ATE118002T1 - 2,3-dihydro-1-(pyridinylamino)-indole, verfahren zu ihrer herstellung und ihre anwendung als arzneimittel. - Google Patents

2,3-dihydro-1-(pyridinylamino)-indole, verfahren zu ihrer herstellung und ihre anwendung als arzneimittel.

Info

Publication number: ATE118002T1
Authority: AT; Austria
Prior art keywords: loweralkyl; pyridinylamino; indoles; dihydro; aryl
Prior art date: 1989-08-02

Application number

AT90114661T

Other languages

English (en)

Inventor

Richard Charles Dr Effland

David Gordon Dr Wettlaufer

Joseph Thomas Klein

Original Assignee

Hoechst Roussel Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-08-02

Filing date

1990-07-31

Publication date

1995-02-15

1990-07-31 Application filed by Hoechst Roussel Pharma filed Critical Hoechst Roussel Pharma

1995-02-15 Application granted granted Critical

1995-02-15 Publication of ATE118002T1 publication Critical patent/ATE118002T1/de

Links

229940126601 medicinal product Drugs 0.000 title 1
-1 loweralkyl Chemical group 0.000 abstract 6
125000003118 aryl group Chemical group 0.000 abstract 3
150000002431 hydrogen Chemical group 0.000 abstract 3
229910052739 hydrogen Inorganic materials 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
125000006513 pyridinyl methyl group Chemical group 0.000 abstract 2
125000005301 thienylmethyl group Chemical group [H]C1=C([H])C([H])=C(S1)C([H])([H])* 0.000 abstract 2
208000024827 Alzheimer disease Diseases 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
125000003342 alkenyl group Chemical group 0.000 abstract 1
125000000304 alkynyl group Chemical group 0.000 abstract 1
229940035676 analgesics Drugs 0.000 abstract 1
239000000730 antalgic agent Substances 0.000 abstract 1
229940125681 anticonvulsant agent Drugs 0.000 abstract 1
239000001961 anticonvulsive agent Substances 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
230000002708 enhancing effect Effects 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
UPQBWVOMAKRBQF-UHFFFAOYSA-N n-pyridin-2-yl-2,3-dihydroindol-1-amine Chemical class C1CC2=CC=CC=C2N1NC1=CC=CC=N1 UPQBWVOMAKRBQF-UHFFFAOYSA-N 0.000 abstract 1
230000003287 optical effect Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Indole Compounds (AREA)

AT90114661T 1989-08-02 1990-07-31 2,3-dihydro-1-(pyridinylamino)-indole, verfahren zu ihrer herstellung und ihre anwendung als arzneimittel. ATE118002T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US38841589A	1989-08-02	1989-08-02

Publications (1)

Publication Number	Publication Date
ATE118002T1 true ATE118002T1 (de)	1995-02-15

Family

ID=23534038

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT90114661T ATE118002T1 (de)	1989-08-02	1990-07-31	2,3-dihydro-1-(pyridinylamino)-indole, verfahren zu ihrer herstellung und ihre anwendung als arzneimittel.

Country Status (17)

Country	Link
EP (1)	EP0415103B1 (de)
JP (1)	JPH0674266B2 (de)
KR (1)	KR0164595B1 (de)
AT (1)	ATE118002T1 (de)
AU (1)	AU628201B2 (de)
CA (1)	CA2022488C (de)
DE (1)	DE69016531T2 (de)
DK (1)	DK0415103T3 (de)
ES (1)	ES2068294T3 (de)
FI (1)	FI95466C (de)
GR (1)	GR3015228T3 (de)
IE (1)	IE66601B1 (de)
IL (1)	IL95251A (de)
NO (1)	NO176398C (de)
NZ (1)	NZ234726A (de)
PT (1)	PT94880B (de)
ZA (1)	ZA906048B (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4868190A (en) *	1988-12-27	1989-09-19	Hoechst-Roussel Pharmaceuticals, Inc.	N-pyridinyl-9H-carbazol-9-amines
US5214038A (en) *	1991-04-15	1993-05-25	Hoechst-Roussel Pharmaceuticals Inc.	1-(pyrido[3,4-b]-1,4-oxazinyl-4-yl)-1H-indoles and intermediates for the preparation thereof
US5202319A (en) *	1991-09-23	1993-04-13	Hoechst-Roussel Pharmaceuticals Inc.	Substituted 3-amino-2,3,4,5-tetrahydro-1-aryloxy-3-benzazepines
US5459274A (en) *	1994-05-13	1995-10-17	Hoechst-Roussel Pharmaceuticals Inc.	Preparation of N-alkyl-N-pyridinyl-1H-indol-1-amines
US6100276A (en) *	1996-04-12	2000-08-08	Aventis Pharmaceuticals Inc.	Isatin derivatives as acetylcholinesterase inhibitors and analgesics
DE69715668T2 (de) *	1996-12-27	2003-07-31	Aventis Pharmaceuticals Inc., Bridgewater	N-(pyridinylamino)isoindoline und verwandte verbindungen
GB0119435D0 (en) *	2001-02-15	2001-10-03	Aventis Pharm Prod Inc	Method of treating of demyelinating diseases or conditions
KR20230062158A (ko)	2021-10-29	2023-05-09	대우조선해양 주식회사	극지용 선박의 발전기 엔진의 외기 흡입구조 및 상기 외기 흡입구조를 포함하는 극지용 선박
KR20230062160A (ko)	2021-10-29	2023-05-09	대우조선해양 주식회사	극지용 선박의 공조 시스템 및 상기 극지용 선박의 외기 흡입구조
KR20230062159A (ko)	2021-10-29	2023-05-09	대우조선해양 주식회사	극지용 선박의 발전기 엔진의 외기 흡입구조 및 상기 외기 흡입구조를 포함하는 극지용 선박

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3852335T2 (de) *	1987-04-24	1995-05-11	Hoechst Roussel Pharma	N-(Pyridinyl)-1H-indol-1-amine, Verfahren zu deren Herstellung und ihre Verwendung als Arzneimittel.
US4868190A (en) *	1988-12-27	1989-09-19	Hoechst-Roussel Pharmaceuticals, Inc.	N-pyridinyl-9H-carbazol-9-amines
US4983615A (en) *	1989-06-28	1991-01-08	Hoechst-Roussel Pharmaceuticals Inc.	Heteroarylamino- and heteroaryloxypyridinamine compounds which are useful in treating skin disorders

1990
- 1990-07-31 DK DK90114661.3T patent/DK0415103T3/da active
- 1990-07-31 AT AT90114661T patent/ATE118002T1/de not_active IP Right Cessation
- 1990-07-31 DE DE69016531T patent/DE69016531T2/de not_active Expired - Fee Related
- 1990-07-31 EP EP90114661A patent/EP0415103B1/de not_active Expired - Lifetime
- 1990-07-31 NZ NZ234726A patent/NZ234726A/en unknown
- 1990-07-31 ES ES90114661T patent/ES2068294T3/es not_active Expired - Lifetime
- 1990-07-31 IL IL9525190A patent/IL95251A/en not_active IP Right Cessation
- 1990-07-31 FI FI903820A patent/FI95466C/fi not_active IP Right Cessation
- 1990-08-01 JP JP2202619A patent/JPH0674266B2/ja not_active Expired - Fee Related
- 1990-08-01 KR KR1019900011817A patent/KR0164595B1/ko not_active Expired - Fee Related
- 1990-08-01 IE IE278890A patent/IE66601B1/en not_active IP Right Cessation
- 1990-08-01 PT PT94880A patent/PT94880B/pt not_active IP Right Cessation
- 1990-08-01 ZA ZA906048A patent/ZA906048B/xx unknown
- 1990-08-01 AU AU60003/90A patent/AU628201B2/en not_active Ceased
- 1990-08-01 NO NO903390A patent/NO176398C/no unknown
- 1990-08-01 CA CA002022488A patent/CA2022488C/en not_active Expired - Fee Related
1995
- 1995-02-28 GR GR950400433T patent/GR3015228T3/el unknown

Also Published As

Publication number	Publication date
NO176398B (no)	1994-12-19
FI903820A0 (fi)	1990-07-31
AU6000390A (en)	1991-02-07
IL95251A (en)	1996-08-04
PT94880B (pt)	1997-12-31
NO176398C (no)	1995-03-29
IE902788A1 (en)	1991-02-27
NO903390D0 (no)	1990-08-01
FI95466C (fi)	1996-02-12
KR910004598A (ko)	1991-03-29
NO903390L (no)	1991-02-04
DE69016531D1 (de)	1995-03-16
IL95251A0 (en)	1991-06-10
GR3015228T3 (en)	1995-05-31
ES2068294T3 (es)	1995-04-16
AU628201B2 (en)	1992-09-10
KR0164595B1 (ko)	1999-01-15
ZA906048B (en)	1991-05-29
NZ234726A (en)	1992-01-29
EP0415103A1 (de)	1991-03-06
JPH03118378A (ja)	1991-05-20
JPH0674266B2 (ja)	1994-09-21
DK0415103T3 (da)	1995-06-19
CA2022488C (en)	2000-11-07
PT94880A (pt)	1991-04-18
DE69016531T2 (de)	1995-07-06
FI95466B (fi)	1995-10-31
IE66601B1 (en)	1996-01-24
CA2022488A1 (en)	1991-02-03
EP0415103B1 (de)	1995-02-01

Legal Events

Date	Code	Title	Description
1995-06-15	UEP	Publication of translation of european patent specification
2006-04-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
AU628202B2 (en)	1992-09-10	1,3-dihydro-1-(pyridinylamino)-2h-indol-2-ones, a process for their preparation and their use as medicaments
ATE163012T1 (de)	1998-02-15	N-substituierte 4-pyrimidinamine und - pyrimidindiamine, verfahren zu ihrer herstellung und ihre anwendung als arzneimittel
DE3772905D1 (de)	1991-10-17	Alpha-alkyl-4-amino-3-chinolin-methanole und 1-(4-aralkylamino-3-chinolyl)alkanone, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel.
AU635051B2 (en)	1993-03-11	1-(pyridinylamino)-2-pyrrolidinones, a process for their preparation and their use as medicaments
AU628201B2 (en)	1992-09-10	2,3-dihydro-1-(pyridinylamino)-indoles, a process for their preparation and their use as medicaments
AU1485292A (en)	1992-10-22	1-(pyrido(3,4.b)-1,4-oxazinyl-4-yl)-1h-indoles, intermediates and a process for their preparation, and their use as medicaments
DE68918402D1 (de)	1994-10-27	1,2,3,4-Tetrahydro-1,9-Acridindiamine, ein Verfahren zu ihrer Herstellung und ihre Verwendung als Medikamente.