|
AU3596599A
(en)
*
|
1998-01-26 |
1999-08-09 |
Unilever Plc |
Method for producing antibody fragments
|
|
US7297478B1
(en)
|
2000-09-22 |
2007-11-20 |
Large Scale Biology Corporation |
Creation of variable length and sequence linker regions for dual-domain or multi-domain molecules
|
|
CA2441903C
(en)
|
2000-05-26 |
2012-07-31 |
National Research Council Of Canada |
Single-domain brain-targeting antibody fragments derived from llama antibodies
|
|
US20030190598A1
(en)
*
|
2000-05-26 |
2003-10-09 |
Jasmid Tanha |
Single-domain antigen-binding antibody fragments derived from llama antibodies
|
|
CN1306272C
(zh)
|
2000-11-17 |
2007-03-21 |
罗切斯特大学 |
筛选编码抗原特异性免疫球蛋白分子或其抗原特异性片段的方法
|
|
JP4213586B2
(ja)
*
|
2001-09-13 |
2009-01-21 |
株式会社抗体研究所 |
ラクダ抗体ライブラリーの作製方法
|
|
EP1318195A1
(de)
|
2001-12-10 |
2003-06-11 |
CatchMabs B.V. |
Ein Struktur für die Präsentation erwünschter Peptidsequenzen
|
|
PL2368554T3
(pl)
|
2003-04-08 |
2015-05-29 |
Progenics Pharm Inc |
Preparaty farmaceutyczne zawierające metylonaltrekson
|
|
CN1214118C
(zh)
*
|
2003-07-18 |
2005-08-10 |
文剑 |
Dna抗体及其应用
|
|
DE602004032042D1
(de)
*
|
2003-08-27 |
2011-05-12 |
Proterec Ltd |
Bibliotheken rekombinanter chimärischer proteine
|
|
US7642341B2
(en)
|
2003-12-18 |
2010-01-05 |
Merck Serono S.A. |
Angiogenesis inhibiting molecules, their selection, production and their use in the treatment of cancer
|
|
EP1733055A4
(de)
*
|
2004-02-27 |
2009-03-11 |
Harvard College |
Polynukleotidsynthese
|
|
US7785903B2
(en)
|
2004-04-09 |
2010-08-31 |
Genentech, Inc. |
Variable domain library and uses
|
|
US20050272917A1
(en)
*
|
2004-05-14 |
2005-12-08 |
Hematech, Llc |
Methods for immunoglobulin purification
|
|
EP1750759A4
(de)
*
|
2004-06-04 |
2008-06-04 |
Genencor Int |
Screeningverfahren unter verwendung von antikörper schweren ketten
|
|
KR20070084069A
(ko)
|
2004-10-08 |
2007-08-24 |
도만티스 리미티드 |
Tnfr1에 대한 단일 도메인 항체 및 이의 사용 방법
|
|
SI1836500T1
(sl)
|
2005-01-14 |
2010-11-30 |
Ablynx Nv |
Postopki in testi za razlikovanje med različnimioblikami bolezni in motenj ki so označene s trombocitopenijo in ali s spontano interakcijo med von Willebrandovim faktorjem vWF in krvnimi ploščicami
|
|
AU2006249144B2
(en)
|
2005-05-18 |
2011-11-17 |
Ablynx Nv |
Improved NanobodiesTM against Tumor Necrosis Factor-alpha
|
|
LT2444424T
(lt)
|
2005-05-20 |
2018-10-25 |
Ablynx N.V. |
Pagerintos tm nanodalelės, skirtos agregacijos sąlygotų sutrikimų gydymui
|
|
EP1943341A4
(de)
*
|
2005-09-27 |
2010-07-07 |
Ca Nat Research Council |
Blut-hirn-schranke-epitope und verwendungen davon
|
|
EP2016101A2
(de)
*
|
2006-05-09 |
2009-01-21 |
Genentech, Inc. |
Bindung von polypeptiden mit optimierten gerüsten
|
|
US20090318308A1
(en)
*
|
2006-05-30 |
2009-12-24 |
Millegen |
Highly diversified antibody libraries
|
|
TWI489984B
(zh)
|
2006-08-04 |
2015-07-01 |
Wyeth Corp |
用於非經腸道傳輸化合物之配方及其用途
|
|
AU2007301599B2
(en)
*
|
2006-09-28 |
2013-01-10 |
Merck Serono S.A. |
Junctional Adhesion Molecule-C (JAM-C) binding compounds and methods of their use
|
|
LT3028716T
(lt)
|
2006-10-10 |
2020-12-10 |
Regenesance B.V. |
Komplemento slopinimas nervų regeneracijos pagerinimui
|
|
GB0621513D0
(en)
|
2006-10-30 |
2006-12-06 |
Domantis Ltd |
Novel polypeptides and uses thereof
|
|
JP5105468B2
(ja)
*
|
2006-12-05 |
2012-12-26 |
独立行政法人産業技術総合研究所 |
細胞内で機能する抗体の創製および細胞表現型を制御するタンパク質の同定
|
|
US9156914B2
(en)
|
2006-12-19 |
2015-10-13 |
Ablynx N.V. |
Amino acid sequences directed against a metalloproteinase from the ADAM family and polypeptides comprising the same for the treatment of ADAM-related diseases and disorders
|
|
AU2007336242B2
(en)
|
2006-12-19 |
2012-08-30 |
Ablynx N.V. |
Amino acid sequences directed against GPCRs and polypeptides comprising the same for the treatment of GPCR-related diseases and disorders
|
|
WO2008118013A2
(en)
|
2007-03-23 |
2008-10-02 |
To-Bbb Holding B.V. |
Targeted intracellular delivery of antiviral agents
|
|
MX2009010550A
(es)
|
2007-03-29 |
2009-12-14 |
Progenics Pharm Inc |
Formas de cristal de bromuro de (r)-n-metilnaltrexona y uso de las mismas.
|
|
AU2008270274B2
(en)
|
2007-07-03 |
2012-06-28 |
Ablynx N.V. |
Providing improved immunoglobulin sequences by mutating CDR and/or FR positions
|
|
CA2706425A1
(en)
|
2007-11-27 |
2009-06-04 |
Ablynx N.V. |
Method for obtaining polypeptide constructs comprising two or more single domain antibodies
|
|
US8420081B2
(en)
|
2007-11-30 |
2013-04-16 |
Abbvie, Inc. |
Antibody formulations and methods of making same
|
|
US8883146B2
(en)
|
2007-11-30 |
2014-11-11 |
Abbvie Inc. |
Protein formulations and methods of making same
|
|
EP2238165B1
(de)
|
2008-01-07 |
2017-07-05 |
Government of the United States of America, as represented by the Secretary, Department of Health and Human Services |
Anti-hiv-domäne-antikörper sowie verfahren zu ihrer herstellung und verwendung
|
|
AU2008349873B2
(en)
|
2008-02-06 |
2014-02-13 |
Progenics Pharmaceuticals, Inc. |
Preparation and use of (R),(R)-2,2'-bis-methylnaltrexone
|
|
US20110091462A1
(en)
|
2008-03-05 |
2011-04-21 |
Ablynx N.V. |
Novel antigen binding dimer-complexes, methods of making and uses thereof
|
|
US9908943B2
(en)
|
2008-04-03 |
2018-03-06 |
Vib Vzw |
Single domain antibodies capable of modulating BACE activity
|
|
US8568717B2
(en)
|
2008-04-03 |
2013-10-29 |
Vib Vzw |
Single domain antibodies capable of modulating BACE activity
|
|
GB0809069D0
(en)
|
2008-05-19 |
2008-06-25 |
Univ Leuven Kath |
Gene signatures
|
|
US8557965B2
(en)
|
2008-04-07 |
2013-10-15 |
Ablynx N.V. |
Single variable domains against notch pathway members
|
|
CA2721202A1
(en)
|
2008-04-17 |
2009-10-22 |
Hilde Adi Pierrette Revets |
Peptides capable of binding to serum proteins and compounds, constructs and polypeptides comprising the same
|
|
US9212226B2
(en)
|
2008-05-16 |
2015-12-15 |
Ablynx N.V. |
Amino acid sequences directed against CXCR4 and other GPCRs and compounds comprising the same
|
|
LT2285408T
(lt)
|
2008-06-05 |
2019-01-25 |
Ablynx N.V. |
Aminorūgščių sekos, nukreiptos prieš viruso apvalkalo baltymus, ir tokias sekas turintys polipeptidai, skirti virusinių ligų gydymui
|
|
CA2747644C
(en)
|
2008-12-19 |
2023-01-24 |
Ablynx N.V. |
Method for generation of immunoglobulin sequences
|
|
EP2403873A1
(de)
|
2009-03-05 |
2012-01-11 |
Ablynx N.V. |
Neue antigenbindende dimerkomplexe, verfahren zur herstellung/vermeidung und anwendungen davon
|
|
CA2759370C
(en)
|
2009-04-30 |
2020-02-11 |
Peter Schotte |
Method for the production of domain antibodies
|
|
AU2010249470B2
(en)
|
2009-05-20 |
2015-06-25 |
Novimmune S.A. |
Synthetic Polypeptide Libraries And Methods For Generating Naturally Diversified Polypeptide Variants
|
|
WO2010141511A2
(en)
|
2009-06-01 |
2010-12-09 |
Halo-Bio Rnai Therapeutics, Inc. |
Polynucleotides for multivalent rna interference, compositions and methods of use thereof
|
|
ES2804450T3
(es)
|
2009-07-10 |
2021-02-08 |
Ablynx Nv |
Método para la producción de dominios variables
|
|
EP2473528B1
(de)
|
2009-09-03 |
2014-12-03 |
Ablynx N.V. |
Stabile formulierungen aus polypeptiden und verwendungen davon
|
|
PT2491056T
(pt)
|
2009-10-22 |
2021-10-26 |
Univ Of Twente |
Vhh para aplicação na reparação de tecidos, regeneração de órgãos, substituição de órgãos e engenharia de tecidos
|
|
US20120321640A1
(en)
|
2009-12-01 |
2012-12-20 |
Ablynx N.V. |
Von willebrand factor specific binding agents and uses thereof
|
|
HRP20251657T1
(hr)
|
2009-12-14 |
2026-02-13 |
Ablynx N.V. |
Imunoglobulinska protutijela s jednostrukom varijabilnom domenom protiv ox40l, konstrukti i njihova terapijska upotreba
|
|
WO2011083140A1
(en)
|
2010-01-08 |
2011-07-14 |
Ablynx Nv |
Immunoglobulin single variable domain directed against human cxcr4
|
|
EP2531523A1
(de)
|
2010-02-05 |
2012-12-12 |
Ablynx N.V. |
An serumalbumin bindende peptide und verbindungen, konstrukte und polypeptide damit
|
|
US9120855B2
(en)
|
2010-02-10 |
2015-09-01 |
Novartis Ag |
Biologic compounds directed against death receptor 5
|
|
SI2533761T1
(sl)
|
2010-02-11 |
2019-08-30 |
Ablynx N.V. |
Postopki in sestavki za pripravo aerosolov
|
|
US9556273B2
(en)
|
2010-03-29 |
2017-01-31 |
Vib Vzw |
Anti-macrophage mannose receptor single variable domains for targeting and in vivo imaging of tumor-associated macrophages
|
|
US9101674B2
(en)
|
2010-03-29 |
2015-08-11 |
Vib Vzw |
Targeting and in vivo imaging of tumor-associated macrophages
|
|
US9932403B2
(en)
|
2010-05-20 |
2018-04-03 |
Ablynx Nv |
Biological materials related to HER3
|
|
WO2011161263A1
(en)
|
2010-06-25 |
2011-12-29 |
Ablynx Nv |
Pharmaceutical compositions for cutaneous administration
|
|
GB201014715D0
(en)
|
2010-09-06 |
2010-10-20 |
Vib Vzw |
Nanobodies stabilizing functional conformational states of GPCRS
|
|
PL2609119T3
(pl)
|
2010-08-26 |
2018-02-28 |
Agrosavfe N.V. |
Białka wiążące chitynowy sacharydowy antygen
|
|
EP2632946B1
(de)
|
2010-10-29 |
2017-12-06 |
Ablynx N.V. |
Verfahren zur herstellung von variablen immunglobulin-einzeldomänen
|
|
WO2012130872A1
(en)
|
2011-03-28 |
2012-10-04 |
Ablynx Nv |
Method for producing solid formulations comprising immunoglobulin single variable domains
|
|
UA117218C2
(uk)
|
2011-05-05 |
2018-07-10 |
Мерк Патент Гмбх |
Поліпептид, спрямований проти il-17a, il-17f та/або il17-a/f
|
|
EP3590950A1
(de)
|
2011-05-09 |
2020-01-08 |
Ablynx NV |
Verfahren zur herstellung von einzelvariablen immunglobulindomänen
|
|
US9505840B2
(en)
|
2011-05-27 |
2016-11-29 |
Ablynx N.V. |
Inhibition of bone resorption with RANKL binding peptides
|
|
US9695227B2
(en)
|
2011-06-21 |
2017-07-04 |
Vrije Universiteit Brussel |
Binding domains directed against GPCR:G protein complexes and uses derived thereof
|
|
AU2012273928A1
(en)
|
2011-06-23 |
2014-02-06 |
Ablynx Nv |
Immunoglobulin single variable domains directed against IgE
|
|
WO2013041722A1
(en)
|
2011-09-23 |
2013-03-28 |
Ablynx Nv |
Prolonged inhibition of interleukin-6 mediated signaling
|
|
US10112987B2
(en)
|
2012-01-09 |
2018-10-30 |
Icb International, Inc. |
Blood-brain barrier permeable peptide compositions comprising a vab domain of a camelid single domain heavy chain antibody against an amyloid-beta peptide
|
|
US10112988B2
(en)
|
2012-01-09 |
2018-10-30 |
Icb International, Inc. |
Methods of assessing amyloid-beta peptides in the central nervous system by blood-brain barrier permeable peptide compositions comprising a vab domain of a camelid single domain heavy chain antibody against an anti-amyloid-beta peptide
|
|
EP2617732A1
(de)
|
2012-01-19 |
2013-07-24 |
Vib Vzw |
Werkzeuge und Verfahren zur Expression von Membranproteinen
|
|
ES2715279T3
(es)
|
2012-05-24 |
2019-06-03 |
Vib Vzw |
Dominios variables individuales inmunoglobulínicos anti-receptor de manosa de macrófagos para elegir como diana y obtener imágenes in vivo de macrófagos asociados a tumores
|
|
WO2014087010A1
(en)
|
2012-12-07 |
2014-06-12 |
Ablynx N.V. |
IMPROVED POLYPEPTIDES DIRECTED AGAINST IgE
|
|
DK2951201T3
(en)
|
2013-01-30 |
2018-01-08 |
Vib Vzw |
Novel chimeric polypeptides for screening and drug detection purposes
|
|
US9553473B2
(en)
|
2013-02-04 |
2017-01-24 |
Ossia Inc. |
Systems and methods for optimally delivering pulsed wireless power
|
|
WO2014122183A1
(en)
|
2013-02-05 |
2014-08-14 |
Vib Vzw |
Muscarinic acetylcholine receptor binding agents and uses thereof
|
|
US9617339B2
(en)
|
2013-03-15 |
2017-04-11 |
Vib Vzw |
Method of imaging a cardiovascular disease with an anti-macrophage mannose receptor immunoglobulin single variable domain
|
|
CN114732017A
(zh)
|
2013-04-29 |
2022-07-12 |
阿格罗塞文公司 |
包含结合至鞘脂的抗体的农用化学组合物
|
|
NL1040254C2
(en)
|
2013-05-17 |
2014-11-24 |
Ablynx Nv |
Stable formulations of immunoglobulin single variable domains and uses thereof.
|
|
EP2883883A1
(de)
|
2013-12-16 |
2015-06-17 |
Cardio3 Biosciences S.A. |
Therapeutische Ziele und Mittel zur Behandlung von ischämiebedingten Reperfusionsschäden
|
|
WO2015121092A1
(en)
|
2014-01-30 |
2015-08-20 |
Vib Vzw |
Opioid receptor binding agents and uses thereof
|
|
NL2013661B1
(en)
|
2014-10-21 |
2016-10-05 |
Ablynx Nv |
KV1.3 Binding immunoglobulins.
|
|
PT3194976T
(pt)
|
2014-07-22 |
2020-07-03 |
Univ Brussel Vrije |
Métodos para selecionar agentes que estabilizam complexos proteicos
|
|
WO2016016329A1
(en)
|
2014-07-29 |
2016-02-04 |
Vrije Universiteit Brussel |
Radio-labelled antibody fragments for use in the prognosis, diagnosis of cancer as well as for the prediction of cancer therapy response
|
|
JP6289733B2
(ja)
|
2014-07-29 |
2018-03-07 |
フレイエ ユニヴェルシテイト ブリュッセルVrije Universiteit Brussel |
癌の予防及び/又は治療に用いるための放射標識抗体断片
|
|
US10858666B2
(en)
|
2014-11-05 |
2020-12-08 |
Biotalys |
Transgenic plants expressing a variable domain of a heavy chain antibody (VHH) that binds to a sphingolipid of a fungus
|
|
AU2015366284B2
(en)
|
2014-12-19 |
2021-07-22 |
Ablynx N.V. |
Cysteine linked nanobody dimers
|
|
EP3297672B1
(de)
|
2015-05-21 |
2021-09-01 |
Harpoon Therapeutics, Inc. |
Trispezifische bindungsproteine und verfahren zur verwendung
|
|
KR20250174696A
(ko)
|
2015-07-17 |
2025-12-12 |
브리제 유니버시타이트 브루셀 |
암 치료에 사용하기 위한 방사성 표지된 항체 단편
|
|
CN105384825B
(zh)
|
2015-08-11 |
2018-06-01 |
南京传奇生物科技有限公司 |
一种基于单域抗体的双特异性嵌合抗原受体及其应用
|
|
MX2018002090A
(es)
|
2015-08-24 |
2018-09-12 |
Halo Bio Rnai Therapeutics Inc |
Nanoparticulas de polinucleótido para modulación de expresión génica y sus usos.
|
|
CA3006398A1
(en)
|
2015-11-27 |
2017-06-01 |
Ablynx Nv |
Polypeptides inhibiting cd40l
|
|
CN109071632B
(zh)
|
2016-02-05 |
2022-12-30 |
奥里尼斯生物科学私人有限公司 |
靶向性治疗剂及其用途
|
|
US11248057B2
(en)
|
2016-03-07 |
2022-02-15 |
Vib Vzw |
CD20 binding single domain antibodies
|
|
WO2017158436A1
(en)
|
2016-03-17 |
2017-09-21 |
Oslo Universitetssykehus Hf |
Fusion proteins targeting tumour associated macrophages for treating cancer
|
|
WO2017182605A1
(en)
|
2016-04-22 |
2017-10-26 |
Université Libre de Bruxelles |
A new biomarker expressed in pancreatic beta cells useful in imaging or targeting beta cells
|
|
US11243214B2
(en)
|
2016-04-22 |
2022-02-08 |
Université Libre de Bruxelles |
Biomarker expressed in pancreatic beta cells useful in imaging or targeting beta cells
|
|
WO2017191108A1
(en)
|
2016-05-02 |
2017-11-09 |
Ablynx Nv |
Treatment of rsv infection
|
|
EP3455245A2
(de)
|
2016-05-13 |
2019-03-20 |
Orionis Biosciences NV |
Therapeutisches targeting von nichtzellulären strukturen
|
|
HRP20251020T1
(hr)
|
2016-05-20 |
2025-10-24 |
Harpoon Therapeutics, Inc. |
Proteini s jednolančanim varijabilnim fragmentom koji vežu cd3
|
|
KR102530742B1
(ko)
|
2016-05-20 |
2023-05-09 |
하푼 테라퓨틱스, 인크. |
단일 도메인 혈청 알부민 결합 단백질
|
|
US11623958B2
(en)
|
2016-05-20 |
2023-04-11 |
Harpoon Therapeutics, Inc. |
Single chain variable fragment CD3 binding proteins
|
|
WO2018007442A1
(en)
|
2016-07-06 |
2018-01-11 |
Ablynx N.V. |
Treatment of il-6r related diseases
|
|
WO2018014260A1
(en)
|
2016-07-20 |
2018-01-25 |
Nanjing Legend Biotech Co., Ltd. |
Multispecific antigen binding proteins and methods of use thereof
|
|
WO2018029182A1
(en)
|
2016-08-08 |
2018-02-15 |
Ablynx N.V. |
Il-6r single variable domain antibodies for treatment of il-6r related diseases
|
|
PL3896091T3
(pl)
|
2016-08-10 |
2024-04-29 |
Legend Biotech Ireland Limited |
Chimeryczne receptory antygenowe nakierowane na bcma i sposoby ich zastosowania
|
|
US11098113B2
(en)
|
2016-09-15 |
2021-08-24 |
Vib Vzw |
Immunoglobulin single variable domains directed against macrophage migration inhibitory factor
|
|
WO2018068201A1
(en)
|
2016-10-11 |
2018-04-19 |
Nanjing Legend Biotech Co., Ltd. |
Single-domain antibodies and variants thereof against ctla-4
|
|
WO2018069480A1
(en)
*
|
2016-10-14 |
2018-04-19 |
Institut Curie |
New anti-lsp1 antibody
|
|
US11840569B2
(en)
|
2016-11-16 |
2023-12-12 |
Ablynx N.V. |
T cell recruiting polypeptides capable of binding CD123 and TCR alpha/beta
|
|
JP7215997B2
(ja)
|
2016-11-23 |
2023-01-31 |
ハープーン セラピューティクス,インク. |
前立腺特異的膜抗原(psma)を標的とする三重特異性タンパク質と使用方法
|
|
KR102275008B1
(ko)
|
2016-11-23 |
2021-07-13 |
하푼 테라퓨틱스, 인크. |
전립선 특이 막 항원 결합 단백질
|
|
WO2018099968A1
(en)
|
2016-11-29 |
2018-06-07 |
Ablynx N.V. |
Treatment of infection by respiratory syncytial virus (rsv)
|
|
KR102642385B1
(ko)
|
2017-02-06 |
2024-03-04 |
오리오니스 바이오사이언시스 엔브이 |
표적화된 키메라 단백질 및 이의 용도
|
|
WO2018160754A2
(en)
|
2017-02-28 |
2018-09-07 |
Harpoon Therapeutics, Inc. |
Inducible monovalent antigen binding protein
|
|
JP7186401B2
(ja)
|
2017-02-28 |
2022-12-09 |
フエー・イー・ベー・フエー・ゼツト・ウエー |
タンパク質の経口送達のための手段及び方法
|
|
CA3058290A1
(en)
|
2017-04-18 |
2018-10-25 |
Universite Libre De Bruxelles |
Biomarkers and targets for proliferative diseases
|
|
KR20200005635A
(ko)
|
2017-05-11 |
2020-01-15 |
브이아이비 브이지더블유 |
가변 면역글로불린 도메인의 글리코실화
|
|
SG10202107880XA
(en)
|
2017-05-12 |
2021-09-29 |
Harpoon Therapeutics Inc |
Mesothelin binding proteins
|
|
US10730954B2
(en)
|
2017-05-12 |
2020-08-04 |
Harpoon Therapeutics, Inc. |
MSLN targeting trispecific proteins and methods of use
|
|
WO2018222587A1
(en)
|
2017-05-30 |
2018-12-06 |
The Regents Of The University Of California |
NANOBODIES AGAINST CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR (CFTR) INHIBITORY FACTOR (Cif)
|
|
CN110997001A
(zh)
|
2017-06-02 |
2020-04-10 |
默克专利股份有限公司 |
Mmp13结合免疫球蛋白
|
|
IL270951B2
(en)
|
2017-06-02 |
2025-05-01 |
Merck Patent Gmbh |
ADAMTS5, MMP13 and aggrecan-binding polypeptides
|
|
CN118085076A
(zh)
|
2017-06-02 |
2024-05-28 |
埃博灵克斯股份有限公司 |
结合聚集蛋白聚糖的免疫球蛋白
|
|
US11261260B2
(en)
|
2017-06-02 |
2022-03-01 |
Merck Patent Gmbh |
ADAMTS binding immunoglobulins
|
|
WO2019000223A1
(en)
|
2017-06-27 |
2019-01-03 |
Nanjing Legend Biotech Co., Ltd. |
ENABLERS OF IMMUNE EFFECTOR CELLS OF CHIMERIC ANTIBODIES AND METHODS OF USE THEREOF
|
|
CA3070253A1
(en)
|
2017-07-19 |
2019-01-24 |
Vib Vzw |
Serum albumin binding agents
|
|
CA3078969A1
(en)
|
2017-10-13 |
2019-04-18 |
Harpoon Therapeutics, Inc. |
Trispecific proteins and methods of use
|
|
IL315737A
(en)
|
2017-10-13 |
2024-11-01 |
Harpoon Therapeutics Inc |
B-cell maturation antigen-binding proteins
|
|
EP4635987A3
(de)
|
2017-10-31 |
2026-01-14 |
Vib Vzw |
Neue antigenbindende chimäre proteine sowie verfahren und verwendungen davon
|
|
SG11202004158QA
(en)
|
2017-12-28 |
2020-06-29 |
Nanjing Legend Biotech Co Ltd |
Single-domain antibodies and variants thereof against tigit
|
|
CA3084518A1
(en)
|
2018-01-15 |
2019-07-18 |
Nanjing Legend Biotech Co., Ltd. |
Single-domain antibodies and variants thereof against pd-1
|
|
US12655186B2
(en)
|
2018-01-26 |
2026-06-16 |
Orionis Biosciences, Inc. |
Chimeric protein comprising anti-XCR1 antibody and modified interferon alpha 2
|
|
CA3090406A1
(en)
|
2018-02-05 |
2019-08-08 |
Orionis Biosciences, Inc. |
Fibroblast binding agents and use thereof
|
|
WO2019155041A1
(en)
|
2018-02-12 |
2019-08-15 |
Vib Vzw |
Gβγ COMPLEX ANTIBODIES AND USES THEREOF
|
|
WO2019166622A1
(en)
|
2018-03-01 |
2019-09-06 |
Vrije Universiteit Brussel |
Human pd-l1-binding immunoglobulins
|
|
BR112020018235A2
(pt)
*
|
2018-03-14 |
2020-12-29 |
F. Hoffmann-La Roche Ag |
Métodos para gerar uma biblioteca de polinucleotídeos, bibliotecas de polinucleotídeos, uso de uma biblioteca, método para gerar uma biblioteca de anticorpos e método de seleção de um anticorpo
|
|
JP7390729B2
(ja)
|
2018-03-23 |
2023-12-04 |
ユニヴェルシテ リブル ドゥ ブリュッセル |
Wntシグナル伝達アゴニスト分子
|
|
JP2021519093A
(ja)
|
2018-03-27 |
2021-08-10 |
ユーエムシー ユトレヒト ホールディング ビー.ブイ. |
微小血管血栓症の処置のための標的化血栓溶解
|
|
AU2019241350B2
(en)
|
2018-03-30 |
2025-10-02 |
Nanjing Legend Biotech Co., Ltd. |
Single-domain antibodies against LAG-3 and uses thereof
|
|
MX2020012217A
(es)
|
2018-05-14 |
2021-03-02 |
Harpoon Therapeutics Inc |
Porción de unión para activación condicional de moléculas de inmunoglobulina.
|
|
US12195544B2
(en)
|
2018-09-21 |
2025-01-14 |
Harpoon Therapeutics, Inc. |
EGFR binding proteins and methods of use
|
|
CN119306844A
(zh)
|
2018-09-25 |
2025-01-14 |
哈普恩治疗公司 |
Dll3结合蛋白及使用方法
|
|
EP3890773A4
(de)
|
2018-11-08 |
2022-11-09 |
Orionis Biosciences, Inc. |
Modulation von dendritischen zelllinien
|
|
CA3131689A1
(en)
|
2019-02-26 |
2020-09-03 |
Twist Bioscience Corporation |
Variant nucleic acid libraries for glp1 receptor
|
|
WO2020198665A1
(en)
|
2019-03-28 |
2020-10-01 |
Orionis Biosciences, Inc. |
Fibroblast activation protein binding agents and use thereof
|
|
CA3314168A1
(en)
|
2019-04-29 |
2026-08-05 |
Confo Therapeutics N.V. |
Screening methods and assays for use with transmembrane proteins, in particular with gpcrs
|
|
US20220289837A1
(en)
|
2019-04-30 |
2022-09-15 |
Vib Vzw |
Cystic Fibrosis Transmembrane Conductance Regulator Stabilizing Agents
|
|
WO2020232303A1
(en)
|
2019-05-14 |
2020-11-19 |
Harpoon Therapeutics, Inc. |
EpCAM BINDING PROTEINS AND METHODS OF USE
|
|
WO2020239945A1
(en)
|
2019-05-28 |
2020-12-03 |
Vib Vzw |
Cancer treatment by targeting plexins in the immune compartment
|
|
EP3976067A1
(de)
|
2019-05-28 |
2022-04-06 |
Vib Vzw |
Cd8+-t-zellen ohne plexine und ihre anwendung zur krebsbehandlung
|
|
CN115023440B
(zh)
|
2019-09-23 |
2025-09-12 |
特韦斯特生物科学公司 |
结合CD3ε的抗体
|
|
US20220380456A1
(en)
|
2019-10-21 |
2022-12-01 |
Vib Vzw |
Nanodisc-specific antigen-binding chimeric proteins
|
|
CA3160506A1
(en)
|
2019-11-11 |
2021-05-20 |
Ibi-Ag Innovative Bio Insecticides Ltd. |
Insect control nanobodies and uses thereof
|
|
CA3158991A1
(en)
|
2019-11-27 |
2021-06-03 |
Vib Vzw |
Positive allosteric modulators of the calcium-sensing receptor
|
|
GB201918279D0
(en)
|
2019-12-12 |
2020-01-29 |
Vib Vzw |
Glycosylated single chain immunoglobulin domains
|
|
WO2021123360A1
(en)
|
2019-12-20 |
2021-06-24 |
Vib Vzw |
Nanobody exchange chromatography
|
|
WO2021140205A1
(en)
|
2020-01-10 |
2021-07-15 |
Confo Therapeutics N.V. |
Methods for generating antibodies and antibody fragments and libraries comprising same
|
|
WO2021156490A2
(en)
|
2020-02-06 |
2021-08-12 |
Vib Vzw |
Corona virus binders
|
|
BR112022016550A2
(pt)
|
2020-02-21 |
2022-11-16 |
Harpoon Therapeutics Inc |
Proteínas de ligação a flt3 e métodos de uso
|
|
CA3173090A1
(en)
|
2020-02-25 |
2021-09-02 |
Vib Vzw |
Leucine-rich repeat kinase 2 allosteric modulators
|
|
AU2021250446A1
(en)
|
2020-03-31 |
2022-11-17 |
Biotalys NV |
Anti-fungal polypeptides
|
|
EP4144758A4
(de)
|
2020-04-22 |
2024-05-15 |
Mabwell (Shanghai) Bioscience Co., Ltd. |
Gegen den humanen liganden 1 für programmierten zelltod (pd-l1) gerichteter einzelvariabler domänenantikörper und derivat davon
|
|
WO2021229104A1
(en)
|
2020-05-15 |
2021-11-18 |
Université de Liège |
Anti-cd38 single-domain antibodies in disease monitoring and treatment
|
|
AU2021274836A1
(en)
|
2020-05-19 |
2023-01-05 |
Aarhus Universitet |
Lysm receptor motifs
|
|
WO2021257679A1
(en)
|
2020-06-17 |
2021-12-23 |
Janssen Biotech, Inc. |
Materials and methods for the manufacture of pluripotent stem cells
|
|
WO2022003156A1
(en)
|
2020-07-02 |
2022-01-06 |
Oncurious Nv |
Ccr8 non-blocking binders
|
|
CA3186065A1
(en)
|
2020-07-16 |
2022-01-20 |
Xiaohu FAN |
Cd19 binding molecules and uses thereof
|
|
JP7846667B2
(ja)
|
2020-07-16 |
2026-04-15 |
レジェンド バイオテック アイルランド リミテッド |
Cd20結合分子及びその使用
|
|
US20240279595A1
(en)
|
2020-07-31 |
2024-08-22 |
Biotalys NV |
Expression host
|
|
CA3190667A1
(en)
|
2020-08-26 |
2022-03-03 |
Aaron Sato |
Methods and compositions relating to glp1r variants
|
|
WO2022063947A1
(en)
|
2020-09-24 |
2022-03-31 |
Vib Vzw |
Combination of p2y6 inhibitors and immune checkpoint inhibitors
|
|
WO2022063957A1
(en)
|
2020-09-24 |
2022-03-31 |
Vib Vzw |
Biomarker for anti-tumor therapy
|
|
WO2022063984A1
(en)
|
2020-09-25 |
2022-03-31 |
Ablynx Nv |
Polypeptides comprising immunoglobulin single variable domains targeting il-13 and ox40l
|
|
WO2022117569A1
(en)
|
2020-12-02 |
2022-06-09 |
Oncurious Nv |
A ccr8 antagonist antibody in combination with a lymphotoxin beta receptor agonist antibody in therapy against cancer
|
|
JP2024508207A
(ja)
|
2020-12-02 |
2024-02-26 |
ブイアイビー ブイゼットダブリュ |
がんに対する組み合わせ治療におけるltbrアゴニスト
|
|
WO2022129572A1
(en)
|
2020-12-18 |
2022-06-23 |
Ablynx Nv |
Polypeptides comprising immunoglobulin single variable domains targeting il-6 and tnf-alpha
|
|
GB202020502D0
(en)
|
2020-12-23 |
2021-02-03 |
Vib Vzw |
Antibody composistion for treatment of corona virus infection
|
|
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(de)
|
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2023-11-01 |
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Menschliche ccr8-bindemittel
|
|
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(en)
|
2020-12-24 |
2022-06-30 |
Vib Vzw |
Murine cross-reactive human ccr8 binders
|
|
WO2022136649A1
(en)
|
2020-12-24 |
2022-06-30 |
Oncurious Nv |
Non-blocking human ccr8 binders
|
|
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(en)
|
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2022-07-28 |
Vrije Universiteit Brussel |
Method and kit for labeling a biomolecule with one or more detectable labels, including a radiolabel
|
|
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(en)
|
2021-01-25 |
2022-07-28 |
Vrije Universiteit Brussel |
Compositions and kits for in vivo imaging of cardiac sarcoidosis
|
|
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(en)
|
2021-01-25 |
2022-07-28 |
Vrije Universiteit Brussel |
Method for preparing a lyophilized composition
|
|
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(de)
|
2021-02-05 |
2023-12-13 |
Vib Vzw |
Sarbecovirus-bindemittel
|
|
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(zh)
|
2021-02-05 |
2024-03-29 |
Vib研究所 |
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|
|
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(zh)
|
2021-02-17 |
2023-12-15 |
非营利性组织佛兰芒综合大学生物技术研究所 |
在癌症治疗中slc4a4的抑制
|
|
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(pt)
|
2021-02-19 |
2023-10-31 |
Seoul Nat Univ R&Db Foundation |
Anticorpo ou um fragmento de ligação ao antígeno do mesmo, molécula de ácido nucleico, métodos para produzir um anticorpo ou um fragmento de ligação ao antígeno do mesmo e para detectar agrupamento de diferenciação 47 ou determinar uma quantidade de agrupamento de diferenciação 47 em uma amostra, e, uso do anticorpo ou de um fragmento de ligação ao antígeno do mesmo
|
|
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(de)
|
2021-02-19 |
2023-12-27 |
The United States of America, as represented by The Secretary, Department of Health and Human Services |
Einzeldomänenantikörper zur neutralisierung von sars-cov-2
|
|
BR112023016706A2
(pt)
|
2021-02-19 |
2023-10-31 |
Seoul Nat Univ R&Db Foundation |
Anticorpo ou um fragmento de ligação ao antígeno do mesmo, molécula de ácido nucleico, métodos para produzir um anticorpo ou um fragmento de ligação ao antígeno do mesmo e para detectar agrupamento de diferenciação 47 ou determinar uma quantidade de agrupamento de diferenciação 47 em uma amostra, e, uso do anticorpo ou de um fragmento de ligação ao antígeno do mesmo
|
|
US20250263490A1
(en)
|
2021-02-19 |
2025-08-21 |
Vib Vzw |
Cation-Independent Mannose-6-Phosphate Receptor Binders
|
|
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(zh)
|
2021-02-19 |
2023-10-20 |
沙裴隆有限公司 |
针对pd-l1及cd47的双特异性单域抗体及其用途
|
|
JP2024507958A
(ja)
|
2021-02-26 |
2024-02-21 |
ナンジン レジェンド バイオテック カンパニー,リミテッド |
外因的に導入されたサイトカインを発現する操作された免疫エフェクター細胞
|
|
WO2022199804A1
(en)
|
2021-03-24 |
2022-09-29 |
Vib Vzw |
Nek6 inhibition to treat als and ftd
|
|
WO2022242892A1
(en)
|
2021-05-17 |
2022-11-24 |
Université de Liège |
Anti-cd38 single-domain antibodies in disease monitoring and treatment
|
|
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(en)
|
2021-06-23 |
2022-12-29 |
Vib Vzw |
Means and methods for selection of specific binders
|
|
US20230174651A1
(en)
|
2021-06-23 |
2023-06-08 |
Janssen Biotech, Inc. |
Materials and methods for hinge regions in functional exogenous receptors
|
|
JP2024524378A
(ja)
|
2021-06-29 |
2024-07-05 |
山▲東▼先声生物制▲薬▼有限公司 |
Cd16抗体及びその応用
|
|
US20240343803A1
(en)
|
2021-07-30 |
2024-10-17 |
Shandong Simcere Biopharmaceutical Co., Ltd. |
Anti-Pvrig/Anti-Tigit Bispecific Antibodies And Applications Thereof
|
|
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(de)
|
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2024-06-05 |
Vib Vzw |
Kationunabhängige mannose-6-phosphat-rezeptorbindemittel für gezielten proteinabbau
|
|
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(en)
|
2021-10-05 |
2025-01-09 |
Vrije Universiteit Brussel |
Fluorescently Labeled Immunoglobulin Single Variable Domains
|
|
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(en)
|
2021-10-06 |
2023-04-13 |
Biotalys NV |
Anti-fungal polypeptides
|
|
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(de)
|
2021-12-03 |
2026-03-04 |
Shandong Simcere Biopharmaceutical Co., Ltd. |
Anti-bcma-nanokörper und verwendung davon
|
|
TW202342508A
(zh)
|
2021-12-17 |
2023-11-01 |
比利時商艾伯霖克斯公司 |
包含靶向TCRαβ、CD33和CD123的免疫球蛋白單可變結構域的多肽
|
|
WO2023125888A1
(zh)
|
2021-12-31 |
2023-07-06 |
山东先声生物制药有限公司 |
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|
|
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(de)
|
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2024-11-20 |
Vib Vzw |
Humane ntcp-bindemittel für therapeutische verwendung und leberspezifische gezielte abgabe
|
|
WO2023148291A1
(en)
|
2022-02-02 |
2023-08-10 |
Biotalys NV |
Methods for genome editing
|
|
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(de)
|
2022-02-07 |
2024-12-18 |
Vib Vzw |
Gentechnisch veränderte stabilisierung aglycosylierter fc-regionen
|
|
US20250188120A1
(en)
|
2022-03-07 |
2025-06-12 |
Takeda Pharmaceutical Company Limited |
Affinity chromatographic production of clinical human igg products
|
|
US20250235534A1
(en)
|
2022-04-13 |
2025-07-24 |
Vib Vzw |
An LTBR Agonist In Combination Therapy Against Cancer
|
|
US20250289904A1
(en)
|
2022-05-02 |
2025-09-18 |
Umc Utrecht Holding B.V. |
Single domain antibodies for the detection of plasmin-cleaved vwf
|
|
US20250313611A1
(en)
|
2022-05-18 |
2025-10-09 |
Vib Vzw |
Sarbecovirus spike s2 subunit binders
|
|
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(zh)
|
2022-06-06 |
2023-12-14 |
山东先声生物制药有限公司 |
靶向bcma、gprc5d和t细胞的多特异性抗体及其应用
|
|
CN115012043A
(zh)
*
|
2022-07-01 |
2022-09-06 |
南京瑞源生物技术有限公司 |
一种构建纳米抗体文库的方法
|
|
US20250304677A1
(en)
|
2022-07-04 |
2025-10-02 |
Vib Vzw |
Blood-Cerebrospinal Fluid Barrier Crossing Antibodies
|
|
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(zh)
|
2022-07-22 |
2025-04-29 |
詹森生物科技公司 |
遗传指令向效应免疫细胞的增强转移
|
|
US20260159606A1
(en)
|
2022-09-27 |
2026-06-11 |
Vib Vzw |
Antivirals Against Human Parainfluenza Virus
|
|
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(de)
|
2022-10-05 |
2024-04-10 |
Vrije Universiteit Brussel |
Variable einzeldomänen des anti-urokinase-plasminogenaktivatorrezeptors immunglobulin
|
|
US20260103529A1
(en)
|
2022-10-18 |
2026-04-16 |
Confo Therapeutics N.V. |
Amino Acid Sequences Directed Against the Melanocortin 4 Receptor and Polypeptides Comprising the Same for the Treatment of MC4R-Related Diseases and Disorders
|
|
JP2025537809A
(ja)
|
2022-11-15 |
2025-11-20 |
アイメック・ヴェーゼットウェー |
液滴操作のための方法およびシステム
|
|
WO2024126805A1
(en)
|
2022-12-15 |
2024-06-20 |
Aarhus Universitet |
Synthetic activation of multimeric transmembrane receptors
|
|
EP4638735A1
(de)
|
2022-12-22 |
2025-10-29 |
Biotalys NV |
Verfahren zur genomeditierung
|
|
WO2024145551A1
(en)
|
2022-12-29 |
2024-07-04 |
Biotalys NV |
Agrochemical compositions
|
|
EP4642916A2
(de)
|
2022-12-30 |
2025-11-05 |
Biotalys NV |
Sekretionssignale
|
|
US20260096562A1
(en)
|
2022-12-30 |
2026-04-09 |
Biotalys NV |
Self-emulsifiable concentrate
|
|
EP4642233A1
(de)
|
2022-12-30 |
2025-11-05 |
Biotalys NV |
Agglomerat
|
|
US20260102527A1
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