ATE273320T1 - Fusogene liposomen - Google Patents
Fusogene liposomenInfo
- Publication number
- ATE273320T1 ATE273320T1 AT97915236T AT97915236T ATE273320T1 AT E273320 T1 ATE273320 T1 AT E273320T1 AT 97915236 T AT97915236 T AT 97915236T AT 97915236 T AT97915236 T AT 97915236T AT E273320 T1 ATE273320 T1 AT E273320T1
- Authority
- AT
- Austria
- Prior art keywords
- fusogenic liposomes
- liposomes
- virosomal
- virosomes
- liposomal
- Prior art date
Links
- 239000002502 liposome Substances 0.000 title abstract 2
- 230000000799 fusogenic effect Effects 0.000 title 1
- 108091005461 Nucleic proteins Proteins 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 239000000277 virosome Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
- A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmacology & Pharmacy (AREA)
- Dispersion Chemistry (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Virology (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Manufacturing Of Micro-Capsules (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1529296P | 1996-04-11 | 1996-04-11 | |
| PCT/CA1997/000245 WO1997038010A2 (en) | 1996-04-11 | 1997-04-10 | Fusogenic liposomes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE273320T1 true ATE273320T1 (de) | 2004-08-15 |
Family
ID=21770580
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT97915236T ATE273320T1 (de) | 1996-04-11 | 1997-04-10 | Fusogene liposomen |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US6417326B1 (de) |
| EP (1) | EP0910576B1 (de) |
| AT (1) | ATE273320T1 (de) |
| AU (1) | AU2284697A (de) |
| CA (1) | CA2252055C (de) |
| DE (1) | DE69730218D1 (de) |
| WO (1) | WO1997038010A2 (de) |
Families Citing this family (77)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030113347A1 (en) * | 1991-05-08 | 2003-06-19 | Schweiz. Serum- & Impfinstitut Bern | Immunostimulating and immunopotentiating reconstituted influenza virosomes and vaccines containing them |
| US5981501A (en) * | 1995-06-07 | 1999-11-09 | Inex Pharmaceuticals Corp. | Methods for encapsulating plasmids in lipid bilayers |
| US7422902B1 (en) * | 1995-06-07 | 2008-09-09 | The University Of British Columbia | Lipid-nucleic acid particles prepared via a hydrophobic lipid-nucleic acid complex intermediate and use for gene transfer |
| WO1997038010A2 (en) | 1996-04-11 | 1997-10-16 | The University Of British Columbia | Fusogenic liposomes |
| CA2289702C (en) * | 1997-05-14 | 2008-02-19 | Inex Pharmaceuticals Corp. | High efficiency encapsulation of charged therapeutic agents in lipid vesicles |
| GB9721901D0 (en) * | 1997-10-16 | 1997-12-17 | Univ Manchester | Particles |
| AU1656799A (en) * | 1997-12-12 | 1999-07-05 | Inex Pharmaceuticals Corp. | Cationic drugs encapsulated in anionic liposomes |
| IL126681A0 (en) * | 1998-10-21 | 1999-08-17 | Opperbas Holding Bv | Treatment of trauma-related conditions |
| US7094423B1 (en) * | 1999-07-15 | 2006-08-22 | Inex Pharmaceuticals Corp. | Methods for preparation of lipid-encapsulated therapeutic agents |
| US20050249794A1 (en) * | 1999-08-27 | 2005-11-10 | Semple Sean C | Compositions for stimulating cytokine secretion and inducing an immune response |
| WO2001080900A2 (en) * | 2000-04-20 | 2001-11-01 | The University Of British Columbia | Enhanced stabilised plasmid-lipid particle-mediated transfection using endosomal membrane |
| US7189705B2 (en) | 2000-04-20 | 2007-03-13 | The University Of British Columbia | Methods of enhancing SPLP-mediated transfection using endosomal membrane destabilizers |
| GB0100196D0 (en) * | 2001-01-04 | 2001-02-14 | Anmat Technology Ltd | Peptides |
| EP1852126B1 (de) * | 2001-03-27 | 2013-05-15 | Oncothyreon Inc. | Impfstoff zur Modulation zwischen T1 und T2 Immunantworten |
| ES2424131T3 (es) * | 2001-03-27 | 2013-09-27 | Oncothyreon Inc. | Vacuna para modular respuestas inmunitarias entre T1 y T2 |
| WO2002087541A1 (en) * | 2001-04-30 | 2002-11-07 | Protiva Biotherapeutics Inc. | Lipid-based formulations for gene transfer |
| WO2003039595A2 (en) * | 2001-11-07 | 2003-05-15 | Inex Pharmaceuticals Corporation | Mucosal adjuvants comprising an oligonucleotide and a cationic lipid |
| US20040009944A1 (en) * | 2002-05-10 | 2004-01-15 | Inex Pharmaceuticals Corporation | Methylated immunostimulatory oligonucleotides and methods of using the same |
| US20040013649A1 (en) * | 2002-05-10 | 2004-01-22 | Inex Pharmaceuticals Corporation | Cancer vaccines and methods of using the same |
| US20060193905A1 (en) * | 2002-05-14 | 2006-08-31 | University Of Louisville Research Foundation, Inc. | Direct cellular energy delivery system |
| US7056529B2 (en) * | 2002-05-14 | 2006-06-06 | University Of Louisville Research Foundation, Inc. | Direct cellular energy delivery system |
| DK1551876T3 (da) | 2002-10-16 | 2011-06-14 | Purdue Pharma Lp | Antistoffer, der binder til celle-associerede ca 125/0722P og fremgangsmåder til anvendelse deraf |
| EP1618897A4 (de) * | 2003-04-04 | 2010-09-29 | Eisai R&D Man Co Ltd | Lipidmembran-struktur mit anti-mt-mmp-monoklonalem antikörper |
| KR20060015534A (ko) * | 2003-04-25 | 2006-02-17 | 더 펜 스테이트 리서치 파운데이션 | 성장 억제, 지질 유래된 생활성 화합물의 전신 전달을 위한방법 및 시스템 |
| TWI329130B (en) * | 2003-06-19 | 2010-08-21 | Bestewil Holding Bv | Functionally reconstituted viral membranes containing adjuvant |
| EP1676588B1 (de) * | 2003-10-01 | 2013-12-11 | Japan Science and Technology Agency | Polyarginin-modifiziertes Liposom, welches zellkerngängig ist |
| CA2542099A1 (en) * | 2003-10-11 | 2005-04-21 | Inex Pharmaceuticals Corporation | Methods and compositions for enhancing innate immunity and antibody dependent cellular cytotoxicity |
| US20050214356A1 (en) * | 2004-03-24 | 2005-09-29 | Joyce Timothy H | Self assembling activation agents targeted using active drug release |
| TW201204410A (en) | 2004-04-01 | 2012-02-01 | Oncothyreon Inc | Mucinous glycoprotein (MUC-1) vaccine |
| US8658203B2 (en) | 2004-05-03 | 2014-02-25 | Merrimack Pharmaceuticals, Inc. | Liposomes useful for drug delivery to the brain |
| KR101462825B1 (ko) | 2004-05-03 | 2014-11-21 | 헤르메스 바이오사이언스, 인코포레이티드 | 약물 전달에 유용한 리포좀 |
| JP4692983B2 (ja) * | 2004-07-12 | 2011-06-01 | 独立行政法人科学技術振興機構 | リポソーム封入物質がエンドソームから脱出可能なリポソーム |
| US20080051323A1 (en) * | 2004-08-21 | 2008-02-28 | Kosak Kenneth M | Chloroquine drug compositions and methods for their synthesis |
| US20060045910A1 (en) * | 2004-09-02 | 2006-03-02 | Ehringer William D | Preserved fusogenic vesicles |
| US20060134189A1 (en) * | 2004-11-17 | 2006-06-22 | Protiva Biotherapeutics, Inc | siRNA silencing of apolipoprotein B |
| PT2366400E (pt) | 2005-06-28 | 2016-02-02 | Oncothyreon Inc | Método de tratamento de doentes com uma vacina à base de glicoproteína mucinosa (muc-1) |
| EP1948674A4 (de) | 2005-11-02 | 2009-02-04 | Protiva Biotherapeutics Inc | Modifizierte sirna-moleküle und anwendungen davon |
| WO2008105178A1 (ja) * | 2007-02-28 | 2008-09-04 | National University Corporation Hokkaido University | リポソーム用生体成分抵抗性増強剤及びこれにより修飾されたリポソーム |
| KR100890317B1 (ko) * | 2008-05-08 | 2009-03-26 | 고려대학교 산학협력단 | 플라티늄 항암제 조성물 및 제제 |
| EP2123258A1 (de) * | 2008-05-23 | 2009-11-25 | Liplasome Pharma A/S | Liposomen zur Arzneimittelverabreichung |
| JP5781929B2 (ja) * | 2008-07-15 | 2015-09-24 | ノバルティス アーゲー | 免疫原性の両親媒性ペプチド組成物 |
| WO2010135714A2 (en) | 2009-05-22 | 2010-11-25 | The Methodist Hospital Research Institute | Methods for modulating adipocyte expression using microrna compositions |
| EP2449106B1 (de) | 2009-07-01 | 2015-04-08 | Protiva Biotherapeutics Inc. | Zusammensetzungen und verfahren zur ausschaltung von apolipoprotein b |
| SI2506857T1 (en) | 2009-12-01 | 2018-08-31 | Translate Bio, Inc. | Delivery of mRNA for the enrichment of proteins and enzymes in human genetic diseases |
| JP5911870B2 (ja) | 2010-08-31 | 2016-04-27 | ノバルティス アーゲー | 免疫原をコードするｒｎａの送達のためのｐｅｇ化リポソーム |
| US8853377B2 (en) | 2010-11-30 | 2014-10-07 | Shire Human Genetic Therapies, Inc. | mRNA for use in treatment of human genetic diseases |
| JP2014518841A (ja) | 2011-02-24 | 2014-08-07 | オンコシレオン インク． | アジュバントを備えたｍｕｃ１ベースのグリコリポペプチドワクチン |
| CN103561725B (zh) * | 2011-03-14 | 2018-08-31 | 国立大学法人北海道大学 | 用于肺递送的载体、导入剂及用途 |
| EP2696678B1 (de) * | 2011-04-15 | 2019-11-20 | Molecular Transfer, Inc. | Mittel zur verbesserten verabreichung von nukleinsäuren in eukaryotische zellen |
| KR20220025112A (ko) | 2011-06-08 | 2022-03-03 | 샤이어 휴먼 지네틱 테라피즈 인크. | Mrna 전달을 위한 지질 나노입자 조성물 및 방법 |
| EP3424564A1 (de) | 2011-10-31 | 2019-01-09 | Mallinckrodt LLC | Kombinatorische liposomzusammensetzungen zur krebstherapie |
| US9080144B2 (en) * | 2012-05-10 | 2015-07-14 | Muhammad Naveed Yousaf | Compositions and methods for promoting liposomal and cellular adhesion |
| EP3536787A1 (de) | 2012-06-08 | 2019-09-11 | Translate Bio, Inc. | Nukleaseresistente polynukleotide und verwendungen davon |
| US10155780B2 (en) | 2012-10-29 | 2018-12-18 | Molecular Transfer, Inc. | Polycationic methyl phospholipids for improved delivery of nucleic acids to eukaryotic cells |
| US8999925B2 (en) * | 2013-02-26 | 2015-04-07 | The Administrators Of The Tulane Educational Fund | Arenavirus inhibiting peptides and uses therefor |
| EA201591229A1 (ru) | 2013-03-14 | 2016-01-29 | Шир Хьюман Дженетик Терапис, Инк. | Способы очистки матричной рнк |
| KR102311614B1 (ko) | 2013-03-14 | 2021-10-08 | 샤이어 휴먼 지네틱 테라피즈 인크. | Cftr mrna 조성물 및 관련 방법 및 사용 |
| WO2014197991A1 (en) | 2013-06-12 | 2014-12-18 | Muhammad Yousaf | Compounds for promoting liposomal and cellular adhesion and compositions and methods of use thereof |
| ES2707966T3 (es) | 2013-10-22 | 2019-04-08 | Translate Bio Inc | Terapia de ARNm para la deficiencia en síntesis de argininosuccinato |
| EP3574923A1 (de) | 2013-10-22 | 2019-12-04 | Translate Bio, Inc. | Mrna-therapie für phenylketonurie |
| EP2910239A1 (de) * | 2014-02-20 | 2015-08-26 | Universitat Autònoma De Barcelona | Neue Zusammensetzungen aus lipidbeschichteten Bakteriophagen |
| EP4729528A3 (de) | 2014-04-25 | 2026-06-24 | Translate Bio, Inc. | Verfahren zur reinigung von messenger-rna |
| US9968683B2 (en) | 2014-12-17 | 2018-05-15 | Organolinx Corp. | Method for conjugating molecules |
| ES3036518T3 (en) | 2015-10-16 | 2025-09-19 | Ipsen Biopharm Ltd | Stabilizing camptothecin pharmaceutical compositions |
| CN105801668B (zh) * | 2016-04-01 | 2020-08-07 | 天津大学 | 一种寡聚精氨酸修饰的磷脂与其组装的纳米粒及制备方法和应用 |
| CN109996809A (zh) | 2016-11-14 | 2019-07-09 | 诺华股份有限公司 | 与促融合蛋白minion相关的组合物、方法和治疗用途 |
| MX2019010155A (es) | 2017-02-27 | 2020-12-10 | Translate Bio Inc | Arnm de cftr optimizado por codón novedoso. |
| IL270631B2 (en) | 2017-05-16 | 2024-03-01 | Translate Bio Inc | Treatment of cystic fibrosis by delivery of codon-optimized mrna encoding cftr |
| US11389405B2 (en) | 2017-09-18 | 2022-07-19 | North Carolina State University | Artificial beta cells and methods of use thereof |
| US10849924B2 (en) | 2017-09-26 | 2020-12-01 | New York Medical College | Compositions and methods for restoring endothelial glycocalyx |
| US11174500B2 (en) | 2018-08-24 | 2021-11-16 | Translate Bio, Inc. | Methods for purification of messenger RNA |
| AU2019384557B2 (en) | 2018-11-21 | 2025-07-17 | Translate Bio, Inc. | Treatment of cystic fibrosis by delivery of nebulized mRNA encoding CFTR |
| CA3155003A1 (en) | 2019-09-20 | 2021-03-25 | Translate Bio, Inc. | Mrna encoding engineered cftr |
| WO2023231959A2 (en) | 2022-05-30 | 2023-12-07 | Shanghai Circode Biomed Co., Ltd | Synthetic circular rna compositions and methods of use thereof |
| US12297285B2 (en) | 2022-06-24 | 2025-05-13 | Orna Therapeutics, Inc. | Circular RNA encoding chimeric antigen receptors targeting BCMA |
| TW202428289A (zh) | 2022-11-08 | 2024-07-16 | 美商歐納醫療公司 | 環狀rna組合物 |
| WO2025101976A1 (en) * | 2023-11-09 | 2025-05-15 | Mercury Bio, Inc. | Chimeric yeast extracellular vesicles for the enhanced delivery of therapeutic molecules to cells |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS4814798B1 (de) * | 1968-12-26 | 1973-05-10 | ||
| DE2455623C3 (de) * | 1974-11-23 | 1981-04-23 | Hoechst Ag, 6000 Frankfurt | Verfahren zur Herstellung von N-Acylaminocarbonsäurepoyläthylenglykolestern |
| JPH0816066B2 (ja) * | 1986-07-18 | 1996-02-21 | エーザイ株式会社 | 持続性薬効製剤 |
| JP2893191B2 (ja) * | 1988-11-08 | 1999-05-17 | 武田薬品工業株式会社 | 放出制御性マトリックス剤 |
| FR2658521B1 (fr) * | 1990-02-19 | 1994-01-21 | Serbioo | Bipeptides symetriques comportant un reste polyalkyleneglycol, procede de preparation et utilisation dans le dosage des proteases. |
| JP2604268B2 (ja) | 1990-04-09 | 1997-04-30 | 富士写真フイルム株式会社 | ペプチド誘導体両親媒性化合物、その中間体、ペプチド誘導体両親媒性化合物を用いたリポソームおよび薄膜 |
| US5372807A (en) | 1990-05-14 | 1994-12-13 | University Of Medicine And Dentistry Of New Jersey | Polymers containing antifibrotic agents, compositions containing such polymers, and methods of preparation and use |
| US5229366A (en) | 1990-10-23 | 1993-07-20 | Fuji Photo Film Co., Ltd. | Peptide-containing polyethylene glycol derivatives and application thereof |
| JPH04208296A (ja) * | 1990-11-30 | 1992-07-29 | Fuji Photo Film Co Ltd | ペプチド誘導体 |
| US5652274A (en) * | 1991-03-01 | 1997-07-29 | Martin; Alain | Therapeutic-wound healing compositions and methods for preparing and using same |
| JPH04297494A (ja) * | 1991-03-26 | 1992-10-21 | Fuji Photo Film Co Ltd | ペプチド誘導体とその用途 |
| GB9120653D0 (en) * | 1991-09-27 | 1991-11-06 | Procter & Gamble | Dispensing agent |
| US5580563A (en) | 1992-05-01 | 1996-12-03 | Tam; James P. | Multiple antigen peptide system having adjuvant properties, vaccines prepared therefrom and methods of use thereof |
| US5885613A (en) * | 1994-09-30 | 1999-03-23 | The University Of British Columbia | Bilayer stabilizing components and their use in forming programmable fusogenic liposomes |
| US5693609A (en) * | 1994-11-17 | 1997-12-02 | Eli Lilly And Company | Acylated insulin analogs |
| WO1997038010A2 (en) | 1996-04-11 | 1997-10-16 | The University Of British Columbia | Fusogenic liposomes |
-
1997
- 1997-04-10 WO PCT/CA1997/000245 patent/WO1997038010A2/en not_active Ceased
- 1997-04-10 CA CA002252055A patent/CA2252055C/en not_active Expired - Fee Related
- 1997-04-10 AT AT97915236T patent/ATE273320T1/de not_active IP Right Cessation
- 1997-04-10 US US08/835,281 patent/US6417326B1/en not_active Expired - Fee Related
- 1997-04-10 DE DE69730218T patent/DE69730218D1/de not_active Expired - Lifetime
- 1997-04-10 EP EP97915236A patent/EP0910576B1/de not_active Expired - Lifetime
- 1997-04-10 AU AU22846/97A patent/AU2284697A/en not_active Abandoned
-
2002
- 2002-06-05 US US10/164,967 patent/US7205273B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CA2252055C (en) | 2007-01-16 |
| WO1997038010A3 (en) | 1998-02-05 |
| EP0910576B1 (de) | 2004-08-11 |
| CA2252055A1 (en) | 1997-10-16 |
| DE69730218D1 (de) | 2004-09-16 |
| US20030125517A1 (en) | 2003-07-03 |
| US7205273B2 (en) | 2007-04-17 |
| AU2284697A (en) | 1997-10-29 |
| EP0910576A2 (de) | 1999-04-28 |
| US6417326B1 (en) | 2002-07-09 |
| WO1997038010A2 (en) | 1997-10-16 |
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