ATE274495T1 - 4-hydroxy-4-phenylpiperidine-derivate mit opioid agonistischer aktivität und diese enthaltende pharmazeutika - Google Patents

4-hydroxy-4-phenylpiperidine-derivate mit opioid agonistischer aktivität und diese enthaltende pharmazeutika

Info

Publication number
ATE274495T1
ATE274495T1 AT00123487T AT00123487T ATE274495T1 AT E274495 T1 ATE274495 T1 AT E274495T1 AT 00123487 T AT00123487 T AT 00123487T AT 00123487 T AT00123487 T AT 00123487T AT E274495 T1 ATE274495 T1 AT E274495T1
Authority
AT
Austria
Prior art keywords
hydroxy
hydrogen atom
lower alkyl
containing same
agonistic activity
Prior art date
Application number
AT00123487T
Other languages
English (en)
Inventor
Kinichi Mogi
Yoshihiko Kanamaru
Noriyuki Kawamoto
Teruo Komoto
Norimitsu Umehara
Susumu Sato
Tetsuo Oka
Original Assignee
Ssp Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ssp Co Ltd filed Critical Ssp Co Ltd
Application granted granted Critical
Publication of ATE274495T1 publication Critical patent/ATE274495T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/52—Oxygen atoms attached in position 4 having an aryl radical as the second substituent in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT00123487T 1999-11-08 2000-11-07 4-hydroxy-4-phenylpiperidine-derivate mit opioid agonistischer aktivität und diese enthaltende pharmazeutika ATE274495T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP31688199 1999-11-08

Publications (1)

Publication Number Publication Date
ATE274495T1 true ATE274495T1 (de) 2004-09-15

Family

ID=18081961

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00123487T ATE274495T1 (de) 1999-11-08 2000-11-07 4-hydroxy-4-phenylpiperidine-derivate mit opioid agonistischer aktivität und diese enthaltende pharmazeutika

Country Status (7)

Country Link
US (1) US6362203B1 (de)
EP (1) EP1097924B1 (de)
KR (1) KR20010051474A (de)
CN (1) CN1304929A (de)
AT (1) ATE274495T1 (de)
CA (1) CA2324330A1 (de)
DE (1) DE60013225T2 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6995168B2 (en) 2002-05-31 2006-02-07 Euro-Celtique S.A. Triazaspiro compounds useful for treating or preventing pain
US7202259B2 (en) * 2002-11-18 2007-04-10 Euro-Celtique S.A. Therapeutic agents useful for treating pain
PT1567493E (pt) * 2002-11-26 2009-04-09 Pfizer Prod Inc Activadores de ppar
KR100886002B1 (ko) * 2004-01-30 2009-03-03 유로-셀띠끄 소시에떼 아노님 4-테트라졸릴-4-페닐피페리딘 화합물의 제조방법
PT1951718E (pt) 2005-11-21 2012-05-21 Purdue Pharma Lp Compostos de 4-oxadiazolil-piperidina e as suas utilizações
JP4694640B2 (ja) * 2006-09-01 2011-06-08 プレオティント エル エル シー リガンド交換サーモクロミック（ｌｅｔｃ）系
ES2433118T3 (es) 2006-11-01 2013-12-09 Purdue Pharma Lp Compuestos de fenilpropionamida y uso de los mismos
CN101260075B (zh) * 2007-03-07 2011-03-16 江苏恩华药业股份有限公司 芳烷基哌啶衍生物及其在制备镇痛、镇静药物中的应用
CN112759538B (zh) * 2019-11-06 2022-01-18 复旦大学 3-(二甲氨基甲基)环己-4-醇衍生物及其制备方法和药物用途
CN115504927A (zh) * 2022-08-15 2022-12-23 广西中医药大学 4-甲基-2-对甲苯基-6-羰基吡啶-3-甲酸及其制备方法和用途

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS47173Y1 (de) 1968-03-30 1972-01-07
US5849761A (en) 1995-09-12 1998-12-15 Regents Of The University Of California Peripherally active anti-hyperalgesic opiates
GB9711118D0 (en) * 1997-05-29 1997-07-23 Rolabo Sl Compound

Also Published As

Publication number Publication date
US6362203B1 (en) 2002-03-26
EP1097924A1 (de) 2001-05-09
CN1304929A (zh) 2001-07-25
EP1097924B1 (de) 2004-08-25
DE60013225D1 (de) 2004-09-30
DE60013225T2 (de) 2005-09-01
KR20010051474A (ko) 2001-06-25
CA2324330A1 (en) 2001-05-08

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