ATE273953T1 - Piperidin- und pirazinverbindungen zur verwendung in der behandlung von alzheimer - Google Patents

Piperidin- und pirazinverbindungen zur verwendung in der behandlung von alzheimer

Info

Publication number: ATE273953T1
Authority: AT; Austria
Prior art keywords: compounds; halogen; alkyl; hydrogen; independently
Prior art date: 2000-03-22

Application number

AT01105498T

Other languages

English (en)

Inventor

Yvo Crameri

Michelangelo Scalone

Pius Waldmeier

Ulrich Widmer

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-03-22

Filing date

2001-03-15

Publication date

2004-09-15

2001-03-15 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2004-09-15 Application granted granted Critical

2004-09-15 Publication of ATE273953T1 publication Critical patent/ATE273953T1/de

Links

150000001875 compounds Chemical class 0.000 title abstract 3
NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 title 2
HOKKHZGPKSLGJE-GSVOUGTGSA-N N-Methyl-D-aspartic acid Chemical compound CN[C@@H](C(O)=O)CC(O)=O HOKKHZGPKSLGJE-GSVOUGTGSA-N 0.000 abstract 2
230000006870 function Effects 0.000 abstract 2
229910052736 halogen Inorganic materials 0.000 abstract 2
150000002367 halogens Chemical class 0.000 abstract 2
150000002431 hydrogen Chemical class 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
-1 hydroxy, amino Chemical group 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
125000000738 acetamido group Chemical group [H]C([H])([H])C(=O)N([H])[*] 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
230000001537 neural effect Effects 0.000 abstract 1
230000007996 neuronal plasticity Effects 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/02—Preparation by ring-closure or hydrogenation
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/42—Oxygen atoms attached in position 3 or 5
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D211/74—Oxygen atoms

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Psychiatry (AREA)
Psychology (AREA)
Pain & Pain Management (AREA)
Hospice & Palliative Care (AREA)
Hydrogenated Pyridines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Plural Heterocyclic Compounds (AREA)

AT01105498T 2000-03-22 2001-03-15 Piperidin- und pirazinverbindungen zur verwendung in der behandlung von alzheimer ATE273953T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP00106210		2000-03-22

Publications (1)

Publication Number	Publication Date
ATE273953T1 true ATE273953T1 (de)	2004-09-15

Family

ID=8168189

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT01105498T ATE273953T1 (de)	2000-03-22	2001-03-15	Piperidin- und pirazinverbindungen zur verwendung in der behandlung von alzheimer

Country Status (12)

Country	Link
US (1)	US6605723B2 (de)
EP (1)	EP1136475B1 (de)
JP (1)	JP3598277B2 (de)
KR (1)	KR100378331B1 (de)
CN (1)	CN1218941C (de)
AT (1)	ATE273953T1 (de)
CA (1)	CA2341010C (de)
DE (1)	DE60104923T2 (de)
DK (1)	DK1136475T3 (de)
ES (1)	ES2225330T3 (de)
JO (1)	JO2275B1 (de)
MX (1)	MXPA01002945A (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB0204129D0 (en) *	2002-02-21	2002-04-10	Novartis Ag	Process for the manufacture of organic compounds
US7569691B2 (en) *	2005-04-20	2009-08-04	Shin-Etsu Chemical Co., Ltd.	Protected piperazino group-bearing organoxysilane compound and making method
WO2009031526A1 (ja)	2007-09-06	2009-03-12	National University Corporation Hokkaido University	光学活性３－キヌクリジノール誘導体の製造方法
JP5276093B2 (ja) *	2008-04-07	2013-08-28	日本曹達株式会社	光学活性アミノアルコール化合物の製造方法
CN102126995A (zh) *	2010-12-14	2011-07-20	台州市华南医化有限公司	一种改进的苯基乙烯基砜的制备工艺
CN102617451B (zh) *	2012-02-22	2014-01-22	华东理工大学	具有杀虫活性的哌啶醇衍生物、及其制备和用途
CN110240561B (zh) *	2018-03-07	2020-08-04	新发药业有限公司	一种低成本的3-羟基吡啶的制备方法
CN110734393B (zh) *	2019-11-11	2022-02-25	南京恒远科技开发有限公司	N-苄基-3-氧代哌啶-4-羧酸乙酯盐酸盐的制备方法
CN119039289A (zh) *	2024-07-30	2024-11-29	安庆多辉生物科技有限公司	一种阿达格西布合成用新型中间体及制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE4410822A1 (de)	1994-03-24	1995-09-28	Schering Ag	Neue Piperidin-Derivate
CA2164685C (en)	1994-12-07	2005-03-08	Takeshi Ohkuma	Method for producing an alcohol
JP4144814B2 (ja)	1997-09-05	2008-09-03	長谷川香料株式会社	光学活性アルコール化合物の製造方法
TWI254043B (en)	1999-06-08	2006-05-01	Hoffmann La Roche	Ethanesulfonyl-piperidine derivatives having good affinity to N-methyl-D-aspartate (NMDA) receptor

2001
- 2001-03-15 ES ES01105498T patent/ES2225330T3/es not_active Expired - Lifetime
- 2001-03-15 DE DE60104923T patent/DE60104923T2/de not_active Expired - Lifetime
- 2001-03-15 AT AT01105498T patent/ATE273953T1/de active
- 2001-03-15 EP EP01105498A patent/EP1136475B1/de not_active Expired - Lifetime
- 2001-03-15 DK DK01105498T patent/DK1136475T3/da active
- 2001-03-15 US US09/809,691 patent/US6605723B2/en not_active Expired - Fee Related
- 2001-03-19 CA CA002341010A patent/CA2341010C/en not_active Expired - Fee Related
- 2001-03-19 JO JO200133A patent/JO2275B1/en active
- 2001-03-20 MX MXPA01002945A patent/MXPA01002945A/es unknown
- 2001-03-20 KR KR10-2001-0014265A patent/KR100378331B1/ko not_active Expired - Fee Related
- 2001-03-22 JP JP2001082991A patent/JP3598277B2/ja not_active Expired - Fee Related
- 2001-03-22 CN CNB011118776A patent/CN1218941C/zh not_active Expired - Fee Related

Also Published As

Publication number	Publication date
JP3598277B2 (ja)	2004-12-08
CN1218941C (zh)	2005-09-14
JP2001270865A (ja)	2001-10-02
DE60104923D1 (de)	2004-09-23
CA2341010A1 (en)	2001-09-22
KR100378331B1 (ko)	2003-05-09
EP1136475B1 (de)	2004-08-18
CN1315319A (zh)	2001-10-03
MXPA01002945A (es)	2002-08-06
DE60104923T2 (de)	2005-08-25
DK1136475T3 (da)	2004-12-27
US6605723B2 (en)	2003-08-12
CA2341010C (en)	2009-09-08
JO2275B1 (en)	2005-04-07
KR20010100822A (ko)	2001-11-14
ES2225330T3 (es)	2005-03-16
US20010037026A1 (en)	2001-11-01
EP1136475A1 (de)	2001-09-26

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