ZA985211B - Benzo (5,6) cycloheptapyridine compounds useful as farnesyl protein transferase inhibitors - Google Patents

Benzo (5,6) cycloheptapyridine compounds useful as farnesyl protein transferase inhibitors

Info

Publication number
ZA985211B
ZA985211B ZA985211A ZA985211A ZA985211B ZA 985211 B ZA985211 B ZA 985211B ZA 985211 A ZA985211 A ZA 985211A ZA 985211 A ZA985211 A ZA 985211A ZA 985211 B ZA985211 B ZA 985211B
Authority
ZA
South Africa
Prior art keywords
cycloheptapyridine
benzo
compounds useful
protein transferase
transferase inhibitors
Prior art date
Application number
ZA985211A
Other languages
English (en)
Inventor
Dinanath F Rane
Stacy W Remiszewski
Ronald J Doll
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of ZA985211B publication Critical patent/ZA985211B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
ZA985211A 1997-06-17 1998-06-15 Benzo (5,6) cycloheptapyridine compounds useful as farnesyl protein transferase inhibitors ZA985211B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/877,366 US5939416A (en) 1997-06-17 1997-06-17 Benzo (5,6) cycloheptapyridine compounds useful as farnesyl protein transferase inhibitors

Publications (1)

Publication Number Publication Date
ZA985211B true ZA985211B (en) 1998-12-15

Family

ID=25369837

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA985211A ZA985211B (en) 1997-06-17 1998-06-15 Benzo (5,6) cycloheptapyridine compounds useful as farnesyl protein transferase inhibitors

Country Status (12)

Country Link
US (1) US5939416A (de)
EP (1) EP1019400B1 (de)
JP (1) JP3258342B2 (de)
CN (1) CN1119345C (de)
AR (1) AR012990A1 (de)
AT (1) ATE273307T1 (de)
AU (1) AU8253398A (de)
CA (1) CA2293711C (de)
DE (1) DE69825608T2 (de)
ES (1) ES2221989T3 (de)
WO (1) WO1998057970A1 (de)
ZA (1) ZA985211B (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6524832B1 (en) * 1994-02-04 2003-02-25 Arch Development Corporation DNA damaging agents in combination with tyrosine kinase inhibitors
US6632455B2 (en) 1997-12-22 2003-10-14 Schering Corporation Molecular dispersion composition with enhanced bioavailability
US6271378B1 (en) 1998-12-18 2001-08-07 Schering Corporation Process for preparing tricyclic compounds having antihistaminic activity
US6316462B1 (en) 1999-04-09 2001-11-13 Schering Corporation Methods of inducing cancer cell death and tumor regression
ES2291368T3 (es) 2000-11-29 2008-03-01 Schering Corporation Inhibidores de la farnesil protein transferasa.
WO2005089518A2 (en) * 2004-03-18 2005-09-29 The Brigham And Women's Hospital, Inc. Uch-l1 expression and cancer therapy
CA2559282A1 (en) * 2004-03-18 2005-09-29 Brigham And Women's Hospital, Inc. Methods for the treatment of synucleinopathies
US20060194821A1 (en) * 2005-02-18 2006-08-31 The Brigham And Women's Hospital, Inc. Compounds inhibiting the aggregation of superoxide dismutase-1
US20070148660A1 (en) * 2005-06-16 2007-06-28 The Regents Of The University Of California Treatment of maladaptive substance use with H-ras antagonists
WO2009151683A2 (en) 2008-03-12 2009-12-17 Link Medicine Corporation Quinolinone farnesyl transferase inhibitors for the treatment of synucleinopathies and other indications
JP2012508768A (ja) 2008-11-13 2012-04-12 リンク・メディスン・コーポレーション アザキノリノン誘導体及びその使用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5089496A (en) * 1986-10-31 1992-02-18 Schering Corporation Benzo[5,6]cycloheptapyridine compounds, compositions and method of treating allergies
US5721236A (en) * 1993-10-15 1998-02-24 Schering Corporation Tricyclic carbamate compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
IL111235A (en) * 1993-10-15 2001-03-19 Schering Plough Corp Medicinal preparations for inhibiting protein G activity and for the treatment of malignant diseases, containing tricyclic compounds, some such new compounds and a process for the preparation of some of them
US5719148A (en) * 1993-10-15 1998-02-17 Schering Corporation Tricyclic amide and urea compounds useful for inhibition of g-protein function and for treatment of proliferative diseases
US5700806A (en) * 1995-03-24 1997-12-23 Schering Corporation Tricyclic amide and urea compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
IL117798A (en) 1995-04-07 2001-11-25 Schering Plough Corp Tricyclic compounds useful for inhibiting the function of protein - G and for the treatment of malignant diseases, and pharmaceutical preparations containing them
IL117797A0 (en) 1995-04-07 1996-08-04 Pharmacopeia Inc Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
SK33699A3 (en) * 1996-09-13 2000-03-13 Schering Corp Tricyclic compounds useful for inhibition of farnesyl protein transferase
CN1104427C (zh) * 1996-09-13 2003-04-02 先灵公司 法呢基蛋白转移酶的三环抑制剂
IL133446A0 (en) 1997-06-17 2001-04-30 Schering Corp Novel phenyl-substituted tricyclic inhibitors of farnesyl-protein transferase

Also Published As

Publication number Publication date
CA2293711A1 (en) 1998-12-23
CA2293711C (en) 2004-08-24
DE69825608D1 (de) 2004-09-16
JP2000513034A (ja) 2000-10-03
AU8253398A (en) 1999-01-04
CN1119345C (zh) 2003-08-27
CN1267302A (zh) 2000-09-20
DE69825608T2 (de) 2005-08-04
EP1019400B1 (de) 2004-08-11
ATE273307T1 (de) 2004-08-15
US5939416A (en) 1999-08-17
AR012990A1 (es) 2000-11-22
ES2221989T3 (es) 2005-01-16
JP3258342B2 (ja) 2002-02-18
WO1998057970A1 (en) 1998-12-23
EP1019400A1 (de) 2000-07-19

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