ATE273318T1 - Uber urethangruppen gebundene, gst-spezifische freisetzungssysteme für moleküle - Google Patents

Uber urethangruppen gebundene, gst-spezifische freisetzungssysteme für moleküle

Info

Publication number: ATE273318T1
Authority: AT; Austria
Prior art keywords: glu; gly; asp; formula; gst
Prior art date: 1995-06-07

Application number

AT96918420T

Other languages

English (en)

Inventor

Lawrence M Kauvar

Matthew H Lyttle

Apparao Satyam

Original Assignee

Telik Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-06-07

Filing date

1996-06-07

Publication date

2004-08-15

1996-06-07 Application filed by Telik Inc filed Critical Telik Inc

2004-08-15 Application granted granted Critical

2004-08-15 Publication of ATE273318T1 publication Critical patent/ATE273318T1/de

Links

JOYRKODLDBILNP-UHFFFAOYSA-N Ethyl urethane Chemical group CCOC(N)=O JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 title 1
229910052760 oxygen Inorganic materials 0.000 abstract 5
CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 abstract 2
ZTEDWFWBGPKUOD-UHFFFAOYSA-N L-beta-aspartyl-L-glycine Chemical compound OC(=O)C(N)CC(=O)NCC(O)=O ZTEDWFWBGPKUOD-UHFFFAOYSA-N 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
229910052711 selenium Inorganic materials 0.000 abstract 2
229910052717 sulfur Inorganic materials 0.000 abstract 2
JHFNSBBHKSZXKB-VKHMYHEASA-N Asp-Gly Chemical compound OC(=O)C[C@H](N)C(=O)NCC(O)=O JHFNSBBHKSZXKB-VKHMYHEASA-N 0.000 abstract 1
LSPKYLAFTPBWIL-BYPYZUCNSA-N Glu-Gly Chemical compound OC(=O)CC[C@H](N)C(=O)NCC(O)=O LSPKYLAFTPBWIL-BYPYZUCNSA-N 0.000 abstract 1
102000005720 Glutathione transferase Human genes 0.000 abstract 1
108010070675 Glutathione transferase Proteins 0.000 abstract 1
WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 abstract 1
ACIJGUBIMXQCMF-UHFFFAOYSA-N N-L-gamma-glutamyl-glycine Natural products OC(=O)C(N)CCC(=O)NCC(O)=O ACIJGUBIMXQCMF-UHFFFAOYSA-N 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
150000001408 amides Chemical class 0.000 abstract 1
150000001413 amino acids Chemical class 0.000 abstract 1
108010047857 aspartylglycine Proteins 0.000 abstract 1
KXAWLANLJYMEGB-UHFFFAOYSA-N beta-Asp-Asp Natural products OC(=O)C(N)CC(=O)NC(C(O)=O)CC(O)=O KXAWLANLJYMEGB-UHFFFAOYSA-N 0.000 abstract 1
108010056625 beta-aspartylglycine Proteins 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
ACIJGUBIMXQCMF-BYPYZUCNSA-N gamma-Glu-Gly Chemical compound OC(=O)[C@@H](N)CCC(=O)NCC(O)=O ACIJGUBIMXQCMF-BYPYZUCNSA-N 0.000 abstract 1
QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
229940002612 prodrug Drugs 0.000 abstract 1
239000000651 prodrug Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1
PIZNQHDTOZMVBH-UHFFFAOYSA-N thionylimide Chemical compound N=S=O PIZNQHDTOZMVBH-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0215—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing natural amino acids, forming a peptide bond via their side chain functional group, e.g. epsilon-Lys, gamma-Glu
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Materials For Medical Uses (AREA)

AT96918420T 1995-06-07 1996-06-07 Uber urethangruppen gebundene, gst-spezifische freisetzungssysteme für moleküle ATE273318T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/476,119 US5908919A (en)	1993-10-01	1995-06-07	Urethane mediated, GST specific molecular release systems
PCT/US1996/009831 WO1996040739A2 (en)	1995-06-07	1996-06-07	Urethane mediated, gst specific molecular release systems

Publications (1)

Publication Number	Publication Date
ATE273318T1 true ATE273318T1 (de)	2004-08-15

Family

ID=23890586

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT96918420T ATE273318T1 (de)	1995-06-07	1996-06-07	Uber urethangruppen gebundene, gst-spezifische freisetzungssysteme für moleküle

Country Status (10)

Country	Link
US (1)	US5908919A (de)
EP (1)	EP0832101B1 (de)
JP (1)	JPH11507370A (de)
AT (1)	ATE273318T1 (de)
AU (1)	AU722595B2 (de)
CA (1)	CA2224191A1 (de)
DE (1)	DE69633126T2 (de)
DK (1)	DK0832101T3 (de)
ES (1)	ES2227592T3 (de)
WO (1)	WO1996040739A2 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5880097A (en) *	1996-01-04	1999-03-09	Terrapin Techologies, Inc.	Tethered prodrugs
US7462605B2 (en)	1998-01-23	2008-12-09	Celmed Oncology (Usa), Inc.	Phosphoramidate compounds and methods of use
AU753155B2 (en)	1998-01-23	2002-10-10	Kiadis Pharma Intellectual Property B.V.	Enzyme catalyzed therapeutic agents
US6683061B1 (en)	1999-07-22	2004-01-27	Newbiotics, Inc.	Enzyme catalyzed therapeutic activation
BR0012676A (pt)	1999-07-22	2003-07-01	Newbiotics Inc	Métodos para tratamento de tumores resistentes a terapia
US7172905B2 (en) *	2001-08-07	2007-02-06	The University Of Chicago	Polypeptide immobilization
AU2003247907A1 (en) *	2002-07-05	2004-01-23	University Of Chicago	Characterization of biochips containing self-assembled monolayers with maldi-tof-ms
DE602006003064D1 (en) *	2005-01-06	2008-11-20	Telik Inc	Tripeptid- und tetrapeptid-thioether
ES2584381T3 (es) *	2010-05-05	2016-09-27	Prolynx Llc	Liberación controlada de compuestos activos desde conjugados macromoleculares

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS60255789A (ja) *	1984-06-01	1985-12-17	Kyowa Hakko Kogyo Co Ltd	マイトマイシン誘導体，その製造法および抗腫瘍剤
DE3586772T2 (de) *	1984-07-24	1993-03-04	Coselco Mimotopes Pty Ltd	Verfahren zur bestimmung von mimotopen.
WO1986006487A1 (en) *	1985-04-22	1986-11-06	Commonwealth Serum Laboratories Commission	Method for determining mimotopes
WO1987004440A1 (en) *	1986-01-23	1987-07-30	Pfizer Inc.	Heptanoyl-glu-asp-ala-amino acid immunostimulants
US4963263A (en) *	1988-03-24	1990-10-16	Terrapin Technologies, Inc.	Method of identity analyte-binding peptides
US5133866A (en) *	1988-03-24	1992-07-28	Terrapin Technologies, Inc.	Method to identify analyte-bending ligands
WO1990012088A1 (en) *	1989-04-13	1990-10-18	The United States Of America, As Represented By The Secretary, U.S. Department Of Commerce	MONOCLONAL ANTIBODIES TO HUMAN GLUTATHIONE S TRANSFERASE Pi
JP2919867B2 (ja) *	1989-09-27	1999-07-19	千寿製薬株式会社	抗腫瘍剤
ES2058050T3 (es) *	1990-05-07	1996-02-16	Dade Int Inc	Metodo y aparato para la realizacion de ensayos de citotoxicidad sobre celulas tumorales humanas.
US5204241A (en) *	1990-10-22	1993-04-20	Oxi-Gene Inc.	Glutathione-S-transferase mu as a measure of drug resistance
WO1992019767A1 (en) *	1991-04-29	1992-11-12	Terrapin Technologies, Inc.	Methods to profile and treat abnormal cells
US5786336A (en) *	1991-04-29	1998-07-28	Terrapin Technologies, Inc.	Target-selective protocols based on mimics
US5545621A (en) *	1991-04-29	1996-08-13	Terrapin Technologies, Inc.	Glutathione S-transferase-activated compounds
US5556942A (en) *	1991-04-29	1996-09-17	Terrapin Technologies, Inc.	Glutathione S-transferase-activated compounds
US5430045A (en) *	1992-04-23	1995-07-04	Free Radical Sciences, Inc.	Method of reducing or preventing bone marrow hypoplasia
AU4406793A (en) *	1992-06-04	1993-12-30	Clover Consolidated, Limited	Water-soluble polymeric carriers for drug delivery

1995
- 1995-06-07 US US08/476,119 patent/US5908919A/en not_active Expired - Fee Related
1996
- 1996-06-07 EP EP96918420A patent/EP0832101B1/de not_active Expired - Lifetime
- 1996-06-07 CA CA002224191A patent/CA2224191A1/en not_active Withdrawn
- 1996-06-07 ES ES96918420T patent/ES2227592T3/es not_active Expired - Lifetime
- 1996-06-07 DK DK96918420T patent/DK0832101T3/da active
- 1996-06-07 JP JP9502035A patent/JPH11507370A/ja active Pending
- 1996-06-07 DE DE69633126T patent/DE69633126T2/de not_active Expired - Fee Related
- 1996-06-07 WO PCT/US1996/009831 patent/WO1996040739A2/en not_active Ceased
- 1996-06-07 AU AU61088/96A patent/AU722595B2/en not_active Ceased
- 1996-06-07 AT AT96918420T patent/ATE273318T1/de not_active IP Right Cessation

Also Published As

Publication number	Publication date
DE69633126T2 (de)	2005-08-11
JPH11507370A (ja)	1999-06-29
US5908919A (en)	1999-06-01
EP0832101B1 (de)	2004-08-11
EP0832101A2 (de)	1998-04-01
CA2224191A1 (en)	1996-12-19
DK0832101T3 (da)	2004-11-29
WO1996040739A2 (en)	1996-12-19
WO1996040739A3 (en)	1997-01-30
ES2227592T3 (es)	2005-04-01
AU722595B2 (en)	2000-08-10
DE69633126D1 (de)	2004-09-16
AU6108896A (en)	1996-12-30

Legal Events

Date	Code	Title	Description
2005-02-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE69424298D1 (de)	2000-06-08	Durch glutathion-s-transferase aktivierte verbindungen
DK0570594T3 (de)	1997-08-25
AU578781B2 (en)	1988-11-03	Novel peptide derivatives having a nitrogenous polycyclic structure, process for the preparation thereof and pharmaceutical compositions containing them
DE69633126D1 (de)	2004-09-16	Uber urethangruppen gebundene, gst-spezifische freisetzungssysteme für moleküle
CA2229077A1 (en)	1997-12-18	Lipid metabolism improving agent
UA66768C2 (uk)	2004-06-15	Гербіцидний засіб на основі арилсульфоніламінокарбонілтриазолінону
CA2238140A1 (en)	1992-08-02	Imidazole, triazole and tetrazole derivatives
DK0749424T3 (da)	2001-11-26	Naphthalenderivater som prostaglandin-I2-agonister
NO924929L (no)	1992-12-18	Farmasoeytisk aktive benzoquinazolinforbindelser
CA2171836A1 (en)	1995-03-23	Crystalline anhydrous mycophenolate mofetil and intravenous formulation thereof
KR870700067A (ko)	1987-02-28	피리도(2,3-d)-피리미딘 유도체
HUP9801156A2 (hu)	1998-09-28	Karbapenem-3-karbonsav-észter-származékok
IE820039L (en)	1982-07-10	Pharmaceutically active amides
JPS5461151A (en)	1979-05-17	Novel aminoglycoside derivative
EP1020447A4 (de)	2000-11-15	Pyrazolderivate und pflanzenschutzmittel
FI934933A0 (fi)	1993-11-08	Foerfarande foer framstaellning av ergolinderivat
RU94046387A (ru)	1996-09-27	Производные пиримидина, способ их получения, фармацевтическая композиция, ее применение и промежуточные продукты
HU9300202D0 (en)	1993-04-28	Benzo-pyrane derivatives, pharmaceutical preparatives containing them as active substance as well as method for producing them
AU6117698A (en)	1998-10-12	Antiviral agents
AU5715894A (en)	1994-07-19	Methotrexate derivative
AU6257396A (en)	1997-01-15	Tetrahydrofuran antifungals
CA2211681A1 (en)	1996-01-30	Novel pyridonecarboxylic acid derivatives or salts thereof and antibacterial agents comprising the same as active ingredient
AU740079C (en)	2002-05-02	Antirheumatic agents
KR970701728A (ko)	1997-04-12	펩티드 유도체
BG104554A (en)	2001-05-31	Thermodynamically stable form of (r)-3-[(-4-fluorophenyl) sulphonyl]amino 1,2,3,4-tetrahydro-9h-carbazole-9-propanoic acid (ramatroban)