV-UHFFFAOYSA-N 0.000 title 1
239000003528 protein farnesyltransferase inhibitor Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

AT98932715T 1997-06-17 1998-06-15 Benzo(5,6)cycloheptapyridin derivate anwendbar als farnesyl protein transferase inhibitoren ATE273307T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/877,366 US5939416A (en)	1997-06-17	1997-06-17	Benzo (5,6) cycloheptapyridine compounds useful as farnesyl protein transferase inhibitors
PCT/US1998/011505 WO1998057970A1 (en)	1997-06-17	1998-06-15	Benzo(5,6)cycloheptapyridine compounds useful as farnesyl protein transferase inhibitors

Publications (1)

Publication Number	Publication Date
ATE273307T1 true ATE273307T1 (de)	2004-08-15

Family

ID=25369837

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT98932715T ATE273307T1 (de)	1997-06-17	1998-06-15	Benzo(5,6)cycloheptapyridin derivate anwendbar als farnesyl protein transferase inhibitoren

Country Status (12)

Country	Link
US (1)	US5939416A (de)
EP (1)	EP1019400B1 (de)
JP (1)	JP3258342B2 (de)
CN (1)	CN1119345C (de)
AR (1)	AR012990A1 (de)
AT (1)	ATE273307T1 (de)
AU (1)	AU8253398A (de)
CA (1)	CA2293711C (de)
DE (1)	DE69825608T2 (de)
ES (1)	ES2221989T3 (de)
WO (1)	WO1998057970A1 (de)
ZA (1)	ZA985211B (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6524832B1 (en)	1994-02-04	2003-02-25	Arch Development Corporation	DNA damaging agents in combination with tyrosine kinase inhibitors
US6632455B2 (en)	1997-12-22	2003-10-14	Schering Corporation	Molecular dispersion composition with enhanced bioavailability
US6271378B1 (en)	1998-12-18	2001-08-07	Schering Corporation	Process for preparing tricyclic compounds having antihistaminic activity
US6316462B1 (en)	1999-04-09	2001-11-13	Schering Corporation	Methods of inducing cancer cell death and tumor regression
AR035660A1 (es)	2000-11-29	2004-06-23	Schering Corp	Compuestos 3,10-dibromo-8-cloro-11h-benzo[5,6]ciclohepta[1,2-b]piridin-11-il-4-piperidinilos o sus sales farmaceuticamente aceptables, composiciones farmaceuticas que los comprenden, usos de los mismos para preparar medicamentos, y un procedimiento para producir un compuesto intermediario para produ
US20050272068A1 (en) *	2004-03-18	2005-12-08	The Brigham And Women's Hospital, Inc.	UCH-L1 expression and cancer therapy
WO2005089496A2 (en) *	2004-03-18	2005-09-29	The Brigham And Women's Hospital, Inc.	Methods for the treatment of synucleinopathies
US20060194821A1 (en) *	2005-02-18	2006-08-31	The Brigham And Women's Hospital, Inc.	Compounds inhibiting the aggregation of superoxide dismutase-1
US20070148660A1 (en) *	2005-06-16	2007-06-28	The Regents Of The University Of California	Treatment of maladaptive substance use with H-ras antagonists
US8232402B2 (en)	2008-03-12	2012-07-31	Link Medicine Corporation	Quinolinone farnesyl transferase inhibitors for the treatment of synucleinopathies and other indications
CA2743717A1 (en)	2008-11-13	2010-05-20	Link Medicine Corporation	Azaquinolinone derivatives and uses thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5089496A (en) *	1986-10-31	1992-02-18	Schering Corporation	Benzo[5,6]cycloheptapyridine compounds, compositions and method of treating allergies
US5721236A (en) *	1993-10-15	1998-02-24	Schering Corporation	Tricyclic carbamate compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
US5719148A (en) *	1993-10-15	1998-02-17	Schering Corporation	Tricyclic amide and urea compounds useful for inhibition of g-protein function and for treatment of proliferative diseases
IL111235A (en) *	1993-10-15	2001-03-19	Schering Plough Corp	Medicinal preparations for inhibiting protein G activity and for the treatment of malignant diseases, containing tricyclic compounds, some such new compounds and a process for the preparation of some of them
US5700806A (en) *	1995-03-24	1997-12-23	Schering Corporation	Tricyclic amide and urea compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
IL117797A0 (en)	1995-04-07	1996-08-04	Pharmacopeia Inc	Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
IL117798A (en)	1995-04-07	2001-11-25	Schering Plough Corp	Tricyclic compounds useful for inhibiting the function of protein - G and for the treatment of malignant diseases, and pharmaceutical preparations containing them
CZ84599A3 (cs)	1996-09-13	1999-07-14	Schering Corporation	Sloučeniny vhodné pro inhibici farnesyl protein transferasy
AU4337997A (en) *	1996-09-13	1998-04-02	Schering Corporation	Tricyclic inhibitors of farnesyl protein transferase
CA2293549C (en)	1997-06-17	2008-08-05	Schering Corporation	Phenyl-substituted tricyclic inhibitors of farnesyl-protein transferase

1997
- 1997-06-17 US US08/877,366 patent/US5939416A/en not_active Expired - Fee Related
1998
- 1998-06-15 CA CA002293711A patent/CA2293711C/en not_active Expired - Fee Related
- 1998-06-15 AT AT98932715T patent/ATE273307T1/de not_active IP Right Cessation
- 1998-06-15 DE DE69825608T patent/DE69825608T2/de not_active Expired - Lifetime
- 1998-06-15 EP EP98932715A patent/EP1019400B1/de not_active Expired - Lifetime
- 1998-06-15 JP JP50450099A patent/JP3258342B2/ja not_active Expired - Fee Related
- 1998-06-15 CN CN98808188A patent/CN1119345C/zh not_active Expired - Fee Related
- 1998-06-15 ZA ZA985211A patent/ZA985211B/xx unknown
- 1998-06-15 AU AU82533/98A patent/AU8253398A/en not_active Abandoned
- 1998-06-15 ES ES98932715T patent/ES2221989T3/es not_active Expired - Lifetime
- 1998-06-15 WO PCT/US1998/011505 patent/WO1998057970A1/en not_active Ceased
- 1998-06-16 AR ARP980102860A patent/AR012990A1/es unknown

Also Published As

Publication number	Publication date
WO1998057970A1 (en)	1998-12-23
AU8253398A (en)	1999-01-04
AR012990A1 (es)	2000-11-22
JP2000513034A (ja)	2000-10-03
CA2293711A1 (en)	1998-12-23
CA2293711C (en)	2004-08-24
ZA985211B (en)	1998-12-15
JP3258342B2 (ja)	2002-02-18
DE69825608D1 (de)	2004-09-16
EP1019400B1 (de)	2004-08-11
CN1267302A (zh)	2000-09-20
EP1019400A1 (de)	2000-07-19
CN1119345C (zh)	2003-08-27
US5939416A (en)	1999-08-17
ES2221989T3 (es)	2005-01-16
DE69825608T2 (de)	2005-08-04

Legal Events

Date	Code	Title	Description
2005-02-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE185341T1 (de)	1999-10-15	4,9-ethano-benzo(f)isoindolderivate als farnesyl transferase inhibitoren
ATE215541T1 (de)	2002-04-15	(imidazol-5-yl)methyl-2-chinolinoderivate als farnesyl protein transferase inhibitoren
NO996571L (no)	2000-02-23	Inhibitorer for farnesyl-protein-transferase
DE69907964D1 (de)	2003-06-18	1,2-annelierte chinolinderivate
DE69728676D1 (de)	2004-05-19	Substituierte 6,6-heterobicyclische derivate
ID29311A (id)	2001-08-16	Aturan penentuan quinolat posporibosil transferase
DE69933287D1 (de)	2006-11-02	12,13-modifizierte epothilon-derivate
PT1000048E (pt)	2003-03-31	Derivados substituidos do 1,2,3,4-tetrahidronaftaleno
DE69930518D1 (de)	2006-05-11	Als antikrebsmittel verwendbare alkinyl-substituierte chinolin-2-on-derivate
EE04309B1 (et)	2004-06-15	Farnesüül-proteiini transferaasi inhibiitorid
EE9800408A (et)	1999-06-15	Proteiinfarnesüültransferaasi inhibiitorid
EP0891350A4 (de)	2001-01-17	Inhibioten der farnesylprotein-transferase
DE69711020D1 (de)	2002-04-18	Thiazole derivate als protein kinase c inhibitoren
DE69924876D1 (de)	2005-05-25	Farnesyl protein transferase inhibitoren
EP0904080A4 (de)	2001-08-01	Inhibitoren der farnesyl-protein transferase
PT921125E (pt)	2002-06-28	Derivados de 1,38-triaza-espiro 4,5 decan-4-ona
ATE387448T1 (de)	2008-03-15	4,5-pyrazinoxindole als proteinkinasehemmer
ATE273307T1 (de)	2004-08-15	Benzo(5,6)cycloheptapyridin derivate anwendbar als farnesyl protein transferase inhibitoren
ATE240317T1 (de)	2003-05-15	Indolderivate als pkc-inhibitoren
EE200000447A (et)	2001-12-17	1,3,4-oksadiasolooni derivaadid
ATE273299T1 (de)	2004-08-15	Benzpyrido cycloheptan derivate mit farnesyl protein transferase inhibierender wirkung
EP1035852A4 (de)	2001-09-12	Hemmer von farnesyl-protein transferase
EP1035850A4 (de)	2001-09-12	Inhibitoren der farnesyl-protein transferase
EP0891353A4 (de)	2001-08-08	Farnesyl-protein transferase inhibitoren
EP1035849A4 (de)	2001-09-12	Farnesyl-protein transferase inhibitoren