ATE295722T1 - Zielgerichtete liposomen zur verabreichung von genen - Google Patents

Zielgerichtete liposomen zur verabreichung von genen

Info

Publication number
ATE295722T1
ATE295722T1 AT98958643T AT98958643T ATE295722T1 AT E295722 T1 ATE295722 T1 AT E295722T1 AT 98958643 T AT98958643 T AT 98958643T AT 98958643 T AT98958643 T AT 98958643T AT E295722 T1 ATE295722 T1 AT E295722T1
Authority
AT
Austria
Prior art keywords
targeted liposomes
gene administration
virus
gene
administration
Prior art date
Application number
AT98958643T
Other languages
English (en)
Inventor
Esther H Chang
Liang Xu
Kathleen Pirollo
Original Assignee
Univ Georgetown
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Georgetown filed Critical Univ Georgetown
Application granted granted Critical
Publication of ATE295722T1 publication Critical patent/ATE295722T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
    • A61K48/0025—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
AT98958643T 1997-11-19 1998-11-19 Zielgerichtete liposomen zur verabreichung von genen ATE295722T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US6618897P 1997-11-19 1997-11-19
US8317598P 1998-04-27 1998-04-27
PCT/US1998/024657 WO1999025320A1 (en) 1997-11-19 1998-11-19 Targeted liposome gene delivery

Publications (1)

Publication Number Publication Date
ATE295722T1 true ATE295722T1 (de) 2005-06-15

Family

ID=26746455

Family Applications (2)

Application Number Title Priority Date Filing Date
AT01123562T ATE459340T1 (de) 1997-11-19 1998-11-19 Zielgerichtete liposomen zur verabreichung von genen
AT98958643T ATE295722T1 (de) 1997-11-19 1998-11-19 Zielgerichtete liposomen zur verabreichung von genen

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT01123562T ATE459340T1 (de) 1997-11-19 1998-11-19 Zielgerichtete liposomen zur verabreichung von genen

Country Status (12)

Country Link
EP (2) EP1166775B1 (de)
JP (2) JP2001522871A (de)
CN (3) CN1191094C (de)
AT (2) ATE459340T1 (de)
AU (1) AU759164C (de)
CA (1) CA2308584C (de)
DE (2) DE69841536D1 (de)
DK (1) DK1166775T3 (de)
ES (1) ES2339421T3 (de)
HK (1) HK1045641B (de)
PT (1) PT1166775E (de)
WO (1) WO1999025320A1 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU3703100A (en) 1999-02-22 2000-09-14 Georgetown University Antibody fragment-targeted immunoliposomes for systemic gene delivery
US9034329B2 (en) 1999-02-22 2015-05-19 Georgetown University Preparation of antibody or an antibody fragment-targeted immunoliposomes for systemic administration of therapeutic or diagnostic agents and uses thereof
US7780882B2 (en) 1999-02-22 2010-08-24 Georgetown University Simplified and improved method for preparing an antibody or an antibody fragment targeted immunoliposome for systemic administration of a therapeutic or diagnostic agent
US8617514B2 (en) 1999-02-22 2013-12-31 Georgetown University Tumor-targeted nanodelivery systems to improve early MRI detection of cancer
US7109165B2 (en) * 2001-05-18 2006-09-19 Sirna Therapeutics, Inc. Conjugates and compositions for cellular delivery
WO2004066908A2 (fr) * 2003-01-17 2004-08-12 Sanofi Pasteur Composition comprenant lipides cationiques et un polynucleotide ou un polpeptide et methode pour leur delivrance ciblee
US20040241088A1 (en) * 2003-01-28 2004-12-02 Georgetown University Method for evaluating the efficacy of certain cancer treatments
CN1327899C (zh) * 2003-05-10 2007-07-25 彭朝晖 腺病毒载体与p53基因的基因重组体的应用
PL1633327T3 (pl) * 2003-06-04 2011-02-28 Univ Georgetown Sposób poprawienia stabilności i okresu trwałości kompleksów liposomowych
US8627821B2 (en) 2005-01-10 2014-01-14 Pulmatrix, Inc. Method and device for decreasing contamination
US7858356B2 (en) * 2005-11-24 2010-12-28 Genomidea, Inc. Mutant paramyxovirus and method for production thereof
EP2023897A4 (de) 2006-05-15 2013-04-03 Univ Georgetown Herstellung von antikörper- oder antikörperfragmentgezielten immunoliposomen zur systemischen verabreichung von therapeutischen oder diagnostischen wirkstoffen und verwendungen davon
CN102133404B (zh) * 2011-03-23 2013-01-16 成都诺恩生物科技有限公司 一种肿瘤靶向治疗药物载体、其制备方法及其应用
RU2014130080A (ru) 2011-12-22 2016-02-10 Нуво Рисерч Гмбх Липосомальные композиции хлоритов или хлоратов
US20140120157A1 (en) 2012-09-19 2014-05-01 Georgetown University Targeted liposomes
AU2013200991B2 (en) 2012-09-19 2015-12-10 Georgetown University Targeted liposomes
WO2014159917A2 (en) 2013-03-14 2014-10-02 Georgetown University Treatment for exposure to nerve agent
SG11201803768WA (en) 2015-10-08 2018-06-28 Univ Utah Res Found Methods and compositions for preventing or treating cancer
CN109996809A (zh) 2016-11-14 2019-07-09 诺华股份有限公司 与促融合蛋白minion相关的组合物、方法和治疗用途
WO2020077039A1 (en) 2018-10-12 2020-04-16 Synergene Therapeutics, Inc. Methods for reducing side effects of immunotherapy

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5635380A (en) * 1994-01-18 1997-06-03 Vanderbilt University Enhancement of nucleic acid transfer by coupling virus to nucleic acid via lipids
US5928944A (en) * 1994-02-04 1999-07-27 The United States Of America As Represented By The Department Of Health And Human Services Method of adenoviral-medicated cell transfection
CN1157570A (zh) * 1994-09-13 1997-08-20 瑟拉技术有限公司 化学药物向特定细胞的细胞内载运
US20020051767A1 (en) * 1995-09-13 2002-05-02 Yawen L. Chiang Cancer treatment
JPH09110722A (ja) * 1995-10-20 1997-04-28 Toray Ind Inc 抗腫瘍活性物質の腫瘍細胞内導入用イムノリポソーム及びその調製法
US6077834A (en) * 1996-02-09 2000-06-20 Cheng; Pi-Wan Receptor ligand-facilitated delivery of biologically active molecules
JP3956402B2 (ja) * 1996-03-04 2007-08-08 日本油脂株式会社 アンホテリシンｂ運搬体

Also Published As

Publication number Publication date
JP2010263920A (ja) 2010-11-25
CN1191094C (zh) 2005-03-02
EP1032369B1 (de) 2005-05-18
CN1616665B (zh) 2010-10-06
HK1035490A1 (en) 2001-11-30
DE69830249T2 (de) 2006-05-04
CN1616665A (zh) 2005-05-18
DE69841536D1 (de) 2010-04-15
EP1166775A2 (de) 2002-01-02
CN1904055A (zh) 2007-01-31
JP2001522871A (ja) 2001-11-20
CN1286630A (zh) 2001-03-07
ATE459340T1 (de) 2010-03-15
ES2339421T3 (es) 2010-05-20
DK1166775T3 (da) 2010-05-03
CA2308584A1 (en) 1999-05-27
WO1999025320A1 (en) 1999-05-27
HK1045641B (en) 2010-10-29
EP1166775A3 (de) 2003-06-25
AU759164B2 (en) 2003-04-10
EP1166775B1 (de) 2010-03-03
HK1078608A1 (en) 2006-03-17
EP1032369A1 (de) 2000-09-06
CA2308584C (en) 2011-07-19
PT1166775E (pt) 2010-04-16
HK1045641A1 (en) 2002-12-06
DE69830249D1 (de) 2005-06-23
AU759164C (en) 2007-03-29
AU1464299A (en) 1999-06-07

Similar Documents

Publication Publication Date Title
ATE459340T1 (de) Zielgerichtete liposomen zur verabreichung von genen
ATE273320T1 (de) Fusogene liposomen
ATE172636T1 (de) Liposomales verabreichungssystem für biologisch aktive stoffe
DE69708919D1 (de) Neue liposomkomplexe mit erhöhter systemischer verabreichung
AU9676198A (en) Drug delivery and gene therapy delivery system
NO994837D0 (no) Intravesikal medikamentavleveringssystem
DK1093383T3 (da) Lægemiddelafgivelsessystem omfattende et homeobox-peptid og et cytotoksisk eller antineoplastisk lægemiddel
MX9800719A (es) Proteinas de transporte y sus usos.
PT1121144E (pt) Preparados de insulina concentrada estavel para administracao pulmonar
DK0852490T3 (da) Emulsionsformuleringer til tilførsel af nukleinsyrer til celler
TR199901949T2 (xx) Lemfositik t�m�rler i�in �areler.
ATE322255T1 (de) Polyamid-oligomere
WO2001080840A3 (en) Cytotoxic agents comprising single-stranded and/or looped dna
WO2003002142A8 (fr) Vaccin anticarcinogene contenant un antigene tumoral base sur un produit de gene wt1 suppresseur de tumeur et des liposomes cationiques
WO1998030709A3 (en) Non-immunogenic prodrugs and selectable markers for use in gene therapy
TR199802648A3 (tr) Gen tedavisi için nüklein asit yapilari.
AU4089899A (en) Stable envelope proteins for retroviral, viral and liposome vectors and use in gene and drug therapy
NO20016247L (no) Streptograminderivater, deres fremstilling samt preparater inneholdende derivatene
ID29405A (id) Protein antigen tumor sart-3 yang baru dan peptida-peptida antigen tumornya
ATE419833T1 (de) Modulares zielgerichtetes liposomales verabreichungssytem
ATE414100T1 (de) Zielgerichtete ligande gegen peyer's flecke- und/oder m-zellen
PT1007717E (pt) Processos e composicoes para terapias do cancro,utilizando genes que codificam o interferao-beta
DE3673436D1 (de) Gene fuer biologisch aktive proteine.
WO1999065461A3 (en) Cationic amphiphile micellar complexes
EP1086116A4 (de) Zusammensetzungen und verfahren für den pulmonativen transport von nuklein-säuren

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties